Entry: PS50020

Forthcoming changes to the profile format
General information about the entry

Entry name [info] WW_DOMAIN_2
Accession [info] PS50020
Entry type [info] MATRIX
Date [info] NOV-1995 (CREATED); OCT-2013 (DATA UPDATE); MAR-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC50020
Associated ProRule [info] PRU00224

Name and characterization of the entry

Description [info] WW/rsp5/WWP domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=34;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=31;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.2776; R2=0.0197; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=602.09630; R2=12.28025; TEXT='HScore';
/CUT_OFF: LEVEL=0; SCORE=417; N_SCORE=8.5; H_SCORE=5109; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=315; N_SCORE=6.5; H_SCORE=4483; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='S'; M= -5, -9,-25,-10, -3,-21, -5,-13,-15, -7,-16, -9, -6, -1,  0, -5,  2,  1,-13,-26,-17, -3;
/M: SY='P'; M= -7, -5,-30, -1, -1,-24, -5,-13,-22, -9,-24,-17, -4, 27, -6,-13,  0, -5,-24,-29,-22, -5;
/M: SY='L'; M= -8,-23,-19,-24,-18,  2,-27,-18, 15,-22, 29, 12,-22,-24,-16,-14,-21, -7, 12,-24, -5,-18;
/M: SY='P'; M= -9,-10,-34, -5,  7,-27,-18,-12,-18, -6,-23,-13,-10, 49,  1,-13, -5, -8,-26,-29,-23,  1;
/M: SY='P'; M= -1, -1,-24,  1, -2,-22, -6,-11,-21, -5,-24,-17,  2, 12, -5,-10,  8,  1,-19,-29,-17, -5;
/M: SY='G'; M= -4, -9,-31, -7,-11,-29, 34,-14,-30,-16,-27,-18, -3,  4,-12,-18, -1,-14,-27,-24,-25,-13;
/M: SY='W'; M=-20,-40,-50,-40,-30, 10,-20,-30,-20,-20,-20,-20,-40,-30,-20,-20,-40,-30,-30,150, 30,-20;
/M: SY='E'; M= -8,  0,-25,  3, 24,-20,-20, -7,-21, 15,-18,-10, -3, -8,  9,  5, -2, -3,-16,-25,-12, 16;
/M: SY='E'; M= -1, -8,-15, -8,  7,-19,-15,-11,-13,  1,-11, -5, -9,-15,  1,  1, -3, -5, -6,-26,-15,  3;
/M: SY='R'; M= -2,-16,-23,-18,-12, -7,-20, -4, -7, -1, -7, -3,-12,-21, -7,  6, -9, -8, -2,-10,  2,-11;
/M: SY='Y'; M=-11,-14,-24,-18, -8,  4,-25,-10, -5, -4, -4,  1,-12,-19, -4, -5,-10, -2, -5, -7,  5, -6;
/M: SY='D'; M= -5, 17,-20, 19,  3,-23,-11,  1,-22, -6,-20,-14, 10,-12, -2, -9, 10, 10,-15,-34,-13,  0;
/M: SY='B'; M= -2,  6,-25,  6,  3,-26, -6, -8,-23, -1,-23,-16,  4,  3, -3, -8,  3,  0,-19,-29,-18, -1;
/M: SY='N'; M= -7, 10,-22, 10,  8,-21,-13, -6,-22,  6,-22,-15, 11,-13,  1,  2,  7,  2,-16,-31,-15,  5;
/I:         MD=-27;
/M: SY='G'; M= -3, -5,-26, -7,-11,-23, 30,-13,-28, -3,-23,-12,  2,-17,-10, -7, -2,-11,-22,-18,-17,-11; D=-5;
/I:         I=-10; MI=-5; MD=-27; IM=-5; DM=-27;
/M: SY='R'; M=-13,-10,-25,-12, -3,-14,-17, -7,-18, 14,-14, -7, -4,-18,  3, 34, -7, -4,-11,-20, -8, -3; D=-5;
/I:         DM=-27;
/M: SY='P'; M= -7,-15,-25,-16, -9, -8,-23,-17, -5, -7,-11, -7,-13,  5,-11, -9, -5,  3, -4,-14, -5,-12;
/M: SY='Y'; M=-19,-24,-26,-27,-24, 40,-30,  5,  4,-17,  4,  1,-20,-30,-19,-14,-20,-10, -3, 20, 59,-24;
/M: SY='Y'; M=-20,-24,-26,-28,-24, 50,-30,  4,  0,-18,  4,  0,-20,-30,-22,-14,-20,-10, -6, 22, 60,-24;
/M: SY='Y'; M=-12,-26,-25,-29,-24, 10,-29, -9, 13,-21,  7,  5,-22,-26,-19,-18,-18, -8, 10,  6, 14,-23;
/M: SY='N'; M=-12, 40,-22, 29,  4,-24, -3, 12,-24,  0,-30,-21, 51,-18,  0, -2,  7, -3,-30,-40,-18,  2;
/M: SY='H'; M=-12, -5,-28, -5, -3,-18,-20, 39,-19, -8,-12, -3, -1, -5,  0, -4, -9,-10,-19,-28,  2, -5;
/M: SY='E'; M= -5,  2,-23,  0,  9,-19,-17, -8,-12,  2,-13, -9,  5,-10,  2, -3, -1, -3,-11,-29,-15,  5;
/M: SY='T'; M= -1,  3,-13, -5, -8,-12,-17,-16,-10,-10,-11,-11,  5,-12, -8,-11, 17, 34, -3,-32,-12, -8;
/M: SY='K'; M=-11,  1,-29, -1,  4,-28, -7,  1,-29, 25,-27,-10,  6,-14, 11, 22, -6,-11,-24,-22,-12,  7;
/M: SY='E'; M= -7,  5,-23,  5, 17,-23,-19, -4,-23, 10,-20,-13,  2, -8,  7,  5,  5, 10,-17,-28,-12, 12;
/M: SY='T'; M=  3,  0,-10, -7, -7,-13,-14,-17,-13,-10,-16,-13,  3,-10, -7,-10, 26, 40, -3,-33,-13, -7;
/M: SY='Q'; M= -6, -5,-11, -8,  0,-19,-19, -5,-16, -3,-14, -7, -3,-15, 14,  1,  7, 11,-14,-25, -7,  6;
/M: SY='W'; M=-19,-36,-45,-37,-28, 14,-21,-24,-17,-19,-16,-17,-35,-29,-20,-19,-34,-24,-25,124, 33,-20;
/M: SY='E'; M= -9,  4,-25,  9, 19,-22,-20, -6,-15,  0,-14,-11, -2,-10,  8, -5,  0, -2,-14,-27,-10, 13;
/M: SY='D'; M=-15,  5,-32, 12,  8,-29,-18,  4,-27, 10,-25,-15,  1, 11,  2,  8, -8,-11,-24,-29,-14,  2;
/M: SY='P'; M=-10,-20,-40,-10,  0,-30,-20,-20,-20,-10,-30,-20,-20, 90,-10,-20,-10,-10,-30,-30,-30,-10;
/M: SY='R'; M= -9,  1,-23,  0,  1,-20,-14, -8,-21, 10,-16,-11,  2,-16,  0, 19, -1,  0,-13,-27,-13, -1;
/M: SY='M'; M=-10,-15,-24,-17, -8, -2,-13,-10, -6,-11, -1,  2,-12,-11,-11, -8,-11, -6, -6,-20, -6,-10;
/I:         E1=0; IE=-105; DE=-105;
» More

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_04 which contains 544'996 sequence entries.


Total number of hits 363 in 210 different sequences
Number of true positive hits 363 in 210 different sequences
Number of 'unknown' hits
Number of false positive hits
Number of false negative sequences 13
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 96.54 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 4
Feature key [info] DOMAIN
Feature description [info] WW
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
210 sequences

APBB1_HUMAN (O00213), APBB1_MOUSE (Q9QXJ1), APBB1_RAT   (P46933), 
APBB2_HUMAN (Q92870), APBB2_MOUSE (Q9DBR4), APBB3_HUMAN (O95704), 
APBB3_MOUSE (Q8R1C9), APBB3_RAT   (O35827), BAG3_HUMAN  (O95817), 
BAG3_MOUSE  (Q9JLV1), C1716_DROME (Q9VYD1), CE164_HUMAN (Q9UPV0), 
CE164_MOUSE (Q5DU05), CMTR1_BOVIN (A2VE39), CMTR1_DANRE (Q803R5), 
CMTR1_MOUSE (Q9DBC3), CMTR1_XENLA (Q6GQ76), DB10_NICSY  (P46942), 
DGCR8_BOVIN (A6QR44), DGCR8_HUMAN (Q8WYQ5), DGCR8_MOUSE (Q9EQM6), 
DMDA_DROME  (Q9VDW6), DMDB_DROME  (Q9VDW3), DMDD_DROME  (Q0KI50), 
DMDE_DROME  (Q7YU29), DMD_CAEEL   (Q9TW65), DMD_CANFA   (O97592), 
DMD_CHICK   (P11533), DMD_HUMAN   (P11532), DMD_MOUSE   (P11531), 
DMD_PIG     (Q5GN48), DOD_DROME   (P54353), DRE4_SCHPO  (Q09685), 
DRP2_HUMAN  (Q13474), DRP2_MOUSE  (Q05AA6), DRP2_RAT    (Q9EPA0), 
DWWA_DICDI  (Q54T86), ESS1_YEAST  (P22696), FCA_ARATH   (O04425), 
FNBP4_HUMAN (Q8N3X1), FNBP4_MOUSE (Q6ZQ03), FRPD4_HUMAN (Q14CM0), 
FRPD4_MOUSE (A2AFR3), GAS7_HUMAN  (O60861), GAS7_MOUSE  (Q60780), 
GAS7_RAT    (O55148), HECW1_HUMAN (Q76N89), HECW1_MOUSE (Q8K4P8), 
HECW2_HUMAN (Q9P2P5), HECW2_MOUSE (Q6I6G8), IQGA1_HUMAN (P46940), 
IQGA2_HUMAN (Q13576), IQGA2_MOUSE (Q3UQ44), ITCH_HUMAN  (Q96J02), 
ITCH_MOUSE  (Q8C863), KIBRA_DROAN (B3LWS4), KIBRA_DROER (B3P3M8), 
KIBRA_DROME (Q9VFG8), KIBRA_DROMO (B4K6I9), KIBRA_DROSE (B4HEJ6), 
KIBRA_DROVI (B4M5X4), KIBRA_DROWI (B4NAD3), KIBRA_DROYA (B4PSQ2), 
KIBRA_HUMAN (Q8IX03), KIBRA_MOUSE (Q5SXA9), KIBRA_XENTR (A4IIJ3), 
MAGI1_HUMAN (Q96QZ7), MAGI1_MOUSE (Q6RHR9), MAGI1_RAT   (Q4L1J4), 
MAGI2_HUMAN (Q86UL8), MAGI2_MOUSE (Q9WVQ1), MAGI2_RAT   (O88382), 
MAGI3_CHICK (Q5F488), MAGI3_HUMAN (Q5TCQ9), MAGI3_MOUSE (Q9EQJ9), 
MAGI3_RAT   (Q9JK71), MAGI3_XENTR (A1A5G4), NCFA_DICDI  (Q867T7), 
NED4L_HUMAN (Q96PU5), NED4L_MOUSE (Q8CFI0), NED4L_PONAB (Q5RBF2), 
NEDD4_DROME (Q9VVI3), NEDD4_HUMAN (P46934), NEDD4_MOUSE (P46935), 
NEDD4_RAT   (Q62940), PCIF1_HUMAN (Q9H4Z3), PCIF1_MOUSE (P59114), 
PIN1_BOVIN  (Q5BIN5), PIN1_HUMAN  (Q13526), PIN1_MACFA  (Q4R383), 
PIN1_MOUSE  (Q9QUR7), PIN1_RHIO9  (P0C1J8), PIN1_SCHPO  (O74448), 
PINL_HUMAN  (O15428), PKHA5_HUMAN (Q9HAU0), PKHA7_DANRE (B6RSP1), 
PKHA7_HUMAN (Q6IQ23), PKHA7_MOUSE (Q3UIL6), PQBP1_BOVIN (Q2HJC9), 
PQBP1_GORGO (A1YFA7), PQBP1_HUMAN (O60828), PQBP1_MOUSE (Q91VJ5), 
PQBP1_PONPY (A2T806), PQBP1_RAT   (Q6PCT5), PR35B_ARATH (F4JCC1), 
PR40A_ARATH (B6EUA9), PR40A_HUMAN (O75400), PR40A_MOUSE (Q9R1C7), 
PR40B_HUMAN (Q6NWY9), PR40B_MOUSE (Q80W14), PR40C_ARATH (Q9LT25), 
PRP40_SCHPO (O14176), PRP40_YEAST (P33203), PUB1_SCHPO  (Q92462), 
PUB2_SCHPO  (Q9UTG2), PUB3_SCHPO  (O14326), RH14_ARATH  (Q8H136), 
RH14_ORYSJ  (Q5VQL1), RH40_ARATH  (Q9SQV1), RH40_ORYSJ  (Q5JKF2), 
RH46_ARATH  (Q9LYJ9), RHG09_HUMAN (Q9BRR9), RHG12_HUMAN (Q8IWW6), 
RHG12_MACFA (Q9BE31), RHG12_MOUSE (Q8C0D4), RHG27_HUMAN (Q6ZUM4), 
RHG27_MOUSE (A2AB59), RHG27_RAT   (Q6TLK4), RHG39_HUMAN (Q9C0H5), 
RHG39_MOUSE (P59281), RSP5_ASPCL  (A1CQG2), RSP5_ASPFC  (B0XQ72), 
RSP5_ASPFN  (B8N7E5), RSP5_ASPFU  (Q4WTF3), RSP5_ASPNC  (A2QQ28), 
RSP5_ASPOR  (Q2UBP1), RSP5_ASPTN  (Q0CCL1), RSP5_EMENI  (Q5BDP1), 
RSP5_NEOFI  (A1D3C5), RSP5_YEAST  (P39940), SAC9_ARATH  (Q7XZU0), 
SAV1_HUMAN  (Q9H4B6), SAV1_MOUSE  (Q8VEB2), SAV1_RAT    (A4V8B4), 
SAV_DROME   (Q9VCR6), SEC24_CRYNB (P0CR41), SEC24_CRYNJ (P0CR40), 
SEC24_USTMA (Q4P9K4), SET2_ASPOR  (Q2UTN6), SET2_CANAL  (Q59XV0), 
SET2_CANGA  (Q6FX50), SET2_CHAGB  (Q2H988), SET2_COCIM  (Q1DU03), 
SET2_DEBHA  (Q6BM04), SET2_EMENI  (Q5ASA5), SET2_GIBZE  (Q4IB50), 
SET2_NEUCR  (Q7RZU4), SET2_YARLI  (Q6C5G5), SETD2_HUMAN (Q9BYW2), 
SETD2_MOUSE (E9Q5F9), SMUF1_DROME (Q9V853), SMUF1_HUMAN (Q9HCE7), 
SMUF1_MOUSE (Q9CUN6), SMUF1_XENLA (Q9PUN2), SMUF2_DANRE (A9JRZ0), 
SMUF2_HUMAN (Q9HAU4), SMUF2_MOUSE (A2A5Z6), SMUF2_XENLA (Q2TAS2), 
SSP1_NEUCR  (O60045), STXB4_HUMAN (Q6ZWJ1), STXB4_MOUSE (Q9WV89), 
SUDX_DROME  (Q9Y0H4), TCRG1_HUMAN (O14776), TCRG1_MOUSE (Q8CGF7), 
TCRGL_HUMAN (Q5VWI1), TCRGL_MOUSE (Q3B807), TG325_CAEEL (P46941), 
URN1_YEAST  (Q06525), UTRO_HUMAN  (P46939), WAC_DANRE   (Q7ZUK7), 
WAC_HUMAN   (Q9BTA9), WAC_MOUSE   (Q924H7), WAC_XENTR   (Q5U4Q0), 
WBP4_CHICK  (Q5F457), WBP4_HUMAN  (O75554), WBP4_MOUSE  (Q61048), 
WBP4_RAT    (Q5HZF2), WWC2_HUMAN  (Q6AWC2), WWC2_MOUSE  (Q6NXJ0), 
WWC2_XENTR  (Q6DJR2), WWM1_YEAST  (P43582), WWOX_CHICK  (Q5F389), 
WWOX_DANRE  (Q803A8), WWOX_DROME  (Q9VLU5), WWOX_HUMAN  (Q9NZC7), 
WWOX_MOUSE  (Q91WL8), WWOX_PONAB  (Q5R9W5), WWP1_HUMAN  (Q9H0M0), 
WWP1_MOUSE  (Q8BZZ3), WWP2_HUMAN  (O00308), WWP2_MOUSE  (Q9DBH0), 
WWTR1_HUMAN (Q9GZV5), WWTR1_MOUSE (Q9EPK5), YAP1_CHICK  (P46936), 
YAP1_HUMAN  (P46937), YAP1_MOUSE  (P46938), YAP1_RAT    (Q2EJA0), 
YO61_CAEEL  (P34600), YORKI_DROME (Q45VV3), ZYS3_CHLRE  (Q8GSP8)
» More

UniProtKB/Swiss-Prot
False negative sequences
13 sequences

CMTR1_AILME (D2HRF1), CMTR1_HUMAN (Q8N1G2), CMTR1_PONAB (Q5R981), 
CMTR1_RAT   (Q5U2Z5), IQGA1_MOUSE (Q9JKF1), SET2_ASHGO  (Q757Y8), 
SET2_ASPFU  (Q4WTT2), SET2_KLULA  (Q6CXP5), SET2_YEAST  (P46995), 
YERE_SCHPO  (O14097), YHK5_SCHPO  (O94425), YHK6_SCHPO  (O94426), 
YNI8_SCHPO  (O13598)
» More

UniProtKB/Swiss-Prot
'Partial' sequences
1 sequence

DMD_RAT     (P11530)

		
PDB
[Detailed view]
121 PDB

1E0L; 1EG3; 1EG4; 1F8A; 1I5H; 1I6C; 1I8G; 1I8H; 1JMQ; 1K5R; 1K9Q; 1K9R; 1NMV; 1O6W; 1PIN; 1TK7; 1WMV; 1WR3; 1WR4; 1WR7; 1YIU; 1YWI; 1YWJ; 1ZCN; 1ZR7; 2DJY; 2DK1; 2DK7; 2DMV; 2DWV; 2DYF; 2E45; 2EZ5; 2F21; 2HO2; 2IDH; 2ITK; 2JMF; 2JO9; 2JOC; 2JUP; 2JX8; 2JXW; 2KBU; 2KCF; 2KPZ; 2KQ0; 2KXQ; 2KYK; 2L5F; 2LAJ; 2LAW; 2LAX; 2LAY; 2LAZ; 2LB0; 2LB1; 2LB2; 2LB3; 2LTV; 2LTW; 2LTX; 2LTY; 2LTZ; 2M3O; 2M9E; 2M9F; 2M9I; 2M9J; 2NNT; 2OEI; 2OP7; 2Q5A; 2RLY; 2RM0; 2XP3; 2XP4; 2XP5; 2XP6; 2XP7; 2XP8; 2XP9; 2XPA; 2XPB; 2YSB; 2YSC; 2YSD; 2YSE; 2YSF; 2YSG; 2YSH; 2YSI; 2ZAJ; 2ZQS; 2ZQT; 2ZQU; 2ZQV; 2ZR4; 2ZR5; 2ZR6; 3KAB; 3KAD; 3KAF; 3KAG; 3KAH; 3KAI; 3KCE; 3L4H; 3LE4; 3NTP; 3ODK; 3OLM; 3OOB; 3TC5; 3TCZ; 3TDB; 4GWT; 4GWV; 4LCD; 4N7F; 4N7H
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