Entry: PS50330

Forthcoming changes to the profile format
General information about the entry

Entry name [info] UIM
Accession [info] PS50330
Entry type [info] MATRIX
Date [info] MAY-2003 (CREATED); OCT-2013 (DATA UPDATE); SEP-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC50330
Associated ProRule [info] PRU00213

Name and characterization of the entry

Description [info] Ubiquitin-interacting motif (UIM) repeat profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=20;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=20;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.2009; R2=0.00802289; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1070.62651; R2=9.43373; TEXT='HScore';
/CUT_OFF: LEVEL=0; SCORE=909; N_SCORE=8.5; H_SCORE=8476; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=599; N_SCORE=6.0; H_SCORE=6712; MODE=1; TEXT='?';
/DEFAULT: B1=-128; E1=-128; MI=0; MD=0; IM=0; ID=0; DM=0; DI=0; M0=-15;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; IM=-76; II=-8; ID=-353;
/M: SY='E'; M= -66,-252,  61,  66, -17, -23,-179,-189, -32,-206,-173,  18,-164,  31,   8,  38,   6, -70,-183, -40;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='E'; M=-111,-251,  79,  98, -41,-167,-180, -77,-155, -98, -16, -38,-165, -24,-152,-111,-153,   4,-182,  36;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='D'; M= -93,-252, 103,  77,-212,-166,-179,-189, -40,-206,-174, -23,-165,  17,-151,  -4, -58,-192,-183,-178;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='E'; M=  29,-252,  38,  91,-212,-166,-179,-189, -50,  -7, -19, -25,  16,  17,-151,-151,-152, -15,-183,-178;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='Q'; M= -80,-252,  67,  61,-212,-166,-179,  -4,-153,  18,  65, -15,-165,  73,  33,-151,-152,-192,-183,-178;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='L'; M=-208,-220,-251,-258,  21,-224,-218,  69,-314,  88,   9,-238,-228,-240,-230,-226,-205,-178,-165,  44;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='Q'; M=  51,-252,   2,  49,-212,-166,-179,-189, -27, -44,  29,-138,-165,  91,  22, -44,-152,-192,-183,-178;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='M'; M=   3, -10,-134, -17,-111,-166,-180, -39,  29,  37,  72,-138,-165,  55,  55,-151, -41,-192,  41,  27;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='A'; M= 101,-227,-180,-184,-178,-198,-203,-166,-203,-183,-159,-181,-198,-189,-190,-188,-121,  17,-169,-172;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='I'; M=-176,-237,-152,-156,-191,-180,-190,  94, -50,  70,  62,-155,-179, -16,-167,-166, -18,  13,-175,-175;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='E'; M=  43,-252,-133,  73,-212,-166,-179,-189,  -4, -42,  16, -43,-165,  64,  40,  -5, -44,-192,-183,-178;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='M'; M=  -4,-237,-153,  72,-190,-180,-190,   4,-174,  56, 111,-156,-180,  24,-168,-167,-166, -28,-175, -96;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='S'; M= -51,-241,-145, -40,-196,-175,-186,-179,-166,-196,-168,-149,-174,-158,-162, 113,-161,-188,-178,-176;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='M'; M= -28,-252,-134,  11,-212,-166,-179,-189,  33,  62,  93,-138,-165,  18,  42,-151, -54, -12,-183,-178;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='E'; M= -10,-252, -34,  65,-113, -33, -28, -20,  40, -27, -33, -37,-165,  65,  23, -10, -52, -62,-183,-178;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='E'; M= -40,-252,  61,  96,-212, -23,-179, -72,-153, -92, -39,  30,-165,  -4,-151, -42,  10, -46,-183, -73;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='E'; M=  31, -93, -40,  48,  14, -48, -26, -39,  -5, -30,  34,  12, -20,  39,-151,   9,  -8, -17,-183,  -3;
/I:         MI=-419; MD=-340; IM=-76; II=-8; ID=-355; DM=-43; DI=-228; DD=-21;
/M: SY='E'; M=  -9,-250, -20,  74,-209,   8,-177,-187,  -9,-203, -56,  47,  -4,  18,  29,  10, -21, -38,-180,-175;
/I:         MI=-419; MD=-340; IM=-76; II=-8; ID=-355; DM=-43; DI=-228; DD=-21;
/M: SY='M'; M=  -2,-250,   9,  56, -63, -40,  -7,-186,  29, -28,  58,   6,   5,  35,   7,  -4, -24,-189,-180, -38;
/I:         MI=-419; MD=-340; IM=-76; II=-8; ID=-355; DM=-43; DI=-228; DD=-21;
/M: SY='R'; M=  -9,-249,  29,  19, -50,  12, -35, -30,  -9, -82,-170, -22,  13,   0,  63,  24, -32, -13,  19,-175;
/I:         E1=0; MI=-419; II=-8; DI=-189;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_10 which contains 546'790 sequence entries.


Total number of hits 201 in 124 different sequences
Number of true positive hits 198 in 121 different sequences
Number of 'unknown' hits
Number of false positive hits 3 in 3 different sequences
Number of false negative sequences 35
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 98.51 %
Recall (true positives / (true positives + false negatives)) 84.98 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 3
Feature key [info] REPEAT
Feature description [info] UIM
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
121 sequences

AKIB1_DANRE (Q1L8G6), AKIB1_HUMAN (Q9P2G1), AKIB1_MOUSE (Q6ZPS6), 
AN13A_HUMAN (Q8IZ07), AN13A_MOUSE (Q80UP5), AN13B_HUMAN (Q86YJ7), 
AN13B_MOUSE (Q5F259), AN13D_HUMAN (Q6ZTN6), AN13D_MOUSE (Q6PD24), 
ASB2_MOUSE  (Q8K0L0), ATX3L_HUMAN (Q9H3M9), ATX3_CAEBR  (Q60XN1), 
ATX3_CHICK  (Q9W689), ATX3_HUMAN  (P54252), ATX3_MOUSE  (Q9CVD2), 
ATX3_RAT    (O35815), DA1_ARATH   (P0C7Q8), DAR1_ARATH  (Q8W4F0), 
DAR6_ARATH  (Q9FJX8), DNJB2_HUMAN (P25686), DNJB2_MOUSE (Q9QYI5), 
ENT1_SCHPO  (O74423), ENT1_YEAST  (Q12518), ENT2_YEAST  (Q05785), 
EP15R_MOUSE (Q60902), EPN1_HUMAN  (Q9Y6I3), EPN1_MOUSE  (Q80VP1), 
EPN1_RAT    (O88339), EPN2_HUMAN  (O95208), EPN2_MOUSE  (Q8CHU3), 
EPN2_RAT    (Q9Z1Z3), EPN3_HUMAN  (Q9H201), EPN3_MOUSE  (Q91W69), 
EPN3_RAT    (Q4V882), EPS15_HUMAN (P42566), EPS15_MOUSE (P42567), 
HGS_BOVIN   (Q0V8S0), HGS_HUMAN   (O14964), HGS_MOUSE   (Q99LI8), 
HGS_RAT     (Q9JJ50), HRS_DROME   (Q960X8), HSE1_ASHGO  (Q75DS3), 
HSE1_CANAL  (Q5A895), HSE1_CANGA  (Q6FN49), HSE1_CHAGB  (Q2GT05), 
HSE1_CRYNB  (P0CR79), HSE1_CRYNJ  (P0CR78), HSE1_DEBHA  (Q6BNP6), 
HSE1_KLULA  (Q6CVA8), HSE1_MAGO7  (A4RF61), HSE1_NEUCR  (Q7S6J4), 
HSE1_PICST  (A3LXQ8), HSE1_SCHPO  (O74749), HSE1_YARLI  (Q6C2N2), 
HSE1_YEAST  (P38753), MAT1_HUMAN  (P51948), MAT1_MOUSE  (P51949), 
MAT1_XENLA  (P51951), POF10_SCHPO (Q9P7W4), PSMD4_ARATH (P55034), 
PSMD4_BOVIN (Q58DA0), PSMD4_DICDI (Q553E0), PSMD4_DROME (P55035), 
PSMD4_HUMAN (P55036), PSMD4_MOUSE (O35226), PSMD4_SCHMA (O17453), 
RAD13_SCHPO (P28706), RN166_CHICK (Q5F3B2), RN166_XENLA (Q3KPU8), 
RPN10_SCHPO (O94444), RPN10_YEAST (P38886), SPP41_YEAST (P38904), 
STAM1_CAEEL (O01498), STAM1_HUMAN (Q92783), STAM1_MOUSE (P70297), 
STAM2_CHICK (O93436), STAM2_HUMAN (O75886), STAM2_MOUSE (O88811), 
STAM2_RAT   (Q5XHY7), UBP25_HUMAN (Q9UHP3), UBP25_MOUSE (P57080), 
UBP37_BOVIN (F1N5V1), UBP37_CANFA (E2RK09), UBP37_CHICK (E1C213), 
UBP37_DANRE (E7F6T8), UBP37_HUMAN (Q86T82), UBP37_MOUSE (Q8C0R0), 
UBP37_PIG   (F1SRY5), UBXN7_DICDI (Q55BU7), UFO1_YEAST  (Q04511), 
UIMC1_HUMAN (Q96RL1), UIMC1_MOUSE (Q5U5Q9), UIMC1_PIG   (A0P8Z5), 
UIMC1_RAT   (Q5PQK4), UIMC1_XENTR (A0JM80), UPL1_ARATH  (Q8GY23), 
UPL2_ARATH  (Q8H0T4), VPS27_ASHGO (Q755J9), VPS27_ASPCL (A1CEK1), 
VPS27_ASPFU (Q4WHN8), VPS27_ASPNC (A2QWA2), VPS27_ASPTN (Q0CJV3), 
VPS27_CANAL (Q5ABD9), VPS27_CANGA (Q6FQJ1), VPS27_CHAGB (Q2GS33), 
VPS27_CRYNB (P0CS27), VPS27_CRYNJ (P0CS26), VPS27_DEBHA (Q6BSD6), 
VPS27_EMENI (Q5BBK9), VPS27_KLULA (Q6CL17), VPS27_MAGO7 (A4QTV1), 
VPS27_NEOFI (A1DFP5), VPS27_NEUCR (Q7RZJ2), VPS27_PHANO (Q0U4Z8), 
VPS27_PICST (A3LX75), VPS27_SCHPO (O13821), VPS27_YARLI (Q6CFT4), 
VPS27_YEAST (P40343), ZFN2B_HUMAN (Q8WV99), ZFN2B_MOUSE (Q91X58), 
ZFN2B_RAT   (Q4KLG9)
» More

UniProtKB/Swiss-Prot
False negative sequences
35 sequences

ASB2_BOVIN  (Q3SX45), ASB2_RAT    (Q5U2S6), ATX3H_ARATH (Q9M391), 
ATX3_CAEEL  (O17850), ATX3_ORYSJ  (Q8LQ36), DAR2_ARATH  (Q0WSN2), 
DAR7_ARATH  (Q9FJX9), HSE1_ASPCL  (A1CEK6), HSE1_ASPFU  (Q4WHP5), 
HSE1_ASPNC  (A2QW93), HSE1_ASPTN  (Q0CJU8), HSE1_COCIM  (Q1E878), 
HSE1_EMENI  (Q5BBL4), HSE1_NEOFI  (A1DFN5), HSE1_PHANO  (Q0U6X7), 
HSE1_USTMA  (Q4P5J4), HUWE1_HUMAN (Q7Z6Z7), HUWE1_MOUSE (Q7TMY8), 
IGBP1_HUMAN (P78318), IGBP1_MOUSE (Q61249), IGBP1_RAT   (O08836), 
OTUD1_HUMAN (Q5VV17), OTUD1_MOUSE (Q9CUB6), PIPSL_HUMAN (A2A3N6), 
RBNS5_HUMAN (Q9H1K0), RBNS5_MOUSE (Q80Y56), RN166_HUMAN (Q96A37), 
RN166_MOUSE (Q3U9F6), RN166_RAT   (Q6J1I7), UBP28_CHICK (Q5ZID5), 
UBP28_HUMAN (Q96RU2), UBP28_MOUSE (Q5I043), UBP28_RAT   (D3ZJ96), 
VPS27_USTMA (Q4P7Q1), Y3893_DICDI (Q54QG5)
» More

UniProtKB/Swiss-Prot
False positive sequences
3 sequences

MPH1_ASPNC  (A2Q8R2), MPH1_ASPTN  (Q0CWI2), MPH1_NEOFI  (A1D4V5)

		
PDB
[Detailed view]
18 PDB

1O06; 1P9C; 1P9D; 1Q0V; 1Q0W; 1UEL; 1YX4; 1YX5; 1YX6; 2D3G; 2KDE; 2KDF; 2KDI; 2KLZ; 2MKF; 2MKG; 2RR9; 3A1Q
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