Entry: PS00697

General information about the entry

Entry name [info] DNA_LIGASE_A1
Accession [info] PS00697
Entry type [info] PATTERN
Date [info] DEC-1992 (CREATED); APR-2006 (DATA UPDATE); MAY-2015 (INFO UPDATE).
PROSITE Doc. [info] PDOC00295
Associated ProRule [info] PRU10135

Name and characterization of the entry

Description [info] ATP-dependent DNA ligase AMP-binding site.
Pattern [info]
[EDQH]-{K}-K-{VEDI}-[DN]-G-{GLYN}-R-[GACIVM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2015_07 which contains 548'872 sequence entries.


Total number of hits 193 in 188 different sequences
Number of true positive hits 152 in 152 different sequences
Number of 'unknown' hits 0
Number of false positive hits 41 in 36 different sequences
Number of false negative sequences 15
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 78.76 %
Recall (true positives / (true positives + false negatives)) 91.02 %

Comments [info]

Taxonomic range [info] Archaea, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 4
Site [info] active_site(?) at position 3
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
152 sequences

DNLI1_ARATH (Q42572), DNLI1_CAEEL (Q27474), DNLI1_DICDI (Q869E1), 
DNLI1_DROME (Q9W1H4), DNLI1_HALWD (Q18HT7), DNLI1_HUMAN (P18858), 
DNLI1_KORCO (B1L3K8), DNLI1_METAC (Q8TSR7), DNLI1_METBF (Q46C04), 
DNLI1_METMA (Q8PVR7), DNLI1_MOUSE (P37913), DNLI1_SCHPO (P12000), 
DNLI1_XENLA (P51892), DNLI1_YEAST (P04819), DNLI2_HALWD (Q18GX5), 
DNLI2_KORCO (B1L3V2), DNLI2_METAC (Q8TMT1), DNLI2_METBF (Q46BA3), 
DNLI2_METMA (Q8PTK1), DNLI2_THEPD (A1RY72), DNLI3_DICDI (Q54QM4), 
DNLI3_HUMAN (P49916), DNLI3_MOUSE (P97386), DNLI3_SCHPO (Q9C1W9), 
DNLI4_ARATH (Q9LL84), DNLI4_ASHGO (Q75CA4), DNLI4_ASPFU (Q4WVG8), 
DNLI4_ASPOR (Q2U6A1), DNLI4_CANAL (P52496), DNLI4_CANGA (Q6FVD8), 
DNLI4_CHICK (Q90YB1), DNLI4_COCIM (Q1DKE7), DNLI4_COPC7 (A8N936), 
DNLI4_COPCI (Q7Z7W5), DNLI4_CRYNB (P0CN09), DNLI4_CRYNJ (P0CN08), 
DNLI4_EMENI (Q5BH83), DNLI4_HUMAN (P49917), DNLI4_MOUSE (Q8BTF7), 
DNLI4_NEUCR (Q7SB49), DNLI4_ORYSJ (Q7X7E9), DNLI4_PHANO (Q0UCI9), 
DNLI4_PONAB (Q5R6L3), DNLI4_SCHPO (O74833), DNLI4_YEAST (Q08387), 
DNLI_ACIAM  (Q02093), DNLI_AERPE  (Q9YD18), DNLI_ANAD2  (B8JBM1), 
DNLI_ANADE  (Q2IH69), DNLI_ANADF  (A7HID3), DNLI_ANASK  (B4UIS1), 
DNLI_AQUAE  (O67398), DNLI_ARCFU  (O29632), DNLI_ARTCA  (B8HCE1), 
DNLI_ASFB7  (P35970), DNLI_ASFK5  (P0C992), DNLI_ASFM2  (P26813), 
DNLI_ASFP4  (P0C990), DNLI_ASFWA  (P0C991), DNLI_BEUC1  (C5BW79), 
DNLI_BPT3   (P07717), DNLI_BPT4   (P00970), DNLI_BPT6   (P19088), 
DNLI_BPT7   (P00969), DNLI_CALMQ  (A8MDU6), DNLI_CENSY  (A0RWD6), 
DNLI_DICT6  (B5YD88), DNLI_DICTD  (B8DZX8), DNLI_FOWPN  (Q67480), 
DNLI_HALLT  (B9LUZ9), DNLI_HALMA  (Q5V4R0), DNLI_HALS3  (B0R4C9), 
DNLI_HALSA  (Q9HR35), DNLI_HALVD  (D4GYZ4), DNLI_HYPBU  (A2BJX6), 
DNLI_IGNH4  (A8AB20), DNLI_KINRD  (A6WG40), DNLI_KORVE  (Q1II25), 
DNLI_META3  (A6UVC4), DNLI_METBU  (Q12X08), DNLI_METJA  (Q57635), 
DNLI_METKA  (Q8TWN3), DNLI_METM5  (A4FY19), DNLI_METM6  (A9AAX4), 
DNLI_METM7  (A6VFQ9), DNLI_METMP  (Q6LYM1), DNLI_METS5  (A4YD25), 
DNLI_METST  (Q2NHF9), DNLI_METTF  (P54875), DNLI_METTH  (Q50566), 
DNLI_METTP  (A0B7F9), DNLI_METVS  (A6UNY0), DNLI_MYCA1  (A0QJL0), 
DNLI_MYCBO  (Q7TTR7), DNLI_MYCBP  (A1KN60), DNLI_MYCBT  (C1AGI1), 
DNLI_MYCGI  (A4TDS2), DNLI_MYCMM  (B2HHE1), DNLI_MYCPA  (Q73V97), 
DNLI_MYCS2  (A0QUP1), DNLI_MYCSJ  (A3PXE2), DNLI_MYCSK  (A1UDY9), 
DNLI_MYCSS  (Q1BB26), DNLI_MYCTA  (A5U776), DNLI_MYCTO  (P9WNV4), 
DNLI_MYCTU  (P9WNV5), DNLI_MYCUA  (A0PTC0), DNLI_MYCVP  (A1T6P2), 
DNLI_NATPD  (Q3IPX0), DNLI_NITMS  (A9A3K1), DNLI_NOCFA  (Q5YNY7), 
DNLI_NOCSJ  (A1SKL2), DNLI_NPVLD  (Q9YMV2), DNLI_OPITP  (B1ZZL9), 
DNLI_PERMH  (C0QSL7), DNLI_PYRAB  (P0CL75), DNLI_PYRAE  (O93723), 
DNLI_PYRAR  (A4WH24), DNLI_PYRAY  (P0CL74), DNLI_PYRCJ  (A3MS62), 
DNLI_PYRFU  (P56709), DNLI_PYRHO  (O59288), DNLI_PYRIL  (A1RTK4), 
DNLI_PYRNV  (B1YA52), DNLI_RHOJR  (Q0SG75), DNLI_RHOOB  (C1AX87), 
DNLI_SACEN  (A4F870), DNLI_SORC5  (A9GU24), DNLI_STAMF  (A3DP49), 
DNLI_STRAW  (Q826P6), DNLI_STRCO  (Q9FCB1), DNLI_STRGG  (B1W5J2), 
DNLI_SULAC  (Q4JAM1), DNLI_SULIA  (C3MZR1), DNLI_SULIK  (C4KIZ2), 
DNLI_SULIL  (C3MJ14), DNLI_SULIM  (C3MYD2), DNLI_SULIN  (C3NF77), 
DNLI_SULIY  (C3N834), DNLI_SULSH  (Q9P9K9), DNLI_SULSO  (Q980T8), 
DNLI_SULTO  (Q976G4), DNLI_SULZI  (D2CJS7), DNLI_THEFM  (Q9HH07), 
DNLI_THEKO  (Q9HHC4), DNLI_THEON  (B6YTR4), DNLI_VACCA  (O57250), 
DNLI_VACCC  (P20492), DNLI_VACCW  (P16272), DNLI_VAR67  (P33798), 
LIGC1_MYCS2 (A0R5T2), Y1287_AQUAE (O67319)
» More

