Entry: PS50330

General information about the entry

Entry name [info] UIM
Accession [info] PS50330
Entry type [info] MATRIX
Date [info] MAY-2003 (CREATED); OCT-2013 (DATA UPDATE); MAY-2016 (INFO UPDATE).
PROSITE Doc. [info] PDOC50330
Associated ProRule [info] PRU00213

Name and characterization of the entry

Description [info] Ubiquitin-interacting motif (UIM) domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=20;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=20;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.2009000; R2=0.0080229; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1468.8551025; R2=0.3444180; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=910; H_SCORE=1782; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=599; H_SCORE=1675; N_SCORE=6.0; MODE=1; TEXT='?';
/DEFAULT: B1=-128; E1=-128; MI=0; MD=0; IM=0; ID=0; DM=0; DI=0; M0=-15;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; IM=-76; II=-8; ID=-353;
/M: SY='E'; M= -66,-252,  61,  66, -17, -23,-179,-189, -32,-206,-173,  18,-164,  31,   8,  38,   6, -70,-183, -40;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='E'; M=-111,-251,  79,  98, -41,-167,-180, -77,-155, -98, -16, -38,-165, -24,-152,-111,-153,   4,-182,  36;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='D'; M= -93,-252, 103,  77,-212,-166,-179,-189, -40,-206,-174, -23,-165,  17,-151,  -4, -58,-192,-183,-178;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='E'; M=  29,-252,  38,  91,-212,-166,-179,-189, -50,  -7, -19, -25,  16,  17,-151,-151,-152, -15,-183,-178;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='Q'; M= -80,-252,  67,  61,-212,-166,-179,  -4,-153,  18,  65, -15,-165,  73,  33,-151,-152,-192,-183,-178;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='L'; M=-208,-220,-251,-258,  21,-224,-218,  69,-314,  88,   9,-238,-228,-240,-230,-226,-205,-178,-165,  44;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='Q'; M=  51,-252,   2,  49,-212,-166,-179,-189, -27, -44,  29,-138,-165,  91,  22, -44,-152,-192,-183,-178;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='M'; M=   3, -10,-134, -17,-111,-166,-180, -39,  29,  37,  72,-138,-165,  55,  55,-151, -41,-192,  41,  27;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='A'; M= 101,-227,-180,-184,-178,-198,-203,-166,-203,-183,-159,-181,-198,-189,-190,-188,-121,  17,-169,-172;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='I'; M=-176,-237,-152,-156,-191,-180,-190,  94, -50,  70,  62,-155,-179, -16,-167,-166, -18,  13,-175,-175;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='E'; M=  43,-252,-133,  73,-212,-166,-179,-189,  -4, -42,  16, -43,-165,  64,  40,  -5, -44,-192,-183,-178;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='M'; M=  -4,-237,-153,  72,-190,-180,-190,   4,-174,  56, 111,-156,-180,  24,-168,-167,-166, -28,-175, -96;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='S'; M= -51,-241,-145, -40,-196,-175,-186,-179,-166,-196,-168,-149,-174,-158,-162, 113,-161,-188,-178,-176;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='M'; M= -28,-252,-134,  11,-212,-166,-179,-189,  33,  62,  93,-138,-165,  18,  42,-151, -54, -12,-183,-178;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='E'; M= -10,-252, -34,  65,-113, -33, -28, -20,  40, -27, -33, -37,-165,  65,  23, -10, -52, -62,-183,-178;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='E'; M= -40,-252,  61,  96,-212, -23,-179, -72,-153, -92, -39,  30,-165,  -4,-151, -42,  10, -46,-183, -73;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='E'; M=  31, -93, -40,  48,  14, -48, -26, -39,  -5, -30,  34,  12, -20,  39,-151,   9,  -8, -17,-183,  -3;
/I:         MI=-419; MD=-340; IM=-76; II=-8; ID=-355; DM=-43; DI=-228; DD=-21;
/M: SY='E'; M=  -9,-250, -20,  74,-209,   8,-177,-187,  -9,-203, -56,  47,  -4,  18,  29,  10, -21, -38,-180,-175;
/I:         MI=-419; MD=-340; IM=-76; II=-8; ID=-355; DM=-43; DI=-228; DD=-21;
/M: SY='M'; M=  -2,-250,   9,  56, -63, -40,  -7,-186,  29, -28,  58,   6,   5,  35,   7,  -4, -24,-189,-180, -38;
/I:         MI=-419; MD=-340; IM=-76; II=-8; ID=-355; DM=-43; DI=-228; DD=-21;
/M: SY='R'; M=  -9,-249,  29,  19, -50,  12, -35, -30,  -9, -82,-170, -22,  13,   0,  63,  24, -32, -13,  19,-175;
/I:         E1=0; MI=-419; II=-8; DI=-189;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2016_06 which contains 551'385 sequence entries.


Total number of hits 207 in 128 different sequences
Number of true positive hits 204 in 125 different sequences
Number of 'unknown' hits 0
Number of false positive hits 3 in 3 different sequences
Number of false negative sequences 38
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 98.55 %
Recall (true positives / (true positives + false negatives)) 84.30 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 3
Feature key [info] DOMAIN
Feature description [info] UIM
Version [info] 4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
125 sequences

AKIB1_DANRE (Q1L8G6    ), AKIB1_HUMAN (Q9P2G1    ), AKIB1_MOUSE (Q6ZPS6    ), 
AN13A_HUMAN (Q8IZ07    ), AN13A_MOUSE (Q80UP5    ), AN13B_HUMAN (Q86YJ7    ), 
AN13B_MOUSE (Q5F259    ), AN13D_HUMAN (Q6ZTN6    ), AN13D_MOUSE (Q6PD24    ), 
ASB2_MOUSE  (Q8K0L0    ), ATX3L_HUMAN (Q9H3M9    ), ATX3_CAEBR  (Q60XN1    ), 
ATX3_CHICK  (Q9W689    ), ATX3_HUMAN  (P54252    ), ATX3_MOUSE  (Q9CVD2    ), 
ATX3_RAT    (O35815    ), DA1_ARATH   (P0C7Q8    ), DAR1_ARATH  (Q8W4F0    ), 
DAR6_ARATH  (Q9FJX8    ), DNJB2_HUMAN (P25686    ), DNJB2_MOUSE (Q9QYI5    ), 
ENT1_SCHPO  (O74423    ), ENT1_YEAST  (Q12518    ), ENT2_YEAST  (Q05785    ), 
EP15R_MOUSE (Q60902    ), EPN1_HUMAN  (Q9Y6I3    ), EPN1_MOUSE  (Q80VP1    ), 
EPN1_RAT    (O88339    ), EPN2_HUMAN  (O95208    ), EPN2_MOUSE  (Q8CHU3    ), 
EPN2_RAT    (Q9Z1Z3    ), EPN3_HUMAN  (Q9H201    ), EPN3_MOUSE  (Q91W69    ), 
EPN3_RAT    (Q4V882    ), EPS15_HUMAN (P42566    ), EPS15_MOUSE (P42567    ), 
HGS_BOVIN   (Q0V8S0    ), HGS_HUMAN   (O14964    ), HGS_MOUSE   (Q99LI8    ), 
HGS_RAT     (Q9JJ50    ), HRS_DROME   (Q960X8    ), HSE1_ASHGO  (Q75DS3    ), 
HSE1_CANAL  (Q5A895    ), HSE1_CANGA  (Q6FN49    ), HSE1_CHAGB  (Q2GT05    ), 
HSE1_CRYNB  (P0CR79    ), HSE1_CRYNJ  (P0CR78    ), HSE1_DEBHA  (Q6BNP6    ), 
HSE1_KLULA  (Q6CVA8    ), HSE1_MAGO7  (A4RF61    ), HSE1_NEUCR  (Q7S6J4    ), 
HSE1_PICST  (A3LXQ8    ), HSE1_SCHPO  (O74749    ), HSE1_YARLI  (Q6C2N2    ), 
HSE1_YEAST  (P38753    ), MAT1_HUMAN  (P51948    ), MAT1_MOUSE  (P51949    ), 
MAT1_XENLA  (P51951    ), PIKI1_CAEEL (G5EDY0    ), POF10_SCHPO (Q9P7W4    ), 
PSMD4_ARATH (P55034    ), PSMD4_BOVIN (Q58DA0    ), PSMD4_DICDI (Q553E0    ), 
PSMD4_DROME (P55035    ), PSMD4_HUMAN (P55036    ), PSMD4_MOUSE (O35226    ), 
PSMD4_SCHMA (O17453    ), PUX7_ARATH  (Q94JZ8    ), PUX8_ARATH  (F4JPR7    ), 
PUX9_ARATH  (Q4V3D3    ), RAD13_SCHPO (P28706    ), RN166_CHICK (Q5F3B2    ), 
RN166_XENLA (Q3KPU8    ), RPN10_SCHPO (O94444    ), RPN10_YEAST (P38886    ), 
SPP41_YEAST (P38904    ), STAM1_CAEEL (O01498    ), STAM1_HUMAN (Q92783    ), 
STAM1_MOUSE (P70297    ), STAM2_CHICK (O93436    ), STAM2_HUMAN (O75886    ), 
STAM2_MOUSE (O88811    ), STAM2_RAT   (Q5XHY7    ), UBP25_HUMAN (Q9UHP3    ), 
UBP25_MOUSE (P57080    ), UBP37_BOVIN (F1N5V1    ), UBP37_CANLF (E2RK09    ), 
UBP37_CHICK (E1C213    ), UBP37_DANRE (E7F6T8    ), UBP37_HUMAN (Q86T82    ), 
UBP37_MOUSE (Q8C0R0    ), UBP37_PIG   (F1SRY5    ), UBXN7_DICDI (Q55BU7    ), 
UFO1_YEAST  (Q04511    ), UIMC1_HUMAN (Q96RL1    ), UIMC1_MOUSE (Q5U5Q9    ), 
UIMC1_PIG   (A0P8Z5    ), UIMC1_RAT   (Q5PQK4    ), UIMC1_XENTR (A0JM80    ), 
UPL1_ARATH  (Q8GY23    ), UPL2_ARATH  (Q8H0T4    ), VPS27_ASHGO (Q755J9    ), 
VPS27_ASPCL (A1CEK1    ), VPS27_ASPFU (Q4WHN8    ), VPS27_ASPNC (A2QWA2    ), 
VPS27_ASPTN (Q0CJV3    ), VPS27_CANAL (Q5ABD9    ), VPS27_CANGA (Q6FQJ1    ), 
VPS27_CHAGB (Q2GS33    ), VPS27_CRYNB (P0CS27    ), VPS27_CRYNJ (P0CS26    ), 
VPS27_DEBHA (Q6BSD6    ), VPS27_EMENI (Q5BBK9    ), VPS27_KLULA (Q6CL17    ), 
VPS27_MAGO7 (A4QTV1    ), VPS27_NEOFI (A1DFP5    ), VPS27_NEUCR (Q7RZJ2    ), 
VPS27_PHANO (Q0U4Z8    ), VPS27_PICST (A3LX75    ), VPS27_SCHPO (O13821    ), 
VPS27_YARLI (Q6CFT4    ), VPS27_YEAST (P40343    ), ZFN2B_HUMAN (Q8WV99    ), 
ZFN2B_MOUSE (Q91X58    ), ZFN2B_RAT   (Q4KLG9    )
» more

UniProtKB/Swiss-Prot
False negative sequences
38 sequences

ASB2_BOVIN  (Q3SX45    ), ASB2_RAT    (Q5U2S6    ), ATX3H_ARATH (Q9M391    ), 
ATX3_CAEEL  (O17850    ), ATX3_ORYSJ  (Q8LQ36    ), DAR2_ARATH  (Q0WSN2    ), 
DAR7_ARATH  (Q9FJX9    ), HSE1_ASPCL  (A1CEK6    ), HSE1_ASPFU  (Q4WHP5    ), 
HSE1_ASPNC  (A2QW93    ), HSE1_ASPTN  (Q0CJU8    ), HSE1_COCIM  (Q1E878    ), 
HSE1_EMENI  (Q5BBL4    ), HSE1_NEOFI  (A1DFN5    ), HSE1_PHANO  (Q0U6X7    ), 
HSE1_USTMA  (Q4P5J4    ), HUWE1_HUMAN (Q7Z6Z7    ), HUWE1_MOUSE (Q7TMY8    ), 
IGBP1_HUMAN (P78318    ), IGBP1_MOUSE (Q61249    ), IGBP1_RAT   (O08836    ), 
OTUD1_HUMAN (Q5VV17    ), OTUD1_MOUSE (Q9CUB6    ), PIPSL_HUMAN (A2A3N6    ), 
RBNS5_HUMAN (Q9H1K0    ), RBNS5_MOUSE (Q80Y56    ), RN166_HUMAN (Q96A37    ), 
RN166_MOUSE (Q3U9F6    ), RN166_RAT   (Q6J1I7    ), UBP28_CHICK (Q5ZID5    ), 
UBP28_HUMAN (Q96RU2    ), UBP28_MOUSE (Q5I043    ), UBP28_RAT   (D3ZJ96    ), 
UBXN7_HUMAN (O94888    ), UBXN7_MOUSE (Q6P5G6    ), UBXN7_PONAB (Q5REY7    ), 
VPS27_USTMA (Q4P7Q1    ), Y3893_DICDI (Q54QG5    )
» more

UniProtKB/Swiss-Prot
False positive sequences
3 sequences

MPH1_ASPNC  (A2Q8R2    ), MPH1_ASPTN  (Q0CWI2    ), MPH1_NEOFI  (A1D4V5    )

		
PDB
[Detailed view]
20 PDB

1O06; 1P9C; 1P9D; 1Q0V; 1Q0W; 1UEL; 1YX4; 1YX5; 1YX6; 2D3G; 2KDE; 2KDF; 2KDI; 2KLZ; 2MKF; 2MKG; 2MUX; 2RR9; 3A1Q; 4XKH
» more

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