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Entry: PS50184

General information about the entry

Entry name [info] VWFC_2
Accession [info] PS50184
Entry type [info] MATRIX
Date [info] 01-NOV-2002 CREATED; 10-MAY-2017 DATA UPDATE; 25-OCT-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC00928
Associated ProRule [info] PRU00220

Name and characterization of the entry

Description [info] VWFC domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=61;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=56;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=-1.8590000; R2=0.0091000; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=4813.4291992; R2=2.8005822; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1139; H_SCORE=8003; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=919; H_SCORE=7387; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-30; E1=-30; MM=1; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='P'; M=  1, -8,-26, -8, -4,-23,  3,-16,-19, -7,-20,-14, -5,  5, -8, -9,  1, -4,-16,-26,-20, -8;
/M: SY='A'; M=  7,-13,-18,-16,-12,-15,-12,-18, -4,-11, -8, -5,-11, -6,-10,-11,  1,  2,  3,-27,-16,-12;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='V'; M= -7,-23,-12,-25,-19,  1,-27,-16, 11,-19,  6,  6,-21,-25,-18,-17,-12, -4, 16,-13,  1,-19;
/M: SY='H'; M=-11, -9,-29, -9, -7,-15,  7, 21,-24,-12,-16, -5, -2,-20,  4, -8, -7,-16,-24,-17,  0, -3;
/M: SY='N'; M=-10, 12,-28, 12,  7,-25, -4, -5,-24, -3,-24,-18, 14,  7, -2, -6,  1, -6,-26,-33,-21,  1;
/I:         MI=-10; MD=-20; IM=-10; II=-8; DM=-20; I=0,0,-15,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0;
/M: SY='G'; M= -1,  0,-26, -4,-14,-27, 51,-14,-34,-16,-30,-20, 11,-19,-14,-16,  6,-12,-28,-26,-27,-14;
/M: SY='E'; M= -2,-10,-20,-10,  2,-16,-21,-12, -6, -1, -6, -2,-10,-16,  2,  1, -2,  2,  1,-26,-12,  2;
/M:         M= -7,-14,-25,-14, -1,-14,-23,-14,  0, -6, -7, -1,-12, -1, -1, -7, -5, -4, -2,-25,-12, -3;
/M: SY='Y'; M=-17,-18,-27,-20,-17, 16,-28, 12, -2, -6, -3,  0,-15,-26,-10, -2,-16,-10, -4,  6, 42,-17;
/M: SY='Q'; M= -2, -3,-26, -3, 10,-27,-11, -2,-22,  9,-20, -9, -1, -7, 16,  8,  0, -7,-21,-24,-14, 12;
/M: SY='N'; M= -7,  5,-24,  4, -1, -9,-14,-10,-15, -9,-19,-15,  6,  5,-10,-12, -1, -4,-15,-28,-14, -6;
/M: SY='G'; M= -5, -5,-28, -7,-12,-25, 35,-13,-32, -6,-24,-16,  5,-20,-11, -1, -2,-14,-25,-23,-23,-12;
/M: SY='E'; M=-12, 19,-28, 29, 33,-32,-16,  9,-32,  6,-24,-19,  8, -7, 13, -2,  2, -9,-28,-33,-15, 22;
/M: SY='T'; M= -1,-11,-18,-14, -8, -9,-20, -7, -2,-13, -8, -2, -9, -8,-10,-13,  3,  7,  3,-28, -8,-10;
/M: SY='W'; M=-16,-36,-36,-38,-30, 24,-24,-28, -6,-22, -8,-10,-34,-30,-26,-20,-30,-20, -9, 85, 23,-24;
/M: SY='Q'; M= -8, -6,-24, -7,  4,-18,-18, -7,-11,  5,-12, -2, -7,-14,  9,  0, -3,  0, -8,-20, -4,  6;
/M: SY='P'; M= -2,-17,-23,-17, -9, -9,-20,-19, -3,-14,-11, -6,-15, 17,-13,-17, -2,  0, -2,-26,-14,-13;
/M: SY='D'; M= -8, 28,-25, 34, 13,-31,  1, -3,-31, -3,-28,-24, 20,-12,  0, -9,  8, -4,-26,-36,-21,  6;
/I:         MI=-5; MD=-20; IM=-5; II=-7; DM=-20; I=0,0,-15,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0;
/M: SY='P'; M= -1, -6,-13, -4, -1,-13, -7, -9, -9, -1,-14, -8, -4, 14, -3, -5,  5,  1, -7,-18,-12, -3; D=-5;
/I:         DM=-20;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='Q'; M=-10,  5,-25,  4,  8,-28,-19,  4,-23, 13,-21, -8,  3,-11, 20, 11,  1,  3,-20,-25, -9, 13;
/M:         M=-11, -2,-25, -3, -2,-13,-24, -6, -1, -5, -7, -4, -4,-16, -6, -9, -6, -2, -1,-23, -1, -5;
/I:         MI=-10; MD=-20; IM=-10; II=-8; DM=-20; I=0,0,-15,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='T'; M= -2,-11,-12,-16,-16, -8,-23,-16,  2,-11, -4, -3,-10,-18,-15, -9,  6, 26, 15,-29, -9,-16;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='T'; M=-10,  2,-23,  2,  0,-17,-20, -9, -9, -5, -2, -2, -1,-16,  2, -5, -4,  3, -9,-27,-10,  1;
/M: SY='D'; M= -6, 22,-23, 26, 12,-28, -6, -5,-26,  0,-25,-20, 15,-12,  0, -7,  7, -2,-20,-35,-19,  6;
/I:         MI=-5; MD=-20; IM=-5; II=-5; DM=-20; I=0,0,-15,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0;
/M: SY='G'; M=  3, -8,-24,-11,-16,-19, 40,-18,-29,-18,-22,-16,  1,-19,-17,-18,  5, -9,-21,-22,-22,-16;
/M: SY='K'; M=  2, -3,-21, -8, -2,-14,-12,-10,-16,  5,-17,-10,  2,-16, -2,  2,  1, -3,-12,-17,-10, -2;
/M: SY='T'; M= -3,-13,-18,-18,-16,-11,-17,-22,  2, -7, -5, -2,-10,-18,-14, -8,  0, 13, 11,-26,-11,-16;
/M: SY='I'; M= -6,-26,-22,-28,-23, -3,-18,-23, 19,-24, 18, 11,-22,-25,-18,-21,-17, -9, 17,-22, -7,-22;
/I:         MI=-5; MD=-20; IM=-5; II=-5; DM=-20; I=0,0,-15,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='R'; M= -8,  3,-24,  4,  1,-22,-18,  1,-18,  4,-15, -7,  1,-14,  4,  6, -1,  0,-13,-27, -9,  1;
/M: SY='P'; M=-11, -2,-32,  3,  7,-29,-19, -2,-23,  4,-23,-13, -5, 26,  6, -3, -6, -7,-25,-28,-16,  5;
/M: SY='V'; M= -8,-17,-23,-20,-12,-11,-27,-18,  7,  2,  0,  5,-14,-20, -6,  1,-12, -5, 10,-23, -7,-11;
/I:         I=-8; MI=-25; MD=-20; IM=-25;
/M: SY='P'; M= -6, -9,-23, -9,  1,-16,-19,-13, -6, -5,-10, -6, -7,  8, -1, -6, -1,  3, -8,-23,-12, -2; D=-6;
/I:         DM=-20;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/I:         MD=-20;
/M: SY='P'; M= -5,  2,-28,  7, 12,-27,-12, -8,-22, -4,-26,-19,  2, 29,  1,-10,  3, -4,-25,-31,-22,  4; D=-4;
/I:         MD=-20;
/M: SY='E'; M= -8, -1,-21,  1,  3,-17,-16, -7,-10, -2, -7, -3, -4, -2,  3, -3, -3, -2,-11,-22,-10,  2; D=-4;
/I:         MD=-20;
/M: SY='E'; M= -1, -1,-17,  1,  6,-16, -4, -7,-14, -1,-13, -9, -3,  6,  0, -5,  0, -3,-12,-17,-13,  3; D=-4;
/I:         MI=-5; MD=-20; IM=-5; II=-5; DM=-20; I=0,0,-15,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0;
/M: SY='P'; M= -4,-11,-25,-13,-10,-14,-15,-16, -3,-13, -4, -1,-10,  7,-11,-15, -6,  0, -6,-27,-15,-12;
/M: SY='D'; M= -4,  6,-23,  8, -2,-22,-10, -8,-18,-10,-18,-15,  2,  1, -7,-13,  6,  5,-14,-32,-16, -5;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='P'; M=  0,-10,-27, -7,  4,-24,-16,-15,-18,  1,-21,-14, -9, 24, -3, -5,  0, -2,-16,-28,-20, -2;
/M: SY='N'; M= -6,  5,-21,  2,  0,-10,-10, -8,-14,-10,-15,-13, 11, -9, -7,-10,  5,  1,-14,-31,-14, -4;
/M: SY='P'; M=  3, -5,-30,  1, -1,-29,  5,-16,-26,-10,-26,-19, -7, 28,-10,-18, -2,-10,-24,-27,-26, -7;
/M: SY='E'; M= -9, -7,-25, -6,  7, -7, -8, -8,-21, -1,-15,-12, -4,-15, -3,  6, -1, -3,-16,-19, -6,  1;
/M: SY='F'; M=-11,-15,-22,-19, -9,  2,-26,-16,  0, -5,  1,  0,-12,-19,-11,  2, -9,  1,  2,-19, -3,-11;
/M: SY='P'; M=-10,-22,-27,-19,-11, -6,-26,-14,  2,-11,  0, -1,-20,  5,-13, -8,-15, -8,  1,-18, -1,-15;
/M: SY='E'; M=-10, -9,-25, -6,  4, -9,-24,-13, -5, -4, -4, -2,-12, -8, -4, -8,-10, -8, -3,-23, -9,  0;
/I:         MI=0; MD=-20; IM=0; II=-5; DM=-20; I=0,0,-50,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0;
/M: SY='P'; M= -1, -3,-15, -4, -4,-12,-11, -3, -5, -6, -8, -5, -1,  3, -4, -8, -3, -4, -5,-19,-10, -5; D=-4;
/I:         DM=-21;
/M: SY='P'; M=  4,  0,-16,  0,  1,-16, -3, -9,-13, -5,-15,-11,  0, 12, -4, -9,  3, -1,-13,-19,-15, -3; D=-4;
/I:         DM=-21;
/M: SY='G'; M= -5,  4,-30,  9, -9,-32, 77,-15,-39,-12,-30,-22,  4,-17,-14,-15, -1,-17,-29,-24,-27,-12;
/M: SY='E'; M= -8,  6,-26, 10, 57,-29,-19, -2,-25, 10,-20,-15,  1, -4, 21,  3,  4, -1,-24,-28,-16, 29;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='P'; M= -6, -5,-32, -1,  9,-29, -3,-12,-26, -1,-27,-19, -3, 31, -3, -9, -4,-10,-28,-28,-25,  1;
/I:         MI=-8; MD=-20; IM=-8; II=-5; DM=-20; I=0,0,-15,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0;
/M: SY='V'; M= -7,-15,-21,-15, -9, -9,-23, -8,  0, -1, -8, -2,-11,-21, -8,  4, -4, -3,  8,-23, -2,-11;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='E'; M= -7, -4,-28,  2,  7,-20,-18,-12,-17, -3,-13,-12, -9,  1, -1, -9, -6, -8,-16,-14,-13,  3;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_10 which contains 556'006 sequence entries.


Total number of hits 268 in 120 different sequences
Number of true positive hits 268 in 120 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 22
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 92.41 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann, N_Hulo
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 23
Feature key [info] DOMAIN
Feature description [info] VWFC
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
120 sequences

BMPER_HUMAN (Q8N8U9    ), BMPER_MOUSE (Q8CJ69    ), CHRD_DANRE  (O57472    ), 
CHRD_HUMAN  (Q9H2X0    ), CHRD_MOUSE  (Q9Z0E2    ), CHRD_RAT    (Q63148    ), 
CHRD_XENLA  (Q91713    ), CO1A1_BOVIN (P02453    ), CO1A1_CANLF (Q9XSJ7    ), 
CO1A1_CHICK (P02457    ), CO1A1_CYNPY (Q9YIB4    ), CO1A1_HUMAN (P02452    ), 
CO1A1_MOUSE (P11087    ), CO1A1_RAT   (P02454    ), CO2A1_BOVIN (P02459    ), 
CO2A1_HUMAN (P02458    ), CO2A1_MOUSE (P28481    ), CO2A1_XENLA (Q91717    ), 
CO2A1_XENTR (Q6P4Z2    ), CO3A1_CHICK (P12105    ), CO3A1_HUMAN (P02461    ), 
CO3A1_MOUSE (P08121    ), CO3A1_RAT   (P13941    ), CO5A2_HUMAN (P05997    ), 
CO5A2_MOUSE (Q3U962    ), CRDL1_CHICK (Q90ZD5    ), CRDL1_HUMAN (Q9BU40    ), 
CRDL1_MOUSE (Q920C1    ), CRDL1_RAT   (Q76LD0    ), CRDL2_HUMAN (Q6WN34    ), 
CRDL2_MOUSE (Q8VEA6    ), CRIM1_CHICK (Q8AWW5    ), CRIM1_DANRE (Q7T3Q2    ), 
CRIM1_HUMAN (Q9NZV1    ), CRIM1_MOUSE (Q9JLL0    ), CTGF_BOVIN  (O18739    ), 
CTGF_HUMAN  (P29279    ), CTGF_MOUSE  (P29268    ), CTGF_PIG    (O19113    ), 
CTGF_RAT    (Q9R1E9    ), CYR61_CHICK (P19336    ), CYR61_HUMAN (O00622    ), 
CYR61_MOUSE (P18406    ), CYR61_PANTR (A5A6L1    ), CYR61_RAT   (Q9ES72    ), 
ECM2_BOVIN  (Q3MHH9    ), ECM2_HUMAN  (O94769    ), ECM2_MOUSE  (Q5FW85    ), 
FRAS1_HUMAN (Q86XX4    ), FRAS1_MOUSE (Q80T14    ), JAG2_HUMAN  (Q9Y219    ), 
KCP_HUMAN   (Q6ZWJ8    ), KCP_MOUSE   (Q3U492    ), KCP_XENLA   (Q9IBG7    ), 
MUC19_HUMAN (Q7Z5P9    ), MUC19_MOUSE (Q6PZE0    ), MUC2L_RAT   (P98089    ), 
MUC2_HUMAN  (Q02817    ), MUC2_MOUSE  (Q80Z19    ), MUC5A_HUMAN (P98088    ), 
MUC5B_CHICK (Q98UI9    ), MUC5B_HUMAN (Q9HC84    ), MUCAP_PIG   (P12021    ), 
MUCB1_XENLA (P38565    ), MUCS_BOVIN  (P98091    ), NELL1_HUMAN (Q92832    ), 
NELL1_MOUSE (Q2VWQ2    ), NELL1_RAT   (Q62919    ), NELL2_BOVIN (A6QR11    ), 
NELL2_DANRE (A1A5Y0    ), NELL2_HUMAN (Q99435    ), NELL2_MOUSE (Q61220    ), 
NELL2_PONAB (Q5R3Z7    ), NELL2_RAT   (Q62918    ), NELL2_XENLA (Q7ZXL5    ), 
NELL2_XENTR (A2VCU8    ), NEL_CHICK   (Q90827    ), NOV_CHICK   (P28686    ), 
NOV_COTJA   (P42642    ), NOV_HUMAN   (P48745    ), NOV_MOUSE   (Q64299    ), 
NOV_RAT     (Q9QZQ5    ), NOV_XENLA   (P51609    ), PXDNL_HUMAN (A1KZ92    ), 
PXDN_DROME  (Q9VZZ4    ), PXDN_HUMAN  (Q92626    ), PXDN_MOUSE  (Q3UQ28    ), 
PXDN_XENTR  (A4IGL7    ), SAS_DROME   (Q04164    ), SOG_DROME   (Q24025    ), 
SSPO_BOVIN  (P98167    ), SSPO_CHICK  (Q2PC93    ), SSPO_HUMAN  (A2VEC9    ), 
SSPO_MOUSE  (Q8CG65    ), SSPO_RAT    (Q700K0    ), TSP1_BOVIN  (Q28178    ), 
TSP1_HUMAN  (P07996    ), TSP1_MOUSE  (P35441    ), TSP1_XENLA  (P35448    ), 
TSP2_BOVIN  (Q95116    ), TSP2_CHICK  (P35440    ), TSP2_HUMAN  (P35442    ), 
TSP2_MOUSE  (Q03350    ), VWC2L_DANRE (B0UZC8    ), VWC2L_HUMAN (B2RUY7    ), 
VWC2L_MOUSE (Q505H4    ), VWC2_HUMAN  (Q2TAL6    ), VWC2_MOUSE  (Q8C8N3    ), 
VWCE_HUMAN  (Q96DN2    ), VWCE_MOUSE  (Q3U515    ), VWF_CANLF   (Q28295    ), 
VWF_HUMAN   (P04275    ), VWF_MOUSE   (Q8CIZ8    ), VWF_PIG     (Q28833    ), 
WISP1_HUMAN (O95388    ), WISP1_MOUSE (O54775    ), WISP1_RAT   (Q99PP0    ), 
WISP2_HUMAN (O76076    ), WISP2_MOUSE (Q9Z0G4    ), WISP2_RAT   (Q9JHC6    )
» more

UniProtKB/Swiss-Prot
False negative sequences
22 sequences

AMNLS_CANLF (Q6UKI2    ), AMNLS_HUMAN (Q9BXJ7    ), AMNLS_MOUSE (Q99JB7    ), 
FSTL1_BOVIN (Q58D84    ), FSTL1_HUMAN (Q12841    ), FSTL1_MACFA (Q9GKY0    ), 
FSTL1_MOUSE (Q62356    ), FSTL1_PONAB (Q5R9Y1    ), FSTL1_RAT   (Q62632    ), 
HMCT_BOMMO  (P98092    ), IDD_HUMAN   (P98153    ), IDD_MOUSE   (P98154    ), 
JAG1B_DANRE (Q90Y54    ), MUC2_RAT    (Q62635    ), TECTA_CHICK (Q9YH85    ), 
TECTA_HUMAN (O75443    ), TECTA_MOUSE (O08523    ), VWC2L_MACFA (Q95K75    ), 
ZAN_HUMAN   (Q9Y493    ), ZAN_MOUSE   (O88799    ), ZAN_PIG     (Q28983    ), 
ZAN_RABIT   (P57999    )
» more

PDB
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1 PDB

1U5M

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