To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
Entry: PS50951

General information about the entry

Entry name [info] SARAH
Accession [info] PS50951
Entry type [info] MATRIX
Date [info] 01-JAN-2004 CREATED; 10-MAY-2017 DATA UPDATE; 22-NOV-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC50951
Associated ProRule [info] PRU00310

Name and characterization of the entry

Description [info] SARAH domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=48;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=44;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.3695838; R2=0.0147013; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2551.2155762; R2=1.7990315; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=452; H_SCORE=3364; N_SCORE=9.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=281; H_SCORE=3057; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-7; D=-20; I=-20; B1=-200; E1=-200; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='V'; M=-10,-20,-21,-21,-14, 12,-29,-18, 12,-19, 10,  4,-20,-24,-20,-18,-15, -7, 14,-16,  5,-17;
/M: SY='A'; M=  8,-11,-20,-11,  0,-13,-13,-17, -2,-13,  3, -3,-13,-16, -9,-16, -6, -6,  1,-24,-14, -5;
/M: SY='Q'; M=-13, -5,-26, -7, 10, -2,-22, -3,-15,  0,-10, -5, -3,-15, 14,  0, -7, -9,-19,-15, -2, 13;
/M: SY='W'; M=-17,-32,-34,-33,-25, 24,-26,-15, -3,-22,  7, -3,-30,-30,-21,-18,-30,-18,-11, 61, 33,-21;
/M: SY='D'; M=-13,  7,-29, 10,  7,-22,-21, -9,-11,  4,-11, -8,  2,-14,  0,  0, -8, -9,-12,-28,-12,  2;
/M: SY='N'; M=  5,  1,-18, -8, -7,-10,-10, -8, -9, -4, -7, -4,  8,-18, -6, -6,  0, -3,-10,-25,-11, -7;
/M: SY='F'; M=-17,-31,-23,-38,-28, 56,-30,-21,  6,-29, 16,  4,-23,-29,-33,-21,-23,-12,  2, 13, 22,-27;
/M: SY='S'; M= -3,  8,-19,  7, 12,-23,-12,  3,-22, -3,-22,-15,  9,-10,  8, -5, 17, 12,-18,-34,-14,  9;
/M: SY='L'; M=-12,-28,-20,-34,-25, 25,-29,-18, 19,-25, 27, 22,-24,-27,-22,-19,-23, -9, 13,-13,  7,-23;
/M: SY='P'; M= -5, -2,-32,  6, 14,-30,-15,-13,-24, -5,-26,-20, -7, 42, -2,-14, -1, -7,-26,-31,-25,  4;
/M: SY='E'; M=-11,  9,-27, 19, 30,-26,-20, -5,-19,  1,-13,-14, -2, -9,  9, -6, -4, -9,-16,-31,-16, 19;
/M: SY='L'; M=-10,-29, -9,-30,-21,  8,-30,-21, 16,-30, 45, 17,-29,-31,-21,-21,-28,-10,  8,-22, -2,-21;
/M: SY='E'; M=-12, 10,-28, 12, 18,-28,-19,  5,-21,  6,-19,-11,  6,-11, 18,  5, -1, -6,-22,-28,-12, 17;
/M: SY='N'; M=  0,  7,-20,  1,  2,-21, -4, -4,-20,  2,-22,-11, 14,-13,  4,  2, 11,  4,-17,-30,-17,  3;
/M: SY='F'; M=-18,-23,-26,-29,-21, 34,-29,-10,  0,-11,  2,  1,-15,-26,-19,  3,-17,-10, -2,  1, 23,-21;
/M: SY='L'; M=-10,-17,-23,-16, -7, -5,-27,-15,  8,-15, 23,  9,-19,-23, -8,-12,-20, -9,  3,-23, -5, -8;
/M: SY='E'; M= -9, -4,-17, -3, 10,-22,-13,  1,-23,  1,-15,-10, -2,-14,  9,  7, -1, -3,-20,-27,-13,  8;
/M: SY='M'; M= -2,-13,-23,-19,-11,-12,-20,-12,  3, -1, -1,  8, -7,-17, -5,  2, -8, -6,  1,-23, -8,-10;
/M: SY='L'; M=-11,-29,-21,-30,-21, 10,-30,-16, 20,-27, 42, 21,-28,-29,-18,-19,-28,-10, 10,-16,  6,-20;
/M: SY='D'; M=-13, 19,-27, 25, 10,-30,-10, -3,-25,  7,-22,-12,  9,-13,  7, -1, -3, -9,-20,-31,-16,  9;
/M: SY='E'; M=-10, -5,-28, -3, 13,-23,-19,  0,-20, 10,-16, -6, -5,  1, 10, 10, -6, -8,-20,-25,-12, 10;
/M: SY='E'; M=-10, -3,-26,  2, 32,-17,-22, -4,-12, -1,  1, -1, -9, -9,  9, -6, -9,-10,-16,-26,-13, 20;
/M: SY='E'; M=-12, -9,-25, -9, 14,  1,-23, -3, -7, -6,  2,  8,-12,-14,  1, -8,-12,-10,-11,-16,  1,  8;
/M: SY='E'; M= -7,  7,-28, 12, 28,-28,-17, -4,-25, 17,-20,-10,  0, -7, 13,  5, -4, -9,-22,-26,-15, 20;
/M: SY='R'; M=-14, -1,-29,  2, 18,-28,-20,  1,-25, 17,-17, -9, -1,-13, 23, 27, -6,-10,-23,-23,-12, 19;
/M: SY='E'; M=-11,  7,-30, 14, 47,-26,-21,  8,-28, 10,-19,-16, -1, -4, 19,  2, -2,-11,-28,-25,-10, 32;
/M: SY='I'; M= -7,-29,-21,-34,-27,  3,-33,-25, 35,-26, 25, 20,-25,-25,-21,-23,-20, -7, 28,-23, -3,-26;
/M: SY='E'; M= -8, -6,-27, -5, 14,-12,-16, -1,-18,  0,-13, -8, -4,-13,  8,  3, -5,-10,-18,-20, -8, 10;
/M: SY='Q'; M=-10,  5,-28,  8, 21,-31,-18, -1,-26, 17,-23,-11,  2, -9, 25, 13,  1, -4,-24,-25,-13, 23;
/M: SY='I'; M= -9,-28,-25,-34,-25,  4,-35,-25, 34,-29, 31, 18,-23,-24,-19,-25,-22, -6, 20,-21, -1,-25;
/M: SY='R'; M= -7,-11,-21,-14, -7,-15,-23,-11, -2,  3, -5,  3, -9,-20,  2,  6, -7, -2,  4,-25, -9, -3;
/M: SY='R'; M=-10, -3,-28, -4,  9,-27,-14, -3,-23, 19,-19, -3, -2,-12, 19, 20, -4, -6,-20,-22,-11, 13;
/M: SY='K'; M=-13, -6,-29, -8,  2,-18,-21, -7,-24, 35,-21, -4, -3,-15,  6, 34,-11,-10,-16,-18, -7,  3;
/M: SY='Y'; M=-20,-22,-28,-23,-22, 38,-30, 14,  0,-13,  2,  0,-20,-30,-15,-12,-20,-10, -8, 27, 72,-22;
/M: SY='E'; M= -3,  8,-22,  4, 14,-24,-13, -3,-21,  6,-21,-13, 11,-10, 12,  5,  7,  4,-20,-29,-16, 13;
/M: SY='A'; M= 11, -6,-19, -9,  1,-19,-13,-10,-16,  7,-16, -9, -5,-12,  2,  2,  3,  0, -8,-20, -9,  1;
/M: SY='Y'; M=-13,-14,-18,-14, -5,  0,-26, -5,-10,  5, -2, -2,-14,-22, -6,  0,-16,-10,-10, -8, 16, -6;
/M: SY='R'; M=-19, -9,-30, -9,  1,-21,-20, -1,-30, 32,-21,-10,  0,-19, 10, 67,-10,-10,-20,-20,-10,  1;
/M: SY='Q'; M= -7, -4,-26, -7,  6,-23,-19,  3,-14,  4,-10, -1, -2,-16, 28, 10, -5, -8,-20,-19, -5, 16;
/M: SY='P'; M= -1,-13,-26,-14, -6,-19,-19,-10, -9,  1,-14, -4,-11, 12, -6, -3, -6, -4, -8,-25,-14, -8;
/M: SY='I'; M=-10,-29,-25,-35,-25,  4,-35,-24, 36,-28, 32, 23,-24,-24,-18,-25,-24,-10, 21,-20,  0,-25;
/M: SY='L'; M=-10,-13,-22,-13, -6, -6,-25,-13,  6,-15, 16,  6,-13,-22, -8,-10,-16, -8,  3,-25, -7, -7;
/M: SY='D'; M= -7, 11,-25, 17, 16,-28,-15, -4,-24,  5,-18,-14,  3,-10, 10,  2,  2, -2,-20,-29,-15, 13;
/M: SY='A'; M= 10, -7, -9, -8,  9,-21,-14,-12,-19,  2,-14,-12, -7,-13, -1,  3,  0, -6,-10,-26,-18,  3;
/M: SY='L'; M=-10,-26,-23,-30,-20,  3,-30,-18, 23,-21, 33, 26,-24,-25,-14,-17,-25,-10, 12,-20, -1,-18;
/M: SY='E'; M=-13, 10,-29, 13, 28,-28,-12, 15,-29,  6,-22,-15, 10,-10, 15,  7, -1,-11,-29,-29,-13, 20;
/M: SY='Q'; M=  5,  2,-22, -3,  8,-23,-12, -5,-15,  2,-17,-10,  7,-12,  9,  3,  4, -4,-15,-26,-16,  7;
/M: SY='R'; M=-11,-12,-16,-13, -5,-17,-23,-12,-14, 16, -9, -4, -8,-19, -2, 22,-11, -8, -8,-24,-10, -5;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_11 which contains 556'196 sequence entries.


Total number of hits 43 in 43 different sequences
Number of true positive hits 43 in 43 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] DOMAIN
Feature description [info] SARAH
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
43 sequences

CST1_CAEBR  (A8XJW8    ), CST1_CAEEL  (Q9NB31    ), HIPPO_DROME (Q8T0S6    ), 
RASF1_HUMAN (Q9NS23    ), RASF1_MOUSE (Q99MK9    ), RASF2_HUMAN (P50749    ), 
RASF2_MOUSE (Q8BMS9    ), RASF2_RAT   (Q3B7D5    ), RASF3_HUMAN (Q86WH2    ), 
RASF3_MOUSE (Q99P51    ), RASF4_HUMAN (Q9H2L5    ), RASF4_MOUSE (Q8CB96    ), 
RASF4_RAT   (Q566C5    ), RASF5_HUMAN (Q8WWW0    ), RASF5_MOUSE (Q5EBH1    ), 
RASF5_RAT   (O35141    ), RASF6_HUMAN (Q6ZTQ3    ), RASF6_MOUSE (Q80UQ2    ), 
RASF6_RAT   (Q4QR82    ), SAV1_HUMAN  (Q9H4B6    ), SAV1_MOUSE  (Q8VEB2    ), 
SAV1_RAT    (A4V8B4    ), SAV_DROME   (Q9VCR6    ), STK3_DANRE  (Q7ZUQ3    ), 