Entry: PS00697

General information about the entry

Entry name [info] DNA_LIGASE_A1
Accession [info] PS00697
Entry type [info] PATTERN
Date [info] DEC-1992 (CREATED); APR-2006 (DATA UPDATE); JUN-2016 (INFO UPDATE).
PROSITE Doc. [info] PDOC00295
Associated ProRule [info] PRU10135

Name and characterization of the entry

Description [info] ATP-dependent DNA ligase AMP-binding site.
Pattern [info]
[EDQH]-{K}-K-{VEDI}-[DN]-G-{GLYN}-R-[GACIVM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2016_07 which contains 551'705 sequence entries.


Total number of hits 195 in 190 different sequences
Number of true positive hits 154 in 154 different sequences
Number of 'unknown' hits 0
Number of false positive hits 41 in 36 different sequences
Number of false negative sequences 15
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 78.97 %
Recall (true positives / (true positives + false negatives)) 91.12 %

Comments [info]

Taxonomic range [info] Archaea, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 4
Site [info] active_site(?) at position 3
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
154 sequences

DNLI1_ARATH (Q42572    ), DNLI1_CAEEL (Q27474    ), DNLI1_DICDI (Q869E1    ), 
DNLI1_DROME (Q9W1H4    ), DNLI1_HALWD (Q18HT7    ), DNLI1_HUMAN (P18858    ), 
DNLI1_KORCO (B1L3K8    ), DNLI1_METAC (Q8TSR7    ), DNLI1_METBF (Q46C04    ), 
DNLI1_METMA (Q8PVR7    ), DNLI1_MOUSE (P37913    ), DNLI1_SCHPO (P12000    ), 
DNLI1_XENLA (P51892    ), DNLI1_YEAST (P04819    ), DNLI2_HALWD (Q18GX5    ), 
DNLI2_KORCO (B1L3V2    ), DNLI2_METAC (Q8TMT1    ), DNLI2_METBF (Q46BA3    ), 
DNLI2_METMA (Q8PTK1    ), DNLI2_THEPD (A1RY72    ), DNLI3_DICDI (Q54QM4    ), 
DNLI3_HUMAN (P49916    ), DNLI3_MOUSE (P97386    ), DNLI3_SCHPO (Q9C1W9    ), 
DNLI4_ARATH (Q9LL84    ), DNLI4_ASHGO (Q75CA4    ), DNLI4_ASPFU (Q4WVG8    ), 
DNLI4_ASPOR (Q2U6A1    ), DNLI4_CANAL (P52496    ), DNLI4_CANGA (Q6FVD8    ), 
DNLI4_CHICK (Q90YB1    ), DNLI4_COCIM (Q1DKE7    ), DNLI4_COPC7 (A8N936    ), 
DNLI4_COPCI (Q7Z7W5    ), DNLI4_CRYNB (P0CN09    ), DNLI4_CRYNJ (P0CN08    ), 
DNLI4_EMENI (Q5BH83    ), DNLI4_HUMAN (P49917    ), DNLI4_MOUSE (Q8BTF7    ), 
DNLI4_NEUCR (Q7SB49    ), DNLI4_ORYSJ (Q7X7E9    ), DNLI4_PHANO (Q0UCI9    ), 
DNLI4_PONAB (Q5R6L3    ), DNLI4_SCHPO (O74833    ), DNLI4_YEAST (Q08387    ), 
DNLI_ACIAM  (Q02093    ), DNLI_AERPE  (Q9YD18    ), DNLI_ANAD2  (B8JBM1    ), 
DNLI_ANADE  (Q2IH69    ), DNLI_ANADF  (A7HID3    ), DNLI_ANASK  (B4UIS1    ), 
DNLI_AQUAE  (O67398    ), DNLI_ARCFU  (O29632    ), DNLI_ASFB7  (P35970    ), 
DNLI_ASFK5  (P0C992    ), DNLI_ASFM2  (P26813    ), DNLI_ASFP4  (P0C990    ), 
