Entry: PS50304

General information about the entry

Entry name [info] TUDOR
Accession [info] PS50304
Entry type [info] MATRIX
Date [info] DEC-2001 (CREATED); OCT-2013 (DATA UPDATE); OCT-2016 (INFO UPDATE).
PROSITE Doc. [info] PDOC50304
Associated ProRule [info] PRU00211

Name and characterization of the entry

Description [info] Tudor domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=61;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=56;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.0072000; R2=0.0201488; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2856.1633301; R2=2.1802721; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=273; H_SCORE=3451; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=174; H_SCORE=3236; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=*; E1=*; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='Q'; M= -1,  0,-18, -3,  1,-24,-12, -9,-19,  0,-19,-12,  2, -2,  5, -3,  5,  5,-17,-28,-16,  3;
/M: SY='W'; M=-10,-26,-25,-28,-20,  8,-22,-23, -8,-19, -6, -9,-24,-11,-18,-18,-18,-10,-10, 33,  6,-18;
/M: SY='K'; M= -4, -2,-19, -3,  6,-24,-18, -8,-20, 16,-21,-11, -1, -9,  5,  9, -2, -6,-15,-24,-12,  5;
/M: SY='V'; M=  2,-17,-17,-20,-17, -9,-20,-20, 11,-12,  1,  2,-13,-22,-16,-10, -6, -3, 18,-27,-12,-17;
/M: SY='G'; M=  0, -3,-28, -3,-13,-29, 48,-17,-36,-11,-28,-19,  3,-18,-15,-14,  1,-14,-27,-22,-26,-14;
/M: SY='D'; M=  4,  6,-22,  9,  1,-24, -5,-12,-19, -6,-14,-12, -1, -9, -5,-12,  1, -3,-12,-28,-17, -2;
/M:         M= -7,-12,-25,-14,-11,-11,-11,-17, -4, -5, -3, -1, -9,-12,-11, -8,-10, -7, -5,-22,-10,-12;
/M: SY='C'; M= -9,-21, 95,-30,-30,-16,-30,-29,-19,-28,-14,-12,-21,-38,-29,-28,-10, -9,  0,-46,-26,-29;
/I:         I=-6; MD=-29;
/M: SY='V'; M=  0,-10, -8,-14,-12, -7,-15,-10,  4, -7, -1,  6, -7,-17, -7, -9, -4, -3,  7,-20, -7,-10; D=-6;
/I:         I=-6; MI=-29; MD=-29; IM=-29; DM=-29;
/M: SY='A'; M= 22,-13,-11,-18,-14,-12, -3,-19,  0,-12, -5, -4,-11,-14,-14,-17,  4,  1,  9,-20,-15,-14; D=-6;
/I:         I=-6; DM=-29;
/M: SY='V'; M= -3,-15,-22,-16, -9, -9,-23,-14,  3, -7,  0,  2,-15,-15, -7, -4,-10, -6,  6,-22, -7,-10;
/M: SY='F'; M= -9,-23,-15,-26,-18, 15,-23,-15, -9,-15, -6, -7,-19,-16,-17,-13,-15,-11,-10, 13, 12,-17;
/M: SY='P'; M= -3, -8,-24, -6,  2,-16,-11, -9,-20, -1,-23,-15, -4,  7,  0, -2,  7,  1,-18,-24,-10, -1;
/M: SY='E'; M= -6,  6,-19, 10, 21,-25,-16, -7,-21,  5,-20,-15,  2,-11,  6,  0,  2, -5,-15,-31,-18, 13;
/M: SY='D'; M=-17, 42,-29, 55, 18,-37, -7,  1,-36,  0,-29,-26, 22,-11,  3, -8,  1, -9,-30,-38,-20, 10;
/M: SY='G'; M= -1, -1,-25, -4, -8,-26, 34,-13,-30,-11,-24,-17,  7,-17, -9,-12,  3, -9,-25,-25,-24, -8;
/M: SY='E'; M= -1, -3,  1, -5,  8,-19,-17, -3,-19, -8,-14,-12, -3,-16,  1,-10,  1, -5,-15,-30,-12,  4;
/M: SY='W'; M=-13,-31,-29,-34,-27, 16,-25,-19,  1,-21, -1, -2,-28,-28,-20,-19,-26,-17, -6, 54, 25,-22;
/M: SY='Y'; M=-18,-17,-29,-18,-15, 19,-27, 18, -5, -8, -3, -1,-16,-26, -6, -8,-17, -9,-12, 19, 56,-14;
/M: SY='R'; M=-16, -6,-31, -3,  3,-23,-19, -6,-27, 15,-22,-14, -3,  6,  4, 36, -7, -5,-22,-25,-15, -1;
/M: SY='A'; M= 38,-11,  5,-21,-13,-18, -5,-19,-12,-12,-11,-11,-11,-15,-12,-20,  7, -1, -2,-22,-17,-13;
/M: SY='T'; M= -7, -7,-22, -8,  0,-17,-19, -6,-15,  1,-15, -7, -5,-10,  4,  3,  3,  7,-10,-20, -9,  1;
/M: SY='I'; M= -4,-28,-22,-35,-28, -1,-34,-29, 38,-26, 16, 15,-22,-22,-22,-26,-15, -4, 32,-23, -4,-28;
/M: SY='T'; M= -3, -7,-17, -9,  2,-17,-20, -8, -9, -3, -9, -5, -6,-14,  1, -3,  2,  4, -5,-27,-11,  1;
/M: SY='E'; M=  0,  4,-24,  4,  5,-23, -9, -8,-22,  4,-22,-15,  5,-13,  3,  3,  5, -3,-17,-21,-15,  4;
/I:         I=-4; MD=-21;
/M: SY='V'; M= -7,-15,-15,-17,-13, -6,-24,-16, 10,-13,  2,  6,-14,-15,-11,-15,-10, -6, 11,-23, -5,-13; D=-4;
/I:         I=-4; MD=-21;
/M: SY='D'; M=-10,  6,-19, 11,  2, -9,-13, -5,-12, -7, -7, -9,  0, -4, -5, -9, -4, -3,-12,-19, -4, -2; D=-4;
/I:         I=-4; MI=0; MD=-21; IM=0; DM=-21;
/M: SY='E'; M= -7,  3,-14,  4,  9,-12,-13,  4,-18,  3,-13, -9,  2,-10,  4,  1, -2, -6,-15,-19, -6,  6; D=-4;
/I:         I=-4; DM=-21;
/M: SY='E'; M=-10,  5,-26, 10, 16,-24,-12, -5,-24,  9,-21,-13,  2,  2,  5,  7, -2, -6,-21,-26,-16,  9; D=-4;
/I:         I=-4; DM=-21;
/M: SY='B'; M=  1,  9,-22,  8,  5,-25,-11, -6,-22,  5,-21,-13,  7, -8,  3,  2,  4,  0,-17,-29,-16,  3;
/M: SY='E'; M= -6,  9,-27, 11, 12,-25, -4,  0,-25, -1,-20,-15,  8, -8,  4, -3,  0, -8,-24,-27,-14,  8;
/M:         M= -7, -7,-21, -8,  0,-18, -3,-10,-19,  0,-12, -6, -5,-16,  0,  0, -3, -2,-15,-22,-10, -1;
/M: SY='V'; M= -6,-22,  8,-27,-23,  7,-26,-16,  1,-15, -1,  0,-20,-28,-21,-14,-12, -7,  9,-16,  7,-22;
/M: SY='H'; M= -9, -8,-25, -7,  3,-10,-17,  4,-14, -3,-13, -7, -6,-12, -4, -1, -5, -8, -9,-22, -3, -2;
/M: SY='V'; M= -2,-29,-14,-31,-29, -1,-27,-29, 30,-22, 11, 11,-27,-28,-28,-21,-12, -3, 42,-28, -9,-29;
/M: SY='F'; M= -9,-19,-20,-23,-14, 11,-26,-14,  1,-10,  4,  1,-15,-23,-15, -1,-11, -3,  6,-17,  1,-14;
/M: SY='Y'; M=-17,-23,-18,-27,-22, 35,-29,  1,  0,-18,  6,  1,-20,-30,-20,-12,-19,-10, -3,  8, 41,-22;
/M: SY='I'; M= -4,-21,-21,-25,-20, -4,-31,-25, 27,-21, 10,  9,-18,-21,-19,-22,-10,  0, 26,-25, -7,-22;
