Entry: PS50276

General information about the entry

Entry name [info] PANCREATIC_HORMONE_2
Accession [info] PS50276
Entry type [info] MATRIX
Date [info] DEC-2001 (CREATED); OCT-2013 (DATA UPDATE); MAY-2016 (INFO UPDATE).
PROSITE Doc. [info] PDOC00238

Name and characterization of the entry

Description [info] Pancreatic hormone family profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=36;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=33;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=-0.3308000; R2=0.0180494; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1727.2871094; R2=2.2454090; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=490; H_SCORE=2828; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=379; H_SCORE=2578; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-20; E1=-40; MI=-105; MD=-105; IM=-105; DM=-105; M0=-10;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='Y'; M=  1,-16,-22,-21,-18,  4, -5, -4, -5,-13, -3,  7,-13,-21,-11,-14, -8, -6, -5, -4, 16,-16;
/M: SY='P'; M=-10,-22,-37,-13, -3,-23,-22,-20,-13,-13,-16,-13,-22, 69,-12,-20,-13,-10,-23,-28,-25,-12;
/M: SY='P'; M=  7,-12,-21,-13, -7,-17,-13,-16, -7,-14,-10, -9, -8, 10, -7,-16,  5,  2, -8,-29,-18, -8;
/M: SY='Q'; M=-10, -1,-32,  3, 21,-33,-20, -4,-26, 21,-25,-11, -3,  9, 22, 10, -5,-10,-26,-24,-16, 21;
/M: SY='P'; M=-10,-20,-40,-10,  0,-30,-20,-20,-20,-10,-30,-20,-20, 90,-10,-20,-10,-10,-30,-30,-30,-10;
/M: SY='E'; M= -9,  5,-25, 10, 18,-24,-20, -2,-19,  2,-17,-11, -2, -1,  5, -5, -1,  0,-15,-30,-14, 11;
/M: SY='Y'; M= -9, -3,-24, -8, -9, -1,-17, 12,-14, -1,-14, -9,  4,-22, -3,  5, -2, -2,-15, -8, 22, -9;
/M: SY='P'; M=-10,-20,-40,-10,  0,-30,-20,-20,-20,-10,-30,-20,-20, 90,-10,-20,-10,-10,-30,-30,-30,-10;
/M: SY='G'; M= -2, -8,-29, -7,-11,-29, 51,-16,-37,-13,-28,-19,  0,-18,-13,-10,  1,-16,-28,-22,-27,-12;
/M: SY='D'; M=-13, 27,-29, 39, 31,-33,-10, -1,-33,  2,-26,-24, 12, -3,  6, -6,  2, -9,-29,-35,-21, 18;
/M: SY='D'; M=-15, 11,-25, 13, -3, -1,-12, -3,-19,-12,-10,-12,  5,-19,-10,-12, -7,-10,-18,-21, -2, -6;
/M: SY='A'; M= 31, -2,-13, -8, -5,-21, -4,-16,-15, -6,-15,-13, -4,-11, -7,-11, 11,  4, -5,-25,-19, -6;
/M: SY='S'; M= -1, -1,-20, -3, -2,-21,-10, -5,-19, -9,-26,-17,  5, 15, -4,-11, 16, 12,-17,-35,-18, -4;
/M: SY='P'; M=  0,-15,-28,-11,  0,-23,-19,-19,-12, -4,-19,-12,-16, 35, -9,-13, -6, -6,-10,-28,-22, -7;
