PROSITE entry PS50915

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General information about the entry

Entry name [info]	CRYSTALLIN_BETA_GAMMA
Accession [info]	PS50915
Entry type [info]	MATRIX
Date [info]	01-JUL-2003 CREATED; 01-OCT-2013 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00197
Associated ProRule [info]	PRU00028

Name and characterization of the entry

Description [info]

Crystallins beta and gamma 'Greek key' motif profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=44;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=40;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.1640513; R2=0.0252941; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=251; N_SCORE=8.5; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=113; N_SCORE=5.0; MODE=1; TEXT='RR';
/DEFAULT: M0=-8; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='G';  M=  1, -9,-26,-10,-12,-20, 21,-16,-23,-15,-21,-14, -2, -1,-12,-16,  0,-10,-20,-24,-22,-13;
/M: SY='R';  M= -4, -6,-10,-10, -4,-21,-19,  1,-16,  2,-17, -8, -2,-13,  2,  3, -1, -1,-12,-28,-10, -3;
/M: SY='W';  M= -7,-31,-32,-36,-27,  2,-26,-26, 14,-21,  2,  6,-28,-24,-19,-22,-23,-15,  7, 39,  8,-23;
/M: SY='V';  M= -5,-15,-19,-18,-17, -8,-26,-15, 12,-13,  3,  5,-14,-21,-15,-10, -7,  3, 17,-27, -7,-18;
/M: SY='L';  M= -5,-27,-18,-31,-23,  9,-29,-22, 21,-25, 27, 15,-25,-26,-22,-20,-19, -5, 19,-20, -1,-23;
/M: SY='Y';  M=-20,-23,-27,-26,-23, 45,-30,  8,  0,-16,  3,  0,-20,-30,-19,-13,-20,-10, -7, 24, 65,-23;
/M: SY='E';  M= -7,  5,-25, 11, 31,-23,-17, -1,-24,  5,-20,-16,  1, -7, 13, -1,  5, -1,-22,-25, -9, 22;
/M: SY='E';  M=-13, 10,-28, 11, 17,-24,-12, 13,-27,  9,-22,-12, 11,-13,  9, 10, -3,-10,-26,-27, -9, 12;
/M: SY='P';  M=-10, -4,-32,  3, 10,-27,-17,-13,-18, -3,-22,-16, -8, 30, -3,-10, -5, -9,-20,-30,-21,  1;
/M: SY='N';  M=-11, 26,-25, 22,  7,-25,  2,  1,-27, -2,-27,-19, 28,-15,  3, -5,  5, -6,-28,-33,-18,  5;
/M: SY='F';  M=-17,-26,-22,-32,-26, 52,-19,-14, -4,-23,  3, -2,-18,-28,-31,-14,-17,-10, -3,  6, 26,-26;
/M: SY='Q';  M= -4, -2,-24, -1,  5,-25, -4, -6,-22,  1,-18,-10,  0,-13, 12,  3,  5,  0,-19,-26,-15,  8;
/M: SY='G';  M=  0, -8,-29, -8,-14,-29, 61,-18,-38,-18,-29,-20,  1,-18,-17,-18,  2,-17,-29,-22,-29,-15;
/M: SY='K';  M=-13,  1,-28,  1,  5,-24,-20,  8,-20, 16,-18, -6,  2,-15,  8, 16, -9,-11,-17,-25, -6,  5;
/M: SY='Q';  M= -5, -8,  7,-11, -2,-24,-16, -6,-19, -7,-15, -6, -7,-15,  9, -8, -2, -5,-17,-30,-16,  3;
/M: SY='Y';  M= -8,-20,-22,-23,-18,  7,-26,-12, 12,-16,  5,  4,-16,-23,-12,-15, -9, -4,  8,-12, 13,-17;
/M: SY='E';  M= -6, -5,-23, -2,  6,-15,-20,-13, -8, -9, -9, -9, -7, -2, -4,-12,  0, -1, -6,-29,-14,  0;
/M: SY='L';  M= -7,-28,-15,-31,-23, 13,-30,-20, 18,-26, 29, 13,-26,-28,-22,-21,-22, -8, 14,-16,  5,-23;
/M: SY='E';  M=-10,  3,-24,  4, 12,-11,-17, -8,-20, -1,-17,-15,  3, -3, -2,  0,  1,  1,-17,-26,-12,  4;
/M: SY='E';  M=  0,  1,-24,  6, 13,-25,-13,-11,-21, -1,-22,-17, -3, 10,  0, -7,  6,  0,-17,-31,-20,  5;
/M: SY='G';  M= -6, 11,-27, 16,  1,-29, 22,-11,-32,-10,-23,-19,  6,-15, -7,-13,  0,-11,-25,-28,-22, -3;
/I:         I=-15; MD=-32;
/M: SY='E';  M= -3, -2,-10, -4,  5,-16,-14, -6,-14, -7,-12, -8, -3,-14, -1,-10,  0,  1,-11,-27,-12,  2; D=-15;
/I:         I=-15; MI=-32; IM=-32; DM=-32;
/M: SY='Y';  M=-12,-16,-22,-14, -6, -1,-25, -2, -5,-10, -8, -5,-16, -4, -5,-12,-10, -5, -9, -7, 20, -9;
/I:         I=-5; MD=-11;
/M: SY='E';  M= -7,  4,-22,  3,  6,-20,-15, -8,-16, -3,-17,-13,  5,  3,  0, -4,  4,  6,-15,-30,-16,  2; D=-5;
/I:         I=-5; MD=-11;
/M: SY='L';  M= -5,-11, -6,-14,-11, -7,-20,-13, -2,-14,  8,  3,-11,-22, -9,-10,-11, -7, -3,-25, -9,-11; D=-5;
/I:         I=-5; MD=-11;
/M:         M=  0, -5,-18, -7, -6, -7,-13, -7, -8, -7, -7, -6, -3,-16, -2, -6, -2, -4, -7, -8, -2, -4; D=-5;
/I:         I=-5; MD=-11;
/M: SY='Q';  M= -5, -1,-15,  1,  5,-10, -8,  0, -9, -2, -7, -3, -2, -8,  6, -3,  1, -3,-10,-12, -1,  5; D=-5;
/I:         I=-5; MD=-11;
/M:         M= -1, -4, -7, -3,  0, -7,-11, -8, -8, -5, -1, -4, -5,-11, -3, -6, -2, -3, -6,-17, -7, -1; D=-5;
/I:         I=-5; MD=-11;
/M: SY='W';  M= -4,-10,-17,-10, -4, -2, -3,-10,-10, -7, -8, -6,-10,-10, -6, -8, -8, -7,-11, 21,  1, -4; D=-5;
/I:         I=-5; MD=-11;
/M: SY='G';  M= -2, -2,-16, -4, -8,-10,  6, -9,-10, -8,-10, -6,  1,-12, -8, -7,  0, -4, -8,-16,-10, -8; D=-5;
/I:         I=-5; MD=-11;
/M: SY='G';  M= -2, -9,-18, -9, -9,-20, 23,-13,-24,-13,-19,-13, -3,-17, -9,-11,  1, -9,-19,-21,-16,-10; D=-5;
/I:         I=-5; MD=-11;
/M: SY='F';  M= -8,-15,-19,-18,-11,  8,-12,-13,-12,-13,-10, -8,-11, -8,-15,-13, -8, -7,-12, -3,  3,-13; D=-5;
/I:         I=-5; MD=-11;
/M: SY='N';  M= -6,  2,-22, -3, -7,-11, -3, -2, -9,-10,-11, -4,  8,-12, -7,-11, -2, -6,-13,-23, -8, -7; D=-5;
/I:         I=-5; MD=-11;
/M: SY='N';  M= -6,  1,-13,  0, -1, -5, -7, -2, -4, -7, -2, -3,  2,-11, -5, -6, -4, -5, -5,-16, -5, -3; D=-5;
/I:         I=-5; MI=0; MD=-11; IM=0; DM=-11;
/M: SY='B';  M= -2, 10,-20,  8, -2,-16,-10, -6,-16, -6,-18,-14, 10,-16, -3, -7,  6,  4,-12,-28,-11, -3;
/M: SY='K';  M= -6,  1,-18, -2,  3,-22,-13, -7,-20,  6,-22,-12,  5, -8,  6,  3,  5,  3,-17,-27,-13,  4;
/M: SY='V';  M= -2,-22,-14,-29,-24,  0,-30,-26, 22,-22,  8,  7,-17,-21,-21,-22, -7,  6, 23,-24, -5,-24;
/M: SY='S';  M= -2, -4,-12, -6, -5,-23,  2, -7,-22, -4,-24,-14,  4,-16,  0, -2, 12,  0,-16,-31,-17, -3;
/M: SY='S';  M=  7, -2,-12, -2, -1,-18, -3, -5,-18,-11,-25,-17,  8,-12, -1,-10, 34, 16,-10,-38,-17, -1;
/M: SY='I';  M= -8,-27, -9,-31,-25,  0,-31,-19, 24,-24, 19, 19,-24,-26,-19,-21,-18, -8, 22,-26, -4,-24;
/M: SY='R';  M=-15, -2,-24, -4,  3,-22,-19, -1,-27, 28,-23,-10,  4,-17, 11, 39, -8, -9,-21,-21, -7,  4;
/M: SY='V';  M= -6,-26,-21,-25,-21, -4,-28,-22, 15,-18,  3,  3,-24, -1,-22,-18,-13, -5, 20,-26,-10,-23;
/M: SY='I';  M= -8,-19,-23,-21,-15, -5,-27,-12, 14,-20,  9,  7,-15,-17,-10,-17,-11, -6,  9,-24, -4,-14;
/M: SY='R';  M= -7, -9,-19, -8, -7,-19, -1,-14,-22, -4,-20,-14, -6,-14, -8,  2,  0, -5,-14,-16,-15, -8;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_05 which contains 572'214 sequence entries.

Total number of hits	448 in 108 different sequences
Number of true positive hits	448 in 108 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	12
Matrix type [info]	protein_domain
Scaling database [info]	window20
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	Beta/gamma crystallin 'Greek key'
Version [info]	3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

108 sequences

CRB11_AQUCT (Q91315), CRB12_AQUCT (Q91314), CRB31_AQUCT (Q91316),

CRB32_AQUCT (Q91317), CRBA1_BOVIN (P11843), CRBA1_CHICK (P10042), 
CRBA1_HUMAN (P05813), CRBA1_MOUSE (P02525), CRBA1_RANTE (P07317), 
CRBA1_RAT   (P14881), CRBA2_BOVIN (P26444), CRBA2_CHICK (P55164), 
CRBA2_HUMAN (P53672), CRBA2_MACFL (Q8HY68), CRBA2_MOUSE (Q9JJV1), 
CRBA2_RABIT (A4L9I9), CRBA4_BOVIN (P11842), CRBA4_CANLF (A2ICR5), 
CRBA4_CHICK (P49152), CRBA4_HUMAN (P53673), CRBA4_MOUSE (Q9JJV0), 
CRBA4_RAT   (P56374), CRBB1_BOVIN (P07318), CRBB1_CHICK (P07530), 
CRBB1_HUMAN (P53674), CRBB1_MOUSE (Q9WVJ5), CRBB1_PIG   (Q007T1), 
CRBB1_RAT   (P02523), CRBB2_AQUCT (Q91318), CRBB2_BOVIN (P02522), 
CRBB2_CANLF (Q2LEC2), CRBB2_CHICK (Q05714), CRBB2_HUMAN (P43320), 
CRBB2_MESAU (P62698), CRBB2_MOUSE (P62696), CRBB2_RABIT (A2IBH5), 
CRBB2_RAT   (P62697), CRBB3_BOVIN (P19141), CRBB3_CHICK (P55165), 
CRBB3_HUMAN (P26998), CRBB3_MOUSE (Q9JJU9), CRBB3_RAT   (P02524), 
CRBG1_HUMAN (Q9Y4K1), CRBG2_HUMAN (Q8N1P7), CRBG3_HUMAN (Q68DQ2), 
CRBG3_MOUSE (Q80W49), CRG11_AQUCT (Q91320), CRG12_AQUCT (Q91321), 
CRG1_RANTE  (P02530), CRG1_XENLA  (Q06254), CRG2_RANTE  (P02531), 
CRG2_RHIAS  (P19865), CRG2_XENLA  (Q91724), CRG3_XENLA  (P55940), 
CRG4_XENLA  (P55941), CRG5_XENLA  (Q06255), CRGA_BOVIN  (P02527), 
CRGA_HUMAN  (P11844), CRGA_MOUSE  (P04345), CRGA_RAT(P10065), 
CRGB_BOVIN  (P02526), CRGB_CANLF  (A3RLE1), CRGB_HUMAN  (P07316), 
CRGB_MACFL  (Q5EF40), CRGB_MACMU  (A3RLD7), CRGB_MOUSE  (P04344), 
CRGB_RAT(P10066), CRGC_BOVIN  (Q28088), CRGC_CANLF  (A3RLE2), 
CRGC_HUMAN  (P07315), CRGC_MACMU  (A3RLD8), CRGC_MOUSE  (Q61597), 
CRGC_RAT(P02529), CRGD_BOVIN  (P08209), CRGD_HUMAN  (P07320), 
CRGD_MACFL  (Q5EF39), CRGD_MOUSE  (P04342), CRGD_RAT(P10067), 
CRGE_MOUSE  (Q03740), CRGE_RAT(P02528), CRGF_BOVIN  (P23005), 
CRGF_MOUSE  (Q9CXV3), CRGF_RAT(P10068), CRGM1_CHIID (P48648), 
CRGM1_CYPCA (P10043), CRGM2_CHIID (P48649), CRGM2_CYPCA (P10044), 
CRGM3_CYPCA (P28022), CRGNA_DANRE (Q5XTN8), CRGNB_DANRE (Q6DGY7), 
CRGN_HUMAN  (Q8WXF5), CRGN_MOUSE  (Q8VHL5), CRGN_RAT(D3ZEG1), 
CRGN_XENTR  (A4QNB6), CRGS1_CHIID (P48646), CRGS2_CHIID (P48647), 
CRYGS_BOVIN (P06504), CRYGS_CANLF (A2IBY7), CRYGS_CYPCA (P10112), 
CRYGS_HUMAN (P22914), CRYGS_MACFL (Q5EF38), CRYGS_MOUSE (O35486), 
CRYGS_RABIT (A4L9I8), CRYGS_RAT   (P0C5E9), DESS_MYXXA  (P02966), 
DEST_MYXXA  (P02967), EDSP_CYNPY  (P46058), SR3A_PHYPO  (P09353)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

73 PDB

1A45; 1A5D; 1A7H; 1AG4; 1AMM; 1BD7; 1BLB; 1DSL; 1E7N; 1ELP; 1GAM; 1GCS; 1H4A; 1HA4; 1HDF; 1HK0; 1I5I; 1M8U; 1NPS; 1OKI; 1PRR; 1PRS; 1YTQ; 1ZGT; 1ZIE; 1ZIQ; 1ZIR; 1ZWM; 1ZWO; 2A5M; 2BB2; 2DAD; 2G98; 2JDF; 2JDG; 2KFB; 2KLJ; 2M3T; 2M3U; 2NBR; 2V2U; 3CW3; 3LWK; 3QK3; 4FD9; 4GCR; 4GR7; 4JGF; 4W9A; 4W9B; 6ETA; 6ETC; 6FD8; 6IF9; 6MYG; 6QDW; 6W5B; 6WCY; 6YS3; 7K7U; 7N36; 7N37; 7N38; 7N39; 7N3A; 7N3B; 7NJE; 7P53; 7RJ0; 8BD0; 8BPI; 8H0R; 8Q3L
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