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Entry: PS50114

General information about the entry
Entry name	GATA_ZN_FINGER_2
Accession number	PS50114
Entry type	MATRIX
Date	DEC-2001 (CREATED); DEC-2001 (DATA UPDATE); DEC-2011 (INFO UPDATE).
PROSITE Documentation	PDOC00300
Associated ProRule	PRU00094
Name and characterization of the entry
Description	GATA-type zinc finger domain profile.
Matrix / Profile	/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=54; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=49; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.6125; R2=0.01318514; TEXT='-LogE'; /CUT_OFF: LEVEL=0; SCORE=598; N_SCORE=8.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=446; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105; A B C D E F G H I K L M N P Q R S T V W Y Z /I: B1=0; BI=-105; BD=-105; /M: SY='R'; M=-10,-10,-19,-10, -4,-12,-19, -2,-19, 6,-17, -9, -5, -7, -2, 9, -3, -4,-14,-24, -7, -4; /M: SY='R'; M= -9, -2,-15, -6, -5,-19,-11, 0,-23, 5,-20,-12, 4,-18, -1, 18, 3, 4,-15,-29,-12, -5; /M: SY='E'; M= 6, -1,-24, 1, 18,-25,-10,-10,-20, -2,-17,-13, -6, 5, 4,-10, 1, -4,-17,-27,-20, 10; /M: SY='G'; M= 2, -5,-28, -3,-13,-28, 45,-18,-33,-17,-25,-19, 0,-14,-16,-19, 1,-15,-25,-23,-26,-15; /M: SY='R'; M=-12,-14,-24,-18, -9,-11,-24,-10, -4, 1, 2, 5, -9,-19, 1, 18,-10, 0, -4,-22, -6, -6; /M: SY='E'; M= -7, -1,-15, 2, 22,-24,-18, -6,-21, 5,-18,-12, -2,-11, 10, 5, 4, -2,-16,-30,-17, 15; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='T'; M= 4,-12,-12,-15,-12,-10,-17,-18, 0,-11, -9, -5, -9,-18, -9,-12, 11, 13, 12,-30,-12,-11; /M: SY='N'; M=-10, 40,-20, 20, 0,-20, 0, 10,-20, 0,-30,-20, 60,-20, 0, 0, 10, 0,-30,-40,-20, 0; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='G'; M= -5, -6,-27, -9, -8,-19, 17, 5,-27,-10,-20,-10, 1,-18, -1, -7, -3,-12,-23,-20,-11, -5; /M: SY='T'; M= 13, -6,-12,-13,-10,-14,-12,-20, -9, -7,-11, -9, -5,-12,-10,-11, 12, 24, 2,-27,-14,-10; /M: SY='T'; M= -3, -6,-16,-13,-10, -9,-20,-12, -4,-10, -8, -3, -2,-14, -6, -8, 10, 25, 0,-28, -8, -9; /M: SY='T'; M= 3, 3,-15, -4, -4,-17,-12, -4,-15, -4,-18,-11, 8,-12, -2, -6, 16, 21, -9,-31,-12, -4; /M: SY='T'; M= 0, 0,-10,-10,-10,-10,-20,-20,-10,-10,-10,-10, 0,-10,-10,-10, 20, 50, 0,-30,-10,-10; /M: SY='P'; M= -5,-13,-30, -9, -2,-25,-18,-19,-18,-10,-26,-18,-12, 57, -9,-17, 2, 6,-21,-31,-25, -9; /M: SY='L'; M=-10,-29,-20,-29,-19, 8,-30,-20, 18,-26, 46, 19,-29,-29,-19,-18,-29,-10, 9,-20, 0,-19; /M: SY='W'; M=-20,-40,-50,-40,-30, 10,-20,-30,-20,-20,-20,-20,-40,-30,-20,-20,-40,-30,-30,150, 30,-20; /M: SY='R'; M=-20, -9,-30, -9, 0,-20,-20, 5,-30, 28,-20, -9, 1,-20, 10, 66,-10,-11,-21,-21, -8, 0; /M: SY='R'; M=-19, -9,-30, -9, 1,-21,-20, -1,-30, 31,-21,-10, 0,-19, 10, 