Entry: PS00697

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General information about the entry

Entry name [info] DNA_LIGASE_A1
Accession [info] PS00697
Entry type [info] PATTERN
Date [info] DEC-1992 (CREATED); APR-2006 (DATA UPDATE); SEP-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC00295
Associated ProRule [info] PRU10135

Name and characterization of the entry

Description [info] ATP-dependent DNA ligase AMP-binding site.
Pattern [info]
[EDQH]-{K}-K-{VEDI}-[DN]-G-{GLYN}-R-[GACIVM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_10 which contains 546'790 sequence entries.


Total number of hits 191 in 186 different sequences
Number of true positive hits 150 in 150 different sequences
Number of 'unknown' hits
Number of false positive hits 41 in 36 different sequences
Number of false negative sequences 15
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 78.53 %
Recall (true positives / (true positives + false negatives)) 90.91 %

Comments [info]

Taxonomic range [info] Archaea, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 4
Site [info] active_site(?) at position 3
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
150 sequences

DNLI1_ARATH (Q42572), DNLI1_CAEEL (Q27474), DNLI1_DICDI (Q869E1), 
DNLI1_DROME (Q9W1H4), DNLI1_HALWD (Q18HT7), DNLI1_HUMAN (P18858), 
DNLI1_KORCO (B1L3K8), DNLI1_METAC (Q8TSR7), DNLI1_METBF (Q46C04), 
DNLI1_METMA (Q8PVR7), DNLI1_MOUSE (P37913), DNLI1_SCHPO (P12000), 
DNLI1_XENLA (P51892), DNLI1_YEAST (P04819), DNLI2_HALWD (Q18GX5), 
DNLI2_KORCO (B1L3V2), DNLI2_METAC (Q8TMT1), DNLI2_METBF (Q46BA3), 
DNLI2_METMA (Q8PTK1), DNLI2_THEPD (A1RY72), DNLI3_DICDI (Q54QM4), 
DNLI3_HUMAN (P49916), DNLI3_MOUSE (P97386), DNLI3_SCHPO (Q9C1W9), 
DNLI4_ARATH (Q9LL84), DNLI4_ASHGO (Q75CA4), DNLI4_ASPFU (Q4WVG8), 
DNLI4_ASPOR (Q2U6A1), DNLI4_CANAL (P52496), DNLI4_CANGA (Q6FVD8), 
DNLI4_CHICK (Q90YB1), DNLI4_COCIM (Q1DKE7), DNLI4_COPC7 (A8N936), 
DNLI4_COPCI (Q7Z7W5), DNLI4_CRYNB (P0CN09), DNLI4_CRYNJ (P0CN08), 
DNLI4_EMENI (Q5BH83), DNLI4_HUMAN (P49917), DNLI4_MOUSE (Q8BTF7), 
DNLI4_NEUCR (Q7SB49), DNLI4_ORYSJ (Q7X7E9), DNLI4_PHANO (Q0UCI9), 
DNLI4_PONAB (Q5R6L3), DNLI4_SCHPO (O74833), DNLI4_YEAST (Q08387), 
DNLI_ACIAM  (Q02093), DNLI_AERPE  (Q9YD18), DNLI_ANAD2  (B8JBM1), 
DNLI_ANADE  (Q2IH69), DNLI_ANADF  (A7HID3), DNLI_ANASK  (B4UIS1), 
DNLI_AQUAE  (O67398), DNLI_ARCFU  (O29632), DNLI_ARTCA  (B8HCE1), 
DNLI_ASFB7  (P35970), DNLI_ASFK5  (P0C992), DNLI_ASFM2  (P26813), 
DNLI_ASFP4  (P0C990), DNLI_ASFWA  (P0C991), DNLI_BEUC1  (C5BW79), 
DNLI_BPT3   (P07717), DNLI_BPT4   (P00970), DNLI_BPT6   (P19088), 
DNLI_BPT7   (P00969), DNLI_CALMQ  (A8MDU6), DNLI_CENSY  (A0RWD6), 
DNLI_DICT6  (B5YD88), DNLI_DICTD  (B8DZX8), DNLI_FOWPN  (Q67480), 
DNLI_HALLT  (B9LUZ9), DNLI_HALMA  (Q5V4R0), DNLI_HALS3  (B0R4C9), 
DNLI_HALSA  (Q9HR35), DNLI_HALVD  (D4GYZ4), DNLI_HYPBU  (A2BJX6), 
DNLI_IGNH4  (A8AB20), DNLI_KINRD  (A6WG40), DNLI_KORVE  (Q1II25), 
DNLI_META3  (A6UVC4), DNLI_METBU  (Q12X08), DNLI_METJA  (Q57635), 
DNLI_METKA  (Q8TWN3), DNLI_METM5  (A4FY19), DNLI_METM6  (A9AAX4), 
DNLI_METM7  (A6VFQ9), DNLI_METMP  (Q6LYM1), DNLI_METS5  (A4YD25), 
DNLI_METST  (Q2NHF9), DNLI_METTF  (P54875), DNLI_METTH  (Q50566), 
DNLI_METTP  (A0B7F9), DNLI_METVS  (A6UNY0), DNLI_MYCA1  (A0QJL0), 
DNLI_MYCBO  (Q7TTR7), DNLI_MYCBP  (A1KN60), DNLI_MYCBT  (C1AGI1), 
DNLI_MYCGI  (A4TDS2), DNLI_MYCMM  (B2HHE1), DNLI_MYCPA  (Q73V97), 
DNLI_MYCS2  (A0QUP1), DNLI_MYCSJ  (A3PXE2), DNLI_MYCSK  (A1UDY9), 
DNLI_MYCSS  (Q1BB26), DNLI_MYCTA  (A5U776), DNLI_MYCTO  (P9WNV4), 
DNLI_MYCTU  (P9WNV5), DNLI_MYCUA  (A0PTC0), DNLI_MYCVP  (A1T6P2), 
DNLI_NATPD  (Q3IPX0), DNLI_NITMS  (A9A3K1), DNLI_NOCFA  (Q5YNY7), 
DNLI_NOCSJ  (A1SKL2), DNLI_NPVLD  (Q9YMV2), DNLI_OPITP  (B1ZZL9), 
DNLI_PERMH  (C0QSL7), DNLI_PYRAB  (P0CL75), DNLI_PYRAE  (O93723), 
DNLI_PYRAR  (A4WH24), DNLI_PYRAY  (P0CL74), DNLI_PYRCJ  (A3MS62), 
DNLI_PYRFU  (P56709), DNLI_PYRHO  (O59288), DNLI_PYRIL  (A1RTK4), 
DNLI_PYRNV  (B1YA52), DNLI_RHOOB  (C1AX87), DNLI_RHOSR  (Q0SG75), 
DNLI_SACEN  (A4F870), DNLI_SORC5  (A9GU24), DNLI_STAMF  (A3DP49), 
DNLI_STRAW  (Q826P6), DNLI_STRCO  (Q9FCB1), DNLI_STRGG  (B1W5J2), 
DNLI_SULAC  (Q4JAM1), DNLI_SULIA  (C3MZR1), DNLI_SULIK  (C4KIZ2), 
DNLI_SULIL  (C3MJ14), DNLI_SULIM  (C3MYD2), DNLI_SULIN  (C3NF77), 
DNLI_SULIY  (C3N834), DNLI_SULSH  (Q9P9K9), DNLI_SULSO  (Q980T8), 
DNLI_SULTO  (Q976G4), DNLI_THEFM  (Q9HH07), DNLI_THEKO  (Q9HHC4), 
DNLI_VACCA  (O57250), DNLI_VACCC  (P20492), DNLI_VACCW  (P16272), 
DNLI_VAR67  (P33798), LIGC1_MYCS2 (A0R5T2), Y1287_AQUAE (O67319)
» More

UniProtKB/Swiss-Prot
False negative sequences
15 sequences

DNLI1_RAT   (Q9JHY8), DNLI1_THEPD (A1RXA6), DNLI_HAEIN  (P44121), 
DNLI_METB6  (A7IAA9), DNLI_METHJ  (Q2FTH4), DNLI_METLZ  (A2SR38), 
DNLI_METMJ  (A3CWP1), DNLI_METPE  (B8GGB8), DNLI_METS3  (A5UKX2), 
DNLI_NANEQ  (Q74M64), DNLI_PICTO  (Q6L195), DNLI_THEAC  (Q9HJ26), 
DNLI_THEVO  (Q979A1), DNLI_UNCMA  (Q0W0X1), LIGD_BACSU  (O34398)
» More

UniProtKB/Swiss-Prot
False positive sequences
36 sequences

ACVS_AMYLA  (P27743), ACVS_STRCL  (Q01757), AUBA_SULAC  (Q4J9H1), 
AUBA_THEKO  (Q5JHN3), BDP1_HUMAN  (A6H8Y1), BDP1_MOUSE  (Q571C7), 
CITS_BACSU  (O34427), COX20_YEAST (Q04935), DDHA_RHOSU  (Q8GPG4), 
DHOM_LACLA  (Q9CGD8), DHOM_LACLC  (P52985), DLTA_LACLA  (Q9CG49), 
DSBC_BORBR  (Q7WEL4), DSBC_BORPA  (Q7W396), DSBC_BORPE  (Q7VU58), 
ERF99_ARATH (Q8L9K1), FABH_PROMM  (Q7V4F6), FOLD_BUCAI  (P57557), 
HAGA1_PORGI (P59915), HAGA2_PORGN (Q51845), INO80_USTMA (Q4PGL2), 
KGP38_PORGN (P72194), KGP66_PORGN (P72197), KGP83_PORGN (Q51817), 
KGP_PORG3   (B2RLK2), KUP_ANADF   (A7H902), MNME_SULNB  (A6QAL0), 
NRPS1_ASPFU (Q4WT66), PAL2_SOLTU  (P31426), PDXB_PORGI  (Q7MV70), 
PKS1_DICDI  (Q55E72), QUEA_DEHM1  (Q3Z8C1), QUEA_STRGC  (A8AYK5), 
RIMM_SYNR3  (A5GQ79), U518_AEDAE  (Q17AI4), U518_ANOGA  (Q7PZ36)
» More

PDB
[Detailed view]
11 PDB

1A0I; 1X9N; 2CFM; 2HIV; 2HIX; 3GDE; 3L2P; 3VNN; 3W1B; 3W1G; 3W5O

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