/M: SY='E'; M= -6, 17,-27, 24, 37,-31,-15,  0,-28,  5,-22,-19,  7, -5, 16, -3,  2, -8,-27,-31,-19, 26;
/M: SY='E'; M= -7, 17,-28, 25, 32,-34,-15,  1,-28,  5,-22,-17,  5, -6, 22, -2,  1, -9,-27,-29,-17, 27;
/M: SY='L'; M=-12,-28,-23,-30,-21, 10,-28,-13, 16,-24, 35, 23,-28,-28,-15,-17,-28,-11,  6, -5, 10,-18;
/M: SY='A'; M= 11, -8,-20,-14, -6,-19,-13,-10,-11,  2,-12, -7, -3,-15,  2, 10,  1, -3, -6,-22,-14, -4;
/M: SY='Q'; M=-13, -1,-29, -1,  7,-23,-21, -3,-18, 13,-17, -6, -1,-14, 20, 17, -5, -9,-18,-21, -8, 13;
/M: SY='Y'; M=-20,-21,-29,-22,-21, 36,-30, 15,  0,-12,  1,  0,-20,-30,-14,-11,-20,-10, -9, 28, 74,-21;
/M: SY='Y'; M=-10,-21,-24,-22,-15, 11,-26,  0,  5,-16, 17,  8,-21,-26,-11,-13,-20, -9, -1, -2, 27,-15;
/M: SY='A'; M=  7,  3,-19,  1, -1,-21,-10,-10,-20,  3,-18,-14,  3,-13, -2,  6,  7,  4,-12,-28,-16, -2;
/M: SY='B'; M=  9, 13,-20, 11, 11,-27, -7, -4,-21, -1,-21,-16, 12,-10,  7, -7,  7, -3,-19,-29,-19,  9;
/M: SY='L'; M= -8,-30,-19,-31,-23,  6,-31,-23, 25,-27, 36, 19,-29,-29,-22,-21,-24, -8, 22,-22, -2,-23;
/M: SY='R'; M=-13,  4,-26, -1,  3,-21,-14,  4,-24, 14,-22,-11, 14,-18, 15, 31,  1, -5,-23,-24, -9,  6;
/M: SY='H'; M=-14,  3,-30,  4, 20,-28,-19, 30,-27, 10,-21, -8,  5,-12, 23, 14, -5,-12,-28,-26, -4, 19;
/M: SY='Y'; M=-20,-20,-30,-20,-20, 30,-30, 20,  0,-10,  0,  0,-20,-30,-10,-10,-20,-10,-10, 30, 80,-20;
/M: SY='I'; M=-12,-28,-26,-33,-25, 13,-34,-19, 27,-23, 19, 13,-21,-25,-20,-19,-21, -9, 16,-11, 13,-25;
/M: SY='N'; M=  2, 19,-18,  6, -1,-20, -4,  1,-16, -3,-20,-14, 31,-17,  3, -5,  9,  2,-20,-33,-18,  1;
/M: SY='L'; M= -9,-24,-21,-29,-22,  6,-30,-20, 23,-24, 26, 17,-20,-26,-19,-18,-20, -6, 16,-21, -1,-22;
/M: SY='I'; M= -8,-28,-22,-33,-26,  4,-32,-20, 32,-23, 19, 21,-24,-25,-19,-21,-19, -7, 26,-18,  5,-25;
/M: SY='T'; M= -1, -5,-17,-12,-14,-12, 10,-20,-20,-14,-16,-13, -1,-14,-15,-14, 11, 23,-10,-25,-15,-14;
/M: SY='R'; M=-20,-10,-30,-10,  0,-20,-20,  0,-30, 30,-20,-10,  0,-20, 10, 70,-10,-10,-20,-20,-10,  0;
/M: SY='P'; M=-11,-10,-33, -6,  6,-30,-20,  5,-21, -4,-24,-10, -8, 37, 15, -7, -5, -7,-28,-27,-16,  7;
/M: SY='R'; M=-20,-10,-30,-10,  0,-20,-20,  0,-30, 30,-20,-10,  0,-20, 10, 70,-10,-10,-20,-20,-10,  0;
/M: SY='Y'; M=-20,-25,-25,-29,-25, 54,-30,  1,  0,-19,  5,  0,-20,-30,-24,-15,-20,-10, -5, 21, 56,-25;
/I:         E1=0;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2016_05 which contains 551'193 sequence entries.


Total number of hits 85 in 85 different sequences
Number of true positive hits 85 in 85 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 7
Number of 'partial' sequences 7
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 92.39 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Version [info] 4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
85 sequences

NPF_ARTTR   (P41334    ), NPF_HELAS   (P41321    ), NPF_MONEX   (P41967    ), 
NPY1_CONBE  (P0CJ22    ), NPY2_CONBE  (P0CJ23    ), NPY_ALLMI   (P68007    ), 
NPY_APLCA   (Q27441    ), NPY_BOVIN   (Q6RUW3    ), NPY_CARAU   (P28672    ), 
NPY_CAVPO   (P68008    ), NPY_CHICK   (P28673    ), NPY_CYPCA   (Q9DGK7    ), 
NPY_DANRE   (Q9I8P3    ), NPY_DICLA   (Q9PTA0    ), NPY_GADMO   (P80167    ), 
NPY_HUMAN   (P01303    ), NPY_ICTPU   (Q9I9D3    ), NPY_LAMFL   (P48097    ), 
NPY_MACMU   (Q9XSW6    ), NPY_MOUSE   (P57774    ), NPY_ONCMY   (P29071    ), 
NPY_PAROL   (Q90WF4    ), NPY_PELRI   (P69101    ), NPY_PIG     (P01304    ), 
NPY_RABIT   (P68006    ), NPY_RANTE   (P69102    ), NPY_RAT     (P07808    ), 
NPY_SHEEP   (P14765    ), NPY_TORMA   (P28674    ), NPY_TYPNA   (Q9PW68    ), 
NPY_XENLA   (P33689    ), PAHO_ALLMI  (P06305    ), PAHO_ANSAN  (P06304    ), 
PAHO_BOVIN  (P01302    ), PAHO_CANLF  (P01299    ), PAHO_CAVPO  (P13083    ), 
PAHO_CERSI  (P37999    ), PAHO_CHICH  (P41519    ), PAHO_CHICK  (P68248    ), 
PAHO_DIDVI  (P18107    ), PAHO_EQUPR  (P68010    ), PAHO_EQUZE  (P68009    ), 
PAHO_ERIEU  (P41335    ), PAHO_FELCA  (P06884    ), PAHO_HUMAN  (P01298    ), 
PAHO_LARAR  (P41337    ), PAHO_LITCT  (P15427    ), PAHO_MACMU  (P33684    ), 
PAHO_MELGA  (P68249    ), PAHO_MOUSE  (P10601    ), PAHO_PIG    (P01300    ), 
PAHO_RABIT  (P41336    ), PAHO_RANTE  (P31229    ), PAHO_RAT    (P06303    ), 
PAHO_SHEEP  (P01301    ), PAHO_STRCA  (P11967    ), PAHO_TAPPI  (P39659    ), 
PMY_PETMA   (P80024    ), PPY_LOPAM   (P09475    ), PYY3_HUMAN  (Q5JQD4    ), 
PYYA_DANRE  (Q9I8P2    ), PYYV_VARER  (E2E4L2    ), PYY_AMICA   (P29205    ), 
PYY_ANGJA   (Q76CL2    ), PYY_ATRSP   (P69094    ), PYY_BOVIN   (P51694    ), 
PYY_CANLF   (P68004    ), PYY_CHICK   (P29203    ), PYY_DICLA   (Q9PT99    ), 
PYY_HUMAN   (P10082    ), PYY_LAMFL   (P48098    ), PYY_MOUSE   (Q9EPS2    ), 
PYY_MYOSC   (P09641    ), PYY_ONCKI   (P69092    ), PYY_ONCMY   (P69093    ), 
PYY_ORENI   (P81028    ), PYY_PELRI   (P29204    ), PYY_PIG     (P68005    ), 
PYY_RABIT   (Q9TR93    ), PYY_RAJRH   (P29206    ), PYY_RAT     (P10631    ), 
PYY_SCYCA   (P69095    ), PYY_SQUAC   (P69096    ), PY_DICLA    (Q9PT98    ), 
SPYY_PHYBI  (P80952    )
» more

UniProtKB/Swiss-Prot
False negative sequences
7 sequences

NPF_AEDAE   (Q8MP00    ), NPF_ANOGA   (Q7Q7R8    ), NPF_DROME   (Q9VET0    ), 
NPF_DROPS   (Q29B55    ), NPF_LOCMI   (P86442    ), PYY2_BOVIN  (P06833    ), 
PYY2_HUMAN  (Q9NRI6    )
» more

UniProtKB/Swiss-Prot
'Partial' sequences
7 sequences

NPF_HELZE   (P85106    ), NPF_SCHGR   (P86443    ), PYF1_PENMO  (P84005    ), 
PYF2_PENMO  (P84006    ), PYF3_PENMO  (P84007    ), PYF4_PENMO  (P84008    ), 
PYF_LOLVU   (P84004    )
» more

PDB
[Detailed view]
25 PDB

1BBA; 1F8P; 1FVN; 1ICY; 1K8V; 1LJV; 1PPT; 1QBF; 1QFA; 1RON; 1RU5; 1RUU; 1TZ4; 1TZ5; 1V1D; 2BF9; 2DEZ; 2DF0; 2H3S; 2H3T; 2H4B; 2L60; 2OON; 2OOP; 2RLK
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