UniProtKB/Swiss-Prot
False negative sequences
15 sequences

DNLI1_RAT   (Q9JHY8), DNLI1_THEPD (A1RXA6), DNLI_HAEIN  (P44121), 
DNLI_METAR  (Q0W0X1), DNLI_METB6  (A7IAA9), DNLI_METHJ  (Q2FTH4), 
DNLI_METLZ  (A2SR38), DNLI_METMJ  (A3CWP1), DNLI_METPE  (B8GGB8), 
DNLI_METS3  (A5UKX2), DNLI_NANEQ  (Q74M64), DNLI_PICTO  (Q6L195), 
DNLI_THEAC  (Q9HJ26), DNLI_THEVO  (Q979A1), LIGD_BACSU  (O34398)
» More

UniProtKB/Swiss-Prot
False positive sequences
36 sequences

ACVS_AMYLA  (P27743), ACVS_STRCL  (Q01757), AUBA_SULAC  (Q4J9H1), 
AUBA_THEKO  (Q5JHN3), BDP1_HUMAN  (A6H8Y1), BDP1_MOUSE  (Q571C7), 
CITS_BACSU  (O34427), COX20_YEAST (Q04935), DDHA_RHOSU  (Q8GPG4), 
DHOM_LACLA  (Q9CGD8), DHOM_LACLC  (P52985), DLTA_LACLA  (Q9CG49), 
DSBC_BORBR  (Q7WEL4), DSBC_BORPA  (Q7W396), DSBC_BORPE  (Q7VU58), 
ERF99_ARATH (Q8L9K1), FABH_PROMM  (Q7V4F6), FOLD_BUCAI  (P57557), 
HAGA1_PORGI (P59915), HAGA2_PORGN (Q51845), INO80_USTMA (Q4PGL2), 
KGP38_PORGN (P72194), KGP66_PORGN (P72197), KGP83_PORGN (Q51817), 
KGP_PORG3   (B2RLK2), KUP_ANADF   (A7H902), MNME_SULNB  (A6QAL0), 
NRPS1_ASPFU (Q4WT66), PAL2_SOLTU  (P31426), PDXB_PORGI  (Q7MV70), 
PKS1_DICDI  (Q55E72), QUEA_DEHM1  (Q3Z8C1), QUEA_STRGC  (A8AYK5), 
RIMM_SYNR3  (A5GQ79), U518_AEDAE  (Q17AI4), U518_ANOGA  (Q7PZ36)
» More

PDB
[Detailed view]
11 PDB

1A0I; 1X9N; 2CFM; 2HIV; 2HIX; 3GDE; 3L2P; 3VNN; 3W1B; 3W1G; 3W5O

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