Entry: PS50199

Forthcoming changes to the profile format
General information about the entry

Entry name [info] ZF_RANBP2_2
Accession [info] PS50199
Entry type [info] MATRIX
Date [info] DEC-2001 (CREATED); OCT-2013 (DATA UPDATE); SEP-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC50199
Associated ProRule [info] PRU00322

Name and characterization of the entry

Description [info] Zinc finger RanBP2 type profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=30;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=27;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.1729; R2=.01129215; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=-157.00000; R2=16.08333; TEXT='HScore';
/CUT_OFF: LEVEL=0; SCORE=605; N_SCORE=8.0; H_SCORE=8142; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=471; N_SCORE=6.5; H_SCORE=7434; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='R'; M= -9, -6,-27, -5,  2,-23,-18, -9,-21, 20,-20, -9, -3, -7,  4, 22, -4, -6,-15,-24,-12,  1;
/M: SY='E'; M=  2, -2,-24,  0, 11,-17,-17,-12,-13, -3,-15,-12, -5, -2, -2,-10,  1, -5,-11,-26,-14,  4;
/M: SY='G'; M= -4,  4,-28,  4, -6,-29, 39,-12,-35, -8,-29,-20,  9,-17,-10,-11,  2,-14,-28,-26,-25, -8;
/I:         I=-8; MI=-5; MD=-10; IM=-5; DM=-10;
/M: SY='D'; M=-11,  9,-27, 15, 11,-21,-15,  0,-25,  1,-22,-16,  2, -9,  8, -4,  1, -5,-23,-18, -5,  9;
/M: SY='W'; M=-20,-40,-50,-40,-30, 10,-20,-30,-20,-20,-20,-20,-40,-30,-20,-20,-40,-30,-30,150, 30,-20;
/M: SY='E'; M= -9,  8,-26, 11, 12,-26,-17,  2,-21,  4,-18,-11,  4, -9, 10, -1, -1, -4,-19,-29,-12, 11;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/I:         MI=-5; MD=-10; IM=-5; II=-9; DM=-10; I=0,0,-30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0;
/M: SY='S'; M= -4,  6,-22,  5,  4,-23,-11, -5,-22, -1,-26,-17,  9,  9, -1, -6, 11,  7,-19,-34,-18,  0;
/M: SY='S'; M=  1, -8,-18, -9, -5,-17,-10,-12,-11, -3,-13, -8, -4,-15, -5, -6,  8,  7, -2,-29,-13, -5;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='T'; M= -5, -6, -7,-11,-12,-10, -3,-13,-14,-14, -8, -9,  0,-21,-12,-13,  1,  3,-11,-26,-11,-12;
/M: SY='V'; M= -7,-13,-18,-17,-15,  4,-24,-14,  8,-14,  6,  2, -9,-25,-18,-12,-10, -2, 12,-22, -1,-16;
/M: SY='Q'; M= -8, -6,-23, -8, -3,-16,-19, -4, -9,  4,-11,  3, -3,-16,  8,  6, -2, -1, -7,-24, -8,  2;
/M: SY='N'; M=-10, 37,-13, 17, -2,-20, -2,  8,-21, -2,-29,-20, 56,-21, -2, -2,  9, -1,-29,-41,-21, -2;
/M: SY='F'; M= -8,-10,-20,-12,  2,  3,-20,-12,-18, -1,-15,-12, -8, -7, -8, -4, -6, -7,-15,-12, -2, -3;
/M: SY='A'; M= 22,-11,-17,-14, -6,-20, -7,-17,-13, -7,-15,-11, -9,  4, -6,-12,  7,  1, -7,-25,-19, -7;
/M: SY='E'; M= -5, -1,-23, -2,  3,-15,-15, -4,-20,  0,-16,-12, -1,-14, -1,  3,  3,  3,-15,-17, -8,  0;
/M: SY='R'; M=  7, -2,-20, -2,  1,-22,-10,-10,-21,  4,-20,-14,  0, -7,  0,  9,  7, -1,-13,-27,-17, -1;
/M: SY='T'; M= -6, -6,-20,-11, -8,-10,-19,-12, -3, -6, -6, -3, -1,-14, -7, -4,  1,  6, -2,-27, -8, -9;
/M: SY='K'; M= -6, -4,-26, -3, 10,-22,-19,  0,-21, 20,-20, -9, -3,-13,  5, 15, -5, -8,-13,-22, -7,  6;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='V'; M= -5,-10,-18,-17,-18,  8,-21,-17,  7,-16,  0, -1, -4,-23,-20,-15, -7, -4, 10,-22, -4,-19;
/M: SY='A'; M=  9, -9,-12,-14, -7,-19,-13,-11,-12,  1,-14, -7, -4,-16,  0,  6,  3, -2, -5,-25,-15, -5;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='G'; M= -7, -2,-29, -3,  2,-25,  8, -8,-27,  0,-24,-13,  2,-15,  8, -2, -1,-10,-26, -8,-14,  5;
/M: SY='S'; M=  9,  2,-13, -7, -7,-14, -4,-12,-15, -8,-17,-13,  8,-14, -8,-10, 13, 13, -9,-28,-14, -8;
/M: SY='P'; M= -3,-12,-27, -7,  0,-21,-17,-12,-14,-10,-15,-12,-11, 28, -7,-12, -1, -2,-15,-30,-19, -6;
/M: SY='K'; M=-10, -1,-28, -2,  4,-25,-16, -7,-27, 34,-25,-11,  3,-14,  7, 34, -7, -9,-18,-22,-12,  4;
/M: SY='P'; M= -8, -8,-29, -4,  1,-21,-10,-13,-21, -1,-20,-13, -7, 17, -4, -7, -3, -5,-20,-25,-16, -3;
/M: SY='D'; M= -3,  3,-24,  4,  1,-24, -2,-11,-20, -6,-19,-14,  1, -3, -3,-10,  3, -1,-16,-29,-19, -2;
/I:         E1=0; IE=-105; DE=-105;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_10 which contains 546'790 sequence entries.


Total number of hits 168 in 98 different sequences
Number of true positive hits 168 in 98 different sequences
Number of 'unknown' hits
Number of false positive hits
Number of false negative sequences 9
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 94.92 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 8
Feature key [info] ZN_FING
Feature description [info] RanBP2-type
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
98 sequences

ARI8_ARATH  (Q8W468), CAN15_HUMAN (O75808), CAN15_MOUSE (Q9JLG8), 
CAND_DROME  (P27398), CAZ_DROME   (Q27294), EWS_HUMAN   (Q01844), 
EWS_MOUSE   (Q61545), FUS_BOVIN   (Q28009), FUS_HUMAN   (P35637), 
FUS_MOUSE   (P56959), HOIL1_DANRE (A9JTG5), HOIL1_DICLA (E6ZIJ1), 
HOIL1_HUMAN (Q9BYM8), HOIL1_MOUSE (Q9WUB0), HOIL1_RAT   (Q62921), 
MDM2_CANFA  (P56950), MDM2_DANRE  (O42354), MDM2_FELCA  (Q7YRZ8), 
MDM2_HORSE  (P56951), MDM2_HUMAN  (Q00987), MDM2_MESAU  (Q60524), 
MDM2_MOUSE  (P23804), MDM2_XENLA  (P56273), MDM4_BOVIN  (Q2HJ21), 
MDM4_DANRE  (Q7ZUW7), MDM4_HUMAN  (O15151), MDM4_MOUSE  (O35618), 
MDM4_RAT    (Q5XIN1), MDM4_XENLA  (Q7ZYI3), NEIL3_BOVIN (Q3MHN7), 
NEIL3_HUMAN (Q8TAT5), NEIL3_MOUSE (Q8K203), NPL4_DROME  (Q9VBP9), 
NPL4_HUMAN  (Q8TAT6), NPL4_MOUSE  (P60670), NPL4_RAT    (Q9ES54), 
NRP1_YEAST  (P32770), NU153_DROME (Q9VXE6), NU153_HUMAN (P49790), 
NU153_RAT   (P49791), NU153_XENLA (Q640Z6), RBM10_HUMAN (P98175), 
RBM10_MOUSE (Q99KG3), RBM10_RAT   (P70501), RBM5A_XENLA (A0JMV4), 
RBM5B_XENLA (Q6DDU9), RBM5_BOVIN  (Q1RMU5), RBM5_HUMAN  (P52756), 
RBM5_MOUSE  (Q91YE7), RBM5_RAT    (B2GV05), RBM5_XENTR  (A4IGK4), 
RBP2_HUMAN  (P49792), RBP2_MOUSE  (Q9ERU9), RBP2_PANTR  (H2QII6), 
RBP56_HUMAN (Q92804), RNF31_HUMAN (Q96EP0), RNF31_MOUSE (Q924T7), 
RYBPA_DANRE (Q7SYB3), RYBPB_DANRE (Q5EG55), RYBP_HUMAN  (Q8N488), 
RYBP_MOUSE  (Q8CCI5), SHRPN_BOVIN (E1BDF2), SHRPN_HUMAN (Q9H0F6), 
SHRPN_MOUSE (Q91WA6), SHRPN_RAT   (Q9EQL9), TA15B_ARATH (Q94KD0), 
TAB2_DANRE  (Q5RFW2), TAB2_HUMAN  (Q9NYJ8), TAB2_MOUSE  (Q99K90), 
TAB2_RAT    (Q5U303), TAB3_HUMAN  (Q8N5C8), TAB3_MOUSE  (Q571K4), 
TAB3_XENLA  (Q7ZXH3), TAF15_ARATH (Q9AST1), TRBID_DROME (Q9VH90), 
TX13A_HUMAN (Q9BXU3), VAR3_ARATH  (Q8S9K3), Y3761_ARATH (Q8RXW0), 
YAF2_HUMAN  (Q8IY57), YAF2_MOUSE  (Q99LW6), YDMD_SCHPO  (P87143), 
YE04_SCHPO  (O13801), ZRAB2_CHICK (Q5ZLX5), ZRAB2_HUMAN (O95218), 
ZRAB2_MOUSE (Q9R020), ZRAB2_PIG   (Q19QU3), ZRAB2_PONAB (Q5R580), 
ZRAB2_RAT   (O35986), ZRAB3_BOVIN (E1BB03), ZRAB3_HUMAN (Q5FWF4), 
ZRAB3_MOUSE (Q6NZP1), ZRAN1_BOVIN (A6QP16), ZRAN1_HUMAN (Q9UGI0), 
ZRAN1_MOUSE (Q7M760), ZRAN1_XENTR (B1H2Q2), ZRN1A_XENLA (Q5U595), 
ZRN1B_DANRE (A0JMQ9), ZRN1B_XENLA (Q6NUB7)
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UniProtKB/Swiss-Prot
False negative sequences
9 sequences

ARI13_ARATH (Q9FFN9), ARI14_ARATH (Q9FFP1), ARI15_ARATH (Q84RQ8), 
ARI16_ARATH (Q9C5A4), HDA15_ARATH (Q8GXJ1), TAMO_DROME  (Q9W1A4), 
VPS36_SCHPO (O43038), VPS36_YEAST (Q06696), YZR3_ARATH  (Q8GZ43)
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PDB
[Detailed view]
32 PDB

1N0Z; 1NJ3; 1Q5W; 2C6A; 2C6B; 2CR8; 2CRC; 2D9G; 2EBQ; 2EBR; 2EBV; 2GQE; 2K0C; 2K1P; 2LK0; 2LK1; 2WWZ; 2WX0; 2WX1; 3A9J; 3A9K; 3B08; 3B0A; 3CH5; 3G9Y; 3GJ3; 3GJ4; 3GJ5; 3GJ6; 3GJ7; 3GJ8; 4OWF
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