Entry: PS50915

General information about the entry

Entry name [info] CRYSTALLIN_BETA_GAMMA
Accession [info] PS50915
Entry type [info] MATRIX
Date [info] JUL-2003 (CREATED); OCT-2013 (DATA UPDATE); MAY-2016 (INFO UPDATE).
PROSITE Doc. [info] PDOC00197
Associated ProRule [info] PRU00028

Name and characterization of the entry

Description [info] Crystallins beta and gamma 'Greek key' motif profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=44;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=40;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.1640513; R2=0.0252941; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=251; N_SCORE=8.5; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=113; N_SCORE=5.0; MODE=1; TEXT='RR';
/DEFAULT: M0=-8; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='G'; M=  1, -9,-26,-10,-12,-20, 21,-16,-23,-15,-21,-14, -2, -1,-12,-16,  0,-10,-20,-24,-22,-13;
/M: SY='R'; M= -4, -6,-10,-10, -4,-21,-19,  1,-16,  2,-17, -8, -2,-13,  2,  3, -1, -1,-12,-28,-10, -3;
/M: SY='W'; M= -7,-31,-32,-36,-27,  2,-26,-26, 14,-21,  2,  6,-28,-24,-19,-22,-23,-15,  7, 39,  8,-23;
/M: SY='V'; M= -5,-15,-19,-18,-17, -8,-26,-15, 12,-13,  3,  5,-14,-21,-15,-10, -7,  3, 17,-27, -7,-18;
/M: SY='L'; M= -5,-27,-18,-31,-23,  9,-29,-22, 21,-25, 27, 15,-25,-26,-22,-20,-19, -5, 19,-20, -1,-23;
/M: SY='Y'; M=-20,-23,-27,-26,-23, 45,-30,  8,  0,-16,  3,  0,-20,-30,-19,-13,-20,-10, -7, 24, 65,-23;
/M: SY='E'; M= -7,  5,-25, 11, 31,-23,-17, -1,-24,  5,-20,-16,  1, -7, 13, -1,  5, -1,-22,-25, -9, 22;
/M: SY='E'; M=-13, 10,-28, 11, 17,-24,-12, 13,-27,  9,-22,-12, 11,-13,  9, 10, -3,-10,-26,-27, -9, 12;
/M: SY='P'; M=-10, -4,-32,  3, 10,-27,-17,-13,-18, -3,-22,-16, -8, 30, -3,-10, -5, -9,-20,-30,-21,  1;
/M: SY='N'; M=-11, 26,-25, 22,  7,-25,  2,  1,-27, -2,-27,-19, 28,-15,  3, -5,  5, -6,-28,-33,-18,  5;
/M: SY='F'; M=-17,-26,-22,-32,-26, 52,-19,-14, -4,-23,  3, -2,-18,-28,-31,-14,-17,-10, -3,  6, 26,-26;
/M: SY='Q'; M= -4, -2,-24, -1,  5,-25, -4, -6,-22,  1,-18,-10,  0,-13, 12,  3,  5,  0,-19,-26,-15,  8;
/M: SY='G'; M=  0, -8,-29, -8,-14,-29, 61,-18,-38,-18,-29,-20,  1,-18,-17,-18,  2,-17,-29,-22,-29,-15;
/M: SY='K'; M=-13,  1,-28,  1,  5,-24,-20,  8,-20, 16,-18, -6,  2,-15,  8, 16, -9,-11,-17,-25, -6,  5;
/M: SY='Q'; M= -5, -8,  7,-11, -2,-24,-16, -6,-19, -7,-15, -6, -7,-15,  9, -8, -2, -5,-17,-30,-16,  3;
/M: SY='Y'; M= -8,-20,-22,-23,-18,  7,-26,-12, 12,-16,  5,  4,-16,-23,-12,-15, -9, -4,  8,-12, 13,-17;
/M: SY='E'; M= -6, -5,-23, -2,  6,-15,-20,-13, -8, -9, -9, -9, -7, -2, -4,-12,  0, -1, -6,-29,-14,  0;
/M: SY='L'; M= -7,-28,-15,-31,-23, 13,-30,-20, 18,-26, 29, 13,-26,-28,-22,-21,-22, -8, 14,-16,  5,-23;
/M: SY='E'; M=-10,  3,-24,  4, 12,-11,-17, -8,-20, -1,-17,-15,  3, -3, -2,  0,  1,  1,-17,-26,-12,  4;
/M: SY='E'; M=  0,  1,-24,  6, 13,-25,-13,-11,-21, -1,-22,-17, -3, 10,  0, -7,  6,  0,-17,-31,-20,  5;
/M: SY='G'; M= -6, 11,-27, 16,  1,-29, 22,-11,-32,-10,-23,-19,  6,-15, -7,-13,  0,-11,-25,-28,-22, -3;
/I:         I=-15; MD=-32;
/M: SY='E'; M= -3, -2,-10, -4,  5,-16,-14, -6,-14, -7,-12, -8, -3,-14, -1,-10,  0,  1,-11,-27,-12,  2; D=-15;
/I:         I=-15; MI=-32; IM=-32; DM=-32;
/M: SY='Y'; M=-12,-16,-22,-14, -6, -1,-25, -2, -5,-10, -8, -5,-16, -4, -5,-12,-10, -5, -9, -7, 20, -9;
/I:         I=-5; MD=-11;
/M: SY='E'; M= -7,  4,-22,  3,  6,-20,-15, -8,-16, -3,-17,-13,  5,  3,  0, -4,  4,  6,-15,-30,-16,  2; D=-5;
/I:         I=-5; MD=-11;
/M: SY='L'; M= -5,-11, -6,-14,-11, -7,-20,-13, -2,-14,  8,  3,-11,-22, -9,-10,-11, -7, -3,-25, -9,-11; D=-5;
/I:         I=-5; MD=-11;
/M:         M=  0, -5,-18, -7, -6, -7,-13, -7, -8, -7, -7, -6, -3,-16, -2, -6, -2, -4, -7, -8, -2, -4; D=-5;
/I:         I=-5; MD=-11;
/M: SY='Q'; M= -5, -1,-15,  1,  5,-10, -8,  0, -9, -2, -7, -3, -2, -8,  6, -3,  1, -3,-10,-12, -1,  5; D=-5;
/I:         I=-5; MD=-11;
/M:         M= -1, -4, -7, -3,  0, -7,-11, -8, -8, -5, -1, -4, -5,-11, -3, -6, -2, -3, -6,-17, -7, -1; D=-5;
/I:         I=-5; MD=-11;
/M: SY='W'; M= -4,-10,-17,-10, -4, -2, -3,-10,-10, -7, -8, -6,-10,-10, -6, -8, -8, -7,-11, 21,  1, -4; D=-5;
/I:         I=-5; MD=-11;
/M: SY='G'; M= -2, -2,-16, -4, -8,-10,  6, -9,-10, -8,-10, -6,  1,-12, -8, -7,  0, -4, -8,-16,-10, -8; D=-5;
/I:         I=-5; MD=-11;
/M: SY='G'; M= -2, -9,-18, -9, -9,-20, 23,-13,-24,-13,-19,-13, -3,-17, -9,-11,  1, -9,-19,-21,-16,-10; D=-5;
/I:         I=-5; MD=-11;
/M: SY='F'; M= -8,-15,-19,-18,-11,  8,-12,-13,-12,-13,-10, -8,-11, -8,-15,-13, -8, -7,-12, -3,  3,-13; D=-5;
/I:         I=-5; MD=-11;
/M: SY='N'; M= -6,  2,-22, -3, -7,-11, -3, -2, -9,-10,-11, -4,  8,-12, -7,-11, -2, -6,-13,-23, -8, -7; D=-5;
/I:         I=-5; MD=-11;
/M: SY='N'; M= -6,  1,-13,  0, -1, -5, -7, -2, -4, -7, -2, -3,  2,-11, -5, -6, -4, -5, -5,-16, -5, -3; D=-5;
/I:         I=-5; MI=0; MD=-11; IM=0; DM=-11;
/M: SY='B'; M= -2, 10,-20,  8, -2,-16,-10, -6,-16, -6,-18,-14, 10,-16, -3, -7,  6,  4,-12,-28,-11, -3;
/M: SY='K'; M= -6,  1,-18, -2,  3,-22,-13, -7,-20,  6,-22,-12,  5, -8,  6,  3,  5,  3,-17,-27,-13,  4;
/M: SY='V'; M= -2,-22,-14,-29,-24,  0,-30,-26, 22,-22,  8,  7,-17,-21,-21,-22, -7,  6, 23,-24, -5,-24;
/M: SY='S'; M= -2, -4,-12, -6, -5,-23,  2, -7,-22, -4,-24,-14,  4,-16,  0, -2, 12,  0,-16,-31,-17, -3;
/M: SY='S'; M=  7, -2,-12, -2, -1,-18, -3, -5,-18,-11,-25,-17,  8,-12, -1,-10, 34, 16,-10,-38,-17, -1;
/M: SY='I'; M= -8,-27, -9,-31,-25,  0,-31,-19, 24,-24, 19, 19,-24,-26,-19,-21,-18, -8, 22,-26, -4,-24;
/M: SY='R'; M=-15, -2,-24, -4,  3,-22,-19, -1,-27, 28,-23,-10,  4,-17, 11, 39, -8, -9,-21,-21, -7,  4;
/M: SY='V'; M= -6,-26,-21,-25,-21, -4,-28,-22, 15,-18,  3,  3,-24, -1,-22,-18,-13, -5, 20,-26,-10,-23;
/M: SY='I'; M= -8,-19,-23,-21,-15, -5,-27,-12, 14,-20,  9,  7,-15,-17,-10,-17,-11, -6,  9,-24, -4,-14;
/M: SY='R'; M= -7, -9,-19, -8, -7,-19, -1,-14,-22, -4,-20,-14, -6,-14, -8,  2,  0, -5,-14,-16,-15, -8;
/I:         E1=0; IE=-105; DE=-105;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2016_05 which contains 551'193 sequence entries.


Total number of hits 442 in 107 different sequences
Number of true positive hits 442 in 107 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 12
Feature key [info] DOMAIN
Feature description [info] Beta/gamma crystallin 'Greek key'
Version [info] 3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
107 sequences

AIM1L_HUMAN (Q8N1P7    ), AIM1_HUMAN  (Q9Y4K1    ), CRB11_LITCT (Q91315    ), 
CRB12_LITCT (Q91314    ), CRB31_LITCT (Q91316    ), CRB32_LITCT (Q91317    ), 
CRBA1_BOVIN (P11843    ), CRBA1_CHICK (P10042    ), CRBA1_HUMAN (P05813    ), 
CRBA1_MOUSE (P02525    ), CRBA1_RANTE (P07317    ), CRBA1_RAT   (P14881    ), 
CRBA2_BOVIN (P26444    ), CRBA2_CHICK (P55164    ), CRBA2_HUMAN (P53672    ), 
CRBA2_MACFL (Q8HY68    ), CRBA2_MOUSE (Q9JJV1    ), CRBA2_RABIT (A4L9I9    ), 
CRBA4_BOVIN (P11842    ), CRBA4_CANLF (A2ICR5    ), CRBA4_CHICK (P49152    ), 
CRBA4_HUMAN (P53673    ), CRBA4_MOUSE (Q9JJV0    ), CRBA4_RAT   (P56374    ), 
CRBB1_BOVIN (P07318    ), CRBB1_CHICK (P07530    ), CRBB1_HUMAN (P53674    ), 
CRBB1_MOUSE (Q9WVJ5    ), CRBB1_PIG   (Q007T1    ), CRBB1_RAT   (P02523    ), 
CRBB2_BOVIN (P02522    ), CRBB2_CANLF (Q2LEC2    ), CRBB2_CHICK (Q05714    ), 
CRBB2_HUMAN (P43320    ), CRBB2_LITCT (Q91318    ), CRBB2_MESAU (P62698    ), 
CRBB2_MOUSE (P62696    ), CRBB2_RABIT (A2IBH5    ), CRBB2_RAT   (P62697    ), 
CRBB3_BOVIN (P19141    ), CRBB3_CHICK (P55165    ), CRBB3_HUMAN (P26998    ), 
CRBB3_MOUSE (Q9JJU9    ), CRBB3_RAT   (P02524    ), CRBG3_HUMAN (Q68DQ2    ), 
CRBG3_MOUSE (Q80W49    ), CRBS1_CHIID (P48646    ), CRBS2_CHIID (P48647    ), 
CRBS_BOVIN  (P06504    ), CRBS_CANLF  (A2IBY7    ), CRBS_CYPCA  (P10112    ), 
CRBS_HUMAN  (P22914    ), CRBS_MACFL  (Q5EF38    ), CRBS_MOUSE  (O35486    ), 
CRBS_RABIT  (A4L9I8    ), CRBS_RAT    (P0C5E9    ), CRG11_LITCT (Q91320    ), 
CRG12_LITCT (Q91321    ), CRG1_RANTE  (P02530    ), CRG1_XENLA  (Q06254    ), 
CRG2_RANTE  (P02531    ), CRG2_RHIAS  (P19865    ), CRG2_XENLA  (Q91724    ), 
CRG3_XENLA  (P55940    ), CRG4_XENLA  (P55941    ), CRG5_XENLA  (Q06255    ), 
CRGA_BOVIN  (P02527    ), CRGA_HUMAN  (P11844    ), CRGA_MOUSE  (P04345    ), 
CRGA_RAT    (P10065    ), CRGB_BOVIN  (P02526    ), CRGB_CANLF  (A3RLE1    ), 
CRGB_HUMAN  (P07316    ), CRGB_MACFL  (Q5EF40    ), CRGB_MACMU  (A3RLD7    ), 
CRGB_MOUSE  (P04344    ), CRGB_RAT    (P10066    ), CRGC_BOVIN  (Q28088    ), 
CRGC_CANLF  (A3RLE2    ), CRGC_HUMAN  (P07315    ), CRGC_MACMU  (A3RLD8    ), 
CRGC_MOUSE  (Q61597    ), CRGC_RAT    (P02529    ), CRGD_BOVIN  (P08209    ), 
CRGD_HUMAN  (P07320    ), CRGD_MACFL  (Q5EF39    ), CRGD_MOUSE  (P04342    ), 
CRGD_RAT    (P10067    ), CRGE_MOUSE  (Q03740    ), CRGE_RAT    (P02528    ), 
CRGF_BOVIN  (P23005    ), CRGF_MOUSE  (Q9CXV3    ), CRGF_RAT    (P10068    ), 
CRGM1_CHIID (P48648    ), CRGM1_CYPCA (P10043    ), CRGM2_CHIID (P48649    ), 
CRGM2_CYPCA (P10044    ), CRGM3_CYPCA (P28022    ), CRGNA_DANRE (Q5XTN8    ), 
CRGNB_DANRE (Q6DGY7    ), CRGN_HUMAN  (Q8WXF5    ), CRGN_MOUSE  (Q8VHL5    ), 
CRGN_XENTR  (A4QNB6    ), DESS_MYXXA  (P02966    ), DEST_MYXXA  (P02967    ), 
EDSP_CYNPY  (P46058    ), SR3A_PHYPO  (P09353    )
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PDB
[Detailed view]
49 PDB

1A45; 1A5D; 1A7H; 1AG4; 1AMM; 1BD7; 1BLB; 1DSL; 1E7N; 1ELP; 1GAM; 1GCS; 1H4A; 1HA4; 1HDF; 1HK0; 1I5I; 1M8U; 1NPS; 1OKI; 1PRR; 1PRS; 1YTQ; 1ZGT; 1ZIE; 1ZIQ; 1ZIR; 1ZWM; 1ZWO; 2A5M; 2BB2; 2DAD; 2G98; 2JDF; 2JDG; 2KFB; 2KLJ; 2M3T; 2M3U; 2V2U; 3CW3; 3LWK; 3QK3; 4FD9; 4GCR; 4GR7; 4JGF; 4W9A; 4W9B
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