Entry: PS50330

General information about the entry

Entry name [info] UIM
Accession [info] PS50330
Entry type [info] MATRIX
Date [info] MAY-2003 (CREATED); OCT-2013 (DATA UPDATE); JUN-2015 (INFO UPDATE).
PROSITE Doc. [info] PDOC50330
Associated ProRule [info] PRU00213

Name and characterization of the entry

Description [info] Ubiquitin-interacting motif (UIM) domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=20;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=20;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.2009; R2=0.00802289; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1070.62651; R2=9.43373; TEXT='HScore';
/CUT_OFF: LEVEL=0; SCORE=909; N_SCORE=8.5; H_SCORE=8476; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=599; N_SCORE=6.0; H_SCORE=6712; MODE=1; TEXT='?';
/DEFAULT: B1=-128; E1=-128; MI=0; MD=0; IM=0; ID=0; DM=0; DI=0; M0=-15;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; IM=-76; II=-8; ID=-353;
/M: SY='E'; M= -66,-252,  61,  66, -17, -23,-179,-189, -32,-206,-173,  18,-164,  31,   8,  38,   6, -70,-183, -40;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='E'; M=-111,-251,  79,  98, -41,-167,-180, -77,-155, -98, -16, -38,-165, -24,-152,-111,-153,   4,-182,  36;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='D'; M= -93,-252, 103,  77,-212,-166,-179,-189, -40,-206,-174, -23,-165,  17,-151,  -4, -58,-192,-183,-178;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='E'; M=  29,-252,  38,  91,-212,-166,-179,-189, -50,  -7, -19, -25,  16,  17,-151,-151,-152, -15,-183,-178;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='Q'; M= -80,-252,  67,  61,-212,-166,-179,  -4,-153,  18,  65, -15,-165,  73,  33,-151,-152,-192,-183,-178;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='L'; M=-208,-220,-251,-258,  21,-224,-218,  69,-314,  88,   9,-238,-228,-240,-230,-226,-205,-178,-165,  44;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='Q'; M=  51,-252,   2,  49,-212,-166,-179,-189, -27, -44,  29,-138,-165,  91,  22, -44,-152,-192,-183,-178;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='M'; M=   3, -10,-134, -17,-111,-166,-180, -39,  29,  37,  72,-138,-165,  55,  55,-151, -41,-192,  41,  27;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='A'; M= 101,-227,-180,-184,-178,-198,-203,-166,-203,-183,-159,-181,-198,-189,-190,-188,-121,  17,-169,-172;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='I'; M=-176,-237,-152,-156,-191,-180,-190,  94, -50,  70,  62,-155,-179, -16,-167,-166, -18,  13,-175,-175;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='E'; M=  43,-252,-133,  73,-212,-166,-179,-189,  -4, -42,  16, -43,-165,  64,  40,  -5, -44,-192,-183,-178;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='M'; M=  -4,-237,-153,  72,-190,-180,-190,   4,-174,  56, 111,-156,-180,  24,-168,-167,-166, -28,-175, -96;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='S'; M= -51,-241,-145, -40,-196,-175,-186,-179,-166,-196,-168,-149,-174,-158,-162, 113,-161,-188,-178,-176;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='M'; M= -28,-252,-134,  11,-212,-166,-179,-189,  33,  62,  93,-138,-165,  18,  42,-151, -54, -12,-183,-178;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='E'; M= -10,-252, -34,  65,-113, -33, -28, -20,  40, -27, -33, -37,-165,  65,  23, -10, -52, -62,-183,-178;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='E'; M= -40,-252,  61,  96,-212, -23,-179, -72,-153, -92, -39,  30,-165,  -4,-151, -42,  10, -46,-183, -73;
/I:         MI=-423; MD=-343; IM=-76; II=-8; ID=-356; DM=-43; DI=-230; DD=-21;
/M: SY='E'; M=  31, -93, -40,  48,  14, -48, -26, -39,  -5, -30,  34,  12, -20,  39,-151,   9,  -8, -17,-183,  -3;
/I:         MI=-419; MD=-340; IM=-76; II=-8; ID=-355; DM=-43; DI=-228; DD=-21;
/M: SY='E'; M=  -9,-250, -20,  74,-209,   8,-177,-187,  -9,-203, -56,  47,  -4,  18,  29,  10, -21, -38,-180,-175;
/I:         MI=-419; MD=-340; IM=-76; II=-8; ID=-355; DM=-43; DI=-228; DD=-21;
/M: SY='M'; M=  -2,-250,   9,  56, -63, -40,  -7,-186,  29, -28,  58,   6,   5,  35,   7,  -4, -24,-189,-180, -38;
/I:         MI=-419; MD=-340; IM=-76; II=-8; ID=-355; DM=-43; DI=-228; DD=-21;
/M: SY='R'; M=  -9,-249,  29,  19, -50,  12, -35, -30,  -9, -82,-170, -22,  13,   0,  63,  24, -32, -13,  19,-175;
/I:         E1=0; MI=-419; II=-8; DI=-189;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2015_08 which contains 320'201 sequence entries.


Total number of hits 206 in 127 different sequences
Number of true positive hits 203 in 124 different sequences
Number of 'unknown' hits 0
Number of false positive hits 3 in 3 different sequences
Number of false negative sequences 38
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 98.54 %
Recall (true positives / (true positives + false negatives)) 84.23 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 3
Feature key [info] DOMAIN
Feature description [info] UIM
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
124 sequences

AKIB1_DANRE (Q1L8G6), AKIB1_HUMAN (Q9P2G1), AKIB1_MOUSE (Q6ZPS6), 
AN13A_HUMAN (Q8IZ07), AN13A_MOUSE (Q80UP5), AN13B_HUMAN (Q86YJ7), 
AN13B_MOUSE (Q5F259), AN13D_HUMAN (Q6ZTN6), AN13D_MOUSE (Q6PD24), 
ASB2_MOUSE  (Q8K0L0), ATX3L_HUMAN (Q9H3M9), ATX3_CAEBR  (Q60XN1), 
ATX3_CHICK  (Q9W689), ATX3_HUMAN  (P54252), ATX3_MOUSE  (Q9CVD2), 
ATX3_RAT    (O35815), DA1_ARATH   (P0C7Q8), DAR1_ARATH  (Q8W4F0), 
DAR6_ARATH  (Q9FJX8), DNJB2_HUMAN (P25686), DNJB2_MOUSE (Q9QYI5), 
ENT1_SCHPO  (O74423), ENT1_YEAST  (Q12518), ENT2_YEAST  (Q05785), 
EP15R_MOUSE (Q60902), EPN1_HUMAN  (Q9Y6I3), EPN1_MOUSE  (Q80VP1), 
EPN1_RAT    (O88339), EPN2_HUMAN  (O95208), EPN2_MOUSE  (Q8CHU3), 
EPN2_RAT    (Q9Z1Z3), EPN3_HUMAN  (Q9H201), EPN3_MOUSE  (Q91W69), 
EPN3_RAT    (Q4V882), EPS15_HUMAN (P42566), EPS15_MOUSE (P42567), 
HGS_BOVIN   (Q0V8S0), HGS_HUMAN   (O14964), HGS_MOUSE   (Q99LI8), 
HGS_RAT     (Q9JJ50), HRS_DROME   (Q960X8), HSE1_ASHGO  (Q75DS3), 
HSE1_CANAL  (Q5A895), HSE1_CANGA  (Q6FN49), HSE1_CHAGB  (Q2GT05), 
HSE1_CRYNB  (P0CR79), HSE1_CRYNJ  (P0CR78), HSE1_DEBHA  (Q6BNP6), 
HSE1_KLULA  (Q6CVA8), HSE1_MAGO7  (A4RF61), HSE1_NEUCR  (Q7S6J4), 
HSE1_PICST  (A3LXQ8), HSE1_SCHPO  (O74749), HSE1_YARLI  (Q6C2N2), 
HSE1_YEAST  (P38753), MAT1_HUMAN  (P51948), MAT1_MOUSE  (P51949), 
MAT1_XENLA  (P51951), POF10_SCHPO (Q9P7W4), PSMD4_ARATH (P55034), 
PSMD4_BOVIN (Q58DA0), PSMD4_DICDI (Q553E0), PSMD4_DROME (P55035), 
PSMD4_HUMAN (P55036), PSMD4_MOUSE (O35226), PSMD4_SCHMA (O17453), 
PUX7_ARATH  (Q94JZ8), PUX8_ARATH  (F4JPR7), PUX9_ARATH  (Q4V3D3), 
RAD13_SCHPO (P28706), RN166_CHICK (Q5F3B2), RN166_XENLA (Q3KPU8), 
RPN10_SCHPO (O94444), RPN10_YEAST (P38886), SPP41_YEAST (P38904), 
STAM1_CAEEL (O01498), STAM1_HUMAN (Q92783), STAM1_MOUSE (P70297), 
STAM2_CHICK (O93436), STAM2_HUMAN (O75886), STAM2_MOUSE (O88811), 
STAM2_RAT   (Q5XHY7), UBP25_HUMAN (Q9UHP3), UBP25_MOUSE (P57080), 
UBP37_BOVIN (F1N5V1), UBP37_CANFA (E2RK09), UBP37_CHICK (E1C213), 
UBP37_DANRE (E7F6T8), UBP37_HUMAN (Q86T82), UBP37_MOUSE (Q8C0R0), 
UBP37_PIG   (F1SRY5), UBXN7_DICDI (Q55BU7), UFO1_YEAST  (Q04511), 
UIMC1_HUMAN (Q96RL1), UIMC1_MOUSE (Q5U5Q9), UIMC1_PIG   (A0P8Z5), 
UIMC1_RAT   (Q5PQK4), UIMC1_XENTR (A0JM80), UPL1_ARATH  (Q8GY23), 
UPL2_ARATH  (Q8H0T4), VPS27_ASHGO (Q755J9), VPS27_ASPCL (A1CEK1), 
VPS27_ASPFU (Q4WHN8), VPS27_ASPNC (A2QWA2), VPS27_ASPTN (Q0CJV3), 
VPS27_CANAL (Q5ABD9), VPS27_CANGA (Q6FQJ1), VPS27_CHAGB (Q2GS33), 
VPS27_CRYNB (P0CS27), VPS27_CRYNJ (P0CS26), VPS27_DEBHA (Q6BSD6), 
VPS27_EMENI (Q5BBK9), VPS27_KLULA (Q6CL17), VPS27_MAGO7 (A4QTV1), 
VPS27_NEOFI (A1DFP5), VPS27_NEUCR (Q7RZJ2), VPS27_PHANO (Q0U4Z8), 
VPS27_PICST (A3LX75), VPS27_SCHPO (O13821), VPS27_YARLI (Q6CFT4), 
VPS27_YEAST (P40343), ZFN2B_HUMAN (Q8WV99), ZFN2B_MOUSE (Q91X58), 
ZFN2B_RAT   (Q4KLG9)
» More

UniProtKB/Swiss-Prot
False negative sequences
38 sequences

ASB2_BOVIN  (Q3SX45), ASB2_RAT    (Q5U2S6), ATX3H_ARATH (Q9M391), 
ATX3_CAEEL  (O17850), ATX3_ORYSJ  (Q8LQ36), DAR2_ARATH  (Q0WSN2), 
DAR7_ARATH  (Q9FJX9), HSE1_ASPCL  (A1CEK6), HSE1_ASPFU  (Q4WHP5), 
HSE1_ASPNC  (A2QW93), HSE1_ASPTN  (Q0CJU8), HSE1_COCIM  (Q1E878), 
HSE1_EMENI  (Q5BBL4), HSE1_NEOFI  (A1DFN5), HSE1_PHANO  (Q0U6X7), 
HSE1_USTMA  (Q4P5J4), HUWE1_HUMAN (Q7Z6Z7), HUWE1_MOUSE (Q7TMY8), 
IGBP1_HUMAN (P78318), IGBP1_MOUSE (Q61249), IGBP1_RAT   (O08836), 
OTUD1_HUMAN (Q5VV17), OTUD1_MOUSE (Q9CUB6), PIPSL_HUMAN (A2A3N6), 
RBNS5_HUMAN (Q9H1K0), RBNS5_MOUSE (Q80Y56), RN166_HUMAN (Q96A37), 
RN166_MOUSE (Q3U9F6), RN166_RAT   (Q6J1I7), UBP28_CHICK (Q5ZID5), 
UBP28_HUMAN (Q96RU2), UBP28_MOUSE (Q5I043), UBP28_RAT   (D3ZJ96), 
UBXN7_HUMAN (O94888), UBXN7_MOUSE (Q6P5G6), UBXN7_PONAB (Q5REY7), 
VPS27_USTMA (Q4P7Q1), Y3893_DICDI (Q54QG5)
» More

UniProtKB/Swiss-Prot
False positive sequences
3 sequences

MPH1_ASPNC  (A2Q8R2), MPH1_ASPTN  (Q0CWI2), MPH1_NEOFI  (A1D4V5)

		
PDB
[Detailed view]
18 PDB

1O06; 1P9C; 1P9D; 1Q0V; 1Q0W; 1UEL; 1YX4; 1YX5; 1YX6; 2D3G; 2KDE; 2KDF; 2KDI; 2KLZ; 2MKF; 2MKG; 2RR9; 3A1Q
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