Entry: PS50001

General information about the entry

Entry name [info] SH2
Accession [info] PS50001
Entry type [info] MATRIX
Date [info] NOV-1995 (CREATED); OCT-2013 (DATA UPDATE); MAY-2016 (INFO UPDATE).
PROSITE Doc. [info] PDOC50001
Associated ProRule [info] PRU00191

Name and characterization of the entry

Description [info] Src homology 2 (SH2) domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=92;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=87;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.3941; R2=0.01483; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=547; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=412; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-60; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='W'; M=-16,-34,-40,-35,-25,  9,-21,-24,-17,-19,-16,-17,-34,-25,-18,-19,-33,-25,-25,111, 26,-18;
/M: SY='Y'; M=-17,-24,-26,-29,-24, 41,-30, -2,  7,-20,  6,  2,-19,-28,-22,-16,-19,-10, -1, 14, 48,-24;
/M: SY='H'; M=-14,-14,-23,-18,-14,  7,-23, 31, -9,-15, -3,  4, -8,-24, -9,-10,-15,-14,-11, -8, 18,-12;
/M: SY='G'; M= -3, -9,-30, -8,-14,-26, 45,-17,-36, -9,-28,-18, -1,-14,-14, -8, -3,-17,-27,-20,-24,-14;
/M: SY='K'; M= -8, -1,-25, -2,  0,-10,-16, -5,-19,  6,-18,-11,  1, -7, -3,  1, -4, -6,-16,-21, -6, -2;
/M: SY='I'; M= -8,-28,-24,-35,-27,  4,-34,-25, 36,-26, 23, 21,-23,-23,-20,-24,-19, -8, 26,-21, -1,-26;
/I:         I=-4; MI=0; IM=0;
/M: SY='S'; M=  1,  3,-18,  1,  0,-21, -4, -9,-20, -6,-25,-17, 10, -3,  0, -8, 20, 14,-16,-34,-19,  0;
/M: SY='R'; M=-16, -9,-30, -9, -1,-23, -8, -5,-31, 26,-23,-11,  0,-18,  6, 51, -9,-11,-21,-18,-12, -1;
/M: SY='E'; M= -2,  2,-25,  1, 12,-25,-12, -3,-21,  6,-20,-12,  2,-11, 10,  3,  2, -4,-18,-23,-14, 11;
/M: SY='E'; M=-10, 10,-29, 16, 26,-30,-15,  0,-26, 10,-21,-14,  3, -9, 19,  5, -2, -9,-25,-26,-13, 22;
/M: SY='A'; M= 36,-11,-11,-17, -7,-18, -6,-20, -6,-10, -9, -8,-11,-12,-10,-18,  8,  1,  4,-23,-18, -9;
/M: SY='E'; M=-10,  4,-28,  9, 36,-22,-20,  2,-23,  5,-16,-14, -1, -7, 12,  2, -2, -8,-22,-26,-12, 23;
/M: SY='R'; M= -6,  4,-25,  5, 10,-24,-14, -1,-23, 10,-19,-11,  3,-13,  9, 11,  0, -5,-19,-25,-11,  8;
/M: SY='L'; M=-10,-23,-23,-25,-15,  1,-27,-12, 13,-19, 28, 17,-22,-25, -8,-12,-22, -9,  4,-18,  2,-12;
/M: SY='L'; M=-10,-30,-20,-30,-20, 10,-30,-20, 20,-30, 49, 20,-30,-30,-20,-20,-30,-10, 11,-20,  0,-20;
/M: SY='R'; M= -8, -9,-23,-12, -6,-13,-19, -9, -6,  1, -1,  4, -6,-18,  1,  5, -8, -4, -6,-23, -7, -4;
/M: SY='N'; M= -4,  9,-22,  7,  5,-23, -9, -2,-21,  0,-21,-13, 11,-10,  5, -2,  5, -1,-19,-30,-15,  4;
/M: SY='K'; M= -8, -5,-27, -4,  3,-22,-12, -9,-19,  7,-20,-11, -2, -1,  2,  5, -3, -5,-16,-24,-13,  1;
/I:         I=-4; MI=-19; MD=-19; IM=-19;
/M: SY='G'; M= -4, -6,-21, -5, -1,-21, 10,-11,-22, -9,-20,-12, -4,  2, -6,-10, -1, -9,-19,-23,-19, -4; D=-4;
/I:         I=-4; MI=-19; MD=-19; IM=-19; DM=-19;
/M: SY='B'; M=-11, 10,-24, 10,  4,-20,-14, -1,-18,  5,-18,-10,  9, -4,  1,  3, -3, -6,-17,-26,-12,  1; D=-4;
/I:         I=-4; MI=-19; MD=-19; IM=-19; DM=-19;
/M: SY='E'; M= -4,  3,-14,  6,  9,-14, -8, -2,-12,  0,-12, -8,  1,  4,  4, -2,  1, -2,-12,-16, -9,  6; D=-4;
/I:         I=-4; MI=0; IM=0; DM=-19;
