Entry: PS50048

General information about the entry
Entry name ZN2_CY6_FUNGAL_2
Accession number PS50048
Entry type MATRIX
Date NOV-1997 (CREATED); NOV-1997 (DATA UPDATE); MAR-2013 (INFO UPDATE).
PROSITE Documentation PDOC00378
Associated ProRule PRU00227
Name and characterization of the entry
DescriptionZn(2)-C6 fungal-type DNA-binding domain profile.
Matrix / Profile 
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=31;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=28;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=-0.3; R2=0.011; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=801; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=619; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-20; E1=-20; MI=-105; MD=-105; IM=-105; DM=-105;

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='A'; M= 26, -9,-14,-14,-10,-20,  5,-18,-15,-12,-17,-13, -6, -7,-10,-17, 13,  3, -5,-26,-21,-10;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='D'; M=-10,  8,-25, 12, -1,-19,-18,-10,-12, -8,-10,-10,  0,-16, -6,-10, -4, -2, -9,-22,-10, -3;
/M: SY='H'; M= -6, -4,-16, -9, -3,-11,-18,  1,-13, -6,-12, -7,  1,-15,  1, -1,  0,  0,-12,-25, -6, -2;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='R'; M=-15, -8,-27, -8,  0,-21,-19,  4,-29, 25,-21,-10,  0,-18,  8, 50, -7, -9,-19,-20, -8,  0;
/M: SY='R'; M= -9, -9,-25,-11, -2,-16,-19, -9,-15, 13,-11, -4, -5,-17,  5, 20, -7, -6,-11,-21, -9,  0;
/M: SY='R'; M=-11, -8,-27, -9,  0,-21,-17, -5,-23, 23,-18, -8, -2,-17,  6, 39, -7, -8,-15,-22,-10,  0;
/M: SY='K'; M=-12, -2,-30, -2,  8,-28,-20,  2,-30, 40,-27, -9,  1,-12, 11, 33,-10,-11,-21,-21, -7,  8;
/M: SY='V'; M= -6,-19,-21,-23,-17, -7,-27,-21, 16,-10,  4,  7,-15,-21,-13, -9, -9, -1, 17,-24, -7,-17;
/M: SY='K'; M=-11, -3,-29, -3,  6,-27,-18, -8,-28, 40,-26,-10, -1,-13,  9, 35, -8, -9,-18,-21,-11,  7;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='D'; M=-14, 32,-23, 42, 11,-31,-10, -4,-30, -3,-26,-24, 16,-11, -2, -9,  4, -3,-23,-38,-19,  4;
/M: SY='R'; M= -4, -8,-26, -9,  1,-17, -2, -8,-21,  4,-15, -8, -5,-16, -1,  6, -5, -9,-16,-19,-10, -1;
/I:         II=-8; MI=0; MD=-20; DM=-20; IM=0; I=0,0,-30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0;
/M: SY='E'; M= -5,  3,-25,  2,  5,-23, -7, -7,-19,  3,-16,-10,  3,-12,  2,  0, -2, -6,-17,-26,-15,  3;
/M: SY='R'; M=-12, -9,-28,-10,  0,-12,-22, -7,-15, 12,-10, -5, -5,-15,  2, 17,-11, -8,-14,-15, -5,  0;
/M: SY='P'; M=-10,-16,-37, -8, -1,-27,-15,-16,-21,-10,-29,-19,-15, 73,-10,-18, -8,-10,-29,-29,-27,-10;
/I:         II=-8; MI=0; MD=-10; DM=-10; IM=0; I=0,0,-30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0;
/M: SY='S'; M= -2, -3,-14, -6, -3, -9,-11, -2, -7, -1,-10, -4,  0, -6, -1, -1,  1,  0, -5,-17, -6, -3; D=-3;
/I:         DM=-10;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='S'; M=  1, -7,-20,-10, -4,-14, -7,-11,-14, -6,-14, -9, -3,-15,  2, -5,  7,  3,-11,-21,-10, -1;
/M: SY='R'; M= -8,  7,-23,  2,  4,-23,-10,  0,-23, 10,-22,-13, 15,-14,  7, 18,  1, -4,-22,-28,-15,  4;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='V'; M= -1,-10,-21,-12, -2,-14,-21,-15, -1, -4, -3, -2, -9,-16, -4, -5, -4, -1,  1,-25,-11, -4;
/M: SY='K'; M= -6, -3,-24, -5,  4,-23,-17, -9,-20, 18,-20, -9,  0,-13,  7, 18,  0,  0,-14,-25,-12,  5;
/M: SY='R'; M= -6,-10,-22,-13, -9, -6,-19, -2, -8, -4, -4, -2, -4,-21, -5,  3, -7, -5, -7,-17, -1, -8;
/M: SY='N'; M= -6,  9,-25,  5, -2,-25, 17, -4,-28, -3,-27,-17, 18,-17, -1, -2,  5, -7,-26,-28,-19, -2;
/M: SY='L'; M= -7,-17,-19,-19,-13, -2,-24,-16,  4,-12, 10,  4,-16,-22,-12, -9,-14, -6,  3,-18, -3,-13;
/I:         II=-8; MI=0; MD=-10; DM=-10; IM=0; I=0,0,-30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0;
/M: SY='E'; M=-10,  5,-27,  8, 10,-24,-18, -4,-20,  5,-18,-12,  1, -1,  5,  0, -3, -6,-19,-28,-13,  7;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='T'; M= -5,-10,-19,-13, -8,-12,-20,-10, -3, -6, -8, -2, -7,-15, -5, -2,  2,  9,  3,-27, -9, -8;
/M: SY='Y'; M=-16,-15,-27,-17,-16, 23,-24,  4, -3,-14, -1, -2,-13,-26,-14,-12,-15, -9, -8, 10, 40,-17;
/I:         E1=0; IE=-105; DE=-105;
Numerical results
  • UniProtKB/Swiss-Prot release number: 2013_05, total number of sequence entries in that release: 540052.
  • Total number of hits in UniProtKB/Swiss-Prot: 237 hits in 237 different sequences
  • Number of hits on proteins that are known to belong to the set under consideration: 237 hits in 237 different sequences
  • Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences
  • Number of false hits (on unrelated proteins): 0 hits in 0 different sequences
  • Number of known missed hits: 5
  • Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 0
  • Precision (true hits / (true hits + false positives)): 100.00 %
  • Recall (true hits / (true hits + false negatives)): 97.93 %
Comments
  • MATRIX_TYPE: protein_domain
  • Scaling database: UniProtKB/Swiss-Prot: reversed
  • Matrix author: K_Hofmann
  • Taxonomic range: Eukaryotes
  • Maximum known number of repetitions of the pattern in a single protein: 1
  • FT_KEY: DNA_BIND
  • FT_DESC: Zn(2)-C6 fungal-type
  • VERSION: 1
Cross-references
UniProtKB/Swiss-Prot True positive hits:
ACE2_HYPJE  (Q96WN6), ACR2_NEUCR  (P78704), ACU15_NEUCR (P87000), 
ACUK_AJECG  (C0NCM1), ACUK_AJECN  (A6R213), ACUK_AJEDR  (C5GF27), 
ACUK_AJEDS  (C5JT39), ACUK_ARTBC  (D4AL61), ACUK_ARTGP  (E4UP58), 
ACUK_ARTOC  (C5FP02), ACUK_ASPCL  (A1C602), ACUK_ASPFC  (B0XVV1), 
ACUK_ASPFU  (Q4WHD1), ACUK_ASPNC  (A2QFG8), ACUK_ASPOR  (Q2UMM2), 
ACUK_ASPTN  (Q0CHR0), ACUK_BOTFB  (A6SP81), ACUK_CHAGB  (Q2GSA4), 
ACUK_COCP7  (C5PHH6), ACUK_EMENI  (Q5AW62), ACUK_NECH7  (C7YM38), 
ACUK_NEOFI  (A1DG01), ACUK_NEUCR  (Q7RUA4), ACUK_PARBA  (C1GR85), 
ACUK_PARBD  (C1G966), ACUK_PENCW  (B6HSQ3), ACUK_PENMQ  (B6Q3B6), 
ACUK_PHANO  (Q0U7C8), ACUK_PODAN  (B2AR36), ACUK_PYRTR  (B2W978), 
ACUK_SCLS1  (A7EAG1), ACUK_SORMK  (D1ZRZ5), ACUK_TALSN  (B8LT44), 
ACUK_TRIVH  (D4D2Y6), ACUK_UNCRE  (C4JFE4), AFLR_ASPFN  (P41765), 
AFLR_ASPPA  (P43651), AFLR_EMENI  (P52957), AHR1_CANAL  (Q5A4F3), 
ALCR_EMENI  (P21228), AMDR_ASPFU  (Q4WK35), AMDR_ASPOR  (Q06157), 
AMDR_EMENI  (P15699), ARGR2_YEAST (P05085), ARO80_YEAST (Q04052), 
ASG1_YEAST  (P40467), ATG2_PICPA  (Q9HFR4), CAT8_YEAST  (P39113), 
CBF3B_YEAST (P40969), CHA4_YEAST  (P43634), CTF1A_FUSSO (P52958), 
CTF1B_FUSSO (P52959), CZF1_CANAL  (Q5A0W9), CZF1_CANAW  (P28875), 
DAL81_YEAST (P21657), ECM22_YEAST (Q05958), EDS1_YEAS1  (B3LNB2), 
EDS1_YEAS2  (C7GXX9), EDS1_YEAS6  (B5VDZ9), EDS1_YEAS7  (A6ZKX7), 
EDS1_YEAS8  (D3UEC9), EDS1_YEAST  (P38073), ERT11_YARLI (Q6C5G3), 
ERT12_YARLI (Q6C764), ERT1_ASHGO  (Q754V2), ERT1_CANAW  (C4YLC3), 
ERT1_CANDC  (B9WLA7), ERT1_CANGA  (Q6FML7), ERT1_COPC7  (A8N767), 
ERT1_DEBHA  (Q6BY37), ERT1_KLULA  (Q6CKI5), ERT1_LACBS  (B0D0T8), 
ERT1_LACTC  (C5E2K7), ERT1_PICGU  (A5DF43), ERT1_PICPG  (C4R1K8), 
ERT1_PICST  (A3LQV7), ERT1_POSPM  (B8PBQ6), ERT1_SCHCM  (D8Q8R5), 
ERT1_USTMA  (Q4PD88), ERT1_YEAS1  (B3LMS3), ERT1_YEAS2  (C7GMR4), 
ERT1_YEAS7  (A6ZLH8), ERT1_YEAS8  (D3UEY7), ERT1_YEAST  (P38140), 
FCR1_CANAX  (O93870), FLUF_NEUCR  (O13360), GAL4_YEAST  (P04386), 
GRT1_SCHPO  (Q9C469), GSM1_ASHGO  (Q754J3), GSM1_CANAL  (Q59WB9), 
GSM1_CANAW  (C4YDV1), GSM1_CANDC  (B9W8A8), GSM1_CANGA  (Q6FLG1), 
GSM1_CANTT  (C5MCK5), GSM1_CLAL4  (C4Y4V1), GSM1_DEBHA  (Q6BJW8), 
GSM1_KLULA  (Q6CK33), GSM1_LODEL  (A5DU46), GSM1_PICGU  (A5DRJ2), 
GSM1_PICPG  (C4QV17), GSM1_PICST  (A3LWY2), GSM1_VANPO  (A7TQK0), 
GSM1_YEAS1  (B3LQ10), GSM1_YEAS2  (C7GR11), GSM1_YEAS7  (A6ZQM3), 
GSM1_YEAS8  (C8ZBB1), GSM1_YEAST  (P42950), GSM1_ZYGRC  (C5DX31), 
HAL9_YEAST  (Q12180), HAP1_YEAS1  (B3RHD9), HAP1_YEAS2  (C7GQY3), 
HAP1_YEAS7  (A7A1D7), HAP1_YEAS8  (C8ZDL9), HAP1_YEASK  (G2WJ80), 
HAP1_YEAST  (P0CE41), HAP1_YEASX  (P0CS82), LAC9_KLULA  (P08657), 
LEUR_YEAST  (P08638), LYS14_YEAST (P40971), MAL13_YEAST (P53338), 
MAL33_YEAST (P38157), MAL63_YEASX (P10508), MOC3_SCHPO  (Q9UT46), 
NIRA_EMENI  (P28348), NIT4_NEUCR  (P28349), OAF1_YEAST  (P39720), 
OAF3_ASHGO  (Q75BN0), OAF3_CANGA  (Q6FJJ1), OAF3_KLULA  (Q6CXS0), 
OAF3_LACTC  (C5DKJ7), OAF3_VANPO  (A7TGQ2), OAF3_YEAS1  (B3LRD9), 
OAF3_YEAS2  (C7GX75), OAF3_YEAS6  (B5VML1), OAF3_YEAS7  (A7A024), 
OAF3_YEAST  (P36023), OAF3_ZYGRC  (C5DUX2), PDR1_YEAST  (P12383), 
PDR3_YEAST  (P33200), PDR8_YEAST  (Q06149), PIP2_YEAST  (P52960), 
