Entry: PS50171

Forthcoming changes to the profile format
General information about the entry

Entry name [info] ZF_MATRIN
Accession [info] PS50171
Entry type [info] MATRIX
Date [info] DEC-2001 (CREATED); OCT-2013 (DATA UPDATE); JUN-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC50171
Associated ProRule [info] PRU00130

Name and characterization of the entry

Description [info] Zinc finger matrin-type profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=33;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=30;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.5940; R2=0.01236233; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=778.07273; R2=13.83182; TEXT='HScore';
/CUT_OFF: LEVEL=0; SCORE=558; N_SCORE=8.5; H_SCORE=7390; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=396; N_SCORE=6.5; H_SCORE=6269; MODE=1; TEXT='?';
/DEFAULT: M0=-8; D=-20; I=-20; B1=-60; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='Y'; M=-18,-22,-27,-26,-21, 37,-30, -1,  2,-12,  2,  1,-18,-27,-18,-11,-19,-10, -4, 13, 46,-21;
/M: SY='Y'; M=-18,-12,-27,-15,-10, 25,-25,  5, -8, -8, -5, -5, -7,-25,-11, -2,-14, -9,-13,  7, 38,-12;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='E'; M=-13, 11,-32, 22, 25,-33,-17, -7,-30, 12,-27,-20,  1, 15,  6,  0, -4,-10,-28,-30,-20, 15;
/M: SY='Y'; M=-14,-27,-27,-31,-24, 20,-33,-10, 21,-23, 19, 11,-22,-27,-18,-20,-22,-10,  9,  0, 30,-24;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='S'; M= -2,  3,-20,  6,  0,-22, -1, -1,-23, -5,-21,-15,  5,-14, -2, -7, 13,  1,-16,-33,-15, -2;
/M: SY='T'; M= -7, -2, -2,-10,-11,-10,-18,-12,-10,-11, -3, -7,  4,-21,-10, -5,  1, 10, -8,-32,-13,-11;
/M: SY='W'; M=-18,-26,-30,-30,-22, 34,-27,-10, -5,-14,  1, -3,-23,-28,-21,-12,-24,-14,-10, 38, 37,-20;
/M: SY='Y'; M=-12,-21,-22,-24,-20, 14,-29,  0,  9,-20, 13,  7,-18,-26,-16,-16,-16, -3,  5, -8, 23,-20;
/M: SY='T'; M=  0, -1,-17, -8, -8, -7,-15, -6,-12, -3,-14,-10,  2,-15, -6, -6,  9, 17, -8,-17,  6, -8;
/M: SY='N'; M=-12, 16,-25, 11, -1,-22, -1, 22,-27, -3,-25,-14, 24,-18,  0,  3,  2, -5,-26,-32,-10, -2;
/M: SY='D'; M= -8, 17,-27, 23, 21,-30,  6, -4,-32, -2,-27,-22, 12,-10,  3, -8,  5, -8,-28,-32,-22, 12;
/M: SY='R'; M= -5, -4,-24, -3,  6,-24, -6,-10,-26,  7,-25,-16,  0, -1,  2, 11,  7,  2,-19,-28,-18,  2;
/I:         I=-6; MD=-32;
/M: SY='P'; M=  1,-10,-21, -9, -2,-17,-12,-12,-13,  1,-13, -9, -8, 15, -3,  0, -2, -4,-12,-20,-14, -4; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='S'; M=  6,-12,-13,-16,-13, -7,-14,-12,  0,-12, -8,  1, -9,-18,-10,-13, 10, 10,  8,-25, -4,-12;
/M: SY='F'; M=  2,-24,-14,-30,-24, 21,-24,-23, 10,-22,  9,  3,-21,-25,-27,-19, -9, -1, 18,-15,  2,-24;
/I:         I=-5; MD=-27;
/M: SY='E'; M=-10,  1,-23,  4, 22,-22,-15,  0,-22, 17,-17,-10,  0, -7, 16, 21, -4, -8,-20,-19,-11, 18; D=-5;
/I:         I=-5; MD=-27;
/M: SY='R'; M= -8,  3,-16,  0,  2,-14, -9, -1,-16, 18,-15, -7,  7, -9,  4, 22, -3, -4,-13,-14, -7,  2; D=-5;
/I:         I=-5; MI=-27; MD=-27; IM=-27; DM=-27;
/M: SY='T'; M=  3,  1,-10, -6, -7, -2, -9,-10,-10, -9,-12,-10,  6,-11, -8, -9, 13, 16, -6,-21, -8, -7; D=-5;
/I:         I=-5; DM=-27;
/M: SY='H'; M=-20,  0,-30,  0,  0,-20,-20,100,-30,-10,-20,  0, 10,-20, 10,  0,-10,-20,-30,-30, 20,  0;
/M: SY='C'; M=-11,-14, 25,-21,-14,  7,-26,-19,-12,-21,  0, -7,-12,-27,-21,-19,-10, -3, -7,-27, -8,-16;
/M: SY='S'; M=  2, -4,-19, -8, -5,-20, -7,-10,-13,  2,-18, -9,  1,-17,  0,  3,  6, -1, -6,-28,-16, -3;
/M: SY='G'; M=  0, -3,-25, -1,  2,-28, 34,-13,-33,-11,-28,-20,  2,-13, -7,-13, 10, -8,-25,-27,-25, -2;
/M: SY='K'; M=-11, -9,-28, -9,  3,-17,-21,-12,-20, 18,-14, -8, -8,-15,  2, 16,-11, -5,-16, -3, -5,  2;
/M: SY='R'; M=-13, -1,-29, -5,  0,-22,-18, -6,-19, 18,-22,-10,  7, -4,  3, 26, -7, -8,-18,-25,-13, -2;
/M: SY='H'; M=-20,  0,-30,  0,  0,-20,-20,100,-30,-10,-20,  0, 10,-20, 10,  0,-10,-20,-30,-30, 20,  0;
/M: SY='K'; M= -5, -9,-27,-11, -2,-16,-22, -8,-11, 17,-11, -2, -8,-15,  5,  7,-11, -9,-10,-14,  2,  0;
/M: SY='Q'; M=-13,  3,-28,  5, 15,-23,-20, 13,-23,  9,-19, -9,  1,-12, 19,  9, -3, -5,-23,-20,  0, 16;
/M: SY='N'; M=-10, 19,-24,  7, -4,-21,  0, 10,-18,  0,-25,-13, 34,-19, -2, -1,  2, -6,-24,-33,-14, -4;
/M: SY='L'; M= -5,-19,-16,-21,-13, -2,-26,-18, 11,-17, 17, 12,-20,-22,-14,-15,-10,  5, 14,-26, -7,-13;
/M: SY='R'; M=  7, -5,-22, -6,  7,-23,-12, -9,-23, 16,-20,-12, -2,-12,  4, 19,  2, -4,-14,-23,-15,  4;
/M: SY='K'; M=-14,  0,  3,  1, -1,-25,-21,-10,-28, 16,-22,-10, -2,-19, -1, 16, -9,-10,-17,-30,-15, -2;
/I:         E1=0; IE=-105; DE=-105;
» More

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_07 which contains 546'000 sequence entries.


Total number of hits 80 in 79 different sequences
Number of true positive hits 80 in 79 different sequences
Number of 'unknown' hits
Number of false positive hits
Number of false negative sequences 42
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 65.57 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] K_Hofmann, N_Hulo
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 2
Feature key [info] ZN_FING
Feature description [info] Matrin-type
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
79 sequences

CIZ1_HUMAN  (Q9ULV3), MATR3_HUMAN (P43243), MATR3_MOUSE (Q8K310), 
MATR3_RAT   (P43244), NOI_DROME   (O46106), PRP9_YEAST  (P19736), 
RBM20_HUMAN (Q5T481), RBM20_RAT   (E9PT37), RU1C1_PUCGT (E3LAN7), 
RU1C1_SORBI (C5XZK6), RU1C2_PUCGT (E3KIY6), RU1C2_SORBI (C5XYW4), 
RU1C_AEDAE  (Q16IW3), RU1C_AJECG  (C0NN85), RU1C_ANODA  (E3X5D6), 
RU1C_ANOGA  (Q7PXU6), RU1C_ARATH  (Q56XE4), RU1C_ASPFU  (Q4WQM6), 
RU1C_BATDJ  (F4NYQ2), RU1C_BOVIN  (Q32PA0), RU1C_BRAFL  (C3Z1P5), 
RU1C_CAEBR  (A8XW44), RU1C_CAEEL  (P90815), RU1C_CANAL  (Q59P44), 
RU1C_CANAW  (C4YIU5), RU1C_CANFA  (E2RGI3), RU1C_CHICK  (E1C6F0), 
RU1C_CIOIN  (Q1RLC9), RU1C_COPC7  (A8NYM5), RU1C_CRYNJ  (Q5KC16), 
RU1C_DANRE  (Q8JGS0), RU1C_DICDI  (Q54YA5), RU1C_DROME  (Q9VE17), 
RU1C_DROPS  (Q298E0), RU1C_EMENI  (Q5BBX9), RU1C_HUMAN  (P09234), 
RU1C_IXOSC  (B7Q2M2), RU1C_MACMU  (F6TFD9), RU1C_MONDO  (F7ARS3), 
RU1C_MOUSE  (Q62241), RU1C_NECH7  (C7YRT4), RU1C_NEMVE  (A7SEP9), 
RU1C_NEUCR  (Q1K7T5), RU1C_PEDHC  (E0VI98), RU1C_PHYIT  (D0NHA2), 
RU1C_PLABA  (Q4YBG7), RU1C_PLACH  (Q4XRM7), RU1C_PLAF7  (Q8IAW3), 
RU1C_PLAKH  (B3LC82), RU1C_PLAVS  (A5JZQ2), RU1C_PLAYO  (Q7RNM5), 
RU1C_POLPA  (D3B3B7), RU1C_RAT    (D3ZCL3), RU1C_SCHPO  (Q9P794), 
RU1C_SCLS1  (A7EYK3), RU1C_THEAN  (Q4UJ14), RU1C_THEPA  (Q4N6K2), 
RU1C_TUBMM  (D5GDH4), RU1C_USTMA  (Q4P2Q5), RU1C_VITVI  (F6HQ26), 
RU1C_XENLA  (Q03369), RU1C_XENTR  (B0JYS7), RU1C_YEAST  (Q05900), 
SAP61_SCHPO (O59706), SAP62_SCHPO (Q9P7L8), SF3A2_BOVIN (A5PJN8), 
SF3A2_HUMAN (Q15428), SF3A2_MOUSE (Q62203), SF3A2_RAT   (Q6AXT8), 
SF3A3_HUMAN (Q12874), SF3A3_MOUSE (Q9D554), WBP4_CHICK  (Q5F457), 
WBP4_HUMAN  (O75554), WBP4_MOUSE  (Q61048), WBP4_RAT    (Q5HZF2), 
YNS7_SCHPO  (O60138), ZMAT4_MOUSE (Q8BZ94), ZN638_HUMAN (Q14966), 
ZN638_MOUSE (Q61464)
» More

UniProtKB/Swiss-Prot
False negative sequences
42 sequences

MOD5_HUMAN  (Q9H3H1), MOD5_MOUSE  (Q80UN9), MOD5_SCHPO  (Q9UT75), 
MOD5_YEAST  (P07884), PRP11_YEAST (Q07350), SCNM1_BOVIN (Q3ZBR0), 
SCNM1_DANRE (Q2YDS5), SCNM1_HUMAN (Q9BWG6), SCNM1_MOUSE (Q8K136), 
SCNM1_XENLA (Q3KQ71), SF3A2_DICDI (Q54B65), SNU23_SCHPO (Q09776), 
UBA1C_ARATH (O64571), Y9776_DROME (Q9V468), Z385A_HUMAN (Q96PM9), 
Z385A_MOUSE (Q8VD12), Z385B_DANRE (Q6PBT9), Z385B_HUMAN (Q569K4), 
Z385B_MOUSE (Q8BXJ8), Z385C_HUMAN (Q66K41), Z385C_MOUSE (A2A5E6), 
Z385D_HUMAN (Q9H6B1), Z385D_RAT   (Q6AXX3), ZMAT1_HUMAN (Q5H9K5), 
ZMAT1_MOUSE (Q3V0C1), ZMAT1_XENTR (Q28EG9), ZMAT2_HUMAN (Q96NC0), 
ZMAT2_MOUSE (Q9CPW7), ZMAT3_BOVIN (Q0IIC4), ZMAT3_HUMAN (Q9HA38), 
ZMAT3_MOUSE (O54836), ZMAT3_RAT   (O08781), ZMAT4_BOVIN (Q0VD35), 
ZMAT4_HUMAN (Q9H898), ZN318_HUMAN (Q5VUA4), ZN318_MOUSE (Q99PP2), 
ZN346_DANRE (A2RV29), ZN346_HUMAN (Q9UL40), ZN346_MOUSE (Q9R0B7), 
ZN346_PONAB (Q5R4W8), ZN346_XENLA (Q8AVN9), ZN346_XENTR (B0JZ85)
» More

PDB
[Detailed view]
4 PDB

2VRD; 3CW1; 3CW10; 4DGW

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