/M: SY='G'; M= -1,-11,-27,-11,-20,-29, 66,-20,-39,-20,-30,-20, -1,-21,-20,-20, -1,-20,-30,-17,-29,-20;
/M: SY='T'; M=  5,  3,-13,  0, -3,-18,-10,-13,-16, -9,-14,-13,  1,-12, -6,-12, 14, 18, -8,-31,-15, -5;
/M: SY='F'; M=-20,-29,-21,-38,-29, 74,-30,-15,  0,-28,  9,  0,-20,-30,-37,-19,-20,-10, -1, 12, 36,-29;
/M: SY='L'; M= -9,-30,-20,-31,-22,  8,-30,-21, 23,-28, 43, 21,-29,-29,-20,-20,-27, -9, 15,-21, -1,-21;
/M: SY='V'; M= -3,-29,-17,-32,-28,  1,-32,-28, 32,-24, 19, 14,-26,-26,-25,-23,-15, -4, 36,-25, -6,-28;
/M: SY='R'; M=-20,-10,-30,-10,  0,-20,-20,  0,-30, 30,-20,-10,  0,-20, 10, 70,-10,-10,-20,-20,-10,  0;
/M: SY='E'; M=-12,  4,-29, 10, 23,-15,-20, -6,-22,  1,-15,-14, -3, -2,  6, -5, -6,-10,-22,-23,-11, 15;
/M: SY='S'; M=  8, -1,-10, -2, -1,-20, -2,-10,-20, -7,-28,-19,  8,-11,  0, -4, 34, 17,-10,-37,-19, -1;
/M: SY='E'; M= -8,  9,-25, 15, 23,-26,-16, -1,-24,  4,-20,-16,  4, -9, 10,  2,  4, -3,-20,-31,-16, 16;
/M: SY='S'; M= -2,  1,-18, -2, -1,-21, -6, -6,-22,  1,-24,-15,  8,-10,  1,  2, 16, 13,-15,-31,-15, -1;
/I:         I=-5; MI=-27; MD=-27; IM=-27;
/M: SY='S'; M= -4,  0,-22, -2,  3,-15,-12, -2,-19,  1,-18,-11,  3, -8,  1, -2,  4,  3,-16,-25, -8,  1; D=-5;
/I:         I=-5; MI=-27; MD=-27; IM=-27; DM=-27;
/M: SY='P'; M= -6,-11,-22,-10, -3,-14,-16,-12, -5,  0, -9, -4,-10, 19, -4, -3, -8, -5, -8,-17,-11, -6; D=-5;
/I:         I=-5; MI=0; IM=0; DM=-27;
/M: SY='G'; M= -1, -2,-29, -3,-12,-30, 50,-15,-36,-15,-29,-19,  5,-15,-13,-16,  1,-16,-29,-23,-27,-13;
/M: SY='D'; M=  0, 10,-20, 15,  8,-28,  4, -9,-28, -6,-22,-19,  5,-12, -1,-11,  6, -5,-21,-31,-21,  4;
/M: SY='Y'; M=-17,-22,-26,-26,-20, 33,-30,  3,  4,-17,  3,  2,-18,-27,-18,-13,-17, -9, -2, 11, 46,-21;
/M: SY='T'; M=  9, -8, -9,-13,-10,-14,-12,-18, -7,-12,-12, -9, -5,-11,-10,-14, 15, 21,  3,-31,-15,-10;
/M: SY='L'; M=-10,-29,-18,-32,-24, 10,-32,-23, 24,-27, 33, 16,-26,-28,-22,-20,-24, -9, 16,-20,  0,-24;
/M: SY='S'; M= 10, -4, -7, -7, -6,-17, -5,-13,-15,-12,-22,-15,  3,-13, -5,-13, 28, 18, -6,-34,-16, -6;
/M: SY='V'; M= -8,-29,-20,-31,-26, 11,-27,-22, 16,-22, 11,  7,-26,-28,-25,-19,-18, -6, 21,  0,  4,-25;
/M: SY='R'; M=-11,-16,-25,-17,-10, -7,-22,-10,-10,  7, -7, -3,-11,-21, -5, 18,-11, -8, -5,-10, -2, -9;
/M:         M= -8, -1,-20,  0, -4, -7,-19, -7,-14, -6,-11, -9, -5,-18, -8, -6, -5, -2, -9,-15,  0, -6;
/M: SY='D'; M=-10,  5,-25,  7,  3,-19, -6, -7,-25,  0,-20,-15,  3,-15,  0, -1, -3, -9,-22,-16,-11,  1;
/M: SY='G'; M= -4,  7,-25, 11, -3,-25, 13,-11,-27, -9,-23,-18,  4,-16, -8,-10,  3, -7,-18,-25,-19, -5;
/I:         I=-2; MI=0; IM=0;
/M: SY='Q'; M= -8,  2,-23,  1,  4,-22,-13,  0,-17,  4,-16, -9,  4,-15,  5,  4, -2, -6,-15,-28,-12,  4;
/M: SY='V'; M= -4,-19,-17,-21,-21, -3,-23,-20, 14,-16,  0,  2,-16,-19,-21,-14, -8, -3, 23,-27, -9,-22;
/M: SY='K'; M=-10, -2,-28, -4,  3,-23,-11, -4,-23, 20,-21, -8,  1,-14,  9, 18, -5, -6,-19,-21, -9,  5;
/M: SY='H'; M=-18, -2,-29, -2,  2,-18,-20, 78,-26, -8,-16, -1,  6,-19,  8,  1, -9,-17,-26,-29, 14,  1;
/M: SY='Y'; M=-15,-24,-14,-29,-24, 26,-30, -9,  3,-20,  2, -1,-21,-23,-22,-18,-18, -8, -1,  8, 31,-24;
/M: SY='R'; M=-13, -4,-27, -5,  0,-21,-21, -2,-16, 16,-15, -4, -1,-17,  7, 22, -9, -8,-11,-24, -8,  1;
/M: SY='I'; M= -9,-30,-25,-37,-29,  4,-37,-29, 41,-27, 19, 17,-22,-23,-22,-26,-19, -8, 30,-20,  0,-29;
/M: SY='Q'; M=-12, -3,-21, -5,  4,-19,-20,  3,-16,  8,-13, -2,  1,-17, 12, 12, -8, -9,-17,-23, -7,  7;
/M: SY='K'; M= -4, -1,-19, -3,  3,-20,-15, -3,-21,  5,-21,-12,  2, -6,  2,  5,  4,  2,-16,-26,-12,  1;
/M: SY='T'; M= -6, -7,-19, -8, -6, -7,-21,-13, -3,-11,  1, -2, -7,-17, -9, -8, -4,  4, -1,-26, -8, -8;
/M: SY='D'; M= -5, 11,-24, 17, 14,-29, -3, -7,-27, -3,-21,-17,  3, -4,  3, -9,  1, -6,-23,-29,-19,  8;
/I:         I=-2; MI=-12; MD=-12; IM=-12;
/M: SY='N'; M= -6, 13,-20, 10,  3,-22,  0, -4,-22,  0,-21,-15, 16,-12,  1, -1,  7,  3,-19,-28,-16,  2; D=-2;
/I:         I=-2; MI=-12; MD=-12; IM=-12; DM=-12;
/M: SY='G'; M= -1, -2,-14, -3, -4,-16, 22, -8,-20, -6,-16,-11,  2,-10, -6, -5,  2, -7,-15,-14,-15, -5; D=-2;
/I:         I=-2; MI=0; IM=0; DM=-12;
/M: SY='K'; M= -8, -6,-27, -5, -2,-20, -6, -7,-20,  4,-17, -9, -4, -6, -2,  0, -6, -7,-16,-24,-12, -3;
/M: SY='Y'; M=-17,-24,-26,-26,-23, 35,-27,  2,  2,-18,  7,  2,-21,-30,-19,-14,-20,-10, -4, 18, 51,-23;
/M: SY='Y'; M= -9,-10,-17,-13,-13,  6,-18, -4, -9, -9, -8, -5, -7,-22,-10, -4, -3,  0, -7,-10, 15,-13;
/M: SY='I'; M= -7,-25,-22,-29,-20,  2,-31,-23, 23,-19, 17, 12,-21,-20,-19,-19,-17, -7, 19,-21, -3,-21;
/M: SY='S'; M= -2,  1,-23, -1, -1,-20,  0,-11,-23, -3,-22,-16,  3, -9, -3, -5,  6,  4,-18,-20,-13, -3;
/M: SY='E'; M= -6,  4,-26,  6,  9,-25,  3, -7,-25, -4,-22,-16,  5, -8,  1, -5,  3, -4,-21,-27,-18,  4;
/I:         I=-6; MI=-29; MD=-29; IM=-29;
/M: SY='R'; M= -5, -2,-16, -3,  0,-13, -1, -5,-14,  6,-11, -7,  2, -7,  0, 10, -3, -5,-12,-14, -9, -1; D=-6;
/I:         I=-6; MI=0; IM=0; DM=-29;
/M:         M= -6, -6,-23, -5, -1,-15,-19, -1, -9, -4, -5, -3, -6,-13, -2, -1, -6, -5, -7,-26, -8, -2;
/M: SY='R'; M= -4, -4,-18, -8, -4,-16,-12, -9,-17,  3,-16,-10,  0,-13,  0,  4,  2,  3,-12,-24, -9, -3;
/M: SY='F'; M=-15,-26,-19,-34,-26, 59,-28,-14,  0,-26,  8,  0,-17,-28,-32,-19,-18, -9, -1,  5, 27,-26;
/M: SY='N'; M= -4,  6,-19,  5,  1,-24, -1, -7,-23, -5,-22,-15,  9, -6, -3, -5,  3, -5,-20,-31,-20, -1;
/M: SY='S'; M=  3,  5, -9,  2, -3,-19, -5,-12,-19, -9,-24,-18,  9,-12, -5,-10, 25, 20,-11,-36,-18, -4;
/M: SY='L'; M=-10,-30,-22,-33,-23, 11,-32,-23, 26,-28, 35, 18,-26,-25,-21,-22,-25, -9, 16,-19,  1,-23;
/M: SY='P'; M= -1, -5,-24, -7, -3,-20,-10, -7,-14, -6,-16, -8, -3,  2,  2, -9,  0, -2,-14,-22,-12, -2;
/M: SY='E'; M=-10, 13,-28, 21, 30,-28,-18,  1,-25,  3,-17,-15,  2, -8, 15, -4, -2, -8,-24,-27,-12, 22;
/M: SY='L'; M=-10,-29,-22,-31,-21,  8,-31,-20, 23,-27, 41, 22,-27,-28,-18,-18,-27,-10, 12,-20,  0,-20;
/M: SY='I'; M= -5,-30,-17,-35,-29,  0,-35,-29, 38,-25, 16, 15,-25,-25,-25,-25,-16, -5, 37,-25, -5,-29;
/M: SY='E'; M= -8,  3,-25,  5, 11,-20,-15,  4,-19,  2,-16, -8,  2,-13,  9,  2, -1, -5,-18,-23, -6,  9;
/M: SY='H'; M=-17, -5,-28, -5, -6, -2,-20, 49,-17,-10,-12, -3, -1,-22, -1, -6,-11,-14,-19,-11, 30, -7;
/M: SY='Y'; M=-19,-16,-29,-17,-15, 19,-28, 32, -6,-12, -1,  1,-14,-27, -7, -9,-18,-12,-13, 11, 56,-15;
/M: SY='Q'; M= -6, -6,-23, -6,  4,-20,-17, -6,-17,  8,-15, -5, -3, -9, 10,  9,  2,  1,-14,-24,-10,  6;
/M: SY='Q'; M=-11,  0,-26,  1,  7,-23,-20,  9,-18, 10,-18, -6,  1,-14, 12,  6, -4, -6,-15,-24, -4,  8;
/M: SY='N'; M= -5,  6,-21,  1,  1,-18,-12,  4,-14, -3,-15, -6, 11,-15,  1, -2,  3,  0,-13,-31,-12,  0;
/M: SY='S'; M=  6, -5,-22, -5,  0,-24, -5, -6,-20, -2,-21,-11, -2,  1,  2, -6,  7, -2,-16,-27,-17,  0;
/M:         M= -2, -2,-20, -1, -6,-16,-12,-14, -6,-11, -1, -3, -7,-18, -8,-13, -8, -7, -4,-26,-13, -8;
/M: SY='G'; M= -2, -9,-26, -7, -6,-20, 12,-15,-21, -9,-17,-12, -7, -8,-10,-10, -3, -9,-15,-22,-17, -9;
/M: SY='L'; M=-11,-12,-19,-13, -5, -7,-25,-11,  3,-13, 15,  4,-10,-22, -6, -7,-16, -8, -3,-25, -7, -6;
/I:         I=-4; MI=-19; MD=-19; IM=-19;
/M: SY='C'; M= -4,-14, 11,-20,-17,-11,-22,-17, -3,-15, -4, -3,-12,-21,-15,-16, -6,  0,  3,-29,-11,-17; D=-4;
/I:         I=-4; MI=-19; MD=-19; IM=-19; DM=-19;
/M:         M= -9, -4, -6, -7, -3,-10,-17, -1,-16, -6,-15, -8, -1,-13, -4, -5, -1, -1,-13,-25, -6, -4; D=-4;
/I:         I=-4; MI=0; IM=0; DM=-19;
/M: SY='R'; M=-11, -9,-24,-10, -2,-14,-22, -7,-14, 14,-13, -5, -6,-15,  0, 17, -9, -5, -9,-20, -4, -3;
/M: SY='L'; M=-11,-29,-21,-29,-20, 11,-30,-16, 19,-27, 43, 19,-28,-29,-18,-19,-28,-10,  9,-15,  8,-20;
/M: SY='R'; M= -7,-11,-22,-13, -7,-11,-20, -9, -8,  2, -4, -2, -8,-18, -3,  8, -5,  2, -4,-22, -4, -6;
/M: SY='Y'; M=-12, -4,-25, -5, -4, -4,-20,  5,-12, -1,-12, -7, -4,-19, -1,  1, -5, -3,-12,-10, 16, -4;
/M: SY='P'; M= -5,-18,-34,-12, -3,-26,-19,-18,-15,-11,-24,-15,-17, 65,-10,-19, -6, -6,-21,-29,-26,-10;
/M: SY='V'; M= -5,-22,  7,-24,-20, -2,-28,-22,  7,-18,  4,  2,-22,-26,-22,-18,-12, -6, 17,-27, -8,-21;
/I:         E1=0; IE=-105; DE=-105;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2016_05 which contains 551'193 sequence entries.


Total number of hits 463 in 421 different sequences
Number of true positive hits 463 in 421 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 23
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 95.27 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] P_Bucher
Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 2
Feature key [info] DOMAIN
Feature description [info] SH2
Version [info] 3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
421 sequences

3BP2_HUMAN  (P78314    ), 3BP2_MOUSE  (Q06649    ), ABL1_CAEEL  (P03949    ), 
ABL1_HUMAN  (P00519    ), ABL1_MOUSE  (P00520    ), ABL2_HUMAN  (P42684    ), 
ABL2_MOUSE  (Q4JIM5    ), ABL_DROME   (P00522    ), ABL_FSVHY   (P10447    ), 
ABL_MLVAB   (P00521    ), BCAR3_BOVIN (Q58DL5    ), BCAR3_HUMAN (O75815    ), 
BCAR3_MACFA (Q4R8R1    ), BCAR3_MOUSE (Q9QZK2    ), BCAR3_XENLA (Q6INP9    ), 
BLK_HUMAN   (P51451    ), BLK_MOUSE   (P16277    ), BLNK_CHICK  (Q9YGC1    ), 
BLNK_HUMAN  (Q8WV28    ), BLNK_MOUSE  (Q9QUN3    ), BLNK_RAT    (Q4KM52    ), 
BMX_HUMAN   (P51813    ), BMX_MOUSE   (P97504    ), BTKL_DROME  (P08630    ), 
BTK_CHICK   (Q8JH64    ), BTK_HUMAN   (Q06187    ), BTK_MOUSE   (P35991    ), 
CED2_CAEBR  (A8XI74    ), CED2_CAEEL  (Q9NHC3    ), CHIN_HUMAN  (P15882    ), 
CHIN_MOUSE  (Q91V57    ), CHIO_HUMAN  (P52757    ), CISH_BOVIN  (Q2HJ53    ), 
CISH_CHICK  (Q9PW70    ), CISH_HUMAN  (Q9NSE2    ), CISH_MOUSE  (Q62225    ), 
CISH_RAT    (O70512    ), CLNK_HUMAN  (Q7Z7G1    ), CLNK_MOUSE  (Q9QZE2    ), 
CRKL_HUMAN  (P46109    ), CRKL_MOUSE  (P47941    ), CRKL_RAT    (Q5U2U2    ), 
CRK_CHICK   (Q04929    ), CRK_DROME   (Q9XYM0    ), CRK_HUMAN   (P46108    ), 
CRK_MOUSE   (Q64010    ), CRK_RAT     (Q63768    ), CRK_XENLA   (P87378    ), 
CSK1_CAEEL  (G5ECJ6    ), CSK_BOVIN   (Q0VBZ0    ), CSK_CHICK   (P41239    ), 
CSK_HUMAN   (P41240    ), CSK_MOUSE   (P41241    ), CSK_RAT     (P32577    ), 
CSW_DROME   (P29349    ), CSW_DROVI   (Q24708    ), DAPP1_HUMAN (Q9UN19    ), 
DAPP1_MOUSE (Q9QXT1    ), DRK_DROME   (Q08012    ), DRK_DROSI   (Q6YKA8    ), 
FER_CANLF   (Q9TTY2    ), FER_DROME   (P18106    ), FER_HUMAN   (P16591    ), 
FER_MOUSE   (P70451    ), FER_RAT     (P09760    ), FES_FELCA   (P14238    ), 
FES_FSVGA   (P00542    ), FES_FSVST   (P00543    ), FES_HUMAN   (P07332    ), 
FES_MOUSE   (P16879    ), FGR_FSVGR   (P00544    ), FGR_HUMAN   (P09769    ), 
FGR_MOUSE   (P14234    ), FGR_RAT     (Q6P6U0    ), FPS_AVISP   (P00541    ), 
FPS_FUJSV   (P00530    ), FRK1_CAEEL  (Q22146    ), FRK_HUMAN   (P42685    ), 
FRK_MOUSE   (Q922K9    ), FRK_RAT     (Q62662    ), FYNA_DANRE  (Q6EWH2    ), 
FYNB_DANRE  (F1RDG9    ), FYN_BOVIN   (A0JNB0    ), FYN_CHICK   (Q05876    ), 
FYN_HUMAN   (P06241    ), FYN_MOUSE   (P39688    ), FYN_PIG     (A1Y2K1    ), 
FYN_RAT     (Q62844    ), FYN_XENLA   (P13406    ), FYN_XIPHE   (P27446    ), 
GAGC_AVISC  (P05433    ), GRAP2_HUMAN (O75791    ), GRAP2_MOUSE (O89100    ), 
GRAPL_HUMAN (Q8TC17    ), GRAP_BOVIN  (A6QLK6    ), GRAP_HUMAN  (Q13588    ), 
GRAP_MOUSE  (Q9CX99    ), GRB10_HUMAN (Q13322    ), GRB10_MOUSE (Q60760    ), 
GRB10_PIG   (B5KFD7    ), GRB10_RAT   (P0CE43    ), GRB14_BOVIN (Q5ICW4    ), 
GRB14_HUMAN (Q14449    ), GRB14_MOUSE (Q9JLM9    ), GRB14_RAT   (O88900    ), 
GRB2A_XENLA (P87379    ), GRB2B_XENLA (Q6GPJ9    ), GRB2_CHICK  (Q07883    ), 
GRB2_HUMAN  (P62993    ), GRB2_MOUSE  (Q60631    ), GRB2_PONAB  (Q5R4J7    ), 
GRB2_RAT    (P62994    ), GRB2_XENTR  (Q66II3    ), GRB7_BOVIN  (Q1RMW5    ), 
GRB7_HUMAN  (Q14451    ), GRB7_MOUSE  (Q03160    ), GRB7_RAT    (Q9QZC5    ), 
HCK_HUMAN   (P08631    ), HCK_MACFA   (Q95M30    ), HCK_MOUSE   (P08103    ), 
HCK_RAT     (P50545    ), HSH2D_DANRE (Q56A36    ), HSH2D_HUMAN (Q96JZ2    ), 
HSH2D_MOUSE (Q6VYH9    ), HTK16_HYDVU (P53356    ), ITK_HUMAN   (Q08881    ), 
ITK_MOUSE   (Q03526    ), JAK1_HUMAN  (P23458    ), JAK1_MOUSE  (P52332    ), 
JAK2_CHICK  (Q75R65    ), JAK2_HUMAN  (O60674    ), JAK2_MOUSE  (Q62120    ), 
JAK2_PIG    (O19064    ), JAK2_PONAB  (Q5RB23    ), JAK2_RAT    (Q62689    ), 
KSYK_CHICK  (F1N9Y5    ), KSYK_HUMAN  (P43405    ), KSYK_MOUSE  (P48025    ), 
KSYK_PIG    (Q00655    ), KSYK_RAT    (Q64725    ), LCK_AOTNA   (Q5PXS1    ), 
LCK_CHICK   (P42683    ), LCK_HUMAN   (P06239    ), LCK_MOUSE   (P06240    ), 
LCK_RAT     (Q01621    ), LCK_SAISC   (Q95KR7    ), LCP2_HUMAN  (Q13094    ), 
LCP2_MOUSE  (Q60787    ), LYN_HUMAN   (P07948    ), LYN_MOUSE   (P25911    ), 
LYN_RAT     (Q07014    ), MATK_HUMAN  (P42679    ), MATK_MOUSE  (P41242    ), 
MATK_RAT    (P41243    ), NCK1_HUMAN  (P16333    ), NCK1_MOUSE  (Q99M51    ), 
NCK2_HUMAN  (O43639    ), NCK2_MOUSE  (O55033    ), P55G_BOVIN  (O46404    ), 
P55G_HUMAN  (Q92569    ), P55G_MOUSE  (Q64143    ), P55G_RAT    (Q63789    ), 
P85AA_XENLA (Q8UUU2    ), P85A_BOVIN  (P23727    ), P85A_HUMAN  (P27986    ), 
P85A_MOUSE  (P26450    ), P85A_PONAB  (Q5R685    ), P85A_RAT    (Q63787    ), 
P85B_BOVIN  (P23726    ), P85B_HUMAN  (O00459    ), P85B_MOUSE  (O08908    ), 
P85B_RAT    (Q63788    ), PLCG1_BOVIN (P08487    ), PLCG1_HUMAN (P19174    ), 
PLCG1_MOUSE (Q62077    ), PLCG1_RAT   (P10686    ), PLCG2_HUMAN (P16885    ), 
PLCG2_MOUSE (Q8CIH5    ), PLCG2_RAT   (P24135    ), PTK6_HUMAN  (Q13882    ), 
PTK6_MOUSE  (Q64434    ), PTN11_CHICK (Q90687    ), PTN11_HUMAN (Q06124    ), 
PTN11_MOUSE (P35235    ), PTN11_RAT   (P41499    ), PTN6_HUMAN  (P29350    ), 
PTN6_MOUSE  (P29351    ), PTN6_RAT    (P81718    ), PTP2_CAEEL  (G5EC24    ), 
RASA1_BOVIN (P09851    ), RASA1_HUMAN (P20936    ), RASA1_RAT   (P50904    ), 
RIN1_HUMAN  (Q13671    ), RIN1_RAT    (P97680    ), RIN2_HUMAN  (Q8WYP3    ), 
RIN2_MOUSE  (Q9D684    ), RIN3_HUMAN  (Q8TB24    ), SEM5_CAEEL  (P29355    ), 
SH21A_BOVIN (Q3ZBB1    ), SH21A_HUMAN (O60880    ), SH21A_MACMU (Q71S10    ), 
SH21A_MOUSE (O88890    ), SH21A_PIG   (Q06AA1    ), SH21A_RAT   (B2RZ59    ), 
SH21A_SAGOE (Q9BG88    ), SH21B_HUMAN (O14796    ), SH21B_MOUSE (O35324    ), 
SH21C_MOUSE (Q45HK4    ), SH22A_HUMAN (Q9NP31    ), SH22A_MOUSE (Q9QXK9    ), 
SH23A_HUMAN (Q9BRG2    ), SH24A_HUMAN (Q9H788    ), SH24A_MOUSE (Q9D7V1    ), 
SH24A_RAT   (Q6AYC8    ), SH24A_XENTR (Q08CX2    ), SH24B_HUMAN (Q5SQS7    ), 
SH24B_MOUSE (A6X942    ), SH2B1_HUMAN (Q9NRF2    ), SH2B1_MOUSE (Q91ZM2    ), 
SH2B1_RAT   (Q62985    ), SH2B2_HUMAN (O14492    ), SH2B2_MOUSE (Q9JID9    ), 
SH2B2_RAT   (Q9Z200    ), SH2B3_HUMAN (Q9UQQ2    ), SH2B3_MOUSE (O09039    ), 
SH2B3_RAT   (P50745    ), SH2D3_HUMAN (Q8N5H7    ), SH2D3_MOUSE (Q9QZS8    ), 
SH2D5_HUMAN (Q6ZV89    ), SH2D5_MOUSE (Q8JZW5    ), SH2D5_PONAB (Q5R732    ), 
SH2D6_HUMAN (Q7Z4S9    ), SH2D6_MOUSE (Q9D413    ), SH2D7_HUMAN (A6NKC9    ), 
SH2D7_MOUSE (Q8BI17    ), SHARK_DROME (Q24145    ), SHB_HUMAN   (Q15464    ), 
SHB_MOUSE   (Q6PD21    ), SHC1_BOVIN  (Q0IIE2    ), SHC1_HUMAN  (P29353    ), 
SHC1_MOUSE  (P98083    ), SHC1_PONAB  (Q5R7W7    ), SHC1_RAT    (Q5M824    ), 
SHC1_XENLA  (Q8AY68    ), SHC2_HUMAN  (P98077    ), SHC2_MOUSE  (Q8BMC3    ), 
SHC2_RAT    (O70142    ), SHC3_HUMAN  (Q92529    ), SHC3_MOUSE  (Q61120    ), 
SHC3_RAT    (O70143    ), SHC4_HUMAN  (Q6S5L8    ), SHC4_MOUSE  (Q6S5L9    ), 
SHCH1_CAEEL (Q9TYT3    ), SHD_HUMAN   (Q96IW2    ), SHD_MOUSE   (O88834    ), 
SHE_HUMAN   (Q5VZ18    ), SHE_MOUSE   (Q8BSD5    ), SHF_HUMAN   (Q7M4L6    ), 
SHF_MOUSE   (Q8CG80    ), SHIP1_HUMAN (Q92835    ), SHIP1_MOUSE (Q9ES52    ), 
SHIP1_RAT   (P97573    ), SHIP1_XENLA (Q6P4S2    ), SHIP2_HUMAN (O15357    ), 
SHIP2_MOUSE (Q6P549    ), SHIP2_RAT   (Q9WVR3    ), SHKA_DICDI  (Q54RB7    ), 
SHKB_DICDI  (Q54IP4    ), SHKC_DICDI  (Q54Y55    ), SHKD_DICDI  (Q54U31    ), 
SHKE_DICDI  (Q54G43    ), SHP2A_DANRE (Q2I6J1    ), SHP2B_DANRE (Q2I6J0    ), 
SLAP1_HUMAN (Q13239    ), SLAP1_MOUSE (Q60898    ), SLAP1_RAT   (P59622    ), 
SLAP2_HUMAN (Q9H6Q3    ), SLAP2_MOUSE (Q8R4L0    ), SOCS1_HUMAN (O15524    ), 
SOCS1_MOUSE (O35716    ), SOCS1_RAT   (Q9QX78    ), SOCS2_BOVIN (Q861R0    ), 
SOCS2_HUMAN (O14508    ), SOCS2_MOUSE (O35717    ), SOCS2_PIG   (Q7YRV6    ), 
SOCS2_RAT   (O88582    ), SOCS3_BOVIN (Q9BEG9    ), SOCS3_CANLF (Q68AM8    ), 
SOCS3_CHICK (Q90X67    ), SOCS3_HUMAN (O14543    ), SOCS3_MOUSE (O35718    ), 
SOCS3_RAT   (O88583    ), SOCS4_BOVIN (Q0VC91    ), SOCS4_HUMAN (Q8WXH5    ), 
SOCS4_MOUSE (Q91ZA6    ), SOCS4_PONAB (Q5RDX2    ), SOCS5_BOVIN (Q29RN6    ), 
SOCS5_HUMAN (O75159    ), SOCS5_MOUSE (O54928    ), SOCS6_HUMAN (O14544    ), 
SOCS6_MOUSE (Q9JLY0    ), SOCS6_PONAB (Q5RCM6    ), SOCS7_HUMAN (O14512    ), 
SOCS7_MOUSE (Q8VHQ2    ), SPE8_CAEBR  (A8WZ92    ), SPE8_CAEEL  (O01798    ), 
SPK1_GIRTI  (P42687    ), SPRI_DROME  (Q8MQW8    ), SPT6H_DANRE (Q8UVK2    ), 
SPT6H_HUMAN (Q7KZ85    ), SPT6H_MOUSE (Q62383    ), SPT6_ASHGO  (Q75EP8    ), 
SPT6_ASPFU  (Q4WWH6    ), SPT6_CANAL  (Q3MNT0    ), SPT6_CANGA  (Q6FLB1    ), 
SPT6_DEBHA  (Q6BVE1    ), SPT6_KLULA  (Q6CVK3    ), SPT6_YEAST  (P23615    ), 
SRC1_CAEEL  (G5EE56    ), SRC1_XENLA  (P13115    ), SRC2_CAEEL  (O45539    ), 
SRC2_XENLA  (P13116    ), SRC42_DROME (Q9V9J3    ), SRC64_DROME (P00528    ), 
SRC_AVIS2   (P15054    ), SRC_AVISR   (P00525    ), SRC_AVISS   (P14084    ), 
SRC_AVIST   (P14085    ), SRC_CHICK   (P00523    ), SRC_DANRE   (Q1JPZ3    ), 
SRC_HUMAN   (P12931    ), SRC_MOUSE   (P05480    ), SRC_RAT     (Q9WUD9    ), 
SRC_RSVH1   (P25020    ), SRC_RSVP    (P00526    ), SRC_RSVPA   (P31693    ), 
SRC_RSVSA   (P00524    ), SRC_RSVSE   (P63185    ), SRK1_SPOLA  (P42686    ), 
SRK2_SPOLA  (P42688    ), SRK3_SPOLA  (P42689    ), SRK4_SPOLA  (P42690    ), 
SRMS_HUMAN  (Q9H3Y6    ), SRMS_MOUSE  (Q62270    ), STA31_XENLA (Q9PVX8    ), 
STA32_XENLA (Q7ZXK3    ), STA5A_BOVIN (Q95115    ), STA5A_HUMAN (P42229    ), 
STA5A_MOUSE (P42230    ), STA5A_PIG   (Q9TUZ1    ), STA5A_RAT   (Q62771    ), 
STA5A_SHEEP (P42231    ), STA5B_BOVIN (Q9TUM3    ), STA5B_HUMAN (P51692    ), 
STA5B_MOUSE (P42232    ), STA5B_PIG   (Q9TUZ0    ), STA5B_RAT   (P52632    ), 
STAP1_HUMAN (Q9ULZ2    ), STAP1_MOUSE (Q9JM90    ), STAP2_HUMAN (Q9UGK3    ), 
STAP2_MOUSE (Q8R0L1    ), STAT1_HUMAN (P42224    ), STAT1_MOUSE (P42225    ), 
STAT1_PIG   (Q764M5    ), STAT2_HUMAN (P52630    ), STAT2_MOUSE (Q9WVL2    ), 
STAT2_PIG   (O02799    ), STAT3_BOVIN (P61635    ), STAT3_CHICK (Q6DV79    ), 
STAT3_HUMAN (P40763    ), STAT3_MOUSE (P42227    ), STAT3_PIG   (Q19S50    ), 
STAT3_RAT   (P52631    ), STAT4_HUMAN (Q14765    ), STAT4_MOUSE (P42228    ), 
STAT6_HUMAN (P42226    ), STAT6_MOUSE (P52633    ), STATA_DICDI (O00910    ), 
STATB_CAEEL (Q20977    ), STATB_DICDI (Q70GP4    ), STATC_DICDI (Q54BD4    ), 
STAT_ANOGA  (Q7QDU4    ), STAT_DROME  (Q24151    ), STK_HYDVU   (P17713    ), 
TEC_HUMAN   (P42680    ), TEC_MOUSE   (P24604    ), TENS1_BOVIN (Q9GLM4    ), 
TENS1_HUMAN (Q9HBL0    ), TENS3_HUMAN (Q68CZ2    ), TENS3_MOUSE (Q5SSZ5    ), 
TENS4_BOVIN (Q32PJ7    ), TENS4_HUMAN (Q8IZW8    ), TENS4_MOUSE (Q8BZ33    ), 
TENS4_RAT   (Q4V8I3    ), TENS_CHICK  (Q04205    ), TNS2_HUMAN  (Q63HR2    ), 
TNS2_MOUSE  (Q8CGB6    ), TXK_HUMAN   (P42681    ), TXK_MOUSE   (P42682    ), 
VAV2_HUMAN  (P52735    ), VAV2_MOUSE  (Q60992    ), VAV3_HUMAN  (Q9UKW4    ), 
VAV3_MOUSE  (Q9R0C8    ), VAV_BOVIN   (Q08DN7    ), VAV_CAEEL   (Q45FX5    ), 
VAV_DROME   (Q9NHV9    ), VAV_HUMAN   (P15498    ), VAV_MOUSE   (P27870    ), 
VAV_RAT     (P54100    ), YES_AVISY   (P00527    ), YES_CANLF   (Q28923    ), 
YES_CHICK   (P09324    ), YES_DANRE   (A1A5H8    ), YES_HUMAN   (P07947    ), 
YES_MOUSE   (Q04736    ), YES_RAT     (F1LM93    ), YES_XENLA   (P10936    ), 
YES_XIPHE   (P27447    ), YRK_CHICK   (Q02977    ), ZAP70_HUMAN (P43403    ), 
ZAP70_MOUSE (P43404    )
» more

UniProtKB/Swiss-Prot
False negative sequences
23 sequences

JAK1_CYPCA  (Q09178    ), JAK1_DANRE  (O12990    ), JAK3_HUMAN  (P52333    ), 
JAK3_MOUSE  (Q62137    ), JAK3_RAT    (Q63272    ), JAK_DROME   (Q24592    ), 
RIN1_MOUSE  (Q921Q7    ), RIN3_MOUSE  (P59729    ), SPT6H_CAEBR (Q93148    ), 
SPT6H_CAEEL (P34703    ), SPT6H_DROME (Q9W420    ), SPT6_ASPOR  (Q2U561    ), 
SPT6_CRYNB  (P0CR73    ), SPT6_CRYNJ  (P0CR72    ), SPT6_EMENI  (Q5B7Q7    ), 
SPT6_GIBZE  (Q4HYQ4    ), SPT6_NEUCR  (Q8NIV6    ), SPT6_SCHPO  (Q09915    ), 
SPT6_USTMA  (Q4PI89    ), STAT1_CAEBR (Q61AP6    ), STAT1_CAEEL (Q9NAD6    ), 
TYK2_HUMAN  (P29597    ), TYK2_MOUSE  (Q9R117    )
» more

PDB
[Detailed view]
349 PDB

1A07; 1A08; 1A09; 1A1A; 1A1B; 1A1C; 1A1E; 1A81; 1AB2; 1AD5; 1AOT; 1AOU; 1AYA; 1AYB; 1AYC; 1AYD; 1BF5; 1BFI; 1BFJ; 1BG1; 1BHF; 1BHH; 1BKL; 1BKM; 1BLJ; 1BLK; 1BM2; 1BMB; 1CJ1; 1CSY; 1CSZ; 1CWD; 1CWE; 1D1Z; 1D4T; 1D4W; 1F1W; 1F2F; 1FBZ; 1FHS; 1FMK; 1FU5; 1FU6; 1FYR; 1G83; 1GHU; 1GRI; 1H9O; 1HCS; 1HCT; 1I3Z; 1IJR; 1IS0; 1JU5; 1JWO; 1JYQ; 1JYR; 1JYU; 1K9A; 1KA6; 1KA7; 1KC2; 1KSW; 1LCJ; 1LCK; 1LKK; 1LKL; 1LUI; 1LUK; 1LUM; 1LUN; 1M27; 1M61; 1MIL; 1MW4; 1NRV; 1NZL; 1NZV; 1O41; 1O42; 1O43; 1O44; 1O45; 1O46; 1O47; 1O48; 1O49; 1O4A; 1O4B; 1O4C; 1O4D; 1O4E; 1O4F; 1O4G; 1O4H; 1O4I; 1O4J; 1O4K; 1O4L; 1O4M; 1O4N; 1O4O; 1O4P; 1O4Q; 1O4R; 1OO3; 1OO4; 1OPK; 1OPL; 1P13; 1PIC; 1QAD; 1QCF; 1QG1; 1R1P; 1R1Q; 1R1S; 1RJA; 1RPY; 1RQQ; 1SHA; 1SHB; 1SHD; 1SKJ; 1SPR; 1SPS; 1TCE; 1TZE; 1UUR; 1UUS; 1WQU; 1X0N; 1X27; 1X6C; 1XA6; 1Y1U; 1Y57; 1YVL; 1Z3K; 1ZFP; 2ABL; 2AOA; 2AOB; 2AUG; 2B3O; 2BBU; 2C0I; 2C0O; 2C0T; 2C9W; 2CI8; 2CI9; 2CIA; 2CR4; 2CRH; 2CS0; 2DCR; 2DLY; 2DLZ; 2DM0; 2DVJ; 2DX0; 2ECD; 2EKX; 2EL8; 2EO3; 2EO6; 2EOB; 2ETZ; 2EU0; 2EYV; 2EYY; 2EYZ; 2FCI; 2FO0; 2GE9; 2GSB; 2H46; 2H5K; 2H8H; 2HCK; 2HDV; 2HDX; 2HMH; 2HUW; 2IUG; 2IUH; 2IUI; 2IZV; 2JYQ; 2K79; 2K7A; 2KK6; 2KNO; 2L3T; 2L4K; 2L6K; 2LCT; 2LNW; 2LNX; 2LQN; 2LQW; 2MC1; 2MK2; 2MQI; 2MRJ; 2MRK; 2OQ1; 2OZO; 2PLD; 2PLE; 2PNA; 2PNB; 2PTK; 2QMS; 2RMX; 2ROR; 2RSY; 2SHP; 2SRC; 2VIF; 2Y3A; 2YSX; 2YU7; 3BKB; 3C7I; 3CBL; 3CD3; 3CWG; 3CXL; 3EAC; 3EAZ; 3GQI; 3GXW; 3GXX; 3HCK; 3HHM; 3HIZ; 3IMD; 3IMJ; 3IN7; 3IN8; 3K2M; 3KFJ; 3M7F; 3MAZ; 3MXC; 3MXY; 3N7Y; 3N84; 3N8M; 3NHN; 3OV1; 3OVE; 3PJP; 3PQZ; 3PS5; 3PSJ; 3PSK; 3QWX; 3QWY; 3S8L; 3S8N; 3S8O; 3S9K; 3T04; 3TKZ; 3TL0; 3UF4; 3US4; 3UYO; 3VRY; 3VRZ; 3VS0; 3VS1; 3VS2; 3VS3; 3VS4; 3VS5; 3VS6; 3VS7; 3WA4; 4D8K; 4DGP; 4DGX; 4E68; 4E93; 4EIH; 4EY0; 4F59; 4F5A; 4F5B; 4FBN; 4FL2; 4FL3; 4GL9; 4GWF; 4H1O; 4H34; 4JE4; 4JEG; 4JGH; 4JMG; 4JMH; 4JPS; 4K11; 4K2R; 4K44; 4K45; 4L1B; 4L23; 4L2Y; 4LUD; 4LUE; 4M4Z; 4NWF; 4NWG; 4OHD; 4OHE; 4OHH; 4OHI; 4OHL; 4OVU; 4OVV; 4P9V; 4P9Z; 4QSY; 4ROJ; 4TZI; 4U17; 4U1P; 4U5W; 4WAF; 4WWQ; 4X6S; 4XEY; 4XI2; 4XZ0; 4XZ1; 4Y5U; 4Y5W; 4YKN; 5BO4; 5DC0; 5DC4; 5DC9; 5DF6; 5EG3; 5FI4
» more

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