Entry: PS50063

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General information about the entry

Entry name [info] BH4_2
Accession [info] PS50063
Entry type [info] MATRIX
Date [info] NOV-1997 (CREATED); OCT-2013 (DATA UPDATE); JUL-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC00829
Associated ProRule [info] PRU00025

Name and characterization of the entry

Description [info] Apoptosis regulator, Bcl-2 family BH4 motif profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=20;
/DISJOINT: DEFINITION=PROTECT; N1=3; N2=18;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=-0.3853; R2=0.01803082; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=-511.85258; R2=7.77887; TEXT='HScore';
/CUT_OFF: LEVEL=0; SCORE=492; N_SCORE=8.5; H_SCORE=2888; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=381; N_SCORE=6.5; H_SCORE=2460; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=0; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='N'; M= -5,  6,-21, -6,-11,-13,-14, -9,  5,-13,-12, -6, 20,-18, -7,-13,  6,  1, -4,-33,-13,-11;
/M: SY='R'; M=-16, -5,-30, -3, 15,-25,-20,  2,-28, 23,-20,-10,  0,-15, 20, 47, -6,-10,-24,-22,-12, 14;
/M: SY='E'; M= -9, 12,-30, 21, 22,-32, 14, -7,-36, -3,-26,-22,  5, -9,  1, -9,  0,-14,-30,-29,-24, 12;
/M: SY='F'; M=-14,-30,-23,-36,-26, 32,-33,-23, 20,-30, 28, 13,-24,-27,-27,-23,-24,-10, 12, -9, 11,-26;
/M: SY='V'; M=  0,-30,-10,-30,-30,  0,-30,-30, 30,-20, 10, 10,-30,-30,-30,-20,-10,  0, 50,-30,-10,-30;
/M: SY='V'; M= -5,-19,-17,-18, -7, -6,-26,-18, 13,-13,  9, 11,-22,-22,-13,-14,-11, -5, 21,-27,-10,-10;
/M: SY='D'; M=-15, 26,-30, 36, 15,-35,-15, -5,-35, 24,-30,-20, 10,-10,  5,  9, -5,-10,-25,-30,-15, 10;
/M: SY='Y'; M=-20,-24,-26,-28,-24, 49,-30,  4,  0,-18,  4,  0,-20,-30,-22,-14,-20,-10, -6, 22, 61,-24;
/M: SY='F'; M=-11,-30,-20,-36,-28, 30,-33,-25, 23,-28, 19, 11,-24,-27,-29,-23,-19, -8, 21,-12,  8,-28;
/M: SY='T'; M= -1,  0,-15, -4, -4,-16,-12, 14,-19,-10,-20,-11,  6,-13, -1, -7, 20, 21,-12,-34, -6, -4;
/M: SY='Y'; M=-18,-12,-30,-12, -9,  7,-26, 28,-13,  4,-11, -2,-10,-23, -2,  1,-16,-12,-16,  7, 48, -9;
/M: SY='R'; M=-14, -4,-30, -4,  6,-26,-20, -6,-30, 43,-26,-10,  0,-14, 10, 44,-10,-10,-20,-20,-10,  6;
/M: SY='L'; M=-10,-30,-24,-34,-24,  6,-34,-24, 31,-30, 39, 20,-26,-26,-20,-24,-26,-10, 17,-20,  0,-24;
/M: SY='S'; M= 11, -4,-14, -5, -2,-20, -4,-10,-20, -3,-25,-16,  5,-12,  0,  3, 26, 11,-10,-33,-18, -2;
/M: SY='Q'; M=-10,  0,-30,  0, 20,-40,-20, 10,-20, 10,-20,  0,  0,-10, 60, 10,  0,-10,-30,-20,-10, 40;
/M: SY='N'; M=-13, 21,-24,  9,  2,-22, -8,  4,-24, 15,-27,-16, 35,-18,  4, 22,  2, -4,-26,-32,-16,  2;
/M: SY='G'; M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='Y'; M=-15,-22,-25,-25,-20, 18,-28,  6,  9,-14, 16, 19,-22,-28,-10,-12,-22,-10, -1,  7, 43,-18;
/M: SY='D'; M=-10, 23,-26, 34, 33,-32,-12, -2,-32,  2,-26,-24,  9, -6,  9, -6,  8, -4,-26,-36,-20, 21;
/M: SY='W'; M=-20,-40,-50,-40,-30, 10,-20,-30,-20,-20,-20,-20,-40,-30,-20,-20,-40,-30,-30,150, 30,-20;
/I:         E1=0; IE=-105; DE=-105;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_08 which contains 546'238 sequence entries.


Total number of hits 19 in 19 different sequences
Number of true positive hits 19 in 19 different sequences
Number of 'unknown' hits
Number of false positive hits
Number of false negative sequences 7
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 73.08 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] MOTIF
Feature description [info] BH4
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
19 sequences

B2CL1_CHICK (Q07816), B2CL1_HUMAN (Q07817), B2CL1_MOUSE (Q64373), 
B2CL1_PIG   (O77737), B2CL1_RAT   (P53563), B2CL2_BOVIN (Q1RMX3), 
B2CL2_CANFA (Q45T69), B2CL2_HUMAN (Q92843), B2CL2_MOUSE (P70345), 
BCL2_BOVIN  (O02718), BCL2_CANFA  (Q6R755), BCL2_CHICK  (Q00709), 
BCL2_CRIGR  (Q9JJV8), BCL2_HUMAN  (P10415), BCL2_MOUSE  (P10417), 
BCL2_RAT    (P49950), BOKB_DANRE  (Q7T381), CED9_CAEBR  (P41957), 
CED9_CAEEL  (P41958)
» More

UniProtKB/Swiss-Prot
False negative sequences
7 sequences

B2L13_HUMAN (Q9BXK5), B2L13_MOUSE (P59017), BOKA_DANRE  (Q6DC66), 
BOK_CHICK   (Q9I8I2), BOK_HUMAN   (Q9UMX3), BOK_MOUSE   (O35425), 
BOK_RAT     (Q792S6)
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PDB
[Detailed view]
85 PDB

1AF3; 1BXL; 1G5J; 1G5M; 1GJH; 1LXL; 1MAZ; 1MK3; 1O0L; 1OHU; 1PQ0; 1PQ1; 1R2D; 1R2E; 1R2G; 1R2H; 1R2I; 1TY4; 1YSG; 1YSI; 1YSN; 1YSW; 1ZY3; 2A5Y; 2B48; 2BZW; 2LP8; 2LPC; 2M03; 2M04; 2ME8; 2ME9; 2MEJ; 2O1Y; 2O21; 2O22; 2O2F; 2O2M; 2O2N; 2P1L; 2PON; 2W3L; 2XA0; 2Y6W; 2YJ1; 2YQ6; 2YQ7; 2YXJ; 3CVA; 3FDL; 3FDM; 3IHC; 3IHD; 3IHE; 3IHF; 3IIG; 3IIH; 3ILB; 3ILC; 3INQ; 3IO8; 3PL7; 3QKD; 3R85; 3SP7; 3SPF; 3WIZ; 3ZK6; 3ZLN; 3ZLO; 3ZLR; 4A1U; 4A1W; 4AQ3; 4BPK; 4C52; 4C5D; 4EHR; 4HNJ; 4IEH; 4K5A; 4K5B; 4LVT; 4LXD; 4MAN
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