Entry: PS50876

General information about the entry

Entry name [info] ZF_INTEGRASE
Accession [info] PS50876
Entry type [info] MATRIX
Date [info] APR-2004 (CREATED); OCT-2013 (DATA UPDATE); MAY-2016 (INFO UPDATE).
PROSITE Doc. [info] PDOC50876
Associated ProRule [info] PRU00450

Name and characterization of the entry

Description [info] Zinc finger integrase-type profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=42;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=38;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.3575423; R2=0.0122680; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2595.2043457; R2=0.6439499; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=501; H_SCORE=2918; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=338; H_SCORE=2813; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-8; D=-30; I=-30; B1=-300; E1=-300; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='E'; M= -7,  2,-26,  6, 16,-21, -9,-10,-24, -1,-17,-16, -2,-11,  2, -6,  1, -2,-20,-15,-13,  9;
/M: SY='N'; M=  4,  6,-22, -2, -2,-22, -5, -8,-21,  7,-23,-14, 13, -6, -2,  5,  3, -1,-18,-27,-18, -3;
/M: SY='I'; M= -9,-28,-24,-33,-25,  1,-34,-24, 32,-23, 24, 18,-22,-24,-18,-18,-21, -9, 23,-21, -2,-24;
/M: SY='E'; M= -8,  9,-28, 16, 20,-29,-17, -5,-22,  2,-19,-15,  1,  0, 11, -2, -1, -6,-21,-29,-17, 14;
/M: SY='E'; M= -3, -2,-29,  2, 22,-29,-17, -6,-24,  9,-23,-14, -4, 11, 14,  4,  0, -7,-24,-26,-18, 17;
/M: SY='A'; M= 39,-11,-13,-18, -9,-20, -3,-20,-10,-10,-12,-11,-10, -2,-10,-19, 10,  1, -1,-23,-20,-10;
/M: SY='Q'; M= -4, -7,-27, -7,  8,-26,-14, -6,-14,  5,-14, -4, -5,-13, 18,  7, -4, -9,-14,-22,-13, 12;
/M: SY='E'; M= -9, 10,-28, 15, 35,-30,-17,  0,-24,  8,-21,-15,  5, -6, 20,  1,  2, -7,-25,-29,-17, 27;
/M: SY='E'; M= -6,  7,-24,  9, 18,-19,-15, -4,-19,  1,-12,-13,  4,-12,  3, -4,  0, -5,-18,-27,-11, 11;
/M: SY='H'; M=-18, -1,-29,  0,  4,-19,-20, 83,-26, -8,-17,  3,  7,-18, 10, -1,-10,-18,-27,-29, 15,  3;
/M: SY='E'; M=  2,  2,-20,  2, 14,-17,-15, -5,-18, -3,-16,-14, -2,-10,  4, -8,  8,  7,-14,-22, -5,  8;
/M: SY='K'; M=-11, -7,-25, -9, -1,-12,-22,-10,-16, 17, -9, -3, -4,-17,  2, 14,-10, -5,-13,-19, -6,  1;
/M: SY='Y'; M=-16,-21,-30,-23,-17, 14,-25,  4, -8,-12, -1, -3,-19,-26,-12,-10,-21,-11,-12, 29, 32,-15;
/M: SY='H'; M=-19, -3,-30, -4, -3,-18,-22, 88,-23,-12,-16,  2,  7,-20,  7, -3,-11,-19,-25,-29, 18, -3;
/M: SY='T'; M= -1,-11,-16,-13, -8,-13,-13,-14, -4,-13, -3, -3, -8,-17, -2,-11,  7, 10, -1,-28,-12, -5;
/M: SY='N'; M= -2, 23,-22, 15, -3,-24, 12, -3,-26, -6,-27,-20, 30,-17, -5, -8,  9, -2,-25,-34,-22, -4;
/M: SY='A'; M= 15,-18,-19,-22,-16,-10,-12,-20, -4,-13, -9, -3,-17,-12,-13,-18, -1, -1,  2,  1, -9,-14;
/M: SY='R'; M= -9, -4,-27, -5,  5,-21,-19,  9,-23, 18,-20, -7, -1,-14, 13, 19, -5, -6,-19,-18,  0,  7;
/M: SY='A'; M=  9, -8,-21,-12, -4,-16, -5,-12,-12, -5,-14, -9, -5,-13, -3,-10,  4,  1, -8,-19, -8, -5;
/M: SY='L'; M=-10,-23,-20,-26,-18,  7,-27,-16, 16,-26, 41, 18,-21,-29,-17,-18,-26, -9,  6,-22, -2,-18;
/M: SY='S'; M=  7, -6, -7, -9, -1,-24,-11,-11,-22,  7,-22,-12, -2,-14,  4,  7,  8,  0,-13,-28,-17,  1;
/M: SY='H'; M=-13, -4,-26, -3,  3,-14,-19,  6,-17, -3, -9, -7, -1, -8,  3,  5, -6, -6,-18,-25, -7,  1;
/M: SY='E'; M= -8,  9,-25,  9, 22,-26,-16, -2,-23, 12,-21,-11,  7, -8, 14,  4,  3, -2,-22,-29,-15, 18;
/M: SY='F'; M=-18,-28,  1,-37,-29, 56,-30,-19, -3,-29,  8, -2,-21,-32,-35,-21,-19,-10, -1, -1, 21,-29;
/M: SY='N'; M= -7, 11,-26,  7,  0,-28, 10,  0,-29,  5,-29,-16, 17,-16,  3,  1,  3, -8,-26,-28,-18,  1;
/M: SY='I'; M= -9,-30,-25,-35,-26,  4,-35,-26, 37,-29, 31, 19,-25,-25,-21,-25,-23, -9, 23,-21, -1,-26;
/M: SY='P'; M= -8,-17,-36, -9, -1,-28,-19,-19,-19,-10,-29,-19,-17, 77, -9,-19, -5, -4,-27,-31,-28, -9;
/M: SY='R'; M=-13, -6,-26,-10, -6,-13,-18, -6,-14,  4, -9, -3,  1,-15,  1, 16, -9, -4,-15,-13, -8, -4;
/M: SY='L'; M=  0,-14,-19,-16, -5, -9,-22,-16,  0, -5,  6,  3,-15,-18, -8, -6, -8,  1,  4,-24, -9, -7;
/M: SY='V'; M=  2,-19,-17,-20,-12,-12,-25,-19, 14,-12,  1,  5,-19,-21, -6,-14, -6, -4, 22,-26,-11, -9;
/M: SY='A'; M= 46,-12,-10,-21,-12,-18, -2,-21, -7,-11, -8, -8,-12,-12,-12,-20,  8,  0,  4,-21,-19,-12;
/M: SY='R'; M=-14, -2,-30,  0, 17,-26,-20, -3,-30, 32,-23,-12,  0,-12, 12, 41, -8,-10,-22,-22,-12, 12;
/M: SY='Q'; M=-13, 10,-30, 16, 28,-35,-18,  4,-27, 11,-22,-12,  3, -9, 33, 12, -1,-10,-29,-26,-14, 30;
/M: SY='I'; M= -9,-30,-28,-38,-29,  1,-38,-29, 46,-29, 22, 19,-22,-22,-21,-28,-20, -9, 30,-21, -1,-29;
/M: SY='V'; M= -3,-27,-16,-30,-27, -1,-30,-29, 26,-18,  7,  8,-26,-26,-25,-19,-11, -1, 37,-20, -7,-27;
/M: SY='Q'; M= -6,  7,-26,  3, 11,-27,-14,  5,-23, 14,-22,-10, 12,-13, 19, 16,  0, -7,-24,-26,-13, 14;
/M: SY='S'; M=  0, -1,-19, -2,  7,-22,-13,  5,-21,  1,-21,-12,  3,-11,  9,  3, 13,  8,-16,-30,-11,  7;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='P'; M=  7, -3,-21, -1,  6,-25,-10,-13,-20, -7,-23,-17, -3, 15,  0,-12, 13,  5,-16,-31,-21,  1;
/M: SY='H'; M= -9, -5,-26, -6,  3,-21,-21, 24,-15,  2,-13, -1, -1,-15, 12,  1, -5, -6,-15,-25, -1,  6;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='Q'; M= -6, -1,-26, -3, 10,-32,-18,  1,-17,  7,-19, -4,  1, -7, 34,  7,  0, -5,-21,-23,-12, 21;
/I:         E1=0; IE=-105; DE=-105;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2016_05 which contains 551'193 sequence entries.


Total number of hits 98 in 98 different sequences
Number of true positive hits 98 in 98 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 6
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 94.23 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] N_Hulo
Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 1
Feature key [info] ZN_FING
Feature description [info] Integrase-type
Version [info] 4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
98 sequences

PO113_HUMAN (P63132    ), POK10_HUMAN (P10266    ), POK11_HUMAN (Q9UQG0    ), 
POK18_HUMAN (Q9QC07    ), POK19_HUMAN (Q9WJR5    ), POK25_HUMAN (P63136    ), 
POK6_HUMAN  (Q9BXR3    ), POK7_HUMAN  (P63135    ), POK8_HUMAN  (P63133    ), 
POL1_CHICK  (P10399    ), POL_ALV     (Q7SQ98    ), POL_BIV29   (P19560    ), 
POL_CAEVC   (P33459    ), POL_EIAV9   (P11204    ), POL_EIAVC   (P32542    ), 
POL_EIAVY   (P03371    ), POL_FIVPE   (P16088    ), POL_FIVSD   (P19028    ), 
POL_FIVT2   (P31822    ), POL_HV190   (O93215    ), POL_HV192   (O12158    ), 
POL_HV193   (O89290    ), POL_HV196   (Q9QBY3    ), POL_HV197   (Q9QBZ9    ), 
POL_HV19N   (O41798    ), POL_HV1A2   (P03369    ), POL_HV1AN   (Q77373    ), 
POL_HV1B1   (P03366    ), POL_HV1B5   (P04587    ), POL_HV1B9   (Q73368    ), 
POL_HV1BR   (P03367    ), POL_HV1EL   (P04589    ), POL_HV1ET   (Q75002    ), 
POL_HV1H2   (P04585    ), POL_HV1JR   (P20875    ), POL_HV1LW   (P0C6F2    ), 
POL_HV1M2   (Q9QBZ1    ), POL_HV1MA   (P04588    ), POL_HV1MN   (P05961    ), 
POL_HV1MP   (Q9QBZ5    ), POL_HV1MV   (Q79666    ), POL_HV1N5   (P12497    ), 
POL_HV1ND   (P18802    ), POL_HV1OY   (P20892    ), POL_HV1RH   (P05959    ), 
POL_HV1S2   (Q9WC54    ), POL_HV1S9   (Q9WC63    ), POL_HV1SE   (O89940    ), 
POL_HV1U4   (P24740    ), POL_HV1V9   (Q9Q720    ), POL_HV1VI   (Q9QSR3    ), 
POL_HV1Y2   (P35963    ), POL_HV1YB   (Q9IDV9    ), POL_HV1YF   (O91080    ), 
POL_HV1Z2   (P12499    ), POL_HV2BE   (P18096    ), POL_HV2CA   (P24107    ), 
POL_HV2D1   (P17757    ), POL_HV2D2   (P15833    ), POL_HV2EH   (Q89928    ), 
POL_HV2G1   (P18042    ), POL_HV2KR   (Q74120    ), POL_HV2NZ   (P05962    ), 
POL_HV2RO   (P04584    ), POL_HV2SB   (P12451    ), POL_HV2ST   (P20876    ), 
POL_HV2UC   (Q76634    ), POL_IPHA    (P04026    ), POL_IPMAI   (P12894    ), 
POL_JEMBR   (Q82851    ), POL_JSRV    (P31623    ), POL_MMTVB   (P03365    ), 
POL_MMTVC   (P11283    ), POL_MPMV    (P07572    ), POL_OMVVS   (P16901    ), 
POL_RSVP    (P03354    ), POL_RSVSA   (Q04095    ), POL_RSVSB   (O92956    ), 
POL_SIVCZ   (P17283    ), POL_SIVEK   (Q1A249    ), POL_SIVG1   (Q02836    ), 
POL_SIVGB   (P22382    ), POL_SIVM1   (P05896    ), POL_SIVMB   (Q1A267    ), 
POL_SIVMK   (P05897    ), POL_SIVS4   (P12502    ), POL_SIVSP   (P19505    ), 
POL_SIVTN   (Q8AII1    ), POL_SIVV1   (P27973    ), POL_SIVVG   (P27980    ), 
POL_SIVVT   (P05895    ), POL_SMRVH   (P03364    ), POL_SRV1    (P04025    ), 
POL_SRV2    (P51517    ), POL_VILV    (P03370    ), POL_VILV1   (P23426    ), 
POL_VILV2   (P23427    ), POL_VILVK   (P35956    )
» more

UniProtKB/Swiss-Prot
False negative sequences
6 sequences

POL_HTL1A   (P03362    ), POL_HTL1C   (P14078    ), POL_HTL1L   (P0C211    ), 
POL_HTL32   (Q0R5R2    ), POL_HTL3P   (Q4U0X6    ), POL_HTLV2   (P03363    )
» more

PDB
[Detailed view]
13 PDB

1E0E; 1K6Y; 1WJA; 1WJB; 1WJC; 1WJD; 1WJE; 1WJF; 3F9K; 3HPG; 3HPH; 5CZ2; 5EJK
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