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Entry: PS50192

General information about the entry

Entry name [info] T_SNARE
Accession [info] PS50192
Entry type [info] MATRIX
Date [info] 01-APR-2002 CREATED; 10-MAY-2017 DATA UPDATE; 22-NOV-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC50192
Associated ProRule [info] PRU00202

Name and characterization of the entry

Description [info] t-SNARE coiled-coil homology domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=63; TOPOLOGY=LINEAR;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=58;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.8449000; R2=0.0289058; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1186.7148438; R2=1.0950705; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=231; H_SCORE=1440; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=162; H_SCORE=1364; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MM=5; MI=-105; MD=-105; IM=-105; DM=-105; M0=-5;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='D'; M=-12, -1,-25,  7,-11,-20,-18, -2,-19, -8,-12,-10, -5,-15, -5, -8, -8,-10,-17,-26, -9, -2;
/M: SY='A'; M=  1,-10,-23,-12, -9,-20,-13,-10,-14, -9,-17,-11, -8,-10, -3,-14,  1, -5,-14,-25,-14, -6;
/M: SY='M'; M=-15,-19,-21,-19,-18, -7,-26,-10,  1,-17,  1,  4,-20,-17,-12,-15,-12, -5, -4,-19,  2,-13;
/M: SY='E'; M=-11,-10,-28, -9,  2,-16,-25,-12, -8,-10,-11, -8,-16,-15, -6,-13,-11, -8, -4,-26,-14, -3;
/M: SY='Q'; M=-16, -4,-27,  2,  0,-27,-18, -2,-22, -3,-18,-12, -2,-13, 10,  2, -3, -8,-23,-28,-13,  8;
/M: SY='E'; M= -8,  0,-27,  8, 20,-31,-15, -5,-28,  0,-24,-19, -5, -6,  6, -8,  1, -7,-26,-30,-18, 15;
/M: SY='R'; M=-18, -7,-26, -9, -4,-21,-16, -6,-18,  4,-30,-10,  3,-17,  7, 21,  0, -6,-17,-29,-17,  0;
/M: SY='D'; M=-12,  0,-25, 12,-11,-19,-19,  6,-19,-14,-11,-12, -7,-15,-11,-16, -9,-13,-15,-28, -7, -5;
/M: SY='E'; M=-13, -1,-29,  5,  8,-29,-13, -5,-29,  4,-25,-16, -6,-11,  5,  3, -3,-10,-25,-27,-16,  7;
/M: SY='E'; M= -8,  1,-22,  1, -2,-24, -9, -3,-22, -6,-23,-15,  3,-11, -1, -9,  5, -2,-23,-30,-16,  2;
/M: SY='L'; M= -9,-23,-23,-27,-21, -1,-27,-22,  8,-27, 13,  7,-25,-22,-17,-23,-14,  1,  8,-23, -9,-20;
/M: SY='E'; M=-14, -8,-26, -2, -1,-24,-13, -8,-20, -5,-16,-10, -8,-12, -4, -2, -6, -8,-18,-27,-15,  0;
/M: SY='Q'; M= -7, -8,-26, -8, -6,-26,-12, -6,-21, -1,-18, -9, -5,-14,  3,  1, -3, -5,-20,-25,-14, -1;
/M: SY='I'; M=-16,-28,-23,-32,-26,  0,-30,-25, 24,-26, 10, 15,-24,-24,-21,-21,-20, -7, 17,-26, -9,-24;
/M: SY='E'; M= -5, -8,-23, -2, -8,-21,-10, -2,-21,-11,-15,-13, -5,-12, -7,-10, -1, -8,-18,-28,-15, -1;
/M: SY='R'; M= -7, -7,-24, -8, -9,-24, -6, -8,-25,  0,-24,-13, -4,-13, -2,  2,  4, -1,-20,-27,-16, -5;
/M: SY='S'; M= -7,-12,-21,-13,-22,-17,-10,-12,-10,-12,-14, -7, -8,-15,-13,-12,  2,  0, -8,-28,-12,-15;
/M: SY='I'; M= -8,-27,-23,-32,-25, -3,-30,-26, 20,-30,  9,  8,-26,-22,-19,-28,-16, -7, 16,-23, -9,-25;
/M: SY='Q'; M= -8,-17,-24,-15,-14,-21, -6,-12,-17, -9,-14, -9,-10,-15, -5, -4, -4, -6,-15,-24,-14, -7;
/M: SY='E'; M=-10,  2,-26,  8, 10,-27,-17, -5,-25, -2,-21,-17, -1,-10, -2, -4, -2, -5,-22,-30,-17,  5;
/M: SY='L'; M=-13,-27,-21,-28,-21,  2,-26,-22, 12,-25, 12,  8,-24,-25,-18,-18,-19, -9,  7,-25, -9,-19;
/M: SY='K'; M=-12, -5,-27, -2,-14,-25,-12,  6,-28, 10,-26,-13,  1,-14, -3, 11, -6,-12,-22,-25,-11, -3;
/M: SY='N'; M=-12,  1,-22,  2, -6,-26, -7, -4,-24, -8,-24,-16,  0,-14, -5,-10,  1, -6,-21,-31,-16, -5;
/M: SY='M'; M= -9,-30,-22,-34,-35, -1,-26,-18, 22,-28, 19, 24,-28,-21,-21,-26,-19,-10, 12,-21, -3,-26;
/M: SY='F'; M=  2,-15,-22,-21,-17, 11,  2,-19,-24,-23,-20,-19,-11,-19,-20,-21,  0, -6,-15,-13, -9,-17;
/M: SY='M'; M=-12,-23,-23,-23,-22,-12,-21, -5,  0,-18,  4,  6,-15,-20, -6,-12,-13, -8, -5,-24, -5,-11;
/M: SY='D'; M=-16, 10,-29, 20,  5,-31,-15, -3,-31, -1,-25,-19,  0,-11,  1, -2, -4, -8,-26,-30,-16,  4;
/M: SY='M'; M=-17,-24,-22,-30,-24,  1,-27,-20, 16,-23,  6, 18,-21,-22,-17,-17,-17, -2, 10,-25, -8,-20;
/M: SY='G'; M=  5,-14,-23,-11,-26,-23, 17,-11,-24,-21,-17,-13, -9,-16,-16,-21, -2,-13,-18,-23,-20,-15;
/M: SY='B'; M=-11, -4,-25, -2, -8,-21,-13,  0,-18, -9,-17, -8, -6,-15, -7,-11, -2, -5,-14,-29,-12, -8;
/M: SY='E'; M=-12,-13,-25, -9,  2,-16,-21, -3,-10,-10, -2,  4,-17,-12, -1,-10,-11,-13,-14,-25,-10,  4;
/M: SY='L'; M= -9,-29,-21,-30,-25,  3,-30,-27, 14,-30, 16,  4,-31,-27,-24,-25,-19, -4, 19,-23, -9,-25;
/M: SY='E'; M=-15, -2,-26,  7,  6,-26,-17, -6,-22, -4,-19,-16, -5,-11, -2, -6, -4, -8,-19,-30,-15,  5;
/M: SY='E'; M= -8, -1,-20,  4,  4,-26,-13, -3,-25, -9,-21,-17, -3,-11, -4,-12,  2, -3,-21,-32,-16,  1;
/M: SY='Q'; M=-19,  0,-31,  2, 16,-41,-19,  6,-25,  7,-37, -8,  0,-10, 53,  9, -1,-12,-33,-24,-17, 36;
/M: SY='G'; M= -4,  3,-24,  5,-21,-27, 18, -7,-31,-14,-30,-21, 10,-15,-13,-14,  5,-10,-26,-30,-23,-10;
/M: SY='E'; M=-12, -3,-28,  2, 16,-26,-20, -7,-24,  0,-21,-16, -8, -4,  3, -5, -1, -5,-22,-29,-17, 10;
/M: SY='M'; M=-12,-20,-23,-23,-23,-12,-23, -8,  4,-13,  1, 14,-18,-19, -3,-10,-12, -8, -2,-21, -4,-10;
/M: SY='L'; M=-13,-31,-26,-33,-26,  3,-33,-26, 21,-32, 22, 11,-31,-26,-22,-27,-24, -9, 17,-22, -7,-25;
/M: SY='D'; M=-18, 23,-25, 32, -1,-28,-12, -3,-31, -9,-26,-25, 14,-12, -8,-13,  1, -3,-27,-35,-17, -1;
/M: SY='R'; M=-14, -2,-27,  0, -8,-26,-11, -4,-27,  3,-23,-15,  2,-16, -3, 13, -4, -7,-22,-27,-15, -6;
/M: SY='I'; M=-19,-30,-28,-37,-30,  3,-35,-27, 34,-28,  6, 18,-22,-22,-21,-25,-22,-11, 19,-22, -5,-27;
/M: SY='E'; M= -9,  6,-25, 18,  5,-27,-12, -6,-28, -8,-21,-20, -3, -8, -5,-14,  0, -6,-22,-31,-19,  7;
/M: SY='E'; M= -9,  0,-25,  2, -1,-20,-13,  0,-23, -6,-22,-16, -3,-13, -5,-10,  1, -4,-20,-25, -7, -3;
/M: SY='N'; M=-11, 11,-22,  5,-11,-22, -2,  1,-23, -7,-26,-18, 20,-16, -9, -8,  4, -5,-26,-33,-17, -7;
/M: SY='V'; M= -8,-26,-16,-29,-24,  3,-25,-24,  7,-26,  5,  4,-28,-26,-22,-23,-15, -4, 16,-22, -9,-23;
/M: SY='D'; M=-17,  9,-28, 22, 10,-29,-13, -1,-28,-10,-21,-20, -1, -9, -3,-13, -3, -9,-26,-32,-15,  6;
/M: SY='N'; M=-13,  5,-24,  5, -9,-24,-10,  6,-24, -8,-24,-14,  9,-15, -3, -7,  3, -2,-24,-31,-11, -5;
/M: SY='T'; M= -2,-11,-18,-18,-17,-12,-15,-20, -1,-16,-17, -5, -5,-17,-15,-16,  1,  7,  1,-30,-17,-16;
/M: SY='D'; M= -9, -3,-23,  3,-15,-19,-16, -2,-19,-10,-18,-12, -4,-14, -8,-11, -1, -4,-14,-29,-12, -4;
/M:         M=-10,-10,-24, -7,-15,-14,-15,-13,-10,-16, -8, -8,-13,-18,-17,-16, -7, -5, -6,-27,-12,-16;
/M: SY='N'; M=-16,  1,-26,  1,-14,-16,-16,  2,-20, -3,-19,-13,  2,-17, -7,  2, -6, -9,-20,-22, -2, -8;
/M: SY='I'; M=-10,-25,-22,-28,-24, -1,-28,-24, 14,-27, 11,  7,-26,-24,-20,-23,-15, -3, 16,-25,-10,-23;
/M: SY='E'; M=-12, -2,-27,  3,  1,-29,-14, -3,-28,  6,-25,-16, -1,-10,  5,  4, -3, -7,-25,-27,-14,  6;
/M: SY='Q'; M= -8,-11,-25,-11,-12,-23,-12, -9,-15, -5,-16, -6, -9,-16, -6, -5, -6, -6,-12,-26,-13, -8;
/M: SY='A'; M= 13,-10,-17,-15,-12,-22,  2,-21,-17,-11,-30,-16, -7,-13,-11,-14,  7,  1, -7,-27,-24,-10;
/M: SY='N'; M= -9, -2,-21,  0,-19,-16,-15,  0,-16,-10,-17, -9,  2,-16, -9, -7,  0, -5,-13,-30,-12, -7;
/M: SY='R'; M=-12, -7,-29, -5, -6,-25, -7, -5,-29,  7,-26,-15, -7,-14, -3,  8, -4,-10,-23,-24,-12, -4;
/M: SY='R'; M=-17,  0,-28,  2,  1,-27,-16,  3,-28, 11,-26,-15,  3,-13,  5, 16, -5,-11,-27,-27,-13,  5;
/M: SY='L'; M= -8,-26,-22,-29,-22,  4,-26,-22,  9,-28, 15,  7,-28,-25,-20,-23,-18, -4, 11,-21, -8,-21;
/M: SY='K'; M= -8,-12,-22,-11,-12,-18,-15, -9,-19, -1,-16,-10, -6,-14, -8,  2, -2,  1,-15,-25,-12, -7;
/M: SY='K'; M=-12,-11,-29, -8, -2,-27,-18, -8,-26, 14,-23,-12,-11,-11, -1,  9, -8, -7,-20,-19,-11,  0;
/M: SY='L'; M=  1,-22,-18,-26,-20, -3,-18,-19,  5,-20, -3,  4,-20,-21,-17,-18,-11, -7,  5,-21, -8,-18;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_11 which contains 556'196 sequence entries.


Total number of hits 217 in 192 different sequences
Number of true positive hits 209 in 184 different sequences
Number of 'unknown' hits 0
Number of false positive hits 8 in 8 different sequences
Number of false negative sequences 6
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 96.31 %
Recall (true positives / (true positives + false negatives)) 97.21 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] window20_shuffled
Author [info] K_Hofmann
Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 2
Feature key [info] DOMAIN
Feature description [info] t-SNARE coiled-coil homology
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
184 sequences

ABI1_HUMAN  (Q8IZP0    ), ABI1_MOUSE  (Q8CBW3    ), ABI1_RAT    (Q9QZM5    ), 
ABI2_HUMAN  (Q9NYB9    ), ABI2_MOUSE  (P62484    ), AEX4_CAEEL  (G5EEN8    ), 
BET11_ARATH (Q9M2J9    ), BET12_ARATH (Q94CG2    ), BET1L_BOVIN (Q3MHP8    ), 
BET1L_DANRE (Q68EL3    ), BET1L_HUMAN (Q9NYM9    ), BET1L_MOUSE (O35153    ), 
BET1L_PONAB (Q5RBX2    ), BET1L_RAT   (O35152    ), BET1_HUMAN  (O15155    ), 
BET1_MOUSE  (O35623    ), BET1_RAT    (Q62896    ), BET1_SCHPO  (O13932    ), 
BET1_YEAST  (P22804    ), BETL1_ARATH (Q8VXX9    ), BETL2_ARATH (Q8L9S0    ), 
FSV1_SCHPO  (O14222    ), NPS11_ARATH (Q944A9    ), NPS12_ARATH (Q9LNH6    ), 
NPS13_ARATH (Q9LRP1    ), PEP12_SCHPO (O94651    ), PEP12_YEAST (P32854    ), 
PSY1_SCHPO  (Q9USH7    ), SEC9_ASHGO  (Q752V4    ), SEC9_CANAL  (Q59XP0    ), 
SEC9_CANGA  (Q6FY22    ), SEC9_DEBHA  (Q6BKU3    ), SEC9_KLULA  (Q6CSD1    ), 
SEC9_SCHPO  (O74786    ), SEC9_YARLI  (Q6C5G0    ), SEC9_YEAST  (P40357    ), 
SED5_SCHPO  (O13644    ), SED5_YEAST  (Q01590    ), SFT1_YEAST  (P43682    ), 
SN25A_CARAU (P36977    ), SN25A_DANRE (Q5TZ66    ), SN25B_CARAU (P36978    ), 
SN25B_DANRE (Q6PC54    ), SNA29_CAEEL (P83351    ), SNP23_HUMAN (O00161    ), 
SNP23_MOUSE (O09044    ), SNP23_RAT   (O70377    ), SNP25_BOVIN (Q17QQ3    ), 
SNP25_CHICK (P60878    ), SNP25_DROME (P36975    ), SNP25_HUMAN (P60880    ), 
SNP25_MACMU (P60877    ), SNP25_MOUSE (P60879    ), SNP25_PANTR (Q5R1X1    ), 
SNP25_PONAB (Q5NVG5    ), SNP25_RAT   (P60881    ), SNP25_TORMA (P36976    ), 
SNP29_ARATH (Q9SD96    ), SNP29_BOVIN (Q0II86    ), SNP29_HUMAN (O95721    ), 
SNP29_MOUSE (Q9ERB0    ), SNP29_PONAB (Q5R5K4    ), SNP29_RAT   (Q9Z2P6    ), 
SNP30_ARATH (Q9LMG8    ), SNP33_ARATH (Q9S7P9    ), SNP47_BOVIN (A6QP11    ), 
SNP47_DANRE (Q0P4A7    ), SNP47_HUMAN (Q5SQN1    ), SNP47_MOUSE (Q8R570    ), 
SNP47_RAT   (Q6P6S0    ), SPO20_YEAST (Q04359    ), SSO1_YEAST  (P32867    ), 
SSO2_CANAL  (Q59YF0    ), SSO2_YEAST  (P39926    ), STX10_HUMAN (O60499    ), 
STX11_HUMAN (O75558    ), STX11_MOUSE (Q9D3G5    ), STX12_HUMAN (Q86Y82    ), 
STX12_MOUSE (Q9ER00    ), STX12_PONAB (Q5RBW6    ), STX12_RAT   (G3V7P1    ), 
STX16_HUMAN (O14662    ), STX16_MOUSE (Q8BVI5    ), STX17_BOVIN (Q5E9Y2    ), 
STX17_HUMAN (P56962    ), STX17_MOUSE (Q9D0I4    ), STX17_RAT   (Q9Z158    ), 
STX19_BOVIN (Q0VCI2    ), STX19_HUMAN (Q8N4C7    ), STX19_MOUSE (Q8R1Q0    ), 
STX19_PONAB (Q5RAL4    ), STX1A_BOVIN (P32850    ), STX1A_CAEBR (A8WVD0    ), 
STX1A_CAEEL (O16000    ), STX1A_DROME (Q24547    ), STX1A_HUMAN (Q16623    ), 
STX1A_MOUSE (O35526    ), STX1A_PONAB (Q5R4L2    ), STX1A_RAT   (P32851    ), 
STX1B_BOVIN (P61267    ), STX1B_HUMAN (P61266    ), STX1B_MOUSE (P61264    ), 
STX1B_RAT   (P61265    ), STX1B_SHEEP (P61268    ), STX2_CAEEL  (Q20574    ), 
STX2_HUMAN  (P32856    ), STX2_MOUSE  (Q00262    ), STX2_RAT    (P50279    ), 
STX3_CAEEL  (Q20024    ), STX3_HUMAN  (Q13277    ), STX3_MOUSE  (Q64704    ), 
STX3_RAT    (Q08849    ), STX4_BOVIN  (Q3SWZ3    ), STX4_CAEEL  (P91409    ), 
STX4_DROME  (Q7KVY7    ), STX4_HUMAN  (Q12846    ), STX4_MOUSE  (P70452    ), 
STX4_RAT    (Q08850    ), STX5_BOVIN  (Q08DB5    ), STX5_CAEEL  (Q20797    ), 
STX5_DROME  (Q24509    ), STX5_HUMAN  (Q13190    ), STX5_MOUSE  (Q8K1E0    ), 
STX5_RAT    (Q08851    ), STX6_CAEEL  (P83528    ), STX6_CHICK  (Q5ZL19    ), 
STX6_HUMAN  (O43752    ), STX6_MOUSE  (Q9JKK1    ), STX6_PONAB  (Q5R6Q2    ), 
STX6_RAT    (Q63635    ), STX7A_DICDI (Q54JY7    ), STX7B_DICDI (Q54X86    ), 
STX7_BOVIN  (Q3ZBT5    ), STX7_HUMAN  (O15400    ), STX7_MOUSE  (O70439    ), 
STX7_PONAB  (Q5R602    ), STX7_RAT    (O70257    ), STX8A_DICDI (Q553P5    ), 
STX8B_DICDI (Q54IX6    ), STX8_BOVIN  (Q3T075    ), STX8_HUMAN  (Q9UNK0    ), 
STX8_MOUSE  (O88983    ), STX8_RAT    (Q9Z2Q7    ), STX8_YEAST  (P31377    ), 
STX_APLCA   (Q16932    ), SY111_ARATH (Q42374    ), SY112_ARATH (Q9ZPV9    ), 
SY121_ARATH (Q9ZSD4    ), SY122_ARATH (Q9SVC2    ), SY123_ARATH (Q9ZQZ8    ), 
SY124_ARATH (O64791    ), SY125_ARATH (Q9SXB0    ), SY131_ARATH (Q9SRV7    ), 
SY132_ARATH (Q8VZU2    ), SYP21_ARATH (Q39233    ), SYP22_ARATH (P93654    ), 
SYP23_ARATH (O04378    ), SYP24_ARATH (Q9C615    ), SYP31_ARATH (Q9FFK1    ), 
SYP32_ARATH (Q9LK09    ), SYP41_ARATH (O65359    ), SYP42_ARATH (Q9SWH4    ), 
SYP43_ARATH (Q9SUJ1    ), SYP51_ARATH (Q9SA23    ), SYP52_ARATH (Q94KK7    ), 
SYP61_ARATH (Q946Y7    ), SYP71_ARATH (Q9SF29    ), SYP72_ARATH (Q94KK6    ), 
SYP73_ARATH (Q94KK5    ), TLG1_SCHPO  (Q9HGN3    ), TLG1_YEAST  (Q03322    ), 
TLG2_SCHPO  (Q9P6P1    ), TLG2_YEAST  (Q08144    ), TSNA1_HUMAN (Q96NA8    ), 
UACA_HUMAN  (Q9BZF9    ), UACA_MOUSE  (Q8CGB3    ), UFE1_YEAST  (P41834    ), 
VAM3_YEAST  (Q12241    ), VAM7_SCHPO  (O74509    ), VAM7_YEAST  (P32912    ), 
VTI1A_DICDI (Q54CK6    ), VTI1_YEAST  (Q04338    ), Y5975_DICDI (Q54MG4    ), 
YL657_MIMIV (Q5UR18    )
» more

UniProtKB/Swiss-Prot
False negative sequences
6 sequences

STX18_DANRE (Q4VBI7    ), STX18_HUMAN (Q9P2W9    ), STX18_MOUSE (Q8VDS8    ), 
STX18_PONAB (Q5REB4    ), STX18_RAT   (Q68FW4    ), UFE1_SCHPO  (O94531    )
» more

UniProtKB/Swiss-Prot
False positive sequences
8 sequences

HLYB_VIBCH  (P15492    ), MALCR_PSEAE (Q9I0I6    ), MCP2_THEMA  (Q9X0M7    ), 
NAHY_PSEPU  (Q9Z429    ), PCTA_PSEAE  (G3XD24    ), PCTC_PSEAE  (Q9HW93    ), 
Y504_MYCPN  (P75282    ), YIQ9_YEAST  (P40442    )
» more

PDB
[Detailed view]
34 PDB

1FIO; 1GL2; 1HVV; 1JTH; 1KIL; 1N7S; 1NHL; 1SFC; 1URQ; 1XTG; 2M8R; 2N1T; 2NPS; 3B5N; 3C98; 3HD7; 3IPD; 3J96; 3J97; 3J98; 3J99; 3P8C; 3RK2; 3RK3; 3RL0; 4JEH; 4JEU; 4N78; 4WY4; 5CCG; 5CCH; 5CCI; 5KJ7; 5KJ8
» more

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission