Entry: PS50225

General information about the entry

Entry name [info] SOCS
Accession [info] PS50225
Entry type [info] MATRIX
Date [info] MAY-2002 (CREATED); OCT-2013 (DATA UPDATE); MAY-2016 (INFO UPDATE).
PROSITE Doc. [info] PDOC50225
Associated ProRule [info] PRU00194

Name and characterization of the entry

Description [info] SOCS box domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=50;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=45;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.1047000; R2=0.0177183; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2404.3457031; R2=2.7730870; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=474; H_SCORE=3719; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=361; H_SCORE=3405; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-20; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='M'; M= -9,-16,-24,-17, -9,-10,-15, -7, -1, -6,  3, 10,-15,-21,  4, -6,-13,-10, -3,-16,  0, -3;
/M: SY='L'; M= -9,-29,-19,-30,-21,  8,-29,-19, 21,-27, 42, 23,-29,-29,-19,-19,-26, -9, 15,-21, -1,-20;
/M: SY='R'; M= -6, -1,-21, -1, -4,-21, -6,-12,-21,  4,-20,-13,  1,-15, -4, 10,  6,  7,-11,-28,-15, -5;
/M: SY='R'; M= -5,-11,-25,-16, -7,-17,-23, -4, -4,  2, -9, -1, -5,-16,  2, 10, -6, -3, -4,-22, -6, -5;
/M: SY='P'; M=-11, -9,-31, -2,  0,-24,-18,-12,-20, -2,-19,-15, -9, 31, -4,  2, -5, -6,-21,-29,-20, -5;
/M: SY='L'; M=-13,-30,-26,-32,-23, 18,-30,-17, 15,-26, 29, 11,-28,-29,-20,-20,-28,-12,  4,  7, 16,-22;
/I:         I=-5; MI=0; MD=-28; IM=0; DM=-28;
/M: SY='R'; M=-14, -2,-22, -4,  0,-15,-13,  1,-22, 19,-16, -9,  7,-15,  6, 45, -5, -6,-16,-18, -9,  0; D=-5;
/I:         I=-5; DM=-28;
/M: SY='R'; M= -5,-10,-27, -9, -1,-19,-16, -4,-20,  6,-20,-11, -6,  3,  7, 17, -1, -5,-19,-20, -7,  0;
/M: SY='S'; M=  7, -3,-15, -6, -2,-19, -9,-12,-19,  2,-22,-14,  3,-11, -1,  3, 20, 17, -9,-30,-15, -2;
/M: SY='N'; M= -9,  7,-23,  2,  6,-12,-12, -4,-22,  9,-23,-15, 14,-15,  1, 10,  5, -2,-20,-27,-11,  4;
/M: SY='P'; M=  6,-23,-21,-21,-15,-15,-21,-25,  4,-15, -8, -5,-23, 17,-19,-20, -6, -4, 12,-28,-19,-19;
/M: SY='H'; M= -9,-15,-27,-15, -7, -8,-20,  9,-15, -5, -7, -4, -9, -1, -5,  7,-12,-11,-15,-21, -4, -9;
/M: SY='S'; M=  4, -4,-16, -4, -2,-20, -8,-14,-18,-10,-26,-18,  2,  9, -4,-12, 27, 20,-12,-36,-20, -4;
/M: SY='L'; M=-10,-30,-20,-30,-20, 10,-30,-20, 20,-30, 50, 20,-30,-30,-20,-20,-30,-10, 10,-20,  0,-20;
/M: SY='Q'; M= -5, -4,-27, -5, 13,-33,-19,  4,-15,  4,-11,  1, -4,-12, 45,  4, -2, -9,-23,-20,-10, 29;
/M: SY='H'; M=-19,  7,-30, 11,  7,-19,-19, 67,-29, -6,-20, -7,  8,-17,  8, -2, -8,-17,-28,-26, 16,  4;
/M: SY='L'; M=-11,-30,-21,-32,-22, 15,-31,-21, 21,-30, 44, 18,-28,-29,-22,-21,-28,-10, 11,-18,  2,-22;
/M: SY='C'; M= -8,-18,106,-27,-27,-20,-27,-28,-29,-28,-21,-20,-17,-37,-27,-28, -5, -7,-10,-49,-29,-27;
/M: SY='R'; M=-18,-12, -7,-13, -5,-20,-22, -5,-30, 21,-20,-12, -3,-23,  4, 55,-10,-10,-18,-25,-13, -5;
/M: SY='L'; M= -6,-18,-24,-20, -9, -9,-23,-12,  3, -4, 12, 11,-15,-20, -1,  3,-16, -9, -1,-20, -6, -6;
/M: SY='T'; M=  4,-11, -1,-15,-10,-17,-17,-15,-11, -4,-13, -8, -8,-18, -4,  1,  5,  7,  0,-29,-15, -8;
/M: SY='I'; M= -6,-30,-22,-36,-30,  0,-36,-30, 42,-26, 16, 16,-24,-24,-24,-26,-16, -6, 38,-24, -4,-30;
