PROSITE entry PS50818

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General information about the entry

Entry name [info]	INTEIN_C_TER
Accession [info]	PS50818
Entry type [info]	MATRIX
Date [info]	01-MAY-2002 CREATED; 10-MAY-2017 DATA UPDATE; 27-MAR-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00687

Name and characterization of the entry

Description [info]

Intein C-terminal splicing motif profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=22;
/DISJOINT: DEFINITION=PROTECT; N1=3; N2=20;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.8533000; R2=0.0226396; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=656.6232910; R2=0.7982063; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=290; H_SCORE=888; N_SCORE=7.4; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=250; H_SCORE=856; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-8; D=-20; I=-20; B0=-60; B1=-60; E0=-60; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B0=0; B1=0; BI=-105; BD=-105;
/M: SY='Y';  M=-15,-11,-29, -9, -6,  3,-23, -5,-14, -1,-13,-10,-10, -2, -9,  0,-12, -8,-15, -5, 12, -9;
/M: SY='V';  M=  1,-25,-13,-27,-26, -1,-24,-27, 20,-18,  7,  6,-24,-26,-25,-17, -8,  1, 34,-27, -9,-26;
/M: SY='Y';  M=-19,-17,-28,-18,-17, 29,-28,  9, -2,-11, -1, -1,-16,-27,-11, -9,-18,-10, -9, 17, 55,-17;
/M: SY='D';  M=-13, 27, -1, 33,  5,-29,-12, -6,-30, -8,-25,-23, 15,-17, -6,-12,  4, -3,-22,-41,-21, -1;
/M: SY='L';  M= -6,-25,-20,-27,-22,  3,-30,-24, 23,-25, 26, 13,-24,-25,-21,-21,-18, -4, 20,-23, -3,-23;
/M: SY='T';  M= -1,  1,-18, -1,  4,-16,-10,-10,-14, -7,-16,-13,  3,-12, -3, -9, 11, 12, -9,-28,-11,  0;
/M: SY='V';  M=  3,-18, -3,-21,-22, -8,-21,-25, 10,-18,  1,  0,-17,-24,-22,-19, -4,  4, 23,-30,-13,-22;
/I:         I=-5; MD=-27;
/M: SY='E';  M=-10,  0,-25,  7, 15,-17,-19, -7,-21,  2,-19,-15, -5, 11,  0, -6, -6, -9,-21,-21, -9,  6; D=-5;
/I:         I=-5; MD=-27;
/M: SY='N';  M= -2, 10,-17,  7,  0,-18,  5, -1,-18, -2,-18,-12, 13,-11, -3, -3,  2, -3,-16,-22,-13, -2; D=-5;
/I:         I=-5; MI=-27; MD=-27; IM=-27; DM=-27;
/M: SY='H';  M=-12,  0,-26,  1,  5,-22, -6, 42,-25, -8,-18, -6,  5,-16,  7, -4, -4,-13,-24,-27,  0,  4; D=-5;
/I:         I=-5; DM=-27;
/M: SY='N';  M= -5, 14,-19,  2, -5,-10, -8, -2,-13, -4,-15,-11, 27,-20, -5, -2,  3,  0,-17,-30,-13, -5;
/M: SY='F';  M=-16,-25,-24,-30,-25, 40,-25, -8,  5,-22,  9,  3,-20,-29,-25,-17,-20,-10,  0,  8, 37,-25;
/I:         I=-6; MD=-32;
/M: SY='V';  M= -6,-27,-18,-30,-25,  7,-30,-20, 24,-24, 18, 12,-23,-26,-23,-20,-16, -4, 25,-21, -1,-25; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='A';  M= 15,-14,-14,-20,-15, -7,-14,-20,  1,-15, -2, -3,-12,-17,-13,-17,  4,  8,  8,-23,-11,-14;
/I:         I=-5; MD=-25;
/M: SY='N';  M= -1,  8,-22,  1, -3,-17,  1, -4,-18, -4,-20,-14, 15,-15, -5, -3,  1, -6,-17,-22,-12, -5; D=-5;
/I:         I=-5; MD=-25;
/M: SY='G';  M= -5, -1,-21, -5, -7,-13, 14, -8,-19, -9,-17,-12,  6,-16, -7, -8,  2, -5,-17,-19,-11, -7; D=-5;
/I:         I=-5; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='I';  M= -6,-28,-15,-34,-27,  9,-30,-27, 27,-27, 16, 11,-22,-25,-24,-25,-17, -8, 22,-20, -1,-27;
/M: SY='V';  M= -6,-28,-20,-31,-25,  8,-30,-24, 22,-23, 16, 11,-25,-23,-24,-21,-17, -5, 23,-15,  0,-25;
/M: SY='V';  M=  5,-15, -9,-20,-18, -7,-21,-23,  7,-16,  1, -1,-14,-20,-18,-17,  3, 14, 18,-29,-11,-18;
/M: SY='H';  M=-12, -3,-28, -3, -3,-20, -5, 62,-30, -7,-21, -5,  6,-19,  3, -2, -7,-17,-27,-26,  7, -3;
/M: SY='N';  M=-10, 35,-21, 17,  3,-23, -3, 10,-20,  1,-29,-17, 52,-19,  8,  1,  9, -1,-30,-37,-19,  5;
/M: SY='C';  M= -3,-11, 63,-18,-18,-18,-20,-23,-24,-21,-21,-18, -8,-27,-18,-21,  9,  8, -8,-44,-24,-18;
/I:         E0=0; E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_02 which contains 571'282 sequence entries.

Total number of hits	111 in 98 different sequences
Number of true positive hits	111 in 98 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	8
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	93.28 %

Comments [info]

Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Taxonomic range [info]	Archaea, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info]	3
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

98 sequences

DNAB_GUITH  (O78411), DNAB_MYCBO  (P59966), DNAB_MYCTO  (P9WMR2),

DNAB_MYCTU  (P9WMR3), DNAB_NEOYE  (Q1XDF3), DNAB_NOSS1  (Q8YZA1), 
DNAB_PORPU  (P51333), DNAB_RHOMR  (O30477), DNAB_SYNY3  (Q55418), 
DP2L_METHJ  (Q2FSF9), DP2L_METMJ  (A3CXE7), DP2L_PYRAB  (Q9V2F4), 
DP2L_PYRHO  (O57861), DP2L_THEKO  (Q5JET0), DPO3A_SYNY3 (P74750), 
DPOL_BPAPS  (Q9T1Q3), DPOL_CEV01  (A7U6F1), DPOL_METJA  (Q58295), 
DPOL_MIMIV  (Q5UQR0), DPOL_PYRHO  (O59610), DPOL_PYRSD  (Q51334), 
DPOL_THEAG  (O33845), DPOL_THEFM  (P74918), DPOL_THEG8  (Q9HH84), 
DPOL_THEHY  (Q9HH05), DPOL_THEKO  (P77933), DPOL_THELI  (P30317), 
EF2_METKA   (Q8TXJ4), GLMS_METJA  (Q58815), GYRA_MYCFV  (Q49166), 
GYRA_MYCGO  (Q49467), GYRA_MYCKA  (Q49608), GYRA_MYCLE  (Q57532), 
GYRA_MYCMA  (O33149), GYRA_MYCXE  (P72065), GYRB_SYNY3  (P77966), 
HELS_METJA  (Q58524), HELS_THEKO  (Q5JGV6), IF2P_METJA  (Q57710), 
IF2P_PYRAB  (Q9UZK7), IF2P_PYRFU  (Q8U1R8), IF2P_PYRHO  (O58822), 
IF2P_THEKO  (Q5JGR9), LONB_PYRAB  (Q9UYC6), LONB_PYRHO  (O58221), 
NDRZ_PYRFU  (E7FHX6), NRDEB_BACSU (O31875), NRDEB_BPSPB (O64173), 
PPSA_METJA  (Q57962), RADA_PYRHO  (O58001), RADA_THEKO  (Q5JET4), 
RECA_MYCBO  (P0A5U5), RECA_MYCCI  (Q9F417), RECA_MYCFA  (Q9F416), 
RECA_MYCFV  (Q9F415), RECA_MYCGS  (Q9F414), RECA_MYCLE  (P35901), 
RECA_MYCSH  (Q9F410), RECA_MYCT3  (Q9F407), RECA_MYCTO  (P9WHJ2), 
RECA_MYCTU  (P9WHJ3), RFCS_HALWD  (Q18E75), RFCS_METJA  (Q58817), 
RFCS_METKA  (Q8TZC4), RFCS_PYRAB  (Q9V2G4), RFCS_PYRFU  (Q8U4J3), 
RFCS_PYRHO  (O57852), RFCS_THEKO  (Q5JHP2), RGYR_METJA  (Q58907), 
RGYR_PYRHO  (O58530), RGYR_THEKO  (Q6F598), RIR2_AQUAE  (O67475), 
RPC2_DICDI  (Q54IZ9), RPO1C_METJA (Q58446), RPO1N_METJA (Q58445), 
RTCB_METJA  (Q58095), RTCB_METKA  (Q8TUS2), RTCB_PYRAB  (Q9V168), 
RTCB_PYRFU  (Q8U0H4), RTCB_PYRHO  (O59245), TF2B_METJA  (Q58192), 
TOP1_PYRFU  (O73954), VATA_PYRAB  (Q9UXU7), VATA_PYRFU  (Q8U4A6), 
VATA_PYRHO  (O57728), VATA_THEAC  (Q9P997), VATA_THEVO  (Q97CQ0), 
VATA_YEAST  (P17255), VATB_METKA  (Q8TUT0), Y043_METJA  (Q60348), 
Y1054_METJA (Q58454), Y1461_MYCTO (P9WFP6), Y1461_MYCTU (P9WFP7), 
Y1496_MYCBO (P67126), Y450_MYCPN  (Q50362), Y593_MYCLE  (Q49689), 
Y781_METJA  (Q58191), Y832_METJA  (Q58242)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

8 sequences

CLPP_CHLMO  (P42379), DNAB_MYCIT  (Q9F5P4), DNAB_MYCLE  (P46394),

DP2L_HALMA  (Q5UZ40), DP2L_HALSA  (Q9HMX8), DP2L_HALWD  (Q18ER3), 
RIR1_IIV6   (O55716), VATA_CANTR  (P38078)

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PDB
[Detailed view]

27 PDB

1AM2; 1DQ3; 1EF0; 1MI8; 2CW7; 2CW8; 2IMZ; 2IN0; 2IN9; 2L8L; 2LQM; 3IFJ; 3IGD; 4E2T; 4E2U; 4O1S; 4OZ6; 5BKH; 5I0A; 5K08; 5O9J; 5OL1; 5OL5; 6FRE; 6FRG; 6FRH; 7QST
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