PPR1_YEAST  (P07272), PRIB_LENED  (P49412), PRO1_NEUCR  (Q9P326), 
PRTT_ASPCL  (A1CHV7), PRTT_ASPFC  (B0Y6K1), PRTT_ASPFU  (Q4WPQ8), 
PRTT_ASPNC  (A2QJF9), PRTT_ASPOR  (A7BJS7), PRTT_EMENI  (Q5B8L0), 
PRTT_PENCW  (B6HRH5), PUT3_YEAST  (P25502), QA1F_NEUCR  (P11638), 
QUTA_EMENI  (P10563), RDR1_GIBZE  (Q4I0C5), RDR1_YEAST  (Q08904), 
RDS1_YEAST  (P25611), RDS2_YEAST  (P19541), RGT1_ASHGO  (Q750N3), 
RGT1_CANGA  (Q6FLP2), RGT1_KLULA  (Q6CIL8), RGT1_LACTC  (C5DGQ7), 
RGT1_VANPO  (A7TE38), RGT1_YEAS1  (B3LR49), RGT1_YEAS2  (C7GP35), 
RGT1_YEAS7  (A6ZZS7), RGT1_YEAST  (P32862), RGT1_ZYGRC  (C5E4G1), 
RSC30_YEAST (P38781), RSC3_YEAST  (Q06639), SEF1_ASHGO  (Q74Z37), 
SEF1_KLULA  (P87164), SEF1_YEAST  (P34228), SIP4_YEAST  (P46954), 
STB4_YEAST  (P50104), STB5_YEAST  (P38699), SUC1_CANAL  (P33181), 
TBS1_YEAST  (P38114), TEA1_YEAST  (P47988), THI1_SCHPO  (P36598), 
THI2_YEAST  (P38141), THI5_SCHPO  (O94278), UAY_EMENI   (P49413), 
UGA3_YEAST  (P26370), UME6_YEAST  (P39001), UPC2_YEAST  (Q12151), 
URC2_YEAST  (Q04411), WOR2_CANAL  (Q5ANB1), XLNR_ASPCL  (A1C7P9), 
XLNR_ASPFC  (B0XUL1), XLNR_ASPFN  (B8N6M6), XLNR_ASPFU  (Q4WZV6), 
XLNR_ASPKA  (Q96WP8), XLNR_ASPNC  (A2R5W7), XLNR_ASPNG  (O42804), 
XLNR_ASPOR  (Q2UD93), XLNR_ASPTN  (Q0CV52), XLNR_EMENI  (Q5AVS0), 
XLNR_NEOFI  (A1DIC0), YAKB_SCHPO  (Q09922), YAO7_SCHPO  (Q10086), 
YAOB_SCHPO  (G2TRN9), YAS8_SCHPO  (Q10144), YBCB_SCHPO  (O13658), 
YC79_SCHPO  (O94490), YCN3_SCHPO  (O59780), YCUA_SCHPO  (O59830), 
YCV2_SCHPO  (O74541), YE14_YEAST  (P39961), YF54_SCHPO  (O14130), 
YFF2_YEAST  (P43551), YFN1_SCHPO  (Q1MTM9), YG55_SCHPO  (O60056), 
YGDC_SCHPO  (O94569), YGDG_SCHPO  (O94573), YH7G_SCHPO  (O60130), 
YH7H_SCHPO  (O60131), YHDD_SCHPO  (Q9P6I9), YI35_SCHPO  (Q9HE16), 
YI4C_SCHPO  (G2TRT1), YII3_SCHPO  (Q9UTN0), YJ74_SCHPO  (O74915), 
YJU6_YEAST  (P39529), YKM1_SCHPO  (Q9C0Z1), YKN4_SCHPO  (Q9HDX1), 
YKW2_YEAST  (P35995), YL054_YEAST (Q12244), YL278_YEAST (Q05854), 
YL8B_SCHPO  (Q9UTA7), YLV1_SCHPO  (O94392), YN25_SCHPO  (O59741), 
YN28_SCHPO  (O59744), YN92_YEAST  (P53749), YOG2_SCHPO  (O74308), 
YP196_YEAST (Q06595), YRM1_YEAST  (Q12340), YRR1_YEAST  (Q12172)
False negative hits (sequences which belong to the set under consideration, but which have not been picked up by the pattern or profile):
ERT1_ZYGRC  (C5E1J9), URC2_LACKL  (Q6YFE6), WAR1_YEAST  (Q03631), 
YIT3_SCHPO  (Q9P7H9), YN2B_SCHPO  (O59746)
Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:

[Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format]

Retrieve the sequence logo from the alignment

PDB
[Detailed view]		 1AJY; 1AW6; 1CLD; 1D66; 1F4S; 1F5E; 1HWT; 1PYC; 1PYI; 1QP9; 1ZME; 2ALC; 2ER8; 2ERE; 2ERG; 2HAP; 3ALC; 3COQ;

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