/M: SY='D'; M=-15, 34,-29, 49, 14,-34, -5, -2,-36, -1,-27,-25, 13,-12, -1, -7, -1,-10,-27,-33,-16,  6;
/M: SY='Y'; M=-19,-22,-28,-24,-22, 33,-30,  8,  2,-14,  1,  0,-20,-29,-15,-13,-19, -8, -7, 26, 62,-22;
/M: SY='G'; M=  1, -9,-28, -9,-18,-29, 64,-19,-38,-19,-30,-20,  1,-19,-18,-19,  3,-17,-28,-22,-29,-18;
/M: SY='N'; M= -7, 21,-22,  9, -5,-20, 12,  1,-24, -3,-28,-18, 36,-19, -5, -4,  7, -2,-26,-32,-17, -5;
/M: SY='T'; M= -6, -8,-14,-10, -1,-13,-21, -9, -9, -2,-10, -6, -6,-17,  0,  1, -1,  4, -5,-23, -5, -2;
/M: SY='E'; M=  2,  0,-21,  1, 16,-21,-16,-10,-14, -3,-14,-12, -2, -8,  5, -8,  7,  2,-12,-29,-16, 10;
/M: SY='V'; M= -6, -8,-15, -8,  1,-15,-23,-14, -3, -5, -5, -4, -9,-18, -4, -6, -4,  2,  4,-29,-12, -2;
/M: SY='V'; M= -5,-21,-12,-24,-19, -6,-28,-22, 15,-13,  8,  9,-20,-24,-14,-13,-10,  0, 22,-26, -8,-17;
/M: SY='P'; M= -3,  1,-25,  3,  4,-26,-13, -6,-21,  0,-25,-16,  2, 14,  2, -6,  7,  1,-19,-32,-19,  2;
/M:         M= -7, -8,-23, -8, -5,-11,-18, -8, -8, -3, -3,  0, -7,-14, -3, -1, -7, -4, -7,-18, -5, -5;
/M: SY='E'; M= -6,  1,-18,  3,  9,-20,-18, -5,-18, -1,-15,-11, -1,-10,  3, -5,  1, -2,-14,-29,-13,  6;
/M: SY='D'; M=-13, 11,-25, 13,  1,-19,-15, -4,-19,  2,-15,-12,  8,-17,  0,  3, -4, -5,-17,-22, -9,  0;
/M: SY='L'; M= -8,-22,-22,-23,-14, -1,-28,-16, 17,-22, 29, 17,-22,-24,-10,-17,-21, -9,  8,-21, -3,-13;
/I:         I=-6; MD=-32;
/M: SY='L'; M=-10,-20,-26,-21,-15, -5,-15,-10, -5, -7,  4,  3,-16,-23,-10,  2,-17,-12, -4, -5, -2,-13; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='P'; M= -6, -9,-29, -6,  8,-24,-18, -6,-18, -2,-16,-10, -9, 14,  8, -5, -3, -5,-21,-21,-14,  7;
/M: SY='L'; M= -8,-17,-26,-18, -5,-10,-26,-15,  9,-16, 10,  7,-15, -5, -5,-16,-15, -9,  0,-24, -9, -7;
/M: SY='E'; M= -4, -4,-27,  1, 15,-22,-18,-11,-17, -3,-14,-13, -7, 11,  1, -5, -2, -4,-17,-28,-18,  6;
/M: SY='P'; M= -7,-13,-20,-13,  0,-12,-22,-12,-11, -6,-10, -5,-11,  3,  0, -2, -7, -6,-13,-23,-12, -2;
/M: SY='E'; M= -1,  4,-25,  7,  8,-25, -4, -9,-25,  3,-21,-17,  1,-10, -1,  1,  0, -6,-19,-21,-17,  3;
/M: SY='F'; M= -8,-16,-22,-19, -9,  7,-23,-10,  1,-14,  6,  5,-13,-17,-11,-10,-11, -7, -1,-19, -1,-10;
/M: SY='A'; M=  2,-12,-22,-14, -5, -7,-20, -9, -1,-11,  1,  0,-12,-13, -8,-14, -6, -4, -1,-19, -2, -7;
/M: SY='E'; M= -7,  3,-24,  4,  6,-19,-18,-10,-12, -4,-10,-10,  0, -6, -3, -6, -2, -1,-12,-30,-15,  1;
/M: SY='S'; M= -3, -7,-22, -6,  0,-15,-15, -8,-12, -7,-12, -7, -4, -1, -1, -7,  3, -1,-11,-28,-13, -1;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2016_11 which contains 553'231 sequence entries.


Total number of hits 152 in 97 different sequences
Number of true positive hits 148 in 93 different sequences
Number of 'unknown' hits 0
Number of false positive hits 4 in 4 different sequences
Number of false negative sequences 63
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 97.37 %
Recall (true positives / (true positives + false negatives)) 70.14 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] V_Jongeneel
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 9
Feature key [info] DOMAIN
Feature description [info] Tudor
Version [info] 4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
93 sequences

AKAP1_CAEEL (Q09285    ), AKAP1_HUMAN (Q92667    ), AKAP1_MOUSE (O08715    ), 
AKAP1_RAT   (O88884    ), ALG13_HUMAN (Q9NP73    ), ALG13_MOUSE (Q9D8C3    ), 
OTU_DROME   (P10383    ), RNF17_HUMAN (Q9BXT8    ), RNF17_MACFA (Q4R3G4    ), 
RNF17_MOUSE (Q99MV7    ), SMN1_DANRE  (Q9W6S8    ), SMN_BOVIN   (O18870    ), 
SMN_CANLF   (O02771    ), SMN_FELCA   (Q8HYB8    ), SMN_HUMAN   (Q16637    ), 
SMN_MACFA   (Q4R4F8    ), SMN_MOUSE   (P97801    ), SMN_PONAB   (Q5RE18    ), 
SMN_RAT     (O35876    ), SND1_BOVIN  (Q863B3    ), SND1_DANRE  (Q7ZT42    ), 
SND1_HUMAN  (Q7KZF4    ), SND1_MOUSE  (Q78PY7    ), SND1_PONAB  (Q5REU4    ), 
SND1_RAT    (Q66X93    ), SND1_SCHPO  (Q9Y7U7    ), SPF30_BOVIN (Q3T045    ), 
SPF30_DANRE (Q7ZV80    ), SPF30_HUMAN (O75940    ), SPF30_MOUSE (Q8BGT7    ), 
SPF30_PONAB (Q5R591    ), SPF30_RAT   (Q4QQU6    ), SPF30_XENTR (Q6DEY1    ), 
SPNE_CULQU  (B0XDC4    ), SPNE_DROAN  (B3M383    ), SPNE_DROER  (B3P3W1    ), 
SPNE_DROME  (Q9VF26    ), SPNE_DROMO  (B4K5R2    ), SPNE_DROPE  (B4GEU5    ), 
SPNE_DROPS  (Q296Q5    ), SPNE_DROSE  (B4HLH4    ), SPNE_DROVI  (B4LX81    ), 
SPNE_DROWI  (B4NBB0    ), SPNE_DROYA  (B4PRJ9    ), STK31_HUMAN (Q9BXU1    ), 
STK31_MOUSE (Q99MW1    ), TDR12_BOMMO (Q1XG89    ), TDR15_HUMAN (B5MCY1    ), 
TDRD1_DANRE (Q58EK5    ), TDRD1_HUMAN (Q9BXT4    ), TDRD1_MOUSE (Q99MV1    ), 
TDRD1_ORYLA (A9CPT4    ), TDRD3_BOVIN (Q2HJG4    ), TDRD3_CHICK (Q5ZMS6    ), 
TDRD3_DANRE (Q6NYG6    ), TDRD3_HUMAN (Q9H7E2    ), TDRD3_MOUSE (Q91W18    ), 
TDRD3_RAT   (Q66HC1    ), TDRD3_XENLA (Q6NRP6    ), TDRD3_XENTR (Q6P1U3    ), 
TDRD5_AILME (D2H3M0    ), TDRD5_BOVIN (E1BPH3    ), TDRD5_CANLF (E2QTD3    ), 
TDRD5_DANRE (Q1L981    ), TDRD5_HUMAN (Q8NAT2    ), TDRD5_MOUSE (Q5VCS6    ), 
TDRD5_RAT   (B4F7C4    ), TDRD5_XENLA (A1L1H3    ), TDRD5_XENTR (A0JM98    ), 
TDRD6_HUMAN (O60522    ), TDRD6_MOUSE (P61407    ), TDRD7_AILME (D2H0H6    ), 
TDRD7_BOVIN (A6QLE1    ), TDRD7_CANLF (E2RDV1    ), TDRD7_CHICK (E1C3S7    ), 
TDRD7_HUMAN (Q8NHU6    ), TDRD7_MOUSE (Q8K1H1    ), TDRD7_PONAB (Q5RAH6    ), 
TDRD7_RAT   (Q9R1R4    ), TDRD7_XENLA (Q6NU04    ), TDRD7_XENTR (Q5M7P8    ), 
TDRD9_DANRE (B8A4F4    ), TDRD9_HUMAN (Q8NDG6    ), TDRD9_MOUSE (Q14BI7    ), 
TDRD9_RAT   (Q3MHU3    ), TDRKH_HUMAN (Q9Y2W6    ), TDRKH_MOUSE (Q80VL1    ), 
TRD7A_DANRE (A6NAF9    ), TRD7B_DANRE (E7FDW8    ), TSN1_ARATH  (Q8VZG7    ), 
TSN2_ARATH  (Q9FLT0    ), TUD_DROME   (P25823    ), VRET_DROME  (Q9VCU7    )
» more

UniProtKB/Swiss-Prot
False negative sequences
63 sequences

BOYB_DROME  (Q9VNP5    ), COIL_ARATH  (Q8RWK8    ), COIL_HUMAN  (P38432    ), 
COIL_MOUSE  (Q5SU73    ), COIL_XENLA  (Q09003    ), FMR1_DROME  (Q9NFU0    ), 
FMR1_HUMAN  (Q06787    ), FMR1_MOUSE  (P35922    ), FMR1_PONAB  (Q5R9B4    ), 
FMR1_RAT    (Q80WE1    ), FMR1_XENTR  (Q6GLC9    ), FXR1_BOVIN  (Q2TBT7    ), 
FXR1_CRIGR  (O70523    ), FXR1_HUMAN  (P51114    ), FXR1_MOUSE  (Q61584    ), 
FXR1_RAT    (Q5XI81    ), FXR1_XENTR  (Q5BJ56    ), FXR2_HUMAN  (P51116    ), 
FXR2_MOUSE  (Q9WVR4    ), KDM4A_HUMAN (O75164    ), KDM4A_MOUSE (Q8BW72    ), 
KDM4A_PONAB (Q5RD88    ), KDM4B_HUMAN (O94953    ), KDM4B_MOUSE (Q91VY5    ), 
KDM4C_HUMAN (Q9H3R0    ), KDM4C_MOUSE (Q8VCD7    ), LBR_CHICK   (P23913    ), 
LBR_HUMAN   (Q14739    ), LBR_MOUSE   (Q3U9G9    ), LBR_PONAB   (Q5R7H4    ), 
LBR_RAT     (O08984    ), MTF2_HUMAN  (Q9Y483    ), MTF2_MOUSE  (Q02395    ), 
MTF2_PONAB  (Q5R7T9    ), P20L1_BOVIN (A2VE56    ), P20L1_CHICK (Q5F3G6    ), 
P20L1_HUMAN (A8MW92    ), P20L1_MOUSE (Q8CCJ9    ), P20L1_RAT   (Q4V9H5    ), 
PCL_DROME   (Q24459    ), PHF19_HUMAN (Q5T6S3    ), PHF19_MOUSE (Q9CXG9    ), 
PHF1_HUMAN  (O43189    ), PHF1_MOUSE  (Q9Z1B8    ), PHF20_HUMAN (Q9BVI0    ), 
PHF20_MOUSE (Q8BLG0    ), SETB1_DROME (Q32KD2    ), SETB1_DROPS (Q28Z18    ), 
SETB1_HUMAN (Q15047    ), SETB1_MOUSE (O88974    ), SETB1_XENLA (Q6INA9    ), 
SMN_DROME   (Q9VV74    ), SOYB_DROME  (Q9VL52    ), SPF30_SCHPO (O94519    ), 
SPNE_AEDAE  (Q16JS8    ), SPNE_ANOGA  (Q7QCW2    ), SPNE_DROGR  (B4JT42    ), 
STB1A_DANRE (Q1L8U8    ), STB1B_DANRE (Q08BR4    ), TDR10_HUMAN (Q5VZ19    ), 
TDR12_HUMAN (Q587J7    ), TDR12_MOUSE (Q9CWU0    ), TG250_CAEEL (P34344    )
» more

UniProtKB/Swiss-Prot
False positive sequences
4 sequences

NHR61_CAEEL (O62389    ), U90A1_ARATH (Q9ZVX4    ), U90A2_ARATH (Q9SY84    ), 
ZGPAT_NEMVE (A7SBN6    )
» more

PDB
[Detailed view]
30 PDB

1G5V; 1MHN; 2D9T; 2DIQ; 2E6N; 2EQK; 2HQE; 2HQX; 2LTO; 2O4X; 3BDL; 3FDR; 3NTH; 3NTI; 3NTK; 3OMC; 3OMG; 3PMT; 3PNW; 3S6W; 4A4E; 4A4F; 4A4G; 4A4H; 4B9W; 4B9X; 4Q5W; 4Q5Y; 4QQ6; 5J39
» more

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission