To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
Entry: PS50171

General information about the entry

Entry name [info] ZF_MATRIN
Accession [info] PS50171
Entry type [info] MATRIX
Date [info] 01-DEC-2001 CREATED; 10-MAY-2017 DATA UPDATE; 27-SEP-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC50171
Associated ProRule [info] PRU00130

Name and characterization of the entry

Description [info] Zinc finger matrin-type profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=33;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=30;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.5940000; R2=0.0123623; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1566.0997314; R2=1.6650832; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=559; H_SCORE=2497; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=397; H_SCORE=2227; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-8; D=-20; I=-20; B1=-60; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='Y'; M=-18,-22,-27,-26,-21, 37,-30, -1,  2,-12,  2,  1,-18,-27,-18,-11,-19,-10, -4, 13, 46,-21;
/M: SY='Y'; M=-18,-12,-27,-15,-10, 25,-25,  5, -8, -8, -5, -5, -7,-25,-11, -2,-14, -9,-13,  7, 38,-12;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='E'; M=-13, 11,-32, 22, 25,-33,-17, -7,-30, 12,-27,-20,  1, 15,  6,  0, -4,-10,-28,-30,-20, 15;
/M: SY='Y'; M=-14,-27,-27,-31,-24, 20,-33,-10, 21,-23, 19, 11,-22,-27,-18,-20,-22,-10,  9,  0, 30,-24;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='S'; M= -2,  3,-20,  6,  0,-22, -1, -1,-23, -5,-21,-15,  5,-14, -2, -7, 13,  1,-16,-33,-15, -2;
/M: SY='T'; M= -7, -2, -2,-10,-11,-10,-18,-12,-10,-11, -3, -7,  4,-21,-10, -5,  1, 10, -8,-32,-13,-11;
/M: SY='W'; M=-18,-26,-30,-30,-22, 34,-27,-10, -5,-14,  1, -3,-23,-28,-21,-12,-24,-14,-10, 38, 37,-20;
/M: SY='Y'; M=-12,-21,-22,-24,-20, 14,-29,  0,  9,-20, 13,  7,-18,-26,-16,-16,-16, -3,  5, -8, 23,-20;
/M: SY='T'; M=  0, -1,-17, -8, -8, -7,-15, -6,-12, -3,-14,-10,  2,-15, -6, -6,  9, 17, -8,-17,  6, -8;
/M: SY='N'; M=-12, 16,-25, 11, -1,-22, -1, 22,-27, -3,-25,-14, 24,-18,  0,  3,  2, -5,-26,-32,-10, -2;
/M: SY='D'; M= -8, 17,-27, 23, 21,-30,  6, -4,-32, -2,-27,-22, 12,-10,  3, -8,  5, -8,-28,-32,-22, 12;
/M: SY='R'; M= -5, -4,-24, -3,  6,-24, -6,-10,-26,  7,-25,-16,  0, -1,  2, 11,  7,  2,-19,-28,-18,  2;
/I:         I=-6; MD=-32;
/M: SY='P'; M=  1,-10,-21, -9, -2,-17,-12,-12,-13,  1,-13, -9, -8, 15, -3,  0, -2, -4,-12,-20,-14, -4; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='S'; M=  6,-12,-13,-16,-13, -7,-14,-12,  0,-12, -8,  1, -9,-18,-10,-13, 10, 10,  8,-25, -4,-12;
/M: SY='F'; M=  2,-24,-14,-30,-24, 21,-24,-23, 10,-22,  9,  3,-21,-25,-27,-19, -9, -1, 18,-15,  2,-24;
/I:         I=-5; MD=-27;
/M: SY='E'; M=-10,  1,-23,  4, 22,-22,-15,  0,-22, 17,-17,-10,  0, -7, 16, 21, -4, -8,-20,-19,-11, 18; D=-5;
/I:         I=-5; MD=-27;
/M: SY='R'; M= -8,  3,-16,  0,  2,-14, -9, -1,-16, 18,-15, -7,  7, -9,  4, 22, -3, -4,-13,-14, -7,  2; D=-5;
/I:         I=-5; MI=-27; MD=-27; IM=-27; DM=-27;
/M: SY='T'; M=  3,  1,-10, -6, -7, -2, -9,-10,-10, -9,-12,-10,  6,-11, -8, -9, 13, 16, -6,-21, -8, -7; D=-5;
/I:         I=-5; DM=-27;
/M: SY='H'; M=-20,  0,-30,  0,  0,-20,-20,100,-30,-10,-20,  0, 10,-20, 10,  0,-10,-20,-30,-30, 20,  0;
/M: SY='C'; M=-11,-14, 25,-21,-14,  7,-26,-19,-12,-21,  0, -7,-12,-27,-21,-19,-10, -3, -7,-27, -8,-16;
/M: SY='S'; M=  2, -4,-19, -8, -5,-20, -7,-10,-13,  2,-18, -9,  1,-17,  0,  3,  6, -1, -6,-28,-16, -3;
/M: SY='G'; M=  0, -3,-25, -1,  2,-28, 34,-13,-33,-11,-28,-20,  2,-13, -7,-13, 10, -8,-25,-27,-25, -2;
/M: SY='K'; M=-11, -9,-28, -9,  3,-17,-21,-12,-20, 18,-14, -8, -8,-15,  2, 16,-11, -5,-16, -3, -5,  2;
/M: SY='R'; M=-13, -1,-29, -5,  0,-22,-18, -6,-19, 18,-22,-10,  7, -4,  3, 26, -7, -8,-18,-25,-13, -2;
/M: SY='H'; M=-20,  0,-30,  0,  0,-20,-20,100,-30,-10,-20,  0, 10,-20, 10,  0,-10,-20,-30,-30, 20,  0;
/M: SY='K'; M= -5, -9,-27,-11, -2,-16,-22, -8,-11, 17,-11, -2, -8,-15,  5,  7,-11, -9,-10,-14,  2,  0;
/M: SY='Q'; M=-13,  3,-28,  5, 15,-23,-20, 13,-23,  9,-19, -9,  1,-12, 19,  9, -3, -5,-23,-20,  0, 16;
/M: SY='N'; M=-10, 19,-24,  7, -4,-21,  0, 10,-18,  0,-25,-13, 34,-19, -2, -1,  2, -6,-24,-33,-14, -4;
/M: SY='L'; M= -5,-19,-16,-21,-13, -2,-26,-18, 11,-17, 17, 12,-20,-22,-14,-15,-10,  5, 14,-26, -7,-13;
/M: SY='R'; M=  7, -5,-22, -6,  7,-23,-12, -9,-23, 16,-20,-12, -2,-12,  4, 19,  2, -4,-14,-23,-15,  4;
/M: SY='K'; M=-14,  0,  3,  1, -1,-25,-21,-10,-28, 16,-22,-10, -2,-19, -1, 16, -9,-10,-17,-30,-15, -2;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_09 which contains 555'594 sequence entries.


Total number of hits 82 in 81 different sequences
Number of true positive hits 82 in 81 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 43
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 65.60 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] K_Hofmann, N_Hulo
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 2
Feature key [info] ZN_FING
Feature description [info] Matrin-type
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
81 sequences

ATO_ARATH   (Q9FG01    ), CIZ1_HUMAN  (Q9ULV3    ), MATR3_HUMAN (P43243    ), 
MATR3_MOUSE (Q8K310    ), MATR3_RAT   (P43244    ), NOI_DROME   (O46106    ), 
PRP9_YEAST  (P19736    ), RBM20_HUMAN (Q5T481    ), RBM20_RAT   (E9PT37    ), 
RU1C1_PUCGT (E3LAN7    ), RU1C1_SORBI (C5XZK6    ), RU1C2_PUCGT (E3KIY6    ), 
RU1C2_SORBI (C5XYW4    ), RU1C_AEDAE  (Q16IW3    ), RU1C_AJECG  (C0NN85    ), 
RU1C_ANODA  (E3X5D6    ), RU1C_ANOGA  (Q7PXU6    ), RU1C_ARATH  (Q56XE4    ), 
RU1C_ASPFU  (Q4WQM6    ), RU1C_BATDJ  (F4NYQ2    ), RU1C_BOVIN  (Q32PA0    ), 
RU1C_BRAFL  (C3Z1P5    ), RU1C_CAEBR  (A8XW44    ), RU1C_CAEEL  (P90815    ), 
RU1C_CANAL  (Q59P44    ), RU1C_CANAW  (C4YIU5    ), RU1C_CANLF  (E2RGI3    ), 
RU1C_CHICK  (E1C6F0    ), RU1C_CIOIN  (Q1RLC9    ), RU1C_COPC7  (A8NYM5    ), 
RU1C_CRYNJ  (Q5KC16    ), RU1C_DANRE  (Q8JGS0    ), RU1C_DICDI  (Q54YA5    ), 
RU1C_DROME  (Q9VE17    ), RU1C_DROPS  (Q298E0    ), RU1C_EMENI  (Q5BBX9    ), 
RU1C_HUMAN  (P09234    ), RU1C_IXOSC  (B7Q2M2    ), RU1C_MACMU  (F6TFD9    ), 
RU1C_MONDO  (F7ARS3    ), RU1C_MOUSE  (Q62241    ), RU1C_NECH7  (C7YRT4    ), 
RU1C_NEMVE  (A7SEP9    ), RU1C_NEUCR  (Q1K7T5    ), RU1C_PEDHC  (E0VI98    ), 
RU1C_PHYIT  (D0NHA2    ), RU1C_PLABA  (Q4YBG7    ), RU1C_PLACH  (Q4XRM7    ), 
RU1C_PLAF7  (Q8IAW3    ), RU1C_PLAKH  (B3LC82    ), RU1C_PLAVS  (A5JZQ2    ), 
RU1C_PLAYO  (Q7RNM5    ), RU1C_POLPP  (D3B3B7    ), RU1C_RAT    (D3ZCL3    ), 
RU1C_SCHPO  (Q9P794    ), RU1C_SCLS1  (A7EYK3    ), RU1C_THEAN  (Q4UJ14    ), 
RU1C_THEPA  (Q4N6K2    ), RU1C_TUBMM  (D5GDH4    ), RU1C_USTMA  (Q4P2Q5    ), 
RU1C_VITVI  (F6HQ26    ), RU1C_XENLA  (Q03369    ), RU1C_XENTR  (B0JYS7    ), 
RU1C_YEAST  (Q05900    ), SAP61_SCHPO (O59706    ), SAP62_SCHPO (Q9P7L8    ), 
SF3A2_BOVIN (A5PJN8    ), SF3A2_HUMAN (Q15428    ), SF3A2_MOUSE (Q62203    ), 
SF3A2_RAT   (Q6AXT8    ), SF3A3_HUMAN (Q12874    ), SF3A3_MOUSE (Q9D554    ), 
WBP4_CHICK  (Q5F457    ), WBP4_HUMAN  (O75554    ), WBP4_MOUSE  (Q61048    ), 
WBP4_RAT    (Q5HZF2    ), YNS7_SCHPO  (O60138    ), ZMAT4_MOUSE (Q8BZ94    ), 
ZN638_HUMAN (Q14966    ), ZN638_MOUSE (Q61464    ), ZOP1_ARATH  (Q7XA66    )
» more

UniProtKB/Swiss-Prot
False negative sequences
43 sequences

MOD5_HUMAN  (Q9H3H1    ), MOD5_MOUSE  (Q80UN9    ), MOD5_SCHPO  (Q9UT75    ), 
MOD5_YEAST  (P07884    ), PRP11_YEAST (Q07350    ), SCNM1_BOVIN (Q3ZBR0    ), 
SCNM1_DANRE (Q2YDS5    ), SCNM1_HUMAN (Q9BWG6    ), SCNM1_MOUSE (Q8K136    ), 
SCNM1_XENLA (Q3KQ71    ), SF3A2_DICDI (Q54B65    ), SNU23_CAEEL (P34670    ), 
SNU23_SCHPO (Q09776    ), UBA1C_ARATH (O64571    ), Y9776_DROME (Q9V468    ), 
Z385A_HUMAN (Q96PM9    ), Z385A_MOUSE (Q8VD12    ), Z385B_DANRE (Q6PBT9    ), 
Z385B_HUMAN (Q569K4    ), Z385B_MOUSE (Q8BXJ8    ), Z385C_HUMAN (Q66K41    ), 
Z385C_MOUSE (A2A5E6    ), Z385D_HUMAN (Q9H6B1    ), Z385D_RAT   (Q6AXX3    ), 
ZMAT1_HUMAN (Q5H9K5    ), ZMAT1_MOUSE (Q3V0C1    ), ZMAT1_XENTR (Q28EG9    ), 
ZMAT2_HUMAN (Q96NC0    ), ZMAT2_MOUSE (Q9CPW7    ), ZMAT3_BOVIN (Q0IIC4    ), 
ZMAT3_HUMAN (Q9HA38    ), ZMAT3_MOUSE (O54836    ), ZMAT3_RAT   (O08781    ), 
ZMAT4_BOVIN (Q0VD35    ), ZMAT4_HUMAN (Q9H898    ), ZN318_HUMAN (Q5VUA4    ), 
ZN318_MOUSE (Q99PP2    ), ZN346_DANRE (A2RV29    ), ZN346_HUMAN (Q9UL40    ), 
ZN346_MOUSE (Q9R0B7    ), ZN346_PONAB (Q5R4W8    ), ZN346_XENLA (Q8AVN9    ), 
ZN346_XENTR (B0JZ85    )
» more

PDB
[Detailed view]
4 PDB

2VRD; 3CW1; 4DGW; 4PJO

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission