Entry: PS01047

Forthcoming changes to the profile format
General information about the entry

Entry name [info] HMA_1
Accession [info] PS01047
Entry type [info] PATTERN
Date [info] NOV-1995 (CREATED); APR-2006 (DATA UPDATE); JUL-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC00804

Name and characterization of the entry

Description [info] Heavy-metal-associated domain.
Pattern [info]
[LIVNS]-x-{L}-[LIVMFA]-x-C-x-[STAGCDNH]-C-x(3)-[LIVFG]-{LV}-x(2)-[LIV]-
x(9,11)-[IVA]-x-[LVFYS].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_09 which contains 546'439 sequence entries.


Total number of hits 211 in 144 different sequences
Number of true positive hits 198 in 131 different sequences
Number of 'unknown' hits
Number of false positive hits 13 in 13 different sequences
Number of false negative sequences 22
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 93.84 %
Recall (true positives / (true positives + false negatives)) 90.00 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 6
Site [info] metal(?) at position 6
Site [info] metal(?) at position 9
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
131 sequences

ATCS_SYNE7  (P37279), ATCS_SYNY3  (P73241), ATCU1_RHIME (P58341), 
ATCU2_RHIME (P58342), ATCU_SINMW  (Q9X5X3), ATOX1_BOVIN (Q3T0E0), 
ATOX1_CANFA (Q9TT99), ATOX1_HUMAN (O00244), ATOX1_MOUSE (O08997), 
ATOX1_RAT   (Q9WUC4), ATOX1_SHEEP (Q9XT28), ATP7A_CRIGR (P49015), 
ATP7A_HUMAN (Q04656), ATP7A_MOUSE (Q64430), ATP7A_RAT   (P70705), 
ATP7B_HUMAN (P35670), ATP7B_MOUSE (Q64446), ATP7B_RAT   (Q64535), 
ATP7B_SHEEP (Q9XT50), ATSY_SYNE7  (P37385), ATSY_SYNP6  (P07893), 
ATU2_SCHPO  (O59666), ATU2_YEAST  (P38995), ATX1_SCHPO  (O74735), 
ATX1_YEAST  (P38636), ATZN_ECOLI  (P37617), ATZN_SYNY3  (Q59998), 
CADA1_STAAU (P20021), CADA2_STAAU (P37386), CADA_BACPE  (P30336), 
CADA_BACSU  (O32219), CADA_LISMN  (Q60048), CADA_LISMO  (P58414), 
CADA_STAAR  (Q6GIX1), COPA1_HELPX (P77871), COPA2_HELPX (Q59467), 
COPA3_HELPX (O08462), COPA_ARCFU  (O29777), COPA_BACSU  (O32220), 
COPA_ECO57  (Q8XD24), COPA_ECOLI  (Q59385), COPA_ENTHA  (P32113), 
COPA_HELFC  (O32619), COPA_HELPJ  (Q9ZM69), COPA_HELPY  (P55989), 
COPA_SALTI  (Q8Z8S4), COPA_SALTY  (Q8ZR95), COPA_STAA1  (A7X6S1), 
COPA_STAA2  (A6U4T8), COPA_STAA3  (Q2FDV0), COPA_STAA8  (Q2FV64), 
COPA_STAA9  (A5IVY3), COPA_STAAB  (Q2YWA3), COPA_STAAC  (Q5HCZ3), 
COPA_STAAE  (A6QK47), COPA_STAAM  (Q99R80), COPA_STAAN  (Q7A3E6), 
COPA_STAAR  (Q6GDP1), COPA_STAAS  (Q6G6B7), COPA_STAAT  (A8Z3F8), 
COPA_STAAW  (Q8NUQ9), COPA_STAEQ  (Q5HL56), COPA_STAES  (Q8CN02), 
COPA_STAHJ  (Q4L970), COPA_STAS1  (Q4A0G1), COPA_VIBCH  (Q9KPZ7), 
COPA_YERPE  (Q8ZCA7), COPP_HELFC  (O32620), COPP_HELPJ  (Q9ZM70), 
COPP_HELPY  (Q48271), COPZ_ARCFU  (O29901), COPZ_BACSU  (O32221), 
COPZ_ENTHA  (Q47840), COPZ_STAA1  (A7X6S3), COPZ_STAA2  (A6U4T9), 
COPZ_STAA3  (Q2FDU9), COPZ_STAA8  (Q2FV63), COPZ_STAA9  (A5IVY4), 
COPZ_STAAB  (P0C885), COPZ_STAAC  (Q5HCZ2), COPZ_STAAE  (A6QK48), 
COPZ_STAAM  (Q99R79), COPZ_STAAN  (Q7A3E5), COPZ_STAAR  (Q6GDP0), 
COPZ_STAAS  (Q6G6B6), COPZ_STAAT  (A8Z3F9), COPZ_STAAW  (Q79ZY4), 
COPZ_STAEQ  (Q5HL55), COPZ_STAES  (Q8CN01), COPZ_STAHJ  (Q4L971), 
COPZ_STAS1  (Q4A0G2), CTPA_MYCLE  (P46839), CTPA_MYCTO  (P9WPU0), 
CTPA_MYCTU  (P9WPU1), CTPB_MYCBO  (P59947), CTPB_MYCLE  (P46840), 
CTPB_MYCTO  (P9WPT8), CTPB_MYCTU  (P9WPT9), FIXI_BRADU  (Q59207), 
FIXI_RHILV  (O33533), FIXI_RHIME  (P18398), HMA5_ARATH  (Q9SH30), 
HMA6_ARATH  (Q9SZC9), HMA7_ARATH  (Q9S7J8), HMCT_HELPJ  (Q9ZL53), 
HMCT_HELPY  (Q59465), MERA_ACICA  (Q52109), MERA_ACIFR  (P17239), 
MERA_ALCSP  (P94188), MERA_BACCE  (P16171), MERA_ENTAG  (P94702), 
MERA_PSEAI  (P00392), MERA_PSEFL  (Q51772), MERA_SERMA  (P08662), 
MERA_SHEPU  (Q54465), MERA_SHIFL  (P08332), MERA_STAAU  (P0A0E5), 
MERA_STAES  (P0A0E4), MERP_ACICA  (Q52107), MERP_ALCSP  (P94186), 
MERP_ENTAG  (P0A217), MERP_ENTCL  (P0A218), MERP_PSEAI  (P04131), 
MERP_PSEFL  (Q51770), MERP_SALTI  (P0A216), MERP_SERMA  (P13113), 
MERP_SHEPU  (Q54463), MERP_SHIFL  (P04129), Y290_HAEIN  (P77868), 
Y291_HAEIN  (P43979), Y292_HAEIN  (O32622)
» More

UniProtKB/Swiss-Prot
False negative sequences
22 sequences

ATOX1_ARATH (Q94BT9), ATOX1_DICDI (Q54PZ2), ATU1_YEAST  (P38360), 
CCH_ARATH   (O82089), CCS1_ASHGO  (Q75DD6), CCS1_CANGA  (Q6FU61), 
CCS1_DEBHA  (Q6BK66), CCS1_KLULA  (Q6CIG2), CCS1_YARLI  (Q6BZU2), 
CCS1_YEAST  (P40202), CCS_ARATH   (Q9LD47), CCS_DICDI   (Q54F73), 
CCS_HUMAN   (O14618), CCS_MOUSE   (Q9WU84), CCS_ORYSJ   (Q7XTY9), 
CCS_RAT     (Q9JK72), HIP26_ARATH (Q9SZN7), HMA2_ARATH  (Q9SZW4), 
HMA3A_ARATH (P0CW77), HMA3B_ARATH (P0CW78), HMA4_ARATH  (O64474), 
HMCT_HELFE  (Q9RQB4)
» More

UniProtKB/Swiss-Prot
False positive sequences
13 sequences

CG013_HUMAN (Q8NI28), CSPL7_ORYSJ (Q6YT98), CYC6_ARTMA  (P00118), 
CYC6_GRATL  (Q6B941), CYC6_MICAE  (P00112), GPI7_YEAST  (P40367), 
HMGB7_ARATH (Q8LDF9), NU5C_NEPOL  (Q9TKV7), RECO_LEIXX  (Q6AED5), 
SYFA_THEFY  (Q47N75), UD2A3_HUMAN (Q6UWM9), UD2A3_PONAB (Q5RFJ3), 
YAB4_ARATH  (Q9LDT3)
» More

PDB
[Detailed view]
68 PDB

1AFI; 1AFJ; 1AW0; 1CC7; 1CC8; 1CPZ; 1FD8; 1FE0; 1FE4; 1FEE; 1FES; 1FVQ; 1FVS; 1JWW; 1K0V; 1KQK; 1KVI; 1KVJ; 1MWY; 1MWZ; 1OPZ; 1OQ3; 1OQ6; 1P6T; 1P8G; 1Q8L; 1S6O; 1S6U; 1TL4; 1TL5; 1Y3J; 1Y3K; 1YG0; 1YJR; 1YJT; 1YJU; 1YJV; 2AJ0; 2AJ1; 2AW0; 2EW9; 2G9O; 2GA7; 2GCF; 2GGP; 2HQI; 2K1R; 2KT2; 2KT3; 2LDI; 2LQ9; 2LQB; 2OFG; 2OFH; 2QIF; 2RML; 2ROP; 2VOY; 2XMW; 3CJK; 3DXS; 3FRY; 3I9Z; 3IWL; 3IWX; 3K7R; 4A48; 4A4J
» More

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission