To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
Entry: PS00697

General information about the entry

Entry name [info] DNA_LIGASE_A1
Accession [info] PS00697
Entry type [info] PATTERN
Date [info] 01-DEC-1992 CREATED; 01-APR-2006 DATA UPDATE; 27-SEP-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC00295
Associated ProRule [info] PRU10135

Name and characterization of the entry

Description [info] ATP-dependent DNA ligase AMP-binding site.
Pattern [info]
[EDQH]-{K}-K-{VEDI}-[DN]-G-{GLYN}-R-[GACIVM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_09 which contains 555'594 sequence entries.


Total number of hits 195 in 190 different sequences
Number of true positive hits 154 in 154 different sequences
Number of 'unknown' hits 0
Number of false positive hits 41 in 36 different sequences
Number of false negative sequences 15
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 78.97 %
Recall (true positives / (true positives + false negatives)) 91.12 %

Comments [info]

Taxonomic range [info] Archaea, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 4
Site [info] active_site(?) at position 3
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
154 sequences

DNLI1_ARATH (Q42572    ), DNLI1_CAEEL (Q27474    ), DNLI1_DICDI (Q869E1    ), 
DNLI1_DROME (Q9W1H4    ), DNLI1_HALWD (Q18HT7    ), DNLI1_HUMAN (P18858    ), 
DNLI1_KORCO (B1L3K8    ), DNLI1_METAC (Q8TSR7    ), DNLI1_METBF (Q46C04    ), 
DNLI1_METMA (Q8PVR7    ), DNLI1_MOUSE (P37913    ), DNLI1_SCHPO (P12000    ), 
DNLI1_XENLA (P51892    ), DNLI1_YEAST (P04819    ), DNLI2_HALWD (Q18GX5    ), 
DNLI2_KORCO (B1L3V2    ), DNLI2_METAC (Q8TMT1    ), DNLI2_METBF (Q46BA3    ), 
DNLI2_METMA (Q8PTK1    ), DNLI2_THEPD (A1RY72    ), DNLI3_DICDI (Q54QM4    ), 
DNLI3_HUMAN (P49916    ), DNLI3_MOUSE (P97386    ), DNLI3_SCHPO (Q9C1W9    ), 
DNLI4_ARATH (Q9LL84    ), DNLI4_ASHGO (Q75CA4    ), DNLI4_ASPFU (Q4WVG8    ), 
DNLI4_ASPOR (Q2U6A1    ), DNLI4_CANAL (P52496    ), DNLI4_CANGA (Q6FVD8    ), 
DNLI4_CHICK (Q90YB1    ), DNLI4_COCIM (Q1DKE7    ), DNLI4_COPC7 (A8N936    ), 
DNLI4_COPCI (Q7Z7W5    ), DNLI4_CRYNB (P0CN09    ), DNLI4_CRYNJ (P0CN08    ), 
DNLI4_EMENI (Q5BH83    ), DNLI4_HUMAN (P49917    ), DNLI4_MOUSE (Q8BTF7    ), 
DNLI4_NEUCR (Q7SB49    ), DNLI4_ORYSJ (Q7X7E9    ), DNLI4_PHANO (Q0UCI9    ), 
DNLI4_PONAB (Q5R6L3    ), DNLI4_SCHPO (O74833    ), DNLI4_YEAST (Q08387    ), 
DNLI_ACIAM  (Q02093    ), DNLI_AERPE  (Q9YD18    ), DNLI_ANAD2  (B8JBM1    ), 
DNLI_ANADE  (Q2IH69    ), DNLI_ANADF  (A7HID3    ), DNLI_ANASK  (B4UIS1    ), 
DNLI_AQUAE  (O67398    ), DNLI_ARCFU  (O29632    ), DNLI_ASFB7  (P35970    ), 
DNLI_ASFK5  (P0C992    ), DNLI_ASFM2  (P26813    ), DNLI_ASFP4  (P0C990    ), 
DNLI_ASFWA  (P0C991    ), DNLI_BEUC1  (C5BW79    ), DNLI_BPT3   (P07717    ), 
DNLI_BPT4   (P00970    ), DNLI_BPT6   (P19088    ), DNLI_BPT7   (P00969    ), 
DNLI_CALMQ  (A8MDU6    ), DNLI_CENSY  (A0RWD6    ), DNLI_DICT6  (B5YD88    ), 
DNLI_DICTD  (B8DZX8    ), DNLI_FOWPN  (Q67480    ), DNLI_HALLT  (B9LUZ9    ), 
DNLI_HALMA  (Q5V4R0    ), DNLI_HALS3  (B0R4C9    ), DNLI_HALSA  (Q9HR35    ), 
DNLI_HALVD  (D4GYZ4    ), DNLI_HYPBU  (A2BJX6    ), DNLI_IGNH4  (A8AB20    ), 
DNLI_KINRD  (A6WG40    ), DNLI_KORVE  (Q1II25    ), DNLI_META3  (A6UVC4    ), 
DNLI_METBU  (Q12X08    ), DNLI_METJA  (Q57635    ), DNLI_METKA  (Q8TWN3    ), 
DNLI_METM5  (A4FY19    ), DNLI_METM6  (A9AAX4    ), DNLI_METM7  (A6VFQ9    ), 
DNLI_METMP  (Q6LYM1    ), DNLI_METS5  (A4YD25    ), DNLI_METST  (Q2NHF9    ), 
DNLI_METTF  (P54875    ), DNLI_METTH  (Q50566    ), DNLI_METTP  (A0B7F9    ), 
DNLI_METVS  (A6UNY0    ), DNLI_MYCA1  (A0QJL0    ), DNLI_MYCBO  (Q7TTR7    ), 
DNLI_MYCBP  (A1KN60    ), DNLI_MYCBT  (C1AGI1    ), DNLI_MYCGI  (A4TDS2    ), 
DNLI_MYCMM  (B2HHE1    ), DNLI_MYCPA  (Q73V97    ), DNLI_MYCS2  (A0QUP1    ), 
DNLI_MYCSJ  (A3PXE2    ), DNLI_MYCSK  (A1UDY9    ), DNLI_MYCSS  (Q1BB26    ), 
DNLI_MYCTA  (A5U776    ), DNLI_MYCTO  (P9WNV4    ), DNLI_MYCTU  (P9WNV5    ), 
DNLI_MYCUA  (A0PTC0    ), DNLI_MYCVP  (A1T6P2    ), DNLI_NATPD  (Q3IPX0    ), 
DNLI_NITMS  (A9A3K1    ), DNLI_NOCFA  (Q5YNY7    ), DNLI_NOCSJ  (A1SKL2    ), 
DNLI_NPVLD  (Q9YMV2    ), DNLI_OPITP  (B1ZZL9    ), DNLI_PERMH  (C0QSL7    ), 
DNLI_PSECP  (B8HCE1    ), DNLI_PYRAB  (P0CL75    ), DNLI_PYRAE  (O93723    ), 
DNLI_PYRAR  (A4WH24    ), DNLI_PYRAY  (P0CL74    ), DNLI_PYRCJ  (A3MS62    ), 
DNLI_PYRFU  (P56709    ), DNLI_PYRHO  (O59288    ), DNLI_PYRIL  (A1RTK4    ), 
DNLI_PYRNV  (B1YA52    ), DNLI_RHOJR  (Q0SG75    ), DNLI_RHOOB  (C1AX87    ), 
DNLI_SACEN  (A4F870    ), DNLI_SORC5  (A9GU24    ), DNLI_STAMF  (A3DP49    ), 
DNLI_STRAW  (Q826P6    ), DNLI_STRCO  (Q9FCB1    ), DNLI_STRGG  (B1W5J2    ), 
DNLI_SULAC  (Q4JAM1    ), DNLI_SULIA  (C3MZR1    ), DNLI_SULIK  (C4KIZ2    ), 
DNLI_SULIL  (C3MJ14    ), DNLI_SULIM  (C3MYD2    ), DNLI_SULIN  (C3NF77    ), 
DNLI_SULIY  (C3N834    ), DNLI_SULSH  (Q9P9K9    ), DNLI_SULSO  (Q980T8    ), 
DNLI_SULTO  (Q976G4    ), DNLI_SULZI  (D2CJS7    ), DNLI_THEFM  (Q9HH07    ), 
DNLI_THEKO  (Q9HHC4    ), DNLI_THEON  (B6YTR4    ), DNLI_VACCA  (O57250    ), 
DNLI_VACCC  (P20492    ), DNLI_VACCW  (P16272    ), DNLI_VAR67  (P33798    ), 
LIG6_ARATH  (F4HPZ9    ), LIGC1_MYCS2 (A0R5T2    ), ROQA_PENRW  (B6HJU6    ), 
Y1287_AQUAE (O67319    )
» more

UniProtKB/Swiss-Prot
False negative sequences
15 sequences

DNLI1_RAT   (Q9JHY8    ), DNLI1_THEPD (A1RXA6    ), DNLI_HAEIN  (P44121    ), 
DNLI_METAR  (Q0W0X1    ), DNLI_METB6  (A7IAA9    ), DNLI_METHJ  (Q2FTH4    ), 
DNLI_METLZ  (A2SR38    ), DNLI_METMJ  (A3CWP1    ), DNLI_METPE  (B8GGB8    ), 
DNLI_METS3  (A5UKX2    ), DNLI_NANEQ  (Q74M64    ), DNLI_PICTO  (Q6L195    ), 
DNLI_THEAC  (Q9HJ26    ), DNLI_THEVO  (Q979A1    ), LIGD_BACSU  (O34398    )
» more

UniProtKB/Swiss-Prot
False positive sequences
36 sequences

ACVS_AMYLA  (P27743    ), ACVS_STRCL  (Q01757    ), AUBA_SULAC  (Q4J9H1    ), 
AUBA_THEKO  (Q5JHN3    ), BDP1_HUMAN  (A6H8Y1    ), BDP1_MOUSE  (Q571C7    ), 
CITS_BACSU  (O34427    ), COX20_YEAST (Q04935    ), DDHA_RHOSU  (Q8GPG4    ), 
DHOM_LACLA  (Q9CGD8    ), DHOM_LACLC  (P52985    ), DLTA_LACLA  (Q9CG49    ), 
DSBC_BORBR  (Q7WEL4    ), DSBC_BORPA  (Q7W396    ), DSBC_BORPE  (Q7VU58    ), 
ERF99_ARATH (Q8L9K1    ), FABH_PROMM  (Q7V4F6    ), FOLD_BUCAI  (P57557    ), 
HAGA1_PORGI (P59915    ), HAGA2_PORGN (Q51845    ), INO80_USTMA (Q4PGL2    ), 
KGP38_PORGN (P72194    ), KGP66_PORGN (P72197    ), KGP83_PORGN (Q51817    ), 
KGP_PORG3   (B2RLK2    ), KUP_ANADF   (A7H902    ), MNME_SULNB  (A6QAL0    ), 
NRPS1_ASPFU (Q4WT66    ), PAL2_SOLTU  (P31426    ), PDXB_PORGI  (Q7MV70    ), 
PKS1_DICDI  (Q55E72    ), QUEA_DEHM1  (Q3Z8C1    ), QUEA_STRGC  (A8AYK5    ), 
RIMM_SYNR3  (A5GQ79    ), U518_AEDAE  (Q17AI4    ), U518_ANOGA  (Q7PZ36    )
» more

PDB
[Detailed view]
11 PDB

1A0I; 1X9N; 2CFM; 2HIV; 2HIX; 3GDE; 3L2P; 3VNN; 3W1B; 3W1G; 3W5O

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission