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PROSITE entry PS50071


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PURL: https://purl.expasy.org/prosite/signature/PS50071

Direct ScanProsite submission
General information about the entry

Entry name [info] HOMEOBOX_2
Accession [info] PS50071
Entry type [info] MATRIX
Date [info] 01-NOV-1997 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00027
Associated ProRule [info] PRU00108

Name and characterization of the entry

Description [info] 'Homeobox' domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=61;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=56;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.1179000; R2=0.0161953; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=3296.3750000; R2=2.4588416; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=456; H_SCORE=4418; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=333; H_SCORE=4115; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-60; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 1'714 in 1'637 different sequences
Number of true positive hits 1'702 in 1'625 different sequences
Number of 'unknown' hits 0
Number of false positive hits 12 in 12 different sequences
Number of false negative sequences 54
Number of 'partial' sequences 6
Precision (true positives / (true positives + false positives)) 99.30 %
Recall (true positives / (true positives + false negatives)) 96.92 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 4
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Feature key [info] DNA_BIND
Feature description [info] Homeobox
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
1625 sequences

ABDA_AEDAE  (P29552), ABDA_ANOGA  (O76762), ABDA_APIME  (P15856), 
» more

UniProtKB/Swiss-Prot
False negative sequences
54 sequences

ADN1A_DANRE (F1QLG5), ADN2A_DANRE (A4QP16), ADNP2_HUMAN (Q6IQ32), 
» more

UniProtKB/Swiss-Prot
'Partial' sequences
6 sequences

BCD_DROSU   (P55924), DLX1_RAT(Q64202), DLX2_RAT(Q64204), 
» more

UniProtKB/Swiss-Prot
False positive sequences
12 sequences

CERS2_BOVIN (Q3ZBF8), CERS2_HUMAN (Q96G23), CERS2_MOUSE (Q924Z4), 
» more

PDB
[Detailed view]
232 PDB

1AHD; 1AKH; 1APL; 1AU7; 1B72; 1B8I; 1BW5; 1CQT; 1DU0; 1DU6; 1E3O; 1ENH;
» more