/M: SY='R'; M=-11, -3, -8, -9,-10,-15,-18, -8,-12,  4,-15, -9,  6,-24, -7, 19, -5, -5, -4,-31,-15,-10;
/M: SY='R'; M= -4,  0,-25,  0,  0,-25, -4,  3,-28, 11,-24,-13,  3,-15,  2, 17,  2, -7,-20,-26,-12, -1;
/M: SY='C'; M= -3, -8, 29,-17,-17,-14,-21, -8,-14,-18,-10, -9, -5,-26,-16,-17, -2,  3, -4,-36,-15,-17;
/M: SY='V'; M= -4,-19,-15,-24,-20, -1,-27,-21, 15,-19, 14, 12,-18,-21,-17,-17, -6, 12, 19,-26, -6,-19;
/M: SY='G'; M= -2, -4,-29, -1, -5,-29, 17,-15,-28,-11,-26,-18, -4, 12, -6,-15,  0, -7,-25,-26,-25, -7;
/I:         I=-5; MI=0; MD=-28; IM=0; DM=-28;
/M: SY='V'; M= -6,-13,-14,-16,-13,  0,-20,-11,  6, -9,  5,  3,-12,-16,-10, -4, -6,  6,  8,-13,  3,-13; D=-5;
/I:         I=-5; DM=-28;
/M: SY='H'; M= -7,  5,-20,  8,  9,-22, -2, 12,-22,  2,-19,-10,  4, -9,  8,  0,  1, -7,-19,-21, -8,  8; D=-5;
/I:         I=-5; DM=-28;
/M: SY='E'; M= -7,  1,-23,  2,  7,-18, -9, -7,-15, -8, -6, -8,  1,-15,  3, -8,  0, -2,-16,-28,-14,  5;
/M: SY='V'; M= -8,-28,-19,-30,-26,  8,-32,-18, 26,-22, 17, 12,-26,-28,-22,-20,-18, -6, 27,-14, 12,-26;
/M: SY='D'; M= -7, 17,-27, 25, 14,-30,-12, -5,-29,  3,-25,-20,  5,-11,  7, -5,  1, -7,-24,-17,-14, 11;
/M: SY='K'; M= -1, -4,-14, -7,  0,-24, -3,-14,-26,  9,-22,-13, -2,-14, -3,  5,  0,  0,-16,-25,-17, -2;
/M: SY='L'; M= -9,-30,-20,-31,-22,  8,-31,-22, 24,-29, 42, 19,-29,-29,-21,-21,-27, -9, 16,-21, -1,-22;
/I:         I=-8; MI=-8; MD=-33; IM=-8; DM=-33;
/M: SY='P'; M=-10,-18,-39, -9,  2,-31,-20,-17,-20, -8,-29,-18,-18, 79, -2,-17, -9,-10,-30,-29,-28, -4;
/M: SY='L'; M=-10,-30,-22,-32,-22,  8,-32,-22, 26,-30, 44, 20,-28,-28,-20,-22,-28,-10, 14,-20,  0,-22;
/M: SY='P'; M=-10,-14,-38, -7,  0,-29,-18,-17,-20, -9,-30,-20,-12, 79, -9,-18, -8, -9,-30,-31,-29, -9;
/M: SY='P'; M= -4,-11,-27,-10, -4,-21, -1,-16,-14,-11,-19,-12, -5,  8, -8,-11,  4, -1,-14,-28,-20, -8;
/M: SY='R'; M=  3,-14,-23,-16, -8,-14,-17,-10,-10,  5,-11, -2,-12, -6, -4,  9, -7, -6, -5,-18, -6, -8;
/M: SY='L'; M=-10,-28,-21,-31,-21,  7,-29,-18, 23,-26, 41, 27,-27,-27,-16,-19,-27,-10, 12,-20,  0,-19;
/M: SY='R'; M= -9,-10,-28,-12, -1,-20,-21, -8,-15, 19,-11, -3, -6,-17,  8, 29,-11, -9,-12,-20, -9,  1;
/M: SY='D'; M= -7, 17,-25, 25, 19,-29,-12, -3,-30,  6,-24,-21,  8,-10,  5,  7,  5, -5,-22,-32,-18, 11;
/M: SY='Y'; M=-20,-20,-27,-23,-20, 38,-28, 20, -5,-16,  0,  0,-15,-28,-16,-12,-18,-12,-10, 15, 55,-20;
/M: SY='L'; M=-10,-30,-20,-30,-20, 10,-30,-20, 20,-30, 50, 20,-30,-30,-20,-20,-30,-10, 10,-20,  0,-20;
/M: SY='K'; M= -8,  0,-24,  3,  7,-21,-17, -9,-19, 12,-13, -9, -2,-14,  2,  8, -2, -4,-14,-27,-12,  4;
/M: SY='Y'; M= -7, -5,-25, -3,  7,-11,-10,  3,-18, -4,-17,-10, -3,-15, 10, -5,  4, -3,-19,-12, 11,  7;
/M: SY='Y'; M=-17,-18,-27,-19, -9, 23,-27,  1, -6, -9,  1, -1,-15,-24, -6, -2,-16,-10,-11,  5, 32, -9;
/M: SY='P'; M= -9,  0,-27,  0, -3,-21,-18, -1,-10, -6,-18,-10,  3,  5, -4,-10,  0, -5,-13,-31,-12, -6;
/M: SY='F'; M= -5,-20,-21,-26,-18, 22,-22,-11, -1,-16,  1,  7,-16,-10,-18,-16,-10, -2, -3, -7, 12,-18;
/M: SY='Q'; M=  1, -5,-28, -5,  9,-32,-16, -5,-21, 13,-22, -7, -5,  4, 25,  5, -2, -8,-22,-21,-15, 16;
/I:         E1=0;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2016_05 which contains 551'193 sequence entries.


