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	Entry: PS50915

General information about the entry

Entry name [info]

CRYSTALLIN_BETA_GAMMA

Accession [info]

PS50915

Entry type [info]

MATRIX

Date [info]

01-JUL-2003 CREATED; 01-OCT-2013 DATA UPDATE; 05-JUL-2017 INFO UPDATE.

PROSITE Doc. [info]

PDOC00197

Associated ProRule [info]

PRU00028

Name and characterization of the entry

Description [info]

Crystallins beta and gamma 'Greek key' motif profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=44;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=40;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.1640513; R2=0.0252941; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=251; N_SCORE=8.5; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=113; N_SCORE=5.0; MODE=1; TEXT='RR';
/DEFAULT: M0=-8; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='G'; M=  1, -9,-26,-10,-12,-20, 21,-16,-23,-15,-21,-14, -2, -1,-12,-16,  0,-10,-20,-24,-22,-13;
/M: SY='R'; M= -4, -6,-10,-10, -4,-21,-19,  1,-16,  2,-17, -8, -2,-13,  2,  3, -1, -1,-12,-28,-10, -3;
/M: SY='W'; M= -7,-31,-32,-36,-27,  2,-26,-26, 14,-21,  2,  6,-28,-24,-19,-22,-23,-15,  7, 39,  8,-23;
/M: SY='V'; M= -5,-15,-19,-18,-17, -8,-26,-15, 12,-13,  3,  5,-14,-21,-15,-10, -7,  3, 17,-27, -7,-18;
/M: SY='L'; M= -5,-27,-18,-31,-23,  9,-29,-22, 21,-25, 27, 15,-25,-26,-22,-20,-19, -5, 19,-20, -1,-23;
/M: SY='Y'; M=-20,-23,-27,-26,-23, 45,-30,  8,  0,-16,  3,  0,-20,-30,-19,-13,-20,-10, -7, 24, 65,-23;
/M: SY='E'; M= -7,  5,-25, 11, 31,-23,-17, -1,-24,  5,-20,-16,  1, -7, 13, -1,  5, -1,-22,-25, -9, 22;
/M: SY='E'; M=-13, 10,-28, 11, 17,-24,-12, 13,-27,  9,-22,-12, 11,-13,  9, 10, -3,-10,-26,-27, -9, 12;
/M: SY='P'; M=-10, -4,-32,  3, 10,-27,-17,-13,-18, -3,-22,-16, -8, 30, -3,-10, -5, -9,-20,-30,-21,  1;
/M: SY='N'; M=-11, 26,-25, 22,  7,-25,  2,  1,-27, -2,-27,-19, 28,-15,  3, -5,  5, -6,-28,-33,-18,  5;
/M: SY='F'; M=-17,-26,-22,-32,-26, 52,-19,-14, -4,-23,  3, -2,-18,-28,-31,-14,-17,-10, -3,  6, 26,-26;
/M: SY='Q'; M= -4, -2,-24, -1,  5,-25, -4, -6,-22,  1,-18,-10,  0,-13, 12,  3,  5,  0,-19,-26,-15,  8;
/M: SY='G'; M=  0, -8,-29, -8,-14,-29, 61,-18,-38,-18,-29,-20,  1,-18,-17,-18,  2,-17,-29,-22,-29,-15;
/M: SY='K'; M=-13,  1,-28,  1,  5,-24,-20,  8,-20, 16,-18, -6,  2,-15,  8, 16, -9,-11,-17,-25, -6,  5;
/M: SY='Q'; M= -5, -8,  7,-11, -2,-24,-16, -6,-19, -7,-15, -6, -7,-15,  9, -8, -2, -5,-17,-30,-16,  3;
/M: SY='Y'; M= -8,-20,-22,-23,-18,  7,-26,-12, 12,-16,  5,  4,-16,-23,-12,-15, -9, -4,  8,-12, 13,-17;
/M: SY='E'; M= -6, -5,-23, -2,  6,-15,-20,-13, -8, -9, -9, -9, -7, -2, -4,-12,  0, -1, -6,-29,-14,  0;
/M: SY='L'; M= -7,-28,-15,-31,-23, 13,-30,-20, 18,-26, 29, 13,-26,-28,-22,-21,-22, -8, 14,-16,  5,-23;
/M: SY='E'; M=-10,  3,-24,  4, 12,-11,-17, -8,-20, -1,-17,-15,  3, -3, -2,  0,  1,  1,-17,-26,-12,  4;
/M: SY='E'; M=  0,  1,-24,  6, 13,-25,-13,-11,-21, -1,-22,-17, -3, 10,  0, -7,  6,  0,-17,-31,-20,  5;
/M: SY='G'; M= -6, 11,-27, 16,  1,-29, 22,-11,-32,-10,-23,-19,  6,-15, -7,-13,  0,-11,-25,-28,-22, -3;
/I:         I=-15; MD=-32;
/M: SY='E'; M= -3, -2,-10, -4,  5,-16,-14, -6,-14, -7,-12, -8, -3,-14, -1,-10,  0,  1,-11,-27,-12,  2; D=-15;
/I:         I=-15; MI=-32; IM=-32; DM=-32;
/M: SY='Y'; M=-12,-16,-22,-14, -6, -1,-25, -2, -5,-10, -8, -5,-16, -4, -5,-12,-10, -5, -9, -7, 20, -9;
/I:         I=-5; MD=-11;
/M: SY='E'; M= -7,  4,-22,  3,  6,-20,-15, -8,-16, -3,-17,-13,  5,  3,  0, -4,  4,  6,-15,-30,-16,  2; D=-5;
/I:         I=-5; MD=-11;
/M: SY='L'; M= -5,-11, -6,-14,-11, -7,-20,-13, -2,-14,  8,  3,-11,-22, -9,-10,-11, -7, -3,-25, -9,-11; D=-5;
/I:         I=-5; MD=-11;
/M:         M=  0, -5,-18, -7, -6, -7,-13, -7, -8, -7, -7, -6, -3,-16, -2, -6, -2, -4, -7, -8, -2, -4; D=-5;
/I:         I=-5; MD=-11;
/M: SY='Q'; M= -5, -1,-15,  1,  5,-10, -8,  0, -9, -2, -7, -3, -2, -8,  6, -3,  1, -3,-10,-12, -1,  5; D=-5;
/I:         I=-5; MD=-11;
/M:         M= -1, -4, -7, -3,  0, -7,-11, -8, -8, -5, -1, -4, -5,-11, -3, -6, -2, -3, -6,-17, -7, -1; D=-5;
/I:         I=-5; MD=-11;
/M: SY='W'; M= -4,-10,-17,-10, -4, -2, -3,-10,-10, -7, -8, -6,-10,-10, -6, -8, -8, -7,-11, 21,  1, -4; D=-5;
/I:         I=-5; MD=-11;
/M: SY='G'; M= -2, -2,-16, -4, -8,-10,  6, -9,-10, -8,-10, -6,  1,-12, -8, -7,  0, -4, -8,-16,-10, -8; D=-5;
/I:         I=-5; MD=-11;
/M: SY='G'; M= -2, -9,-18, -9, -9,-20, 23,-13,-24,-13,-19,-13, -3,-17, -9,-11,  1, -9,-19,-21,-16,-10; D=-5;
/I:         I=-5; MD=-11;
/M: SY='F'; M= -8,-15,-19,-18,-11,  8,-12,-13,-12,-13,-10, -8,-11, -8,-15,-13, -8, -7,-12, -3,  3,-13; D=-5;
/I:         I=-5; MD=-11;
/M: SY='N'; M= -6,  2,-22, -3, -7,-11, -3, -2, -9,-10,-11, -4,  8,-12, -7,-11, -2, -6,-13,-23, -8, -7; D=-5;
/I:         I=-5; MD=-11;
/M: SY='N'; M= -6,  1,-13,  0, -1, -5, -7, -2, -4, -7, -2, -3,  2,-11, -5, -6, -4, -5, -5,-16, -5, -3; D=-5;
/I:         I=-5; MI=0; MD=-11; IM=0; DM=-11;
/M: SY='B'; M= -2, 10,-20,  8, -2,-16,-10, -6,-16, -6,-18,-14, 10,-16, -3, -7,  6,  4,-12,-28,-11, -3;
/M: SY='K'; M= -6,  1,-18, -2,  3,-22,-13, -7,-20,  6,-22,-12,  5, -8,  6,  3,  5,  3,-17,-27,-13,  4;
/M: SY='V'; M= -2,-22,-14,-29,-24,  0,-30,-26, 22,-22,  8,  7,-17,-21,-21,-22, -7,  6, 23,-24, -5,-24;
/M: SY='S'; M= -2, -4,-12, -6, -5,-23,  2, -7,-22, -4,-24,-14,  4,-16,  0, -2, 12,  0,-16,-31,-17, -3;
/M: SY='S'; M=  7, -2,-12, -2, -1,-18, -3, -5,-18,-11,-25,-17,  8,-12, -1,-10, 34, 16,-10,-38,-17, -1;
/M: SY='I'; M= -8,-27, -9,-31,-25,  0,-31,-19, 24,-24, 19, 19,-24,-26,-19,-21,-18, -8, 22,-26, -4,-24;
/M: SY='R'; M=-15, -2,-24, -4,  3,-22,-19, -1,-27, 28,-23,-10,  4,-17, 11, 39, -8, -9,-21,-21, -7,  4;
/M: SY='V'; M= -6,-26,-21,-25,-21, -4,-28,-22, 15,-18,  3,  3,-24, -1,-22,-18,-13, -5, 20,-26,-10,-23;
/M: SY='I'; M= -8,-19,-23,-21,-15, -5,-27,-12, 14,-20,  9,  7,-15,-17,-10,-17,-11, -6,  9,-24, -4,-14;
/M: SY='R'; M= -7, -9,-19, -8, -7,-19, -1,-14,-22, -4,-20,-14, -6,-14, -8,  2,  0, -5,-14,-16,-15, -8;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_07 which contains 555'100 sequence entries.

Total number of hits

442 in 107 different sequences

Number of true positive hits

442 in 107 different sequences

Number of 'unknown' hits

Number of false positive hits

Number of false negative sequences

Number of 'partial' sequences

Precision (true positives / (true positives + false positives))

100.00 %

Recall (true positives / (true positives + false negatives))

100.00 %

Comments [info]

Matrix type [info]

protein_domain

Scaling database [info]

window20

Author [info]

CJA_Sigrist

Taxonomic range [info]

Eukaryotes, Prokaryotes (Bacteria)

Maximum number of repetitions [info]

Feature key [info]

DOMAIN

Feature description [info]

Beta/gamma crystallin 'Greek key'

Version [info]

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

107 sequences

CRB11_LITCT (Q91315    ), CRB12_LITCT (Q91314    ), CRB31_LITCT (Q91316    ),

CRB32_LITCT (Q91317    ), CRBA1_BOVIN (P11843    ), CRBA1_CHICK (P10042    ), 
CRBA1_HUMAN (P05813    ), CRBA1_MOUSE (P02525    ), CRBA1_RANTE (P07317    ), 
CRBA1_RAT   (P14881    ), CRBA2_BOVIN (P26444    ), CRBA2_CHICK (P55164    ), 
CRBA2_HUMAN (P53672    ), CRBA2_MACFL (Q8HY68    ), CRBA2_MOUSE (Q9JJV1    ), 
CRBA2_RABIT (A4L9I9    ), CRBA4_BOVIN (P11842    ), CRBA4_CANLF (A2ICR5    ), 
CRBA4_CHICK (P49152    ), CRBA4_HUMAN (P53673    ), CRBA4_MOUSE (Q9JJV0    ), 
CRBA4_RAT   (P56374    ), CRBB1_BOVIN (P07318    ), CRBB1_CHICK (P07530    ), 
CRBB1_HUMAN (P53674    ), CRBB1_MOUSE (Q9WVJ5    ), CRBB1_PIG   (Q007T1    ), 
CRBB1_RAT   (P02523    ), CRBB2_BOVIN (P02522    ), CRBB2_CANLF (Q2LEC2    ), 
CRBB2_CHICK (Q05714    ), CRBB2_HUMAN (P43320    ), CRBB2_LITCT (Q91318    ), 
CRBB2_MESAU (P62698    ), CRBB2_MOUSE (P62696    ), CRBB2_RABIT (A2IBH5    ), 
CRBB2_RAT   (P62697    ), CRBB3_BOVIN (P19141    ), CRBB3_CHICK (P55165    ), 
CRBB3_HUMAN (P26998    ), CRBB3_MOUSE (Q9JJU9    ), CRBB3_RAT   (P02524    ), 
CRBG1_HUMAN (Q9Y4K1    ), CRBG2_HUMAN (Q8N1P7    ), CRBG3_HUMAN (Q68DQ2    ), 
CRBG3_MOUSE (Q80W49    ), CRBS1_CHIID (P48646    ), CRBS2_CHIID (P48647    ), 
CRBS_BOVIN  (P06504    ), CRBS_CANLF  (A2IBY7    ), CRBS_CYPCA  (P10112    ), 
CRBS_HUMAN  (P22914    ), CRBS_MACFL  (Q5EF38    ), CRBS_MOUSE  (O35486    ), 
CRBS_RABIT  (A4L9I8    ), CRBS_RAT    (P0C5E9    ), CRG11_LITCT (Q91320    ), 
CRG12_LITCT (Q91321    ), CRG1_RANTE  (P02530    ), CRG1_XENLA  (Q06254    ), 
CRG2_RANTE  (P02531    ), CRG2_RHIAS  (P19865    ), CRG2_XENLA  (Q91724    ), 
CRG3_XENLA  (P55940    ), CRG4_XENLA  (P55941    ), CRG5_XENLA  (Q06255    ), 
CRGA_BOVIN  (P02527    ), CRGA_HUMAN  (P11844    ), CRGA_MOUSE  (P04345    ), 
CRGA_RAT    (P10065    ), CRGB_BOVIN  (P02526    ), CRGB_CANLF  (A3RLE1    ), 
CRGB_HUMAN  (P07316    ), CRGB_MACFL  (Q5EF40    ), CRGB_MACMU  (A3RLD7    ), 
CRGB_MOUSE  (P04344    ), CRGB_RAT    (P10066    ), CRGC_BOVIN  (Q28088    ), 
CRGC_CANLF  (A3RLE2    ), CRGC_HUMAN  (P07315    ), CRGC_MACMU  (A3RLD8    ), 
CRGC_MOUSE  (Q61597    ), CRGC_RAT    (P02529    ), CRGD_BOVIN  (P08209    ), 
CRGD_HUMAN  (P07320    ), CRGD_MACFL  (Q5EF39    ), CRGD_MOUSE  (P04342    ), 
CRGD_RAT    (P10067    ), CRGE_MOUSE  (Q03740    ), CRGE_RAT    (P02528    ), 
CRGF_BOVIN  (P23005    ), CRGF_MOUSE  (Q9CXV3    ), CRGF_RAT    (P10068    ), 
CRGM1_CHIID (P48648    ), CRGM1_CYPCA (P10043    ), CRGM2_CHIID (P48649    ), 
CRGM2_CYPCA (P10044    ), CRGM3_CYPCA (P28022    ), CRGNA_DANRE (Q5XTN8    ), 
CRGNB_DANRE (Q6DGY7    ), CRGN_HUMAN  (Q8WXF5    ), CRGN_MOUSE  (Q8VHL5    ), 
CRGN_XENTR  (A4QNB6    ), DESS_MYXXA  (P02966    ), DEST_MYXXA  (P02967    ), 
EDSP_CYNPY  (P46058    ), SR3A_PHYPO  (P09353    )

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

50 PDB

1A45; 1A5D; 1A7H; 1AG4; 1AMM; 1BD7; 1BLB; 1DSL; 1E7N; 1ELP; 1GAM; 1GCS; 1H4A; 1HA4; 1HDF; 1HK0; 1I5I; 1M8U; 1NPS; 1OKI; 1PRR; 1PRS; 1YTQ; 1ZGT; 1ZIE; 1ZIQ; 1ZIR; 1ZWM; 1ZWO; 2A5M; 2BB2; 2DAD; 2G98; 2JDF; 2JDG; 2KFB; 2KLJ; 2M3T; 2M3U; 2NBR; 2V2U; 3CW3; 3LWK; 3QK3; 4FD9; 4GCR; 4GR7; 4JGF; 4W9A; 4W9B
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View entry in raw text format (no links)
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