PROSITE entry PS50912

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General information about the entry

Entry name [info]	EAR
Accession [info]	PS50912
Entry type [info]	MATRIX
Date [info]	01-JUN-2003 CREATED; 28-FEB-2018 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50912
Associated ProRule [info]	PRU00075

Name and characterization of the entry

Description [info]

EAR repeat profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=43;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=43;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.7769146; R2=0.0084072; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=979; N_SCORE=9.0; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=562; N_SCORE=5.5; MODE=1; TEXT='R?';
/DEFAULT: M0=-15; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='R';  M=-27,-51,  0, -6,-46,  6,-15,-23, 25, -9, -4, 19,-47, 22, 31, 17, -8,  6,-55,-15;
/M: SY='F';  M=-51,-49,-64,-59,102,-61,-45,-23,-56, 24,-24,-56,-35,-61,-53,-52,-44,-22,  5, 18;
/M: SY='V';  M= -1,-49,-29, -3,-17,-50,-42,  8,-11,-33,-31,-38,-48, 29, 27, -3, 26, 44,-52, 14;
/M: SY='P';  M= -4,-53, -6, -6,-40,-46,-40,-26, 15, 22,-32, 19, 55,-23, -5,  2,-25, -8, 27, -5;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='F';  M=-43,-52,-46,  0, 56,-56, 55,  0,-42,  6,-26,-21,-30, -3,-21,-26,-19, 20,-36, 50;
/M: SY='Q';  M=-30,-60,  6, 19,-65,-21,  1,-54, -8,-50,-38,-27,-43,108,-21,-27,-11,-54,-53,-40;
/M: SY='S';  M=-12,-13, 35, 28,-23,-40,-35,-50, -9,-51,-46, 16,-10,  1,  8, 44, 35,-35,-61,-44;
/M: SY='I';  M=-43,-50,-63,-58, 27,-65,-53, 58,-56, 53,  8,-57,-58,-52,-55,-52,-38, 20,-47,-28;
/M: SY='P';  M=  8,-54,  5, -8,-34, -9, 38,-30,-17,-22,-41, -7, 68,-34,  8, 16, -1,-45,-56,-14;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='W';  M= -8,-20, -3,-32,-10,-22,-19, 20,-34,  0,  7, -7,-52,-45,-50,  4, 27, 29, 52,-38; D=-36;
/I:         I=-36; DM=-90;
/M: SY='Q';  M=-13,-23,-35, 23,  2,-23, 22,-44,-20,-18,-37,-15,  9, 38, 27, 28, -2,-23,-47, 27;
/M: SY='G';  M= 21,-51, 23, -4,-19, 47,-39,-56, -6,-54,-47,  6,-26,  6, 17, 25,-24,-49,-55,-46;
/I:         I=-45; MD=-115;
/M: SY='P';  M= 35, 11,  2,-41,-49,-44,-51,  3,-45,-28,-38,-42, 55,-44,-51, 12,  6, 23,-62,-50; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='R';  M=-28,-23,-41,-14,  5,-35, -2,-15,  6, 16,  7, 19,-50, -7, 28,  0, 19, 13,-50, 13;
/M: SY='D';  M= 15,-49, 55,-18,-54, -4,  5,-45,-22,-49,-44,-25,-44, 26,-13, 44,  4,  3,-63,-44;
/M: SY='W';  M=  4, 63,-62,-55, 35,-55,-59, 26,-52, -5,-13,-54,-57,-53,-54,-44,-24, 43, 92,-26;
/M: SY='E';  M=-10, 37, -2, 59,-53,-49, 16,-49, 36,-28,-41,-32,-42, 20, 13,-23, -2,-14,-58,-44;
/M: SY='P';  M= 19,-52,-44,-39, 19,-16, 60,-29,-42,-15,-35,-38, 62,-27,-45, 12, -2,-11,-49, 16;
/M: SY='F';  M=-47,-49,-64,-58, 93,-61,-17,  8,-55, 18, 15,-55,-61,-59,-53,-51,-41, 17,-28,  4;
/M: SY='T';  M=-18,-48, -9,  2,-32,-42,-22,-40,-19,-14,-38, 15,  5, 29, 11, 40, 42, -6, 19,-41;
/M: SY='I';  M=  0,-48,-50,-48,-21,-13,-47, 46,-36,  6, 14,-26,-11,-43,-15,  6, 20, 27,-51, 11;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='D';  M=  8,-53, 51, 16,-58, 42,-37,-56, -1,-44,-37, 27, 10,  0,-26,-13,-18,-44,-60,-50;
/I:         I=-33; MI=0; MD=-84; IM=0; DM=-84;
/M: SY='G';  M= -9,-52, 26,-16,-34, 46,-37,-51, -8,-26,-45, 32,  0, -9, 14, 17,-10,-29,-57,-28;
/I:         I=-25; MI=0; MD=-63; IM=0; DM=-63;
/M: SY='D';  M=-19,-55, 50, 15,-51,-18,-27,-17, 11,-40,-43, -6,-46, 33, 27, 17,-13,-13,-57,  1; D=-25;
/I:         I=-25; MI=0; MD=-63; IM=0; DM=-63;
/M: SY='P';  M=-13,-52, -5, -1,-20,-47, 20, -5,-25, 10,-31, -2, 36, 34,-13,  7,  6, 12, 27,-29;
/M: SY='Y';  M=-50,  0,-51,-50, 71,-57, 55,-34,-44, -7,-28,-46,-60,-44, -6,-46,-44,-38,-19, 89;
/M: SY='L';  M= -4,-47,-61,-54, 30,-35,-50, 14,-54, 60, -1,-56,-59,-50,-53,-48,-38, 30,-47,-28;
/M: SY='I';  M= 27, 32,-58,-53, 15,-37,-54, 48,-51, 21, -4,-51,-54,-50,-53,-29,-34, 36,-52,-34;
/M: SY='V';  M= 24,-46,-57,-50,-10,-54,-50, 34,-24, 39,  5,-52,-54,-47,-49,-42,-25, 42,-50,  0;
/M: SY='A';  M= 58,  3,-43,-40,-50, 14,-46,-25,-41,-31,-39,-34,-17,-37,-46, 40, 19, -5,-57,-47;
/M: SY='S';  M=-19, -6, 11,-21,-53, -4, 29,-51,-20,-32,-42, 40,-46, 42, 26, 47,  0,-36,-61,-42;
/I:         I=-17; MI=0; MD=-44; IM=0; DM=-44;
/M: SY='F';  M=-31,-57, 17,-41, 40,-32,-20,-33, 18,  9,-38, -8,-30,-23, -1,-10,  4,-43,-47, 21; D=-17;
/I:         I=-17; DM=-44;
/M: SY='Q';  M= 12,-53,-27, -6, 24,-46,-41, -2, 19,-32,-15, -3, -5, 32,-19, 12,  0,-17, 20,  8; D=-17;
/I:         I=-17; DM=-44;
/M: SY='G';  M=  2,-53,-10,  6,-57, 52,-43,-32,-39,-41,-46, 16, -6, 22,-45, 15,  2,-13,-59,-51; D=-17;
/I:         I=-17; DM=-44;
/M: SY='N';  M= -1,-53, 25,-36, 17, 17, -6,-36, -9,-14,-11, 31, -8,  7,  2, 11,-18,-35,-55,-23; D=-17;
/I:         I=-17; DM=-44;
/M: SY='S';  M=-30, 57,-41,-42,-49,-41,-46,-11,-41,-21,-42,-10, 10,-39,-47, 62, 48,-20,-65,-48; D=-17;
/I:         I=-17; DM=-44;
/M: SY='Q';  M= -5,-50,-17, 10,-30,-48, 31, -6, 12, -6,  8,-34,-46, 46,  0, 10, 10, 21,-55,-14;
/M: SY='I';  M=-40,-50,-62,-58, -1,-65,-57, 67,-55, 34,-14,-56,-56,-53,-56,-50,-35, 48,-51,-10;
/M: SY='Y';  M=-49,-31,-55,-54, 60,-58,-27,-27,-48, 19, 20,-53,-61,-46,-46,-48,-44,-33, 29, 98;
/M: SY='R';  M=-30, 27,-35,  9,-51,-49, 18,-20, 44,-35,-18, -3,-47, 44, 45, -2,-17,  2,-56,-41;
/M: SY='W';  M=-50,-68,-65,-38, 15,-53, 33,-42,-43, -4,-39,-59,-57,-44,  4,-54,-55,-32,151, 25;
/M: SY='N';  M=-37,-51, 52,  5,-52,-17, 21,-10,-30,-35,-42, 52,-28, 25, -4,  7, 14, -7,-66,-43;
/M: SY='G';  M= -6,-52,  4,  0,-49, 39, 21,-12, -2,-47, -8,-17, 10, -6, 13, 26,-17,-14,-54, -4;
/I:         E1=0; IE=-380; DE=-380;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_06 which contains 572'619 sequence entries.

Total number of hits	137 in 20 different sequences
Number of true positive hits	137 in 20 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	7
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	REPEAT
Feature description [info]	EAR
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

20 sequences

AGRV1_DANRE (Q6JAN0), AGRV1_HUMAN (Q8WXG9), AGRV1_MOUSE (Q8VHN7),

LGI1_BOVIN  (Q5E9T6), LGI1_HUMAN  (O95970), LGI1_MOUSE  (Q9JIA1), 
LGI1_PANTR  (Q1EGL2), LGI1_PONAB  (Q5R945), LGI1_RAT(Q8K4Y5), 
LGI2_HUMAN  (Q8N0V4), LGI2_MOUSE  (Q8K4Z0), LGI2_PANTR  (Q1EGL1), 
LGI3_HUMAN  (Q8N145), LGI3_MACFA  (Q4R4H3), LGI3_MOUSE  (Q8K406), 
LGI3_PANTR  (Q1EGL0), LGI4_HUMAN  (Q8N135), LGI4_MOUSE  (Q8K1S1), 
TSEAR_HUMAN (Q8WU66), TSEAR_MOUSE (J3S6Y1)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

6 PDB

5Y2Z; 5Y31; 8HPY; 8HQ1; 8HQ2; 8Y6B