Entry: PS50868

General information about the entry
Entry name POST_SET
Accession number PS50868
Entry type MATRIX
Date NOV-2002 (CREATED); NOV-2002 (DATA UPDATE); MAR-2013 (INFO UPDATE).
PROSITE Documentation PDOC50280
Associated ProRule PRU00155
Name and characterization of the entry
DescriptionPost-SET domain profile.
Matrix / Profile 
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=17;
/DISJOINT: DEFINITION=PROTECT; N1=2; N2=16;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.1220; R2=0.01638364; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=359; N_SCORE=8.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=267; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-11; D=-20; I=-20; B0=-60; B1=-60; E0=-60; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B0=0; B1=0; BI=-105; BD=-105;
/M: SY='E'; M= -7,  0,-25, -2,  6,-24,-16, -8,-17,  5,-17,-10,  1,-13,  2, -4, -2, -6,-11,-30,-18,  4;
/M: SY='K'; M= -4, -5,-26, -7,  5,-25,-14, -8,-25, 14,-20,-12, -5,-10,  6,  9, -3,-10,-19,-27,-16,  4;
/M: SY='M'; M=-10,-18,-20,-20, -9, -9,-28,-13, -2, -3,  0,  2,-16,-18,  0, -8,-11, -9, -1,-22, -7, -6;
/M: SY='P'; M= -9, -5,-26,  0,  1,-27,-19,-14,-22, -2,-22,-15, -8, 15, -2,-10, -4, -4,-16,-32,-22, -1;
/M: SY='C'; M=-40,-40,110,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40;
/M: SY='Y'; M=-13,-16,-19,-19, -9, -3,-25,  6,-13, -6, -7, -5, -8,-23, -2, -4, -9,-12,-14,-14,  9, -8;
/M: SY='C'; M=-40,-40,110,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40;
/M: SY='G'; M= -2, -7,-30, -8,-10,-30, 47,-17,-38,-10,-37,-27,  3,-19,-15,-15,  0,-18,-29,-22,-28,-14;
/M: SY='A'; M= 18, -9,-10, -9, -1,-19, -5,-13,-16, -4,-15,-11, -6,-11, -3, -7, 18,  6,-10,-28,-18, -2;
/M: SY='P'; M=  1,-10,-21, -7,  2,-26,-17,-15,-16,  0,-18,-12,-10,  4, -3, -8,  0, -1, -8,-32,-21,  0;
/M: SY='N'; M= -7,  5,-18, -4, -1,-22, -8, -2,-23,  2,-22,-14, 17,-18, -1, -1,  4, -4,-20,-30,-16, -1;
/M: SY='C'; M=-40,-40,110,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40;
/M: SY='R'; M= -7,-11,-24,-18, -3,-25,-20, -7,-20, 12,-14, -5, -3,-18,  5, 27, -4, -4,-19,-28,-18, -2;
/M: SY='G'; M= -3, -6,-29,-10,-11,-29, 31,-10,-35, -2,-33,-23,  3,-18,-10, -6,  0,-16,-27,-24,-24,-11;
/M: SY='Y'; M=-12,-23,-19,-25,-16,  8,-24, -9, -9,-10, -8, -4,-18,-26,-12,-11,-11, -7, -9,  3, 11,-16;
/M: SY='L'; M= -7,-34,-11,-34,-26, -1,-35,-27, 18,-17, 27, 18,-27,-27,-18,-19,-16, -9, 11,-21,-10,-25;
/M: SY='G'; M= -9, -6,-27,-10,-12,-16, 12, -9,-26,-12,-25,-18,  5,-16,-11,-12, -2,-13,-23,-21,-13,-12;
/I:         E0=0; E1=0; IE=-105; DE=-105;
Numerical results
  • UniProtKB/Swiss-Prot release number: 2013_05, total number of sequence entries in that release: 540052.
  • Total number of hits in UniProtKB/Swiss-Prot: 120 hits in 120 different sequences
  • Number of hits on proteins that are known to belong to the set under consideration: 120 hits in 120 different sequences
  • Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences
  • Number of false hits (on unrelated proteins): 0 hits in 0 different sequences
  • Number of known missed hits: 8
  • Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 0
  • Precision (true hits / (true hits + false positives)): 100.00 %
  • Recall (true hits / (true hits + false negatives)): 93.75 %
Comments
  • MATRIX_TYPE: protein_domain
  • Scaling database: UniProtKB/Swiss-Prot: window20_shuffled
  • Matrix author: N_Hulo
  • Taxonomic range: Eukaryotes
  • Maximum known number of repetitions of the pattern in a single protein: 1
  • FT_KEY: DOMAIN
  • FT_DESC: Post-SET
  • VERSION: 1
Cross-references
UniProtKB/Swiss-Prot True positive hits:
ASH1L_HUMAN (Q9NR48), ASH1L_MOUSE (Q99MY8), ASH1_DROME  (Q9VW15), 
ASHH1_ARATH (Q84WW6), ASHH2_ARATH (Q2LAE1), ASHH3_ARATH (Q945S8), 
ASHH4_ARATH (Q9M1X9), ASHR3_ARATH (Q949T8), ATX1_ARATH  (Q9C5X4), 
ATX2_ARATH  (P0CB22), ATX3_ARATH  (Q9M364), ATX4_ARATH  (Q9SUE7), 
ATX5_ARATH  (Q8GZ42), C1716_DROME (Q9VYD1), CLR4_SCHPO  (O60016), 
DIM5_NEUCR  (Q8X225), HKNMT_PLAF7 (C6KTD2), MES4_CAEEL  (Q9NH52), 
MES4_DROME  (Q8MT36), MET2_CAEEL  (P34544), MLL1_HUMAN  (Q03164), 
MLL1_MOUSE  (P55200), MLL2_HUMAN  (O14686), MLL2_MOUSE  (Q6PDK2), 
MLL3_HUMAN  (Q8NEZ4), MLL3_MOUSE  (Q8BRH4), MLL4_HUMAN  (Q9UMN6), 
MLL4_MOUSE  (O08550), NSD1_HUMAN  (Q96L73), NSD1_MOUSE  (O88491), 
NSD2_HUMAN  (O96028), NSD2_MOUSE  (Q8BVE8), NSD3_HUMAN  (Q9BZ95), 
NSD3_MOUSE  (Q6P2L6), SE1BA_DANRE (Q1LY77), SET1A_HUMAN (O15047), 
SET1B_CHICK (Q5F3P8), SET1B_HUMAN (Q9UPS6), SET1B_MOUSE (Q8CFT2), 
SET1B_XENLA (Q66J90), SET1B_XENTR (Q08D57), SET1_ASHGO  (Q75D88), 
SET1_ASPFU  (Q4WNH8), SET1_ASPOR  (Q2UMH3), SET1_CANAL  (Q5ABG1), 
SET1_CANGA  (Q6FKB1), SET1_CHAGB  (Q2GWF3), SET1_COCIM  (Q1DR06), 
SET1_CRYNB  (P0CO27), SET1_CRYNJ  (P0CO26), SET1_DEBHA  (Q6BKL7), 
SET1_DICDI  (Q54HS3), SET1_EMENI  (Q5B0Y5), SET1_GIBZE  (Q4I5R3), 
SET1_KLULA  (Q6CIT4), SET1_NEUCR  (Q8X0S9), SET1_SCHPO  (Q9Y7R4), 
SET1_USTMA  (Q4PB36), SET1_YARLI  (Q6CEK8), SET1_YEAST  (P38827), 
SET23_CAEBR (A8XI75), SET23_CAEEL (Q95Y12), SET2_ASHGO  (Q757Y8), 
SET2_ASPFU  (Q4WTT2), SET2_ASPOR  (Q2UTN6), SET2_CAEEL  (Q18221), 
SET2_CANAL  (Q59XV0), SET2_CANGA  (Q6FX50), SET2_CHAGB  (Q2H988), 
SET2_COCIM  (Q1DU03), SET2_CRYNB  (P0CO29), SET2_CRYNJ  (P0CO28), 
SET2_DEBHA  (Q6BM04), SET2_EMENI  (Q5ASA5), SET2_GIBZE  (Q4IB50), 
SET2_KLULA  (Q6CXP5), SET2_NEUCR  (Q7RZU4), SET2_SCHPO  (O14026), 
SET2_USTMA  (Q4PBL3), SET2_YARLI  (Q6C5G5), SET2_YEAST  (P46995), 
SETB1_DROME (Q32KD2), SETB1_DROPS (Q28Z18), SETB1_HUMAN (Q15047), 
SETB1_MOUSE (O88974), SETB1_XENLA (Q6INA9), SETB2_XENLA (Q6YI93), 
SETD2_HUMAN (Q9BYW2), SETMR_BOVIN (Q0VD24), SETMR_HUMAN (Q53H47), 
SETMR_MOUSE (Q80UJ9), SETMR_RAT   (Q5I0M0), STB1B_DANRE (Q08BR4), 
SUV39_DROME (P45975), SUV39_DROPS (Q294B9), SUV91_BOVIN (Q2NL30), 
SUV91_HUMAN (O43463), SUV91_MOUSE (O54864), SUV91_PONAB (Q5RB81), 
SUV91_XENLA (Q6NRE8), SUV92_BOVIN (Q32PH7), SUV92_CHICK (Q5F3W5), 
SUV92_HUMAN (Q9H5I1), SUV92_MACFA (Q4R3E0), SUV92_MOUSE (Q9EQQ0), 
SUV92_XENTR (Q28CQ7), SUVH1_ARATH (Q9FF80), SUVH1_TOBAC (Q93YF5), 
SUVH3_ARATH (Q9C5P4), SUVH4_ARATH (Q8GZB6), SUVH5_ARATH (O82175), 
SUVH6_ARATH (Q8VZ17), SUVH7_ARATH (Q9C5P1), SUVH8_ARATH (Q9C5P0), 
SUVR3_ARATH (Q9SRV2), SUVR5_ARATH (O64827), SV91A_DANRE (Q6DGD3), 
TRR_DROME   (Q8IRW8), TRX_DROME   (P20659), TRX_DROVI   (Q24742)
False negative hits (sequences which belong to the set under consideration, but which have not been picked up by the pattern or profile):
EHMT2_HUMAN (Q96KQ7), EHMT2_MOUSE (Q9Z148), STB1A_DANRE (Q1L8U8), 
SUVH3_CHLRE (Q5QD03), SUVHA_ARATH (Q3EC60), SUVR1_ARATH (Q946J2), 
SUVR2_ARATH (Q9FNC7), SUVR4_ARATH (Q8W595)
Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:

[Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format]

Retrieve the sequence logo from the alignment

PDB
[Detailed view]		 1PEG; 2R3A; 2W5Y; 2W5Z; 3BO5; 3OOI; 3OPE; 4FMU; 4H12;

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