Entry: PS50063

General information about the entry

Entry name [info] BH4_2
Accession [info] PS50063
Entry type [info] MATRIX
Date [info] NOV-1997 (CREATED); OCT-2013 (DATA UPDATE); JUN-2015 (INFO UPDATE).
PROSITE Doc. [info] PDOC00829
Associated ProRule [info] PRU00025

Name and characterization of the entry

Description [info] Apoptosis regulator, Bcl-2 family BH4 motif profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=20;
/DISJOINT: DEFINITION=PROTECT; N1=3; N2=18;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=-0.3853; R2=0.01803082; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=-511.85258; R2=7.77887; TEXT='HScore';
/CUT_OFF: LEVEL=0; SCORE=492; N_SCORE=8.5; H_SCORE=2888; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=381; N_SCORE=6.5; H_SCORE=2460; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=0; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='N'; M= -5,  6,-21, -6,-11,-13,-14, -9,  5,-13,-12, -6, 20,-18, -7,-13,  6,  1, -4,-33,-13,-11;
/M: SY='R'; M=-16, -5,-30, -3, 15,-25,-20,  2,-28, 23,-20,-10,  0,-15, 20, 47, -6,-10,-24,-22,-12, 14;
/M: SY='E'; M= -9, 12,-30, 21, 22,-32, 14, -7,-36, -3,-26,-22,  5, -9,  1, -9,  0,-14,-30,-29,-24, 12;
/M: SY='F'; M=-14,-30,-23,-36,-26, 32,-33,-23, 20,-30, 28, 13,-24,-27,-27,-23,-24,-10, 12, -9, 11,-26;
/M: SY='V'; M=  0,-30,-10,-30,-30,  0,-30,-30, 30,-20, 10, 10,-30,-30,-30,-20,-10,  0, 50,-30,-10,-30;
/M: SY='V'; M= -5,-19,-17,-18, -7, -6,-26,-18, 13,-13,  9, 11,-22,-22,-13,-14,-11, -5, 21,-27,-10,-10;
/M: SY='D'; M=-15, 26,-30, 36, 15,-35,-15, -5,-35, 24,-30,-20, 10,-10,  5,  9, -5,-10,-25,-30,-15, 10;
/M: SY='Y'; M=-20,-24,-26,-28,-24, 49,-30,  4,  0,-18,  4,  0,-20,-30,-22,-14,-20,-10, -6, 22, 61,-24;
/M: SY='F'; M=-11,-30,-20,-36,-28, 30,-33,-25, 23,-28, 19, 11,-24,-27,-29,-23,-19, -8, 21,-12,  8,-28;
/M: SY='T'; M= -1,  0,-15, -4, -4,-16,-12, 14,-19,-10,-20,-11,  6,-13, -1, -7, 20, 21,-12,-34, -6, -4;
/M: SY='Y'; M=-18,-12,-30,-12, -9,  7,-26, 28,-13,  4,-11, -2,-10,-23, -2,  1,-16,-12,-16,  7, 48, -9;
/M: SY='R'; M=-14, -4,-30, -4,  6,-26,-20, -6,-30, 43,-26,-10,  0,-14, 10, 44,-10,-10,-20,-20,-10,  6;
/M: SY='L'; M=-10,-30,-24,-34,-24,  6,-34,-24, 31,-30, 39, 20,-26,-26,-20,-24,-26,-10, 17,-20,  0,-24;
/M: SY='S'; M= 11, -4,-14, -5, -2,-20, -4,-10,-20, -3,-25,-16,  5,-12,  0,  3, 26, 11,-10,-33,-18, -2;
/M: SY='Q'; M=-10,  0,-30,  0, 20,-40,-20, 10,-20, 10,-20,  0,  0,-10, 60, 10,  0,-10,-30,-20,-10, 40;
/M: SY='N'; M=-13, 21,-24,  9,  2,-22, -8,  4,-24, 15,-27,-16, 35,-18,  4, 22,  2, -4,-26,-32,-16,  2;
/M: SY='G'; M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='Y'; M=-15,-22,-25,-25,-20, 18,-28,  6,  9,-14, 16, 19,-22,-28,-10,-12,-22,-10, -1,  7, 43,-18;
/M: SY='D'; M=-10, 23,-26, 34, 33,-32,-12, -2,-32,  2,-26,-24,  9, -6,  9, -6,  8, -4,-26,-36,-20, 21;
/M: SY='W'; M=-20,-40,-50,-40,-30, 10,-20,-30,-20,-20,-20,-20,-40,-30,-20,-20,-40,-30,-30,150, 30,-20;
/I:         E1=0; IE=-105; DE=-105;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2015_08 which contains 320'201 sequence entries.


Total number of hits 19 in 19 different sequences
Number of true positive hits 19 in 19 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 7
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 73.08 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] MOTIF
Feature description [info] BH4
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
19 sequences

B2CL1_CHICK (Q07816), B2CL1_HUMAN (Q07817), B2CL1_MOUSE (Q64373), 
B2CL1_PIG   (O77737), B2CL1_RAT   (P53563), B2CL2_BOVIN (Q1RMX3), 
B2CL2_CANFA (Q45T69), B2CL2_HUMAN (Q92843), B2CL2_MOUSE (P70345), 
BCL2_BOVIN  (O02718), BCL2_CANFA  (Q6R755), BCL2_CHICK  (Q00709), 
BCL2_CRIGR  (Q9JJV8), BCL2_HUMAN  (P10415), BCL2_MOUSE  (P10417), 
BCL2_RAT    (P49950), BOKB_DANRE  (Q7T381), CED9_CAEBR  (P41957), 
CED9_CAEEL  (P41958)
» More

UniProtKB/Swiss-Prot
False negative sequences
7 sequences

B2L13_HUMAN (Q9BXK5), B2L13_MOUSE (P59017), BOKA_DANRE  (Q6DC66), 
BOK_CHICK   (Q9I8I2), BOK_HUMAN   (Q9UMX3), BOK_MOUSE   (O35425), 
BOK_RAT     (Q792S6)
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PDB
[Detailed view]
89 PDB

1AF3; 1BXL; 1G5J; 1G5M; 1GJH; 1LXL; 1MAZ; 1MK3; 1O0L; 1OHU; 1PQ0; 1PQ1; 1R2D; 1R2E; 1R2G; 1R2H; 1R2I; 1TY4; 1YSG; 1YSI; 1YSN; 1YSW; 1ZY3; 2A5Y; 2B48; 2BZW; 2LP8; 2LPC; 2M03; 2M04; 2ME8; 2ME9; 2MEJ; 2O1Y; 2O21; 2O22; 2O2F; 2O2M; 2O2N; 2P1L; 2PON; 2W3L; 2XA0; 2Y6W; 2YJ1; 2YQ6; 2YQ7; 2YXJ; 3CVA; 3FDL; 3FDM; 3IHC; 3IHD; 3IHE; 3IHF; 3IIG; 3IIH; 3ILB; 3ILC; 3INQ; 3IO8; 3PL7; 3QKD; 3R85; 3SP7; 3SPF; 3WIZ; 3ZK6; 3ZLN; 3ZLO; 3ZLR; 4A1U; 4A1W; 4AQ3; 4BPK; 4C52; 4C5D; 4CIM; 4CIN; 4EHR; 4HNJ; 4IEH; 4K5A; 4K5B; 4LVT; 4LXD; 4MAN; 4PPI; 4TUH
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