Entry: PS50135

General information about the entry
Entry name ZF_ZZ_2
Accession number PS50135
Entry type MATRIX
Date DEC-2001 (CREATED); DEC-2001 (DATA UPDATE); MAR-2013 (INFO UPDATE).
PROSITE Documentation PDOC50135
Associated ProRule PRU00228
Name and characterization of the entry
DescriptionZinc finger ZZ-type profile.
Matrix / Profile 
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=48;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=44;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.4853; R2=.01125105; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=623; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=445; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105;

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='V'; M= -2,-14,-21,-16,-15, -1,-16,-19,  0,-11, -4,  1,-13,-12,-17,-14, -8, -4,  5,-21, -7,-16;
/M: SY='H'; M=-11, -7,-25, -8, -5,-11,-11, 25,-22,  0,-19, -7,  1,-18, -2,  4, -3, -9,-16,-24,  1, -5;
/M: SY='H'; M=-16, -1,-30, -2, -1,-12,-18, 29,-22, -2,-17, -4,  2,-12,  1,  1,-11,-14,-23,-13,  4, -2;
/M: SY='N'; M= -6,  4,-25,  4,  5,-26, -3,  0,-22, -1,-23,-13,  6, -4,  4, -5,  3, -6,-20,-29,-17,  4;
/M: SY='V'; M=  1,-20,-19,-26,-23,  6,-25,-16, 16,-18,  4,  4,-15,-24,-20,-19,-10, -5, 17,-14,  8,-23;
/M: SY='E'; M= -4, -5,-14, -6,  4,-21,-18, -4,-18,  2,-18,-11, -3, -5,  2,  0,  3,  3,-14,-29,-13,  2;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='B'; M= -3, 33,-21, 31,  6,-27, -4,  0,-26, -2,-27,-22, 30,-14, -1, -8,  9, -2,-24,-37,-20,  2;
/M: SY='G'; M= -4, -3,-26, -4, -7,-18,  8,-12,-16, -8,-17,-11,  0,-17,-10,-12, -2, -9,-12,-21,-10, -9;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/I:         I=-6; MI=-29; MD=-29; IM=-29; DM=-29;
/M: SY='G'; M=  0, -4,-15, -4, -2,-16, 10, -6,-18,  4,-15, -8,  0, -9,  1,  4,  1, -5,-13,-13,-11, -1; D=-5;
/I:         DM=-25;
/M:         M= -2, -8, -5,-11, -4, -9, -9,-11, -8,-11, -4, -2, -6,-17, -5,-11, -3, -5, -6,-22,-11, -4; D=-5;
/I:         DM=-25;
/M:         M= -5, -5, -5, -5, -2,-17,-10,-14,-18, -2, -9, -9, -6,-17, -7, -3, -5, -2,-12,-25,-14, -5; D=-5;
/I:         DM=-25;
/M: SY='P'; M= -5,-13,-14,-11, -8,-18,-19, -9, -9,-10,-16, -9,-11, 15,-10,-11, -4, -5, -7,-29,-16,-12; D=-5;
/I:         DM=-25;
/M: SY='I'; M=-10,-22,-22,-29,-22, 11,-29,-13, 19,-23, 11, 13,-15,-22,-18,-20,-12, -4, 13,-18,  4,-21;
/M: SY='I'; M= -2,-16,-20,-21,-16, -8,-23,-18, 14,-16,  3,  8,-12,-13,-11,-16, -5,  0, 13,-27,-10,-15;
/M: SY='G'; M= -3, -9,-31, -8,-11,-29, 50,-17,-37,-13,-29,-19, -2,-10,-14,-12, -2,-18,-29,-22,-28,-13;
/M: SY='F'; M= -3,-15,-17,-20,-16, 13,-19,-13, -3,-18, -3, -5, -9,-13,-19,-15,  0,  4,  1,-19, -1,-17;
/M: SY='R'; M=-18,-12,-28,-13, -4,-17,-21, -2,-21, 23,-14, -3, -4,-21,  6, 56,-11, -9,-12,-21, -9, -3;
/M: SY='Y'; M=-19,-26,-29,-29,-25, 38,-28, -2, -1,-17,  0, -2,-24,-30,-21,-15,-22,-12, -6, 39, 53,-23;
/M: SY='R'; M=-11, -5,-26, -5,  1,-22,-19,  9,-23, 19,-21, -7,  0,-16,  8, 25, -3, -4,-15,-24, -6,  3;
/M: SY='C'; M= -6,-16, 96,-24,-24,-20,-24,-26,-28,-26,-22,-20,-14,-34,-24,-26, -1, -4,-10,-48,-28,-24;
/I:         I=-6; MI=-10; IM=-10; DM=-15; MD=-15;
/M: SY='Q'; M= -2, -7,-20,-10, -1,-14,-18,-10, -5, -6,  0, -1, -5,-17,  3, -6, -2,  0, -6,-26,-11,  1;
/M: SY='V'; M= -7,-15,-23,-16, -6,-14,-25,-13,  3, -2,  0,  3,-12,-19,  1,  1, -8, -6,  4,-24, -8, -4;
/M: SY='C'; M=-11,-16, 92,-24,-24,-21,-28,-14,-30,-22,-21,-17,-15,-36,-23,-22,-10,-11,-13,-46,-23,-24;
/M: SY='P'; M= -7, -5,-27,  0, 10,-14,-18, -3,-19, -8,-19,-14, -6, 14, -4,-12, -1, -6,-18,-27,-13,  2;
/M: SY='D'; M=-13, 40,-24, 41, 13,-30, -6,  4,-30,  0,-29,-24, 35,-14,  1, -5,  7, -4,-29,-39,-20,  7;
/M: SY='Y'; M=-20,-19,-29,-21,-19, 32,-29, 22, -3,-12, -1,  0,-17,-29,-12,-10,-19,-11,-11, 23, 69,-19;
/M: SY='D'; M=-17, 36,-29, 46, 13,-35, -5,  9,-35, -1,-28,-23, 21,-13,  5, -7,  0,-10,-30,-36,-16,  9;
/M: SY='L'; M= -9,-30,-22,-33,-23,  7,-33,-23, 28,-29, 39, 19,-27,-27,-21,-23,-26, -9, 18,-21, -1,-23;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='E'; M=  1,  1,-22,  1,  6,-19,-17, -9,-11, -5,-12, -8, -3,-12,  6, -9,  2, -1, -9,-25,-12,  6;
/M: SY='S'; M= -3, -3,-21, -5, -6,-19, -9,-15,-10, -5,-18,-11,  0, -6, -7, -9,  8,  5, -6,-30,-16, -8;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='Y'; M=-16,-14,-27,-14,  1, 25,-26, -1,-11, -6, -5, -6,-13,-20,-10, -7,-14,-10,-13,  3, 29, -5;
/M: SY='N'; M= -3,  0,-21, -5, -8, -7, -8,-11,-13,-11,-16,-13,  7, -8,-10, -9,  6,  1,-12,-27,-12, -9;
/M: SY='T'; M=  2, -4,-19, -8, -4,-20, -9, -6,-17,  2,-18, -9, -1,-13,  0, -2,  8,  9, -8,-27,-12, -2;
/M: SY='G'; M= -6, -6,-27, -7, -5,-25,  8, -2,-25,  2,-22, -7, -2, -7,  0, -2, -2, -7,-20,-24,-14, -3;
/M: SY='R'; M= -9, -6,-25, -8, -4,-15,-11, -6,-13,  4,-12, -6,  1,-18,  2,  7, -3, -6,-13,-21, -5, -2;
/I:         I=-6; MI=-29; MD=-29; IM=-29;
/M: SY='Y'; M= -4, -3,-12, -5, -8, -3,  3, -3, -7, -7, -8, -5,  1,-12, -7, -7, -1,  0, -6, -6,  4, -8; D=-6;
/I:         DM=-29;
/M: SY='H'; M=  0,  0,-18, -2,  5,-17, -8, 22,-19, -6,-14, -7,  2,-10,  2, -6,  2,  0,-15,-22, -4,  2; D=-6;
/I:         DM=-29;
/M: SY='H'; M=-12,  2,-29,  6,  4,-24, -4, 12,-29,  2,-24,-14,  2, -5,  0,  1, -4, -9,-25,-24, -7,  0;
/M: SY='E'; M= -8,  6,-28, 12, 20,-29, -3, -8,-29,  3,-24,-18,  1,  1,  5, -5,  1, -4,-25,-28,-20, 12;
/M: SY='H'; M=-17,  0,-29, -2,  1,-16,-21, 63,-20, -8,-16, -1,  8,-19,  9, -3, -9,-15,-23,-24, 16,  1;
/M: SY='E'; M= -7, -2,-24, -3,  9,-20,-19,  6,-20,  9,-14, -8, -1,-12,  4,  8, -2,  1,-16,-26, -7,  5;
/M: SY='M'; M=-11,-20,-24,-24,-14, -7,-23, -9,  8, -4,  9, 26,-18,-12, -5,  1,-17, -9,  4,-22, -6,-11;
/M: SY='L'; M= -5,-16,-22,-18, -7,  2,-23,  4,  1,-15,  9,  7,-15,-20, -8,-13,-14,-10, -2,-17,  6, -9;
/M: SY='R'; M=-13,  3,-28,  5,  4,-16,-19,  7,-19,  9,-14, -9,  2,-17,  2, 10, -9,-10,-18,-19,  3,  1;
/I:         E1=0; IE=-105; DE=-105;
Numerical results
  • UniProtKB/Swiss-Prot release number: 2013_05, total number of sequence entries in that release: 540052.
  • Total number of hits in UniProtKB/Swiss-Prot: 95 hits in 86 different sequences
  • Number of hits on proteins that are known to belong to the set under consideration: 95 hits in 86 different sequences
  • Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences
  • Number of false hits (on unrelated proteins): 0 hits in 0 different sequences
  • Number of known missed hits: 3
  • Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 0
  • Precision (true hits / (true hits + false positives)): 100.00 %
  • Recall (true hits / (true hits + false negatives)): 96.94 %
Comments
  • MATRIX_TYPE: protein_domain
  • Scaling database: UniProtKB/Swiss-Prot: reversed
  • Matrix author: K_Hofmann
  • Taxonomic range: Eukaryotes
  • Maximum known number of repetitions of the pattern in a single protein: 3
  • FT_KEY: ZN_FING
  • FT_DESC: ZZ-type
  • VERSION: 1
Cross-references
UniProtKB/Swiss-Prot True positive hits:
ADA2_SCHPO  (Q9P7J7), ADA2_YEAST  (Q02336), BIG_ARATH   (Q9SRU2), 
BIG_ORYSJ   (B9G2A8), CBP1_CAEEL  (P34545), CBP_HUMAN   (Q92793), 
CBP_MOUSE   (P45481), CBP_RAT     (Q6JHU9), DMDA_DROME  (Q9VDW6), 
DMDB_DROME  (Q9VDW3), DMDD_DROME  (Q0KI50), DMDE_DROME  (Q7YU29), 
DMD_CAEEL   (Q9TW65), DMD_CANFA   (O97592), DMD_CHICK   (P11533), 
DMD_HUMAN   (P11532), DMD_MOUSE   (P11531), DMD_PIG     (Q5GN48), 
DRP2_HUMAN  (Q13474), DRP2_MOUSE  (Q05AA6), DRP2_RAT    (Q9EPA0), 
DTN1_CAEEL  (Q9Y048), DTNA_HUMAN  (Q9Y4J8), DTNA_MOUSE  (Q9D2N4), 
DTNB_HUMAN  (O60941), DTNB_MOUSE  (O70585), DTNB_RAT    (P84060), 
DYTN_DANRE  (A2CI97), DYTN_HUMAN  (A2CJ06), DYTN_MOUSE  (A2CI98), 
EP300_HUMAN (Q09472), EP300_MOUSE (B2RWS6), HAC12_ARATH (Q9FWQ5), 
HAC1_ARATH  (Q9C5X9), HAC2_ARATH  (Q9FYH1), HAC4_ARATH  (Q9LG11), 
HAC5_ARATH  (Q9LE42), HACL1_ORYSJ (Q6YXY2), HACL2_ORYSJ (Q5Z8V7), 
HACL3_ORYSJ (Q9XHY7), HERC2_HUMAN (O95714), HERC2_MOUSE (Q4U2R1), 
KCMF1_BOVIN (Q1LZE1), KCMF1_DANRE (Q7T321), KCMF1_HUMAN (Q9P0J7), 
KCMF1_MOUSE (Q80UY2), KCMF1_XENLA (Q6GPB6), MIB1_DANRE  (Q804S5), 
MIB1_HUMAN  (Q86YT6), MIB1_MOUSE  (Q80SY4), MIB1_XENLA  (Q6GNY1), 
MIB2_CHICK  (Q5ZIJ9), MIB2_HUMAN  (Q96AX9), MIB2_MOUSE  (Q8R516), 
MIB2_RAT    (Q68LP1), MIB_DROME   (Q9VUX2), NBR1_HUMAN  (Q14596), 
NBR1_MOUSE  (P97432), NBR1_PONAB  (Q5RC94), NBR1_RAT    (Q501R9), 
PRT1_ARATH  (Q8LBL5), REF2P_DROME (P14199), REF2P_DROSI (Q24629), 
SQSTM_HUMAN (Q13501), SQSTM_MOUSE (Q64337), SQSTM_PONAB (Q5RBA5), 
SQSTM_RAT   (O08623), SWI3D_ARATH (Q8VY05), TAD2A_ARATH (Q9SFD5), 
TAD2B_ARATH (Q9ATB4), TAD2B_DANRE (Q503N9), TAD2B_DROME (Q8I8V0), 
TAD2B_HUMAN (Q86TJ2), TAD2B_PONAB (Q5RBN9), TAD2B_XENLA (Q6NRB5), 
TADA2_ORYSJ (Q75LL6), UTRO_HUMAN  (P46939), Y3893_DICDI (Q54QG5), 
YN8B_SCHPO  (Q9P792), YOY6_CAEEL  (P34664), ZSWM2_HUMAN (Q8NEG5), 
ZSWM2_MOUSE (Q9D9X6), ZZEF1_HUMAN (O43149), ZZEF1_MOUSE (Q5SSH7), 
ZZZ3_HUMAN  (Q8IYH5), ZZZ3_MOUSE  (Q6KAQ7)
False negative hits (sequences which belong to the set under consideration, but which have not been picked up by the pattern or profile):
RSC8_YEAST  (P43609), SSR2_SCHPO  (O14470), TAD2A_DROME (Q7KSD8)
Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:

[Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format]

Retrieve the sequence logo from the alignment

PDB
[Detailed view]		 1TOT; 2DIP; 2E5R; 2FC7;

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