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Entry: PS50020

General information about the entry

Entry name [info] WW_DOMAIN_2
Accession [info] PS50020
Entry type [info] MATRIX
Date [info] NOV-1995 (CREATED); OCT-2013 (DATA UPDATE); OCT-2016 (INFO UPDATE).
PROSITE Doc. [info] PDOC50020
Associated ProRule [info] PRU00224

Name and characterization of the entry

Description [info] WW/rsp5/WWP domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=34;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=31;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.2776000; R2=0.0197000; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1518.2681885; R2=1.0788643; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=418; H_SCORE=1969; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=316; H_SCORE=1859; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='S'; M= -5, -9,-25,-10, -3,-21, -5,-13,-15, -7,-16, -9, -6, -1,  0, -5,  2,  1,-13,-26,-17, -3;
/M: SY='P'; M= -7, -5,-30, -1, -1,-24, -5,-13,-22, -9,-24,-17, -4, 27, -6,-13,  0, -5,-24,-29,-22, -5;
/M: SY='L'; M= -8,-23,-19,-24,-18,  2,-27,-18, 15,-22, 29, 12,-22,-24,-16,-14,-21, -7, 12,-24, -5,-18;
/M: SY='P'; M= -9,-10,-34, -5,  7,-27,-18,-12,-18, -6,-23,-13,-10, 49,  1,-13, -5, -8,-26,-29,-23,  1;
/M: SY='P'; M= -1, -1,-24,  1, -2,-22, -6,-11,-21, -5,-24,-17,  2, 12, -5,-10,  8,  1,-19,-29,-17, -5;
/M: SY='G'; M= -4, -9,-31, -7,-11,-29, 34,-14,-30,-16,-27,-18, -3,  4,-12,-18, -1,-14,-27,-24,-25,-13;
/M: SY='W'; M=-20,-40,-50,-40,-30, 10,-20,-30,-20,-20,-20,-20,-40,-30,-20,-20,-40,-30,-30,150, 30,-20;
/M: SY='E'; M= -8,  0,-25,  3, 24,-20,-20, -7,-21, 15,-18,-10, -3, -8,  9,  5, -2, -3,-16,-25,-12, 16;
/M: SY='E'; M= -1, -8,-15, -8,  7,-19,-15,-11,-13,  1,-11, -5, -9,-15,  1,  1, -3, -5, -6,-26,-15,  3;
/M: SY='R'; M= -2,-16,-23,-18,-12, -7,-20, -4, -7, -1, -7, -3,-12,-21, -7,  6, -9, -8, -2,-10,  2,-11;
/M: SY='Y'; M=-11,-14,-24,-18, -8,  4,-25,-10, -5, -4, -4,  1,-12,-19, -4, -5,-10, -2, -5, -7,  5, -6;
/M: SY='D'; M= -5, 17,-20, 19,  3,-23,-11,  1,-22, -6,-20,-14, 10,-12, -2, -9, 10, 10,-15,-34,-13,  0;
/M: SY='B'; M= -2,  6,-25,  6,  3,-26, -6, -8,-23, -1,-23,-16,  4,  3, -3, -8,  3,  0,-19,-29,-18, -1;
/M: SY='N'; M= -7, 10,-22, 10,  8,-21,-13, -6,-22,  6,-22,-15, 11,-13,  1,  2,  7,  2,-16,-31,-15,  5;
/I:         MD=-27;
/M: SY='G'; M= -3, -5,-26, -7,-11,-23, 30,-13,-28, -3,-23,-12,  2,-17,-10, -7, -2,-11,-22,-18,-17,-11; D=-5;
/I:         I=-10; MI=-5; MD=-27; IM=-5; DM=-27;
/M: SY='R'; M=-13,-10,-25,-12, -3,-14,-17, -7,-18, 14,-14, -7, -4,-18,  3, 34, -7, -4,-11,-20, -8, -3; D=-5;
/I:         DM=-27;
/M: SY='P'; M= -7,-15,-25,-16, -9, -8,-23,-17, -5, -7,-11, -7,-13,  5,-11, -9, -5,  3, -4,-14, -5,-12;
/M: SY='Y'; M=-19,-24,-26,-27,-24, 40,-30,  5,  4,-17,  4,  1,-20,-30,-19,-14,-20,-10, -3, 20, 59,-24;
/M: SY='Y'; M=-20,-24,-26,-28,-24, 50,-30,  4,  0,-18,  4,  0,-20,-30,-22,-14,-20,-10, -6, 22, 60,-24;
/M: SY='Y'; M=-12,-26,-25,-29,-24, 10,-29, -9, 13,-21,  7,  5,-22,-26,-19,-18,-18, -8, 10,  6, 14,-23;
/M: SY='N'; M=-12, 40,-22, 29,  4,-24, -3, 12,-24,  0,-30,-21, 51,-18,  0, -2,  7, -3,-30,-40,-18,  2;
/M: SY='H'; M=-12, -5,-28, -5, -3,-18,-20, 39,-19, -8,-12, -3, -1, -5,  0, -4, -9,-10,-19,-28,  2, -5;
/M: SY='E'; M= -5,  2,-23,  0,  9,-19,-17, -8,-12,  2,-13, -9,  5,-10,  2, -3, -1, -3,-11,-29,-15,  5;
/M: SY='T'; M= -1,  3,-13, -5, -8,-12,-17,-16,-10,-10,-11,-11,  5,-12, -8,-11, 17, 34, -3,-32,-12, -8;
/M: SY='K'; M=-11,  1,-29, -1,  4,-28, -7,  1,-29, 25,-27,-10,  6,-14, 11, 22, -6,-11,-24,-22,-12,  7;
/M: SY='E'; M= -7,  5,-23,  5, 17,-23,-19, -4,-23, 10,-20,-13,  2, -8,  7,  5,  5, 10,-17,-28,-12, 12;
/M: SY='T'; M=  3,  0,-10, -7, -7,-13,-14,-17,-13,-10,-16,-13,  3,-10, -7,-10, 26, 40, -3,-33,-13, -7;
/M: SY='Q'; M= -6, -5,-11, -8,  0,-19,-19, -5,-16, -3,-14, -7, -3,-15, 14,  1,  7, 11,-14,-25, -7,  6;
/M: SY='W'; M=-19,-36,-45,-37,-28, 14,-21,-24,-17,-19,-16,-17,-35,-29,-20,-19,-34,-24,-25,124, 33,-20;
/M: SY='E'; M= -9,  4,-25,  9, 19,-22,-20, -6,-15,  0,-14,-11, -2,-10,  8, -5,  0, -2,-14,-27,-10, 13;
/M: SY='D'; M=-15,  5,-32, 12,  8,-29,-18,  4,-27, 10,-25,-15,  1, 11,  2,  8, -8,-11,-24,-29,-14,  2;
/M: SY='P'; M=-10,-20,-40,-10,  0,-30,-20,-20,-20,-10,-30,-20,-20, 90,-10,-20,-10,-10,-30,-30,-30,-10;
/M: SY='R'; M= -9,  1,-23,  0,  1,-20,-14, -8,-21, 10,-16,-11,  2,-16,  0, 19, -1,  0,-13,-27,-13, -1;
/M: SY='M'; M=-10,-15,-24,-17, -8, -2,-13,-10, -6,-11, -1,  2,-12,-11,-11, -8,-11, -6, -6,-20, -6,-10;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2016_11 which contains 553'231 sequence entries.


Total number of hits 375 in 217 different sequences
Number of true positive hits 375 in 217 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 13
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 96.65 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 4
Feature key [info] DOMAIN
Feature description [info] WW
Version [info] 4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
217 sequences

APBB1_HUMAN (O00213    ), APBB1_MOUSE (Q9QXJ1    ), APBB1_RAT   (P46933    ), 
APBB2_HUMAN (Q92870    ), APBB2_MOUSE (Q9DBR4    ), APBB3_HUMAN (O95704    ), 
APBB3_MOUSE (Q8R1C9    ), APBB3_RAT   (O35827    ), BAG3_HUMAN  (O95817    ), 
BAG3_MOUSE  (Q9JLV1    ), C1716_DROME (Q9VYD1    ), CE164_HUMAN (Q9UPV0    ), 
CE164_MOUSE (Q5DU05    ), CMTR1_BOVIN (A2VE39    ), CMTR1_DANRE (Q803R5    ), 
CMTR1_MOUSE (Q9DBC3    ), CMTR1_XENLA (Q6GQ76    ), DB10_NICSY  (P46942    ), 
DGCR8_BOVIN (A6QR44    ), DGCR8_HUMAN (Q8WYQ5    ), DGCR8_MOUSE (Q9EQM6    ), 
DMDA_DROME  (Q9VDW6    ), DMDB_DROME  (Q9VDW3    ), DMDD_DROME  (Q0KI50    ), 
DMDE_DROME  (Q7YU29    ), DMD_CAEEL   (Q9TW65    ), DMD_CANLF   (O97592    ), 
DMD_CHICK   (P11533    ), DMD_HUMAN   (P11532    ), DMD_MOUSE   (P11531    ), 
DMD_PIG     (Q5GN48    ), DMD_RAT     (P11530    ), DOD_DROME   (P54353    ), 
DRE4_SCHPO  (Q09685    ), DRP2_HUMAN  (Q13474    ), DRP2_MOUSE  (Q05AA6    ), 
DRP2_RAT    (Q9EPA0    ), DWWA_DICDI  (Q54T86    ), ESS1_YEAST  (P22696    ), 
FCA_ARATH   (O04425    ), FEH1_CAEEL  (Q9BKZ9    ), FNBP4_HUMAN (Q8N3X1    ), 
FNBP4_MOUSE (Q6ZQ03    ), FRPD4_HUMAN (Q14CM0    ), FRPD4_MOUSE (A2AFR3    ), 
GAS7_HUMAN  (O60861    ), GAS7_MOUSE  (Q60780    ), GAS7_RAT    (O55148    ), 
HECW1_HUMAN (Q76N89    ), HECW1_MOUSE (Q8K4P8    ), HECW2_HUMAN (Q9P2P5    ), 
HECW2_MOUSE (Q6I6G8    ), IQGA1_HUMAN (P46940    ), IQGA2_HUMAN (Q13576    ), 
IQGA2_MOUSE (Q3UQ44    ), ITCH_HUMAN  (Q96J02    ), ITCH_MOUSE  (Q8C863    ), 
KIBRA_DROAN (B3LWS4    ), KIBRA_DROER (B3P3M8    ), KIBRA_DROME (Q9VFG8    ), 
KIBRA_DROMO (B4K6I9    ), KIBRA_DROSE (B4HEJ6    ), KIBRA_DROVI (B4M5X4    ), 
KIBRA_DROWI (B4NAD3    ), KIBRA_DROYA (B4PSQ2    ), KIBRA_HUMAN (Q8IX03    ), 
KIBRA_MOUSE (Q5SXA9    ), KIBRA_XENTR (A4IIJ3    ), MAGI1_HUMAN (Q96QZ7    ), 
MAGI1_MOUSE (Q6RHR9    ), MAGI1_RAT   (Q4L1J4    ), MAGI2_HUMAN (Q86UL8    ), 
MAGI2_MOUSE (Q9WVQ1    ), MAGI2_RAT   (O88382    ), MAGI3_CHICK (Q5F488    ), 
MAGI3_HUMAN (Q5TCQ9    ), MAGI3_MOUSE (Q9EQJ9    ), MAGI3_RAT   (Q9JK71    ), 
MAGI3_XENTR (A1A5G4    ), NCFA_DICDI  (Q867T7    ), NED4L_HUMAN (Q96PU5    ), 
NED4L_MOUSE (Q8CFI0    ), NED4L_PONAB (Q5RBF2    ), NEDD4_DROME (Q9VVI3    ), 
NEDD4_HUMAN (P46934    ), NEDD4_MOUSE (P46935    ), NEDD4_RAT   (Q62940    ), 
PCIF1_HUMAN (Q9H4Z3    ), PCIF1_MOUSE (P59114    ), PIN1_BOVIN  (Q5BIN5    ), 
PIN1_HUMAN  (Q13526    ), PIN1_MACFA  (Q4R383    ), PIN1_MOUSE  (Q9QUR7    ), 
PIN1_RHIO9  (P0C1J8    ), PIN1_SCHPO  (O74448    ), PINL_HUMAN  (O15428    ), 
PKHA5_HUMAN (Q9HAU0    ), PKHA7_DANRE (B6RSP1    ), PKHA7_HUMAN (Q6IQ23    ), 
PKHA7_MOUSE (Q3UIL6    ), PQBP1_BOVIN (Q2HJC9    ), PQBP1_GORGO (A1YFA7    ), 
PQBP1_HUMAN (O60828    ), PQBP1_MOUSE (Q91VJ5    ), PQBP1_PONPY (A2T806    ), 
PQBP1_RAT   (Q6PCT5    ), PR35B_ARATH (F4JCC1    ), PR40A_ARATH (B6EUA9    ), 
PR40A_HUMAN (O75400    ), PR40A_MOUSE (Q9R1C7    ), PR40B_HUMAN (Q6NWY9    ), 
PR40B_MOUSE (Q80W14    ), PR40C_ARATH (Q9LT25    ), PRP40_SCHPO (O14176    ), 
PRP40_YEAST (P33203    ), PUB1_SCHPO  (Q92462    ), PUB2_SCHPO  (Q9UTG2    ), 
PUB3_SCHPO  (O14326    ), RH14_ARATH  (Q8H136    ), RH14_ORYSJ  (Q5VQL1    ), 
RH40_ARATH  (Q9SQV1    ), RH40_ORYSJ  (Q5JKF2    ), RH46_ARATH  (Q9LYJ9    ), 
RHG09_HUMAN (Q9BRR9    ), RHG12_HUMAN (Q8IWW6    ), RHG12_MACFA (Q9BE31    ), 
RHG12_MOUSE (Q8C0D4    ), RHG27_HUMAN (Q6ZUM4    ), RHG27_MOUSE (A2AB59    ), 
RHG27_RAT   (Q6TLK4    ), RHG39_HUMAN (Q9C0H5    ), RHG39_MOUSE (P59281    ), 
RSP5_ASPCL  (A1CQG2    ), RSP5_ASPFC  (B0XQ72    ), RSP5_ASPFN  (B8N7E5    ), 
RSP5_ASPFU  (Q4WTF3    ), RSP5_ASPNC  (A2QQ28    ), RSP5_ASPOR  (Q2UBP1    ), 
RSP5_ASPTN  (Q0CCL1    ), RSP5_CHATD  (G0S9J5    ), RSP5_EMENI  (Q5BDP1    ), 
RSP5_NEOFI  (A1D3C5    ), RSP5_YEAST  (P39940    ), SAC9_ARATH  (Q7XZU0    ), 
SAV1_HUMAN  (Q9H4B6    ), SAV1_MOUSE  (Q8VEB2    ), SAV1_RAT    (A4V8B4    ), 
SAV_DROME   (Q9VCR6    ), SEC24_CRYNB (P0CR41    ), SEC24_CRYNJ (P0CR40    ), 
SEC24_USTMA (Q4P9K4    ), SET2_ASPOR  (Q2UTN6    ), SET2_CANAL  (Q59XV0    ), 
SET2_CANGA  (Q6FX50    ), SET2_CHAGB  (Q2H988    ), SET2_COCIM  (Q1DU03    ), 
SET2_DEBHA  (Q6BM04    ), SET2_EMENI  (Q5ASA5    ), SET2_GIBZE  (Q4IB50    ), 
SET2_NEUCR  (Q7RZU4    ), SET2_YARLI  (Q6C5G5    ), SETD2_HUMAN (Q9BYW2    ), 
SETD2_MOUSE (E9Q5F9    ), SMUF1_DROME (Q9V853    ), SMUF1_HUMAN (Q9HCE7    ), 
SMUF1_MOUSE (Q9CUN6    ), SMUF1_XENLA (Q9PUN2    ), SMUF2_DANRE (A9JRZ0    ), 
SMUF2_HUMAN (Q9HAU4    ), SMUF2_MOUSE (A2A5Z6    ), SMUF2_XENLA (Q2TAS2    ), 
SSP1_NEUCR  (O60045    ), STXB4_HUMAN (Q6ZWJ1    ), STXB4_MOUSE (Q9WV89    ), 
SUDX_DROME  (Q9Y0H4    ), TCRG1_HUMAN (O14776    ), TCRG1_MOUSE (Q8CGF7    ), 
TCRGL_HUMAN (Q5VWI1    ), TCRGL_MOUSE (Q3B807    ), TG325_CAEEL (P46941    ), 
URN1_YEAST  (Q06525    ), UTRO_HUMAN  (P46939    ), WAC_DANRE   (Q7ZUK7    ), 
WAC_HUMAN   (Q9BTA9    ), WAC_MOUSE   (Q924H7    ), WAC_XENTR   (Q5U4Q0    ), 
WBP4_CHICK  (Q5F457    ), WBP4_HUMAN  (O75554    ), WBP4_MOUSE  (Q61048    ), 
WBP4_RAT    (Q5HZF2    ), WWC2_HUMAN  (Q6AWC2    ), WWC2_MOUSE  (Q6NXJ0    ), 
WWC2_XENTR  (Q6DJR2    ), WWM1_YEAST  (P43582    ), WWOX_CHICK  (Q5F389    ), 
WWOX_DANRE  (Q803A8    ), WWOX_DROME  (Q9VLU5    ), WWOX_HUMAN  (Q9NZC7    ), 
WWOX_MOUSE  (Q91WL8    ), WWOX_PONAB  (Q5R9W5    ), WWP1_HUMAN  (Q9H0M0    ), 
WWP1_MOUSE  (Q8BZZ3    ), WWP2_HUMAN  (O00308    ), WWP2_MOUSE  (Q9DBH0    ), 
WWTR1_HUMAN (Q9GZV5    ), WWTR1_MOUSE (Q9EPK5    ), YAP1A_XENLA (D6C652    ), 
YAP1_CAEEL  (Q19404    ), YAP1_CHICK  (P46936    ), YAP1_DANRE  (Q1L8J7    ), 
YAP1_DROME  (Q45VV3    ), YAP1_HUMAN  (P46937    ), YAP1_MOUSE  (P46938    ), 
YAP1_ORYLA  (H2LBU8    ), YAP1_RAT    (Q2EJA0    ), YO61_CAEEL  (P34600    ), 
ZYS3_CHLRE  (Q8GSP8    )
» more

UniProtKB/Swiss-Prot
False negative sequences
13 sequences

CMTR1_AILME (D2HRF1    ), CMTR1_HUMAN (Q8N1G2    ), CMTR1_PONAB (Q5R981    ), 
CMTR1_RAT   (Q5U2Z5    ), IQGA1_MOUSE (Q9JKF1    ), SET2_ASHGO  (Q757Y8    ), 
SET2_ASPFU  (Q4WTT2    ), SET2_KLULA  (Q6CXP5    ), SET2_YEAST  (P46995    ), 
YERE_SCHPO  (O14097    ), YHK5_SCHPO  (O94425    ), YHK6_SCHPO  (O94426    ), 
YNI8_SCHPO  (O13598    )
» more

PDB
[Detailed view]
154 PDB

1E0L; 1EG3; 1EG4; 1F8A; 1I5H; 1I6C; 1I8G; 1I8H; 1JMQ; 1K5R; 1K9Q; 1K9R; 1NMV; 1O6W; 1PIN; 1TK7; 1WMV; 1WR3; 1WR4; 1WR7; 1YIU; 1YWI; 1YWJ; 1ZCN; 1ZR7; 2DJY; 2DK1; 2DK7; 2DMV; 2DWV; 2DYF; 2E45; 2EZ5; 2F21; 2HO2; 2IDH; 2ITK; 2JMF; 2JO9; 2JOC; 2JUP; 2JX8; 2JXW; 2KBU; 2KCF; 2KPZ; 2KQ0; 2KXQ; 2KYK; 2L5F; 2LAJ; 2LAW; 2LAX; 2LAY; 2LAZ; 2LB0; 2LB1; 2LB2; 2LB3; 2LTV; 2LTW; 2LTX; 2LTY; 2LTZ; 2M3O; 2M8I; 2M8J; 2M9E; 2M9F; 2M9I; 2M9J; 2MDC; 2MDI; 2MDJ; 2MPT; 2MW9; 2MWA; 2MWB; 2MWD; 2MWE; 2MWF; 2N1O; 2N4R; 2N4S; 2N4T; 2N4U; 2N4V; 2N4W; 2N8S; 2N8T; 2N8U; 2NNT; 2OEI; 2OP7; 2Q5A; 2RLY; 2RM0; 2XP3; 2XP4; 2XP5; 2XP6; 2XP7; 2XP8; 2XP9; 2XPA; 2XPB; 2YSB; 2YSC; 2YSD; 2YSE; 2YSF; 2YSG; 2YSH; 2YSI; 2ZAJ; 2ZQS; 2ZQT; 2ZQU; 2ZQV; 2ZR4; 2ZR5; 2ZR6; 3KAB; 3KAD; 3KAF; 3KAG; 3KAH; 3KAI; 3KCE; 3L4H; 3LE4; 3NTP; 3ODK; 3OLM; 3OOB; 3TC5; 3TCZ; 3TDB; 3WH0; 4GWT; 4GWV; 4LCD; 4N7F; 4N7H; 4QIB; 4REX; 4ROF; 4U84; 4U85; 4U86; 5AHT; 5CQ2; 5DWS; 5DZD
» more

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