DNLI_ASFWA  (P0C991    ), DNLI_BEUC1  (C5BW79    ), DNLI_BPT3   (P07717    ), 
DNLI_BPT4   (P00970    ), DNLI_BPT6   (P19088    ), DNLI_BPT7   (P00969    ), 
DNLI_CALMQ  (A8MDU6    ), DNLI_CENSY  (A0RWD6    ), DNLI_DICT6  (B5YD88    ), 
DNLI_DICTD  (B8DZX8    ), DNLI_FOWPN  (Q67480    ), DNLI_HALLT  (B9LUZ9    ), 
DNLI_HALMA  (Q5V4R0    ), DNLI_HALS3  (B0R4C9    ), DNLI_HALSA  (Q9HR35    ), 
DNLI_HALVD  (D4GYZ4    ), DNLI_HYPBU  (A2BJX6    ), DNLI_IGNH4  (A8AB20    ), 
DNLI_KINRD  (A6WG40    ), DNLI_KORVE  (Q1II25    ), DNLI_META3  (A6UVC4    ), 
DNLI_METBU  (Q12X08    ), DNLI_METJA  (Q57635    ), DNLI_METKA  (Q8TWN3    ), 
DNLI_METM5  (A4FY19    ), DNLI_METM6  (A9AAX4    ), DNLI_METM7  (A6VFQ9    ), 
DNLI_METMP  (Q6LYM1    ), DNLI_METS5  (A4YD25    ), DNLI_METST  (Q2NHF9    ), 
DNLI_METTF  (P54875    ), DNLI_METTH  (Q50566    ), DNLI_METTP  (A0B7F9    ), 
DNLI_METVS  (A6UNY0    ), DNLI_MYCA1  (A0QJL0    ), DNLI_MYCBO  (Q7TTR7    ), 
DNLI_MYCBP  (A1KN60    ), DNLI_MYCBT  (C1AGI1    ), DNLI_MYCGI  (A4TDS2    ), 
DNLI_MYCMM  (B2HHE1    ), DNLI_MYCPA  (Q73V97    ), DNLI_MYCS2  (A0QUP1    ), 
DNLI_MYCSJ  (A3PXE2    ), DNLI_MYCSK  (A1UDY9    ), DNLI_MYCSS  (Q1BB26    ), 
DNLI_MYCTA  (A5U776    ), DNLI_MYCTO  (P9WNV4    ), DNLI_MYCTU  (P9WNV5    ), 
DNLI_MYCUA  (A0PTC0    ), DNLI_MYCVP  (A1T6P2    ), DNLI_NATPD  (Q3IPX0    ), 
DNLI_NITMS  (A9A3K1    ), DNLI_NOCFA  (Q5YNY7    ), DNLI_NOCSJ  (A1SKL2    ), 
DNLI_NPVLD  (Q9YMV2    ), DNLI_OPITP  (B1ZZL9    ), DNLI_PERMH  (C0QSL7    ), 
DNLI_PSECP  (B8HCE1    ), DNLI_PYRAB  (P0CL75    ), DNLI_PYRAE  (O93723    ), 
DNLI_PYRAR  (A4WH24    ), DNLI_PYRAY  (P0CL74    ), DNLI_PYRCJ  (A3MS62    ), 
DNLI_PYRFU  (P56709    ), DNLI_PYRHO  (O59288    ), DNLI_PYRIL  (A1RTK4    ), 
DNLI_PYRNV  (B1YA52    ), DNLI_RHOJR  (Q0SG75    ), DNLI_RHOOB  (C1AX87    ), 
DNLI_SACEN  (A4F870    ), DNLI_SORC5  (A9GU24    ), DNLI_STAMF  (A3DP49    ), 
DNLI_STRAW  (Q826P6    ), DNLI_STRCO  (Q9FCB1    ), DNLI_STRGG  (B1W5J2    ), 
DNLI_SULAC  (Q4JAM1    ), DNLI_SULIA  (C3MZR1    ), DNLI_SULIK  (C4KIZ2    ), 
DNLI_SULIL  (C3MJ14    ), DNLI_SULIM  (C3MYD2    ), DNLI_SULIN  (C3NF77    ), 
DNLI_SULIY  (C3N834    ), DNLI_SULSH  (Q9P9K9    ), DNLI_SULSO  (Q980T8    ), 
DNLI_SULTO  (Q976G4    ), DNLI_SULZI  (D2CJS7    ), DNLI_THEFM  (Q9HH07    ), 
DNLI_THEKO  (Q9HHC4    ), DNLI_THEON  (B6YTR4    ), DNLI_VACCA  (O57250    ), 
DNLI_VACCC  (P20492    ), DNLI_VACCW  (P16272    ), DNLI_VAR67  (P33798    ), 
LIG6_ARATH  (F4HPZ9    ), LIGC1_MYCS2 (A0R5T2    ), ROQA_PENRW  (B6HJU6    ), 
Y1287_AQUAE (O67319    )
» more

UniProtKB/Swiss-Prot
False negative sequences
15 sequences

DNLI1_RAT   (Q9JHY8    ), DNLI1_THEPD (A1RXA6    ), DNLI_HAEIN  (P44121    ), 
DNLI_METAR  (Q0W0X1    ), DNLI_METB6  (A7IAA9    ), DNLI_METHJ  (Q2FTH4    ), 
DNLI_METLZ  (A2SR38    ), DNLI_METMJ  (A3CWP1    ), DNLI_METPE  (B8GGB8    ), 
DNLI_METS3  (A5UKX2    ), DNLI_NANEQ  (Q74M64    ), DNLI_PICTO  (Q6L195    ), 
DNLI_THEAC  (Q9HJ26    ), DNLI_THEVO  (Q979A1    ), LIGD_BACSU  (O34398    )
» more

UniProtKB/Swiss-Prot
False positive sequences
36 sequences

ACVS_AMYLA  (P27743    ), ACVS_STRCL  (Q01757    ), AUBA_SULAC  (Q4J9H1    ), 
AUBA_THEKO  (Q5JHN3    ), BDP1_HUMAN  (A6H8Y1    ), BDP1_MOUSE  (Q571C7    ), 
CITS_BACSU  (O34427    ), COX20_YEAST (Q04935    ), DDHA_RHOSU  (Q8GPG4    ), 
DHOM_LACLA  (Q9CGD8    ), DHOM_LACLC  (P52985    ), DLTA_LACLA  (Q9CG49    ), 
DSBC_BORBR  (Q7WEL4    ), DSBC_BORPA  (Q7W396    ), DSBC_BORPE  (Q7VU58    ), 
ERF99_ARATH (Q8L9K1    ), FABH_PROMM  (Q7V4F6    ), FOLD_BUCAI  (P57557    ), 
HAGA1_PORGI (P59915    ), HAGA2_PORGN (Q51845    ), INO80_USTMA (Q4PGL2    ), 
KGP38_PORGN (P72194    ), KGP66_PORGN (P72197    ), KGP83_PORGN (Q51817    ), 
KGP_PORG3   (B2RLK2    ), KUP_ANADF   (A7H902    ), MNME_SULNB  (A6QAL0    ), 
NRPS1_ASPFU (Q4WT66    ), PAL2_SOLTU  (P31426    ), PDXB_PORGI  (Q7MV70    ), 
PKS1_DICDI  (Q55E72    ), QUEA_DEHM1  (Q3Z8C1    ), QUEA_STRGC  (A8AYK5    ), 
RIMM_SYNR3  (A5GQ79    ), U518_AEDAE  (Q17AI4    ), U518_ANOGA  (Q7PZ36    )
» more

PDB
[Detailed view]
11 PDB

1A0I; 1X9N; 2CFM; 2HIV; 2HIX; 3GDE; 3L2P; 3VNN; 3W1B; 3W1G; 3W5O

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