Entry: PS50108

General information about the entry

Entry name [info] CRIB
Accession [info] PS50108
Entry type [info] MATRIX
Date [info] DEC-2001 (CREATED); OCT-2013 (DATA UPDATE); OCT-2016 (INFO UPDATE).
PROSITE Doc. [info] PDOC50108
Associated ProRule [info] PRU00057

Name and characterization of the entry

Description [info] CRIB domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=14;
/DISJOINT: DEFINITION=PROTECT; N1=2; N2=13;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=-0.2255000; R2=0.0176662; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=419.6926270; R2=0.3792415; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=421; H_SCORE=579; N_SCORE=7.2; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=381; H_SCORE=564; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-9; D=-20; I=-20; B1=-60; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='I'; M= -7,-30,-25,-37,-30,  0,-37,-30, 45,-27, 17, 17,-23,-23,-23,-27,-17, -7, 35,-23, -3,-30;
/M: SY='G'; M=  6, -4,-18, -4, -8,-24, 27,-14,-28,-14,-30,-20,  6,-14, -8,-14, 25,  5,-18,-32,-24, -8;
/M: SY='S'; M=  4, -4,-19, -8, -4,-14, -9, -6,-13, -9,-13, -9,  1, -9, -4,-10,  6,  5,-11,-26,-11, -5;
/M: SY='P'; M= -9,-19,-39,-10,  0,-30,-19,-20,-20,-10,-30,-20,-19, 87,-10,-20, -8, -9,-29,-30,-30,-10;
/M: SY='T'; M= -4,-11,-15,-17,-13,  8,-19,-15, -5,-15, -4, -3, -6,-17,-12,-12,  7, 18, -1,-21, -1,-11;
/I:         I=-6; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='N'; M=-12, 39,-23, 31,  4,-26,  2,  4,-27, -2,-30,-23, 43,-17, -2, -4,  7, -4,-30,-38,-21,  1;
/M: SY='F'; M=-13,-29,-19,-35,-27, 50,-29,-21,  6,-26,  9,  2,-22,-24,-34,-20,-17, -8, 10, -2, 18,-28;
/M: SY='K'; M= -9, -1,-26, -1, 12,-25,-20, -7,-20, 22,-20, -8, -1,-12, 11, 18, -4, -5,-14,-24,-12, 11;
/M: SY='H'; M=-20, -1,-30, -1,  0,-19,-20, 91,-29, -7,-20, -1,  9,-20, 10,  5,-10,-19,-29,-28, 19,  0;
/M: SY='T'; M= -7, -6,-21, -9, -5,-13,-23, -9, -2, -6, -4, -2, -5,-17, -4, -4, -3,  4,  1,-27, -8, -6;
/M: SY='V'; M=  3,-20,-14,-25,-21, -2,-17,-19, 11,-18,  1,  5,-16,-21,-18,-19, -3,  0, 17,-23, -6,-20;
/M: SY='H'; M=-20,  0,-30,  0,  0,-20,-20,100,-30,-10,-20,  0, 10,-20, 10,  0,-10,-20,-30,-30, 20,  0;
/M: SY='V'; M= -2,-27,-15,-31,-28, -1,-30,-28, 31,-21, 11, 13,-25,-26,-25,-21,-11,  0, 40,-27, -7,-27;
/M: SY='G'; M= -1, -2,-27, -3,-15,-29, 54,-15,-36,-16,-30,-20,  8,-19,-16,-17,  4,-14,-28,-24,-28,-15;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2016_11 which contains 553'231 sequence entries.


Total number of hits 126 in 126 different sequences
Number of true positive hits 126 in 126 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 4
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 96.92 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] DOMAIN
Feature description [info] CRIB
Version [info] 4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
126 sequences

ARK1_CAEEL  (G5EBZ8    ), BORG1_BOVIN (Q08DN6    ), BORG1_HUMAN (O14613    ), 
BORG1_MOUSE (Q8JZX9    ), BORG1_RAT   (Q5PQP4    ), BORG2_HUMAN (Q9UKI2    ), 
BORG2_MOUSE (Q9CQC5    ), BORG3_HUMAN (Q6NZY7    ), BORG3_MOUSE (Q9Z0X0    ), 
BORG4_HUMAN (Q9H3Q1    ), BORG4_MOUSE (Q9JM96    ), BORG5_BOVIN (Q17QW1    ), 
BORG5_HUMAN (Q00587    ), BORG5_MOUSE (Q91W92    ), BORG5_RAT   (A1A5P0    ), 
C42ES_DROME (Q9VNE7    ), C42S1_BOVIN (Q5BIS3    ), C42S1_CHICK (Q5ZKB1    ), 
C42S1_DANRE (Q6TEL3    ), C42S1_HUMAN (Q9NRR8    ), C42S1_MOUSE (Q8BHL7    ), 
C42S1_PONAB (Q5RDD6    ), C42S1_RAT   (Q5BJM7    ), C42S1_XENTR (Q5BKH3    ), 
C42S2_BOVIN (A6QLJ4    ), C42S2_DANRE (A9JR56    ), C42S2_HUMAN (Q9NRR3    ), 
C42S2_MOUSE (Q8BGH7    ), C42S2_PONAB (Q5R4F8    ), C42S2_RAT   (A1L1K4    ), 
C4S1A_XENLA (Q66KZ1    ), C4S1B_XENLA (Q6GPV4    ), C4S2A_XENLA (Q5FVD7    ), 
C4S2A_XENTR (Q28EW5    ), C4S2B_XENLA (Q6AX78    ), C4S2B_XENTR (Q28GG3    ), 
C4S2C_XENLA (Q4V853    ), CLA4_ASHGO  (Q9HFW2    ), CLA4_CANAL  (Q5APR8    ), 
CLA4_CANAX  (O14427    ), CLA4_YEAST  (P48562    ), GEK_DROME   (Q9W1B0    ), 
GIC1_YEAST  (P38785    ), GIC2_YEAST  (Q06648    ), MAX2_CAEEL  (G5EGQ3    ), 
MRCKA_HUMAN (Q5VT25    ), MRCKA_MOUSE (Q3UU96    ), MRCKA_RAT   (O54874    ), 
MRCKB_HUMAN (Q9Y5S2    ), MRCKB_MOUSE (Q7TT50    ), MRCKB_RAT   (Q7TT49    ), 
MRCKG_HUMAN (Q6DT37    ), MRCKG_MOUSE (Q80UW5    ), MRCK_CAEEL  (O01583    ), 
PAK1_BOVIN  (Q08E52    ), PAK1_HUMAN  (Q13153    ), PAK1_MOUSE  (O88643    ), 
PAK1_RAT    (P35465    ), PAK2_HUMAN  (Q13177    ), PAK2_MOUSE  (Q8CIN4    ), 
PAK2_RABIT  (Q29502    ), PAK2_RAT    (Q64303    ), PAK3_HUMAN  (O75914    ), 
PAK3_MOUSE  (Q61036    ), PAK3_PANTR  (Q7YQL4    ), PAK3_PONPY  (Q7YQL3    ), 
PAK3_RAT    (Q62829    ), PAK3_XENLA  (Q8AXB4    ), PAK4_HUMAN  (O96013    ), 
PAK4_MOUSE  (Q8BTW9    ), PAK5_HUMAN  (Q9P286    ), PAK5_MOUSE  (Q8C015    ), 
PAK5_RAT    (D4A280    ), PAK6_HUMAN  (Q9NQU5    ), PAK6_MOUSE  (Q3ULB5    ), 
PAK6_PONAB  (Q5R8Z4    ), PAKA_DICDI  (Q55D99    ), PAKB_DICDI  (Q869N2    ), 
PAKC_DICDI  (Q55GV3    ), PAKD_DICDI  (Q55DD4    ), PAKG_DICDI  (Q54RV3    ), 
PAKM_DROME  (Q9VXE5    ), PK1_CAEEL   (Q17850    ), PK2_CAEEL   (G5EFU0    ), 
PR2_DROME   (Q9I7F7    ), RGAP1_ARATH (Q9FMR1    ), RGAP2_ARATH (F4JI46    ), 
RGAP4_ARATH (Q9CAX8    ), RGAP5_ARATH (Q6NKT5    ), RIC10_ARATH (Q9M0Y9    ), 
RIC11_ARATH (Q0WL69    ), RIC1_ARATH  (F4IVV0    ), RIC2_ARATH  (Q8GYU0    ), 
RIC3_ARATH  (F4I5N6    ), RIC4_ARATH  (Q9FFD5    ), RIC5_ARATH  (F4J424    ), 
RIC6_ARATH  (Q1PF35    ), RIC7_ARATH  (Q1G3K8    ), RIC8_ARATH  (Q9ZWB8    ), 
RIC9_ARATH  (Q1G3Y0    ), SHK2_SCHPO  (Q10056    ), SKM1_YEAST  (Q12469    ), 
STE20_ASHGO (Q75DK7    ), STE20_ASPFU (Q4WHP3    ), STE20_ASPOR (Q2ULU3    ), 
STE20_CANAL (P0CY24    ), STE20_CANAW (C4YRB7    ), STE20_CANAX (P0CY23    ), 
STE20_CANGA (Q6FN53    ), STE20_DEBHA (Q6BNF3    ), STE20_EMENI (Q5BBL3    ), 
STE20_KLULA (Q6CVA2    ), STE20_MAGO7 (Q7Z8E9    ), STE20_NEUCR (Q7RZD3    ), 
STE20_SCHPO (P50527    ), STE20_TALMA (Q2VWQ3    ), STE20_USTMA (Q4P5N0    ), 
STE20_YARLI (Q6C3D7    ), STE20_YEAST (Q03497    ), WASL_BOVIN  (Q95107    ), 
WASL_HUMAN  (O00401    ), WASL_MOUSE  (Q91YD9    ), WASL_RAT    (O08816    ), 
WASP_HUMAN  (P42768    ), WASP_MOUSE  (P70315    ), YN03_CAEEL  (Q03607    )
» more

UniProtKB/Swiss-Prot
False negative sequences
4 sequences

ACK1_HUMAN  (Q07912    ), ACK1_MOUSE  (O54967    ), PAKF_DICDI  (Q869T7    ), 
RGAP3_ARATH (Q8GYY5    )
» more

PDB
[Detailed view]
7 PDB

1CEE; 1E0A; 1EES; 1F3M; 2ODB; 2OV2; 2QME

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