67,-10,-10,-20,-20,-10, 1; /M: SY='D'; M= -9, 35,-24, 38, 8,-31, 0, -1,-31, -3,-29,-24, 27,-14, -2, -9, 7, -5,-26,-37,-21, 3; /M: SY='P'; M= 2,-11,-29, -8, -1,-27, 11,-16,-24,-10,-23,-16, -8, 20, -9,-15, -2,-11,-23,-25,-26, -7; /M: SY='D'; M= -6, 14,-21, 16, 13,-24,-13, -1,-24, -1,-21,-16, 7, -9, 3, -6, 10, 10,-18,-33,-14, 8; /M: SY='G'; M= -1, -6,-29, -8,-19,-29, 65,-18,-39,-19,-30,-20, 4,-20,-19,-19, 1,-19,-30,-21,-29,-19; /M: SY='H'; M= -9, 12,-24, 12, 9,-24,-13, 29,-24, -4,-21,-12, 15,-14, 8, -3, 4, -5,-24,-33, -6, 7; /M: SY='P'; M=-12,-17,-30,-15,-11, -3,-24, -6, -7,-11, -9, -6,-16, 20,-11,-15,-11, -2,-13,-10, 12,-14; /M: SY='L'; M= -7,-30,-19,-31,-24, 6,-31,-24, 27,-27, 35, 17,-29,-29,-23,-21,-23, -7, 23,-23, -3,-24; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='N'; M=-10, 38,-20, 19, 0,-20, -1, 10,-20, 1,-30,-20, 58,-20, 0, 2, 9, 0,-30,-39,-20, 0; /M: SY='A'; M= 48,-10,-11,-20,-10,-20, -1,-19,-11, -9,-10,-10,-10,-10, -9,-17, 9, 0, -1,-20,-20,-10; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='G'; M= 0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20, 0,-20,-20,-20, 0,-20,-30,-20,-30,-20; /M: SY='L'; M=-10,-30,-20,-30,-20, 12,-30,-20, 19,-30, 49, 19,-30,-30,-21,-20,-30,-10, 10,-19, 1,-20; /M: SY='Y'; M=-20,-22,-28,-24,-22, 40,-30, 12, 0,-14, 2, 0,-20,-30,-16,-12,-20,-10, -8, 26, 70,-22; /M: SY='H'; M=-15,-13,-25,-17,-11, 6,-24, 20, -3,-14, 2, 7, -7,-23, -2, -9,-14,-10, -9,-12, 18, -8; /M: SY='K'; M=-10, 0,-30, 0, 10,-30,-20,-10,-30, 49,-30,-10, 0,-10, 10, 31,-10,-10,-20,-20,-10, 10; /M: SY='L'; M= -9,-23,-21,-27,-18, 2,-25, -5, 16,-21, 29, 28,-21,-24,-11,-16,-20, -9, 7,-22, 0,-15; /M: SY='H'; M=-17, 12,-27, 6, 0,-20,-14, 61,-27, -2,-23, -7, 25,-20, 7, 6, -4,-13,-29,-32, 4, 0; /M: SY='G'; M= -3, -4,-28, -5,-11,-28, 41, -7,-34, -9,-29,-17, 6,-18, -9,-10, 3,-14,-27,-24,-22,-10; /M: SY='V'; M= -6,-16,-19,-19,-13,-10,-26, -6, 9,-11, 1, 8,-14,-20, -5,-11, -7, 0, 14,-26, -5,-10; /M: SY='N'; M= -3, 8,-23, 1, -3,-19,-10, 9,-15, -6,-21,-11, 17, 0, -3, -8, 2, -2,-18,-33,-14, -5; /M: SY='R'; M=-20,-10,-30,-10, 0,-20,-20, 0,-30, 30,-20,-10, 0,-20, 10, 70,-10,-10,-20,-20,-10, 0; /M: SY='P'; M= -9,-19,-38, -9, 0,-29,-19,-19,-20,-10,-30,-20,-18, 83, -9,-19, -7, -8,-29,-31,-29, -9; /M: SY='L'; M= -4,-28,-19,-30,-21, 5,-29,-22, 21,-27, 36, 16,-26,-27,-20,-21,-22, -6, 16,-22, -3,-21; /I: I=-6; MI=-32; MD=-32; IM=-32; /M: SY='T'; M= 4, -9,-17,-14,-10,-13,-14,-18, -2,-10,-12, -6, -3,-13, -8,-12, 13, 14, 2,-29,-12,-10; /I: DM=-32; /M: SY='M'; M=-10,-12,-22,-17, -9, -9,-20, -5, 1, 2, 8, 22,-10,-19, 2, 3,-16, -9, -3,-21, -5, -4; D=-6; /M: SY='K'; M=-12, -8,-33, -5, 5,-28,-20,-12,-27, 26,-28,-13, -7, 23, 3, 19,-10,-10,-23,-23,-17, 2; /M: SY='K'; M= -8, -3,-25, -5, 4,-23,-20,-10,-21, 25,-19, -7, -2,-12, 9, 17, -2, 3,-15,-23,-10, 6; /M: SY='D'; M=-10, 17,-27, 25, 17,-31,-13, -4,-32, 14,-26,-20, 8,-10, 6, 11, 1, -6,-23,-31,-17, 11; /I: I=-10; MI=0; IM=0; DM=-25; MD=-25; /M: SY='V'; M= 0,-19,-18,-22,-19, -8, -8,-20, 6,-20, 6, 4,-16,-22,-16,-18, -5, -2, 10,-25,-11,-18; /M: SY='I'; M= -6,-18,-26,-22,-17, -8,-28,-22, 23,-21, 6, 7,-12,-14,-12,-20, -9, -5, 13,-25, -7,-18; /M: SY='Q'; M= 4, -3,-23, -5, 5,-28,-14, -7,-17, 14,-20, -7, -1,-12, 18, 6, 2, -4,-14,-23,-13, 11; /M: SY='T'; M= 5, -2,-16, -6, -2,-20,-12,-13,-19, 7,-21,-13, 2,-11, -1, 6, 15, 16, -9,-29,-14, -2; /M: SY='R'; M=-20,-10,-30,-10, 0,-20,-20, 0,-30, 30,-20,-10, 0,-20, 10, 70,-10,-10,-20,-20,-10, 0; /I: E1=0; IE=-105; DE=-105;
Numerical results
UniProtKB/Swiss-Prot release number: 01, total number of sequence entries in that release: 534242. Total number of hits in UniProtKB/Swiss-Prot: 180 hits in 136 different sequences Number of hits on proteins that are known to belong to the set under consideration: 179 hits in 135 different sequences Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences Number of false hits (on unrelated proteins): 1 hits in 1 different sequences Number of known missed hits: 16 Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 0 Precision (true hits / (true hits + false positives)): 99.44 % Recall (true hits / (true hits + false negatives)): 91.79 %
Comments
MATRIX_TYPE: protein_domain Scaling database: UniProtKB/Swiss-Prot: reversed Matrix author: K_Hofmann Taxonomic range: Eukaryotes Maximum known number of repetitions of the pattern in a single protein: 2 FT_KEY: ZN_FING FT_DESC: GATA-type VERSION: 1
Cross-references
UniProtKB/Swiss-Prot	True positive hits: AMS2_SCHPO (Q9URT4), AREA_ASPNG (O13412), AREA_ASPOR (O13415), AREA_EMENI (P17429), AREA_GIBFU (P78688), AREA_PENCH (Q01582), AREA_PENRO (O13508), ASD4_NEUCR (Q9HEV5), ASH1_YEAST (P34233), CGPB_FUSSO (Q00858), DAL80_YEAST (P26343), ECM23_YEAST (Q02710), EGL27_CAEEL (Q09228), ELT1_CAEEL (P28515), ELT2_CAEEL (Q10655), FEP1_SCHPO (Q10134), GAF1_SCHPO (Q10280), GAT10_ARATH (Q8VZP4), GAT11_ARATH (Q6DBP8), GAT12_ARATH (P69781), GAT13_ARATH (Q9SKN6), GAT14_ARATH (Q9M1U2), GAT15_ARATH (Q8LG10), GAT16_ARATH (Q9FJ10), GAT17_ARATH (Q9LIB5), GAT18_ARATH (Q8LC79), GAT19_ARATH (Q6QPM2), GAT1A_XENLA (P23767), GAT1B_XENLA (P23768), GAT1_YEAST (P43574), GAT20_ARATH (Q9ZPX0), GAT21_ARATH (Q5HZ36), GAT22_ARATH (Q9SZI6), GAT23_ARATH (Q8LC59), GAT24_ARATH (Q8GXL7), GAT25_ARATH (Q9LRH6), GAT26_ARATH (Q8W4H1), GAT27_ARATH (Q5PP38), GAT28_ARATH (Q8H1G0), GAT29_ARATH (Q9LT45), GAT2_YEAST (P40209), GAT3_YEAST (Q07928), GAT4_YEAST (P40569), GAT5A_XENLA (P43695), GAT5B_XENLA (P43696), GAT6A_XENLA (Q91678), GAT6B_XENLA (P70005), GATA1_ARATH (Q8LAU9), GATA1_BOVIN (A2VDY6), GATA1_CHICK (P17678), GATA1_HUMAN (P15976), GATA1_MOUSE (P17679), GATA1_RAT (P43429), GATA2_ARATH (O49741), GATA2_CHICK (P23824), GATA2_HUMAN (P23769), GATA2_MOUSE (O09100), GATA2_RAT (Q924Y4), GATA2_XENLA (P23770), GATA3_ARATH (Q8L4M6), GATA3_BOVIN (Q08DV0), GATA3_CHICK (P23825), GATA3_DANRE (Q91428), GATA3_HUMAN (P23771), GATA3_MOUSE (P23772), GATA3_XENLA (P23773), GATA4_ARATH (O49743), GATA4_CANFA (Q0Q0E4), GATA4_CHICK (P43691), GATA4_HUMAN (P43694), GATA4_MOUSE (Q08369), GATA4_RAT (P46152), GATA4_XENLA (Q91677), GATA5_ARATH (Q9FH57), GATA5_BOVIN (Q3SZJ5), GATA5_CHICK (P43692), GATA5_HUMAN (Q9BWX5), GATA5_MOUSE (P97489), GATA6_ARATH (Q9SD38), GATA6_CHICK (P43693), GATA6_HUMAN (Q92908), GATA6_MOUSE (Q61169), GATA6_PIG (Q95JA5), GATA6_RAT (P46153), GATA7_ARATH (O65515), GATA8_ARATH (Q9SV30), GATA9_ARATH (O82632), GATAB_BOMMO (P52167), GATAC_DROME (P91623), GATD1_DANRE (Q1L8G7), GATD1_HUMAN (Q8WUU5), GATD1_MOUSE (Q920S3), GATD1_XENLA (Q7ZXY4), GLN3_YEAST (P18494), GTAA_DICDI (Q550D5), GTAB_DICDI (Q54V32), GTAC_DICDI (Q75JZ1), GTAD_DICDI (Q54L72), GTAE_DICDI (Q55GK0), GTAF_DICDI (Q55EQ0), GTAG_DICDI (Q55C49), GTAH_DICDI (Q75JZ0), GTAI_DICDI (Q54TM6), GTAJ_DICDI (Q54TE3), GTAK_DICDI (Q5KSV0), GTAL_DICDI (Q54NM5), GTAN_DICDI (Q54KX0), GTAO_DICDI (Q54HA4), GTAP_DICDI (B0G188), GTAQ_DICDI (Q54L80), GTAR_DICDI (Q54WY0), GTAT_DICDI (Q54V37), GTAU_DICDI (Q54US7), GTAW_DICDI (Q54L82), GTAX_DICDI (Q54FV1), GZF3_YEAST (P42944), NIT2_NEUCR (P19212), NRFA_PENUR (Q92269), NUT1_MAGO7 (Q01168), P66A_HUMAN (Q86YP4), P66B_HUMAN (Q8WXI9), P66B_MOUSE (Q8VHR5), PNR_DROME (P52168), RCOR_CAEEL (Q18919), SREP_PENCH (Q92259), SRP_DROME (P52172), TRPS1_HUMAN (Q9UHF7), TRPS1_MOUSE (Q925H1), TRPS1_XENLA (Q90ZS6), URB1_USTMA (P40349), WC1_NEUCR (Q01371), WC2_NEUCR (P78714), YCF8_SCHPO (O94720), ZGLP1_HUMAN (P0C6A0), ZGLP1_MOUSE (Q1WG82) False negative hits (sequences which belong to the set under consideration, but which have not been picked up by the pattern or profile): GTAM_DICDI (Q54L83), GTAV_DICDI (Q54UG8), GTAY_DICDI (Q54X31), MTA1_HUMAN (Q13330), MTA1_MOUSE (Q8K4B0), MTA1_RAT (Q62599), MTA2_HUMAN (O94776), MTA2_MOUSE (Q9R190), MTA3_BOVIN (A6QL72), MTA3_HUMAN (Q9BTC8), MTA3_MOUSE (Q924K8), P66A_MOUSE (Q8CHY6), RERE_HUMAN (Q9P2R6), RERE_MOUSE (Q80TZ9), RERE_RAT (Q62901), SRD1_YEAST (P09007) False positive hits (sequences which do not belong to the set under consideration): IF2B_THEAC (Q9HKJ3) Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
PDB [Detailed view]	1GAT; 1GAU; 1GNF; 1Y0J; 2GAT; 2L6Y; 2L6Z; 2VUS; 2VUT; 2VUU; 3DFV; 3DFX; 3GAT; 4GAT; 5GAT; 6GAT; 7GAT;

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