Entry: PS50171

General information about the entry

Entry name [info] ZF_MATRIN
Accession [info] PS50171
Entry type [info] MATRIX
Date [info] DEC-2001 (CREATED); OCT-2013 (DATA UPDATE); MAY-2015 (INFO UPDATE).
PROSITE Doc. [info] PDOC50171
Associated ProRule [info] PRU00130

Name and characterization of the entry

Description [info] Zinc finger matrin-type profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=33;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=30;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.5940; R2=0.01236233; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=778.07273; R2=13.83182; TEXT='HScore';
/CUT_OFF: LEVEL=0; SCORE=558; N_SCORE=8.5; H_SCORE=7390; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=396; N_SCORE=6.5; H_SCORE=6269; MODE=1; TEXT='?';
/DEFAULT: M0=-8; D=-20; I=-20; B1=-60; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='Y'; M=-18,-22,-27,-26,-21, 37,-30, -1,  2,-12,  2,  1,-18,-27,-18,-11,-19,-10, -4, 13, 46,-21;
/M: SY='Y'; M=-18,-12,-27,-15,-10, 25,-25,  5, -8, -8, -5, -5, -7,-25,-11, -2,-14, -9,-13,  7, 38,-12;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='E'; M=-13, 11,-32, 22, 25,-33,-17, -7,-30, 12,-27,-20,  1, 15,  6,  0, -4,-10,-28,-30,-20, 15;
/M: SY='Y'; M=-14,-27,-27,-31,-24, 20,-33,-10, 21,-23, 19, 11,-22,-27,-18,-20,-22,-10,  9,  0, 30,-24;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='S'; M= -2,  3,-20,  6,  0,-22, -1, -1,-23, -5,-21,-15,  5,-14, -2, -7, 13,  1,-16,-33,-15, -2;
/M: SY='T'; M= -7, -2, -2,-10,-11,-10,-18,-12,-10,-11, -3, -7,  4,-21,-10, -5,  1, 10, -8,-32,-13,-11;
/M: SY='W'; M=-18,-26,-30,-30,-22, 34,-27,-10, -5,-14,  1, -3,-23,-28,-21,-12,-24,-14,-10, 38, 37,-20;
/M: SY='Y'; M=-12,-21,-22,-24,-20, 14,-29,  0,  9,-20, 13,  7,-18,-26,-16,-16,-16, -3,  5, -8, 23,-20;
/M: SY='T'; M=  0, -1,-17, -8, -8, -7,-15, -6,-12, -3,-14,-10,  2,-15, -6, -6,  9, 17, -8,-17,  6, -8;
/M: SY='N'; M=-12, 16,-25, 11, -1,-22, -1, 22,-27, -3,-25,-14, 24,-18,  0,  3,  2, -5,-26,-32,-10, -2;
/M: SY='D'; M= -8, 17,-27, 23, 21,-30,  6, -4,-32, -2,-27,-22, 12,-10,  3, -8,  5, -8,-28,-32,-22, 12;
/M: SY='R'; M= -5, -4,-24, -3,  6,-24, -6,-10,-26,  7,-25,-16,  0, -1,  2, 11,  7,  2,-19,-28,-18,  2;
/I:         I=-6; MD=-32;
/M: SY='P'; M=  1,-10,-21, -9, -2,-17,-12,-12,-13,  1,-13, -9, -8, 15, -3,  0, -2, -4,-12,-20,-14, -4; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='S'; M=  6,-12,-13,-16,-13, -7,-14,-12,  0,-12, -8,  1, -9,-18,-10,-13, 10, 10,  8,-25, -4,-12;
/M: SY='F'; M=  2,-24,-14,-30,-24, 21,-24,-23, 10,-22,  9,  3,-21,-25,-27,-19, -9, -1, 18,-15,  2,-24;
/I:         I=-5; MD=-27;
/M: SY='E'; M=-10,  1,-23,  4, 22,-22,-15,  0,-22, 17,-17,-10,  0, -7, 16, 21, -4, -8,-20,-19,-11, 18; D=-5;
/I:         I=-5; MD=-27;
/M: SY='R'; M= -8,  3,-16,  0,  2,-14, -9, -1,-16, 18,-15, -7,  7, -9,  4, 22, -3, -4,-13,-14, -7,  2; D=-5;
/I:         I=-5; MI=-27; MD=-27; IM=-27; DM=-27;
/M: SY='T'; M=  3,  1,-10, -6, -7, -2, -9,-10,-10, -9,-12,-10,  6,-11, -8, -9, 13, 16, -6,-21, -8, -7; D=-5;
/I:         I=-5; DM=-27;
/M: SY='H'; M=-20,  0,-30,  0,  0,-20,-20,100,-30,-10,-20,  0, 10,-20, 10,  0,-10,-20,-30,-30, 20,  0;
/M: SY='C'; M=-11,-14, 25,-21,-14,  7,-26,-19,-12,-21,  0, -7,-12,-27,-21,-19,-10, -3, -7,-27, -8,-16;
/M: SY='S'; M=  2, -4,-19, -8, -5,-20, -7,-10,-13,  2,-18, -9,  1,-17,  0,  3,  6, -1, -6,-28,-16, -3;
/M: SY='G'; M=  0, -3,-25, -1,  2,-28, 34,-13,-33,-11,-28,-20,  2,-13, -7,-13, 10, -8,-25,-27,-25, -2;
/M: SY='K'; M=-11, -9,-28, -9,  3,-17,-21,-12,-20, 18,-14, -8, -8,-15,  2, 16,-11, -5,-16, -3, -5,  2;
/M: SY='R'; M=-13, -1,-29, -5,  0,-22,-18, -6,-19, 18,-22,-10,  7, -4,  3, 26, -7, -8,-18,-25,-13, -2;
/M: SY='H'; M=-20,  0,-30,  0,  0,-20,-20,100,-30,-10,-20,  0, 10,-20, 10,  0,-10,-20,-30,-30, 20,  0;
/M: SY='K'; M= -5, -9,-27,-11, -2,-16,-22, -8,-11, 17,-11, -2, -8,-15,  5,  7,-11, -9,-10,-14,  2,  0;
/M: SY='Q'; M=-13,  3,-28,  5, 15,-23,-20, 13,-23,  9,-19, -9,  1,-12, 19,  9, -3, -5,-23,-20,  0, 16;
/M: SY='N'; M=-10, 19,-24,  7, -4,-21,  0, 10,-18,  0,-25,-13, 34,-19, -2, -1,  2, -6,-24,-33,-14, -4;
/M: SY='L'; M= -5,-19,-16,-21,-13, -2,-26,-18, 11,-17, 17, 12,-20,-22,-14,-15,-10,  5, 14,-26, -7,-13;
/M: SY='R'; M=  7, -5,-22, -6,  7,-23,-12, -9,-23, 16,-20,-12, -2,-12,  4, 19,  2, -4,-14,-23,-15,  4;
/M: SY='K'; M=-14,  0,  3,  1, -1,-25,-21,-10,-28, 16,-22,-10, -2,-19, -1, 16, -9,-10,-17,-30,-15, -2;
/I:         E1=0; IE=-105; DE=-105;
» More

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2015_07 which contains 548'872 sequence entries.


Total number of hits 80 in 79 different sequences
Number of true positive hits 80 in 79 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 42
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 65.57 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] K_Hofmann, N_Hulo
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 2
Feature key [info] ZN_FING
Feature description [info] Matrin-type
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
79 sequences

CIZ1_HUMAN  (Q9ULV3), MATR3_HUMAN (P43243), MATR3_MOUSE (Q8K310), 
MATR3_RAT   (P43244), NOI_DROME   (O46106), PRP9_YEAST  (P19736), 
RBM20_HUMAN (Q5T481), RBM20_RAT   (E9PT37), RU1C1_PUCGT (E3LAN7), 
RU1C1_SORBI (C5XZK6), RU1C2_PUCGT (E3KIY6), RU1C2_SORBI (C5XYW4), 
RU1C_AEDAE  (Q16IW3), RU1C_AJECG  (C0NN85), RU1C_ANODA  (E3X5D6), 
RU1C_ANOGA  (Q7PXU6), RU1C_ARATH  (Q56XE4), RU1C_ASPFU  (Q4WQM6), 
RU1C_BATDJ  (F4NYQ2), RU1C_BOVIN  (Q32PA0), RU1C_BRAFL  (C3Z1P5), 
RU1C_CAEBR  (A8XW44), RU1C_CAEEL  (P90815), RU1C_CANAL  (Q59P44), 
RU1C_CANAW  (C4YIU5), RU1C_CANFA  (E2RGI3), RU1C_CHICK  (E1C6F0), 
RU1C_CIOIN  (Q1RLC9), RU1C_COPC7  (A8NYM5), RU1C_CRYNJ  (Q5KC16), 
RU1C_DANRE  (Q8JGS0), RU1C_DICDI  (Q54YA5), RU1C_DROME  (Q9VE17), 
RU1C_DROPS  (Q298E0), RU1C_EMENI  (Q5BBX9), RU1C_HUMAN  (P09234), 
RU1C_IXOSC  (B7Q2M2), RU1C_MACMU  (F6TFD9), RU1C_MONDO  (F7ARS3), 
RU1C_MOUSE  (Q62241), RU1C_NECH7  (C7YRT4), RU1C_NEMVE  (A7SEP9), 
RU1C_NEUCR  (Q1K7T5), RU1C_PEDHC  (E0VI98), RU1C_PHYIT  (D0NHA2), 
RU1C_PLABA  (Q4YBG7), RU1C_PLACH  (Q4XRM7), RU1C_PLAF7  (Q8IAW3), 
RU1C_PLAKH  (B3LC82), RU1C_PLAVS  (A5JZQ2), RU1C_PLAYO  (Q7RNM5), 
RU1C_POLPA  (D3B3B7), RU1C_RAT    (D3ZCL3), RU1C_SCHPO  (Q9P794), 
RU1C_SCLS1  (A7EYK3), RU1C_THEAN  (Q4UJ14), RU1C_THEPA  (Q4N6K2), 
RU1C_TUBMM  (D5GDH4), RU1C_USTMA  (Q4P2Q5), RU1C_VITVI  (F6HQ26), 
RU1C_XENLA  (Q03369), RU1C_XENTR  (B0JYS7), RU1C_YEAST  (Q05900), 
SAP61_SCHPO (O59706), SAP62_SCHPO (Q9P7L8), SF3A2_BOVIN (A5PJN8), 
SF3A2_HUMAN (Q15428), SF3A2_MOUSE (Q62203), SF3A2_RAT   (Q6AXT8), 
SF3A3_HUMAN (Q12874), SF3A3_MOUSE (Q9D554), WBP4_CHICK  (Q5F457), 
WBP4_HUMAN  (O75554), WBP4_MOUSE  (Q61048), WBP4_RAT    (Q5HZF2), 
YNS7_SCHPO  (O60138), ZMAT4_MOUSE (Q8BZ94), ZN638_HUMAN (Q14966), 
ZN638_MOUSE (Q61464)
» More

UniProtKB/Swiss-Prot
False negative sequences
42 sequences

MOD5_HUMAN  (Q9H3H1), MOD5_MOUSE  (Q80UN9), MOD5_SCHPO  (Q9UT75), 
MOD5_YEAST  (P07884), PRP11_YEAST (Q07350), SCNM1_BOVIN (Q3ZBR0), 
SCNM1_DANRE (Q2YDS5), SCNM1_HUMAN (Q9BWG6), SCNM1_MOUSE (Q8K136), 
SCNM1_XENLA (Q3KQ71), SF3A2_DICDI (Q54B65), SNU23_SCHPO (Q09776), 
UBA1C_ARATH (O64571), Y9776_DROME (Q9V468), Z385A_HUMAN (Q96PM9), 
Z385A_MOUSE (Q8VD12), Z385B_DANRE (Q6PBT9), Z385B_HUMAN (Q569K4), 
Z385B_MOUSE (Q8BXJ8), Z385C_HUMAN (Q66K41), Z385C_MOUSE (A2A5E6), 
Z385D_HUMAN (Q9H6B1), Z385D_RAT   (Q6AXX3), ZMAT1_HUMAN (Q5H9K5), 
ZMAT1_MOUSE (Q3V0C1), ZMAT1_XENTR (Q28EG9), ZMAT2_HUMAN (Q96NC0), 
ZMAT2_MOUSE (Q9CPW7), ZMAT3_BOVIN (Q0IIC4), ZMAT3_HUMAN (Q9HA38), 
ZMAT3_MOUSE (O54836), ZMAT3_RAT   (O08781), ZMAT4_BOVIN (Q0VD35), 
ZMAT4_HUMAN (Q9H898), ZN318_HUMAN (Q5VUA4), ZN318_MOUSE (Q99PP2), 
ZN346_DANRE (A2RV29), ZN346_HUMAN (Q9UL40), ZN346_MOUSE (Q9R0B7), 
ZN346_PONAB (Q5R4W8), ZN346_XENLA (Q8AVN9), ZN346_XENTR (B0JZ85)
» More

PDB
[Detailed view]
5 PDB

2VRD; 3CW1; 3CW10; 4DGW; 4PJO

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