Entry: PS01259

General information about the entry
Entry name BH3
Accession number PS01259
Entry type PATTERN
Date NOV-1997 (CREATED); JUL-1998 (DATA UPDATE); APR-2013 (INFO UPDATE).
PROSITE Documentation PDOC00829
Name and characterization of the entry
DescriptionApoptosis regulator, Bcl-2 family BH3 motif signature.
Pattern [LIVAT]-x(3)-L-[KARQ]-x-[IVAL]-G-D-[DESG]-[LIMFV]-[DENSHQ]-[LVSHRQ]- [NSR].
Numerical results
  • UniProtKB/Swiss-Prot release number: 2013_06, total number of sequence entries in that release: 540261.
  • Total number of hits in UniProtKB/Swiss-Prot: 30 hits in 30 different sequences
  • Number of hits on proteins that are known to belong to the set under consideration: 30 hits in 30 different sequences
  • Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences
  • Number of false hits (on unrelated proteins): 0 hits in 0 different sequences
  • Number of known missed hits: 38
  • Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 0
  • Precision (true hits / (true hits + false positives)): 100.00 %
  • Recall (true hits / (true hits + false negatives)): 44.12 %
Comments
  • Taxonomic range: Eukaryotes
  • Maximum known number of repetitions of the pattern in a single protein: 1
  • VERSION: 1
Cross-references
UniProtKB/Swiss-Prot True positive hits:
B2CL1_CHICK (Q07816), B2CL1_HUMAN (Q07817), B2CL1_MOUSE (Q64373), 
B2CL1_PIG   (O77737), B2CL1_RAT   (P53563), BAK_HUMAN   (Q16611), 
BAK_MOUSE   (O08734), BAX_BOVIN   (O02703), BAX_HUMAN   (Q07812), 
BAX_MOUSE   (Q07813), BAX_RAT     (Q63690), BCL2_BOVIN  (O02718), 
BCL2_CANFA  (Q6R755), BCL2_CHICK  (Q00709), BCL2_CRIGR  (Q9JJV8), 
BCL2_HUMAN  (P10415), BCL2_MOUSE  (P10417), BCL2_RAT    (P49950), 
BID_HUMAN   (P55957), BID_MOUSE   (P70444), BID_RAT     (Q9JLT6), 
BIK_HUMAN   (Q13323), HRK_HUMAN   (O00198), HRK_MOUSE   (P62816), 
HRK_RAT     (P62817), MCL1_CANFA  (Q8HYS5), MCL1_FELCA  (Q7YRZ9), 
MCL1_HUMAN  (Q07820), MCL1_MOUSE  (P97287), MCL1_RAT    (Q9Z1P3)
False negative hits (sequences which belong to the set under consideration, but which have not been picked up by the pattern or profile):
APR_CANFA   (Q1PCT2), APR_HUMAN   (Q13794), APR_MOUSE   (Q9JM54), 
APR_RAT     (Q5U777), B2L11_HUMAN (O43521), B2L11_MOUSE (O54918), 
B2L11_RAT   (O88498), B2L13_HUMAN (Q9BXK5), B2L13_MOUSE (P59017), 
B2L14_BOVIN (Q5E9L4), B2L14_HUMAN (Q9BZR8), B2L14_MOUSE (Q9CPT0), 
B2L14_RAT   (Q6AYK4), BAD_HUMAN   (Q92934), BAD_MOUSE   (Q61337), 
BAD_RAT     (O35147), BBC3_HUMAN  (Q9BXH1), BBC3_MOUSE  (Q99ML1), 
BBC3_RAT    (Q80ZG6), BID_CHICK   (Q8JGM8), BID_PIG     (Q4JHS0), 
BMF_HUMAN   (Q96LC9), BMF_MOUSE   (Q91ZE9), BMF_RAT     (Q8K589), 
BNI3L_BOVIN (Q3T013), BNI3L_HUMAN (O60238), BNI3L_MOUSE (Q9Z2F7), 
BNIP3_BOVIN (Q32KN2), BNIP3_HUMAN (Q12983), BNIP3_MOUSE (O55003), 
BOKA_DANRE  (Q6DC66), BOKB_DANRE  (Q7T381), BOK_CHICK   (Q9I8I2), 
BOK_HUMAN   (Q9UMX3), BOK_MOUSE   (O35425), BOK_RAT     (Q792S6), 
BOP_HUMAN   (Q7L3V2), BOP_PONAB   (Q5R6M8)
Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:

[Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format]

Retrieve the sequence logo from the alignment

PDB
[Detailed view]		 1AF3; 1BXL; 1DDB; 1F16; 1G5J; 1G5M; 1GJH; 1LXL; 1MAZ; 1PQ0; 1PQ1; 1R2D; 1R2E; 1R2H; 1R2I; 1WSX; 1YSG; 1YSI; 1YSN; 1YSW; 1ZY3; 2B48; 2BID; 2BZW; 2IMS; 2IMT; 2IPE; 2JBY; 2JCN; 2JM6; 2K7W; 2KBW; 2L58; 2LP8; 2LPC; 2LR1; 2M03; 2M04; 2NL9; 2NLA; 2O1Y; 2O21; 2O22; 2O2F; 2O2M; 2O2N; 2P1L; 2PON; 2PQK; 2ROC; 2ROD; 2VOH; 2VOI; 2W3L; 2XA0; 2XPX; 2YJ1; 2YQ6; 2YQ7; 2YV6; 2YXJ; 3CVA; 3D7V; 3FDL; 3FDM; 3IHC; 3IHD; 3IHE; 3IHF; 3IIG; 3IIH; 3ILB; 3ILC; 3INQ; 3IO8; 3IO9; 3KJ0; 3KJ1; 3KJ2; 3KZ0; 3MK8; 3PK1; 3PL7; 3QBR; 3QKD; 3R85; 3SP7; 3SPF; 4A1U; 4A1W; 4AQ3; 4BD2; 4BD6; 4BD7; 4BD8; 4BDU; 4EHR; 4G35; 4HNJ; 4HW2; 4HW3; 4HW4;

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