Total number of hits 116 in 116 different sequences
Number of true positive hits 116 in 116 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 2
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 98.31 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] DOMAIN
Feature description [info] SOCS box
Version [info] 4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
116 sequences

ASB10_HUMAN (Q8WXI3    ), ASB10_MOUSE (Q91ZT7    ), ASB11_BOVIN (Q3SZE4    ), 
ASB11_HUMAN (Q8WXH4    ), ASB11_MOUSE (Q9CQ31    ), ASB11_PONAB (Q5RFS1    ), 
ASB13_HUMAN (Q8WXK3    ), ASB13_MOUSE (Q8VBX0    ), ASB14_HUMAN (A6NK59    ), 
ASB14_MOUSE (Q8C6Y6    ), ASB14_RAT   (P0C927    ), ASB15_BOVIN (Q8HXA6    ), 
ASB15_HUMAN (Q8WXK1    ), ASB15_MOUSE (Q8VHS6    ), ASB16_HUMAN (Q96NS5    ), 
ASB16_MOUSE (Q8VHS5    ), ASB17_BOVIN (Q32KY8    ), ASB17_CANLF (Q8HYV8    ), 
ASB17_HUMAN (Q8WXJ9    ), ASB17_MACFA (Q95LR4    ), ASB17_MOUSE (Q8VHP9    ), 
ASB18_HUMAN (Q6ZVZ8    ), ASB18_MOUSE (Q8VHA6    ), ASB1_HUMAN  (Q9Y576    ), 
ASB1_MOUSE  (Q9WV74    ), ASB2_BOVIN  (Q3SX45    ), ASB2_HUMAN  (Q96Q27    ), 
ASB2_MOUSE  (Q8K0L0    ), ASB2_RAT    (Q5U2S6    ), ASB3_BOVIN  (Q08DV6    ), 
ASB3_HUMAN  (Q9Y575    ), ASB3_MOUSE  (Q9WV72    ), ASB4_HUMAN  (Q9Y574    ), 
ASB4_MOUSE  (Q9WV71    ), ASB5_BOVIN  (Q17QS6    ), ASB5_HUMAN  (Q8WWX0    ), 
ASB5_MOUSE  (Q9D1A4    ), ASB5_RABIT  (Q862Z2    ), ASB6_HUMAN  (Q9NWX5    ), 
ASB6_MOUSE  (Q91ZU1    ), ASB6_PONAB  (Q5R4M7    ), ASB7_HUMAN  (Q9H672    ), 
ASB7_MACFA  (Q9BGT9    ), ASB7_MOUSE  (Q91ZU0    ), ASB7_PONAB  (Q5RCK5    ), 
ASB8_BOVIN  (Q08E43    ), ASB8_HUMAN  (Q9H765    ), ASB8_MACFA  (Q4R544    ), 
ASB8_MOUSE  (Q91ZT9    ), ASB8_PONAB  (Q5R6D7    ), ASB9_HUMAN  (Q96DX5    ), 
ASB9_MOUSE  (Q91ZT8    ), CISH_BOVIN  (Q2HJ53    ), CISH_CHICK  (Q9PW70    ), 
CISH_HUMAN  (Q9NSE2    ), CISH_MOUSE  (Q62225    ), CISH_RAT    (O70512    ), 
DYH12_BOVIN (Q58CT0    ), GUS_DROME   (A1Z6E0    ), NEUL2_HUMAN (Q9BR09    ), 
NEUL2_MOUSE (Q9D0S4    ), RB40A_HUMAN (Q8WXH6    ), RB40B_HUMAN (Q12829    ), 
RB40B_MOUSE (Q8VHP8    ), RB40C_HUMAN (Q96S21    ), RB40C_MOUSE (Q8VHQ4    ), 
RB40L_HUMAN (P0C0E4    ), SOCS1_HUMAN (O15524    ), SOCS1_MOUSE (O35716    ), 
SOCS1_RAT   (Q9QX78    ), SOCS2_BOVIN (Q861R0    ), SOCS2_HUMAN (O14508    ), 
SOCS2_MOUSE (O35717    ), SOCS2_PIG   (Q7YRV6    ), SOCS2_RAT   (O88582    ), 
SOCS3_BOVIN (Q9BEG9    ), SOCS3_CANLF (Q68AM8    ), SOCS3_CHICK (Q90X67    ), 
SOCS3_HUMAN (O14543    ), SOCS3_MOUSE (O35718    ), SOCS3_RAT   (O88583    ), 
SOCS4_BOVIN (Q0VC91    ), SOCS4_HUMAN (Q8WXH5    ), SOCS4_MOUSE (Q91ZA6    ), 
SOCS4_PONAB (Q5RDX2    ), SOCS5_BOVIN (Q29RN6    ), SOCS5_HUMAN (O75159    ), 
SOCS5_MOUSE (O54928    ), SOCS6_HUMAN (O14544    ), SOCS6_MOUSE (Q9JLY0    ), 
SOCS6_PONAB (Q5RCM6    ), SOCS7_HUMAN (O14512    ), SOCS7_MOUSE (Q8VHQ2    ), 
SPSB1_BOVIN (Q5E9X6    ), SPSB1_HUMAN (Q96BD6    ), SPSB1_MOUSE (Q9D5L7    ), 
SPSB2_HUMAN (Q99619    ), SPSB2_MOUSE (O88838    ), SPSB2_RAT   (Q5M877    ), 
SPSB3_BOVIN (Q3MHZ2    ), SPSB3_HUMAN (Q6PJ21    ), SPSB3_MOUSE (Q571F5    ), 
SPSB3_XENLA (Q5M9B1    ), SPSB3_XENTR (Q28DT9    ), SPSB4_HUMAN (Q96A44    ), 
SPSB4_MOUSE (Q8R5B6    ), TULP4_HUMAN (Q9NRJ4    ), TULP4_MOUSE (Q9JIL5    ), 
WSB1_DANRE  (Q7T2F6    ), WSB1_HUMAN  (Q9Y6I7    ), WSB1_MOUSE  (O54927    ), 
WSB1_TAKRU  (Q9W5Z5    ), WSB1_XENTR  (Q6P1V3    ), WSB2_BOVIN  (Q0V8J1    ), 
WSB2_HUMAN  (Q9NYS7    ), WSB2_MOUSE  (O54929    )
» more

UniProtKB/Swiss-Prot
False negative sequences
2 sequences

ASB12_HUMAN (Q8WXK4    ), ASB12_MOUSE (Q9D738    )

		
PDB
[Detailed view]
6 PDB

2C9W; 2IZV; 3ZKJ; 3ZNG; 4JGH; 5BO4

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission