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| Entry: PS50063 |
| General information about the entry | |
|---|---|
| Entry name | BH4_2 |
| Accession number | PS50063 |
| Entry type | MATRIX |
| Date | NOV-1997 (CREATED); NOV-1997 (DATA UPDATE); MAR-2013 (INFO UPDATE). |
| PROSITE Documentation | PDOC00829 |
| Associated ProRule | PRU00025 |
| Name and characterization of the entry | |
| Description | Apoptosis regulator, Bcl-2 family BH4 motif profile. |
| Matrix / Profile | /GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=20;
/DISJOINT: DEFINITION=PROTECT; N1=3; N2=18;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=-0.3853; R2=0.01803082; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=492; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=381; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=0; MI=-105; MD=-105; IM=-105; DM=-105;
A B C D E F G H I K L M N P Q R S T V W Y Z
/I: B1=0; BI=-105; BD=-105;
/M: SY='N'; M= -5, 6,-21, -6,-11,-13,-14, -9, 5,-13,-12, -6, 20,-18, -7,-13, 6, 1, -4,-33,-13,-11;
/M: SY='R'; M=-16, -5,-30, -3, 15,-25,-20, 2,-28, 23,-20,-10, 0,-15, 20, 47, -6,-10,-24,-22,-12, 14;
/M: SY='E'; M= -9, 12,-30, 21, 22,-32, 14, -7,-36, -3,-26,-22, 5, -9, 1, -9, 0,-14,-30,-29,-24, 12;
/M: SY='F'; M=-14,-30,-23,-36,-26, 32,-33,-23, 20,-30, 28, 13,-24,-27,-27,-23,-24,-10, 12, -9, 11,-26;
/M: SY='V'; M= 0,-30,-10,-30,-30, 0,-30,-30, 30,-20, 10, 10,-30,-30,-30,-20,-10, 0, 50,-30,-10,-30;
/M: SY='V'; M= -5,-19,-17,-18, -7, -6,-26,-18, 13,-13, 9, 11,-22,-22,-13,-14,-11, -5, 21,-27,-10,-10;
/M: SY='D'; M=-15, 26,-30, 36, 15,-35,-15, -5,-35, 24,-30,-20, 10,-10, 5, 9, -5,-10,-25,-30,-15, 10;
/M: SY='Y'; M=-20,-24,-26,-28,-24, 49,-30, 4, 0,-18, 4, 0,-20,-30,-22,-14,-20,-10, -6, 22, 61,-24;
/M: SY='F'; M=-11,-30,-20,-36,-28, 30,-33,-25, 23,-28, 19, 11,-24,-27,-29,-23,-19, -8, 21,-12, 8,-28;
/M: SY='T'; M= -1, 0,-15, -4, -4,-16,-12, 14,-19,-10,-20,-11, 6,-13, -1, -7, 20, 21,-12,-34, -6, -4;
/M: SY='Y'; M=-18,-12,-30,-12, -9, 7,-26, 28,-13, 4,-11, -2,-10,-23, -2, 1,-16,-12,-16, 7, 48, -9;
/M: SY='R'; M=-14, -4,-30, -4, 6,-26,-20, -6,-30, 43,-26,-10, 0,-14, 10, 44,-10,-10,-20,-20,-10, 6;
/M: SY='L'; M=-10,-30,-24,-34,-24, 6,-34,-24, 31,-30, 39, 20,-26,-26,-20,-24,-26,-10, 17,-20, 0,-24;
/M: SY='S'; M= 11, -4,-14, -5, -2,-20, -4,-10,-20, -3,-25,-16, 5,-12, 0, 3, 26, 11,-10,-33,-18, -2;
/M: SY='Q'; M=-10, 0,-30, 0, 20,-40,-20, 10,-20, 10,-20, 0, 0,-10, 60, 10, 0,-10,-30,-20,-10, 40;
/M: SY='N'; M=-13, 21,-24, 9, 2,-22, -8, 4,-24, 15,-27,-16, 35,-18, 4, 22, 2, -4,-26,-32,-16, 2;
/M: SY='G'; M= 0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20, 0,-20,-20,-20, 0,-20,-30,-20,-30,-20;
/M: SY='Y'; M=-15,-22,-25,-25,-20, 18,-28, 6, 9,-14, 16, 19,-22,-28,-10,-12,-22,-10, -1, 7, 43,-18;
/M: SY='D'; M=-10, 23,-26, 34, 33,-32,-12, -2,-32, 2,-26,-24, 9, -6, 9, -6, 8, -4,-26,-36,-20, 21;
/M: SY='W'; M=-20,-40,-50,-40,-30, 10,-20,-30,-20,-20,-20,-20,-40,-30,-20,-20,-40,-30,-30,150, 30,-20;
/I: E1=0; IE=-105; DE=-105;
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| Numerical results | |
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| Comments | |
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| Cross-references | |
| UniProtKB/Swiss-Prot | True positive hits:B2CL1_CHICK (Q07816), B2CL1_HUMAN (Q07817), B2CL1_MOUSE (Q64373), B2CL1_PIG (O77737), B2CL1_RAT (P53563), B2CL2_BOVIN (Q1RMX3), B2CL2_CANFA (Q45T69), B2CL2_HUMAN (Q92843), B2CL2_MOUSE (P70345), BCL2_BOVIN (O02718), BCL2_CANFA (Q6R755), BCL2_CHICK (Q00709), BCL2_CRIGR (Q9JJV8), BCL2_HUMAN (P10415), BCL2_MOUSE (P10417), BCL2_RAT (P49950), BOKB_DANRE (Q7T381), CED9_CAEBR (P41957), CED9_CAEEL (P41958)False negative hits (sequences which belong to the set under consideration, but which have not been picked up by the pattern or profile): B2L13_HUMAN (Q9BXK5), B2L13_MOUSE (P59017), BOKA_DANRE (Q6DC66), BOK_CHICK (Q9I8I2), BOK_HUMAN (Q9UMX3), BOK_MOUSE (O35425), BOK_RAT (Q792S6)Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view]
[Clustal format, color]
[Clustal format, plain text]
[Fasta format]
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| PDB [Detailed view] |
1AF3; 1BXL; 1G5J; 1G5M; 1GJH; 1LXL; 1MAZ; 1MK3; 1O0L; 1OHU; 1PQ0; 1PQ1; 1R2D; 1R2E; 1R2G; 1R2H; 1R2I; 1TY4; 1YSG; 1YSI; 1YSN; 1YSW; 1ZY3; 2A5Y; 2B48; 2BZW; 2LP8; 2LPC; 2M03; 2M04; 2O1Y; 2O21; 2O22; 2O2F; 2O2M; 2O2N; 2P1L; 2PON; 2W3L; 2XA0; 2Y6W; 2YJ1; 2YQ6; 2YQ7; 2YXJ; 3CVA; 3FDL; 3FDM; 3IHC; 3IHD; 3IHE; 3IHF; 3IIG; 3IIH; 3ILB; 3ILC; 3INQ; 3IO8; 3PL7; 3QKD; 3R85; 3SP7; 3SPF; 4A1U; 4A1W; 4AQ3; 4EHR; 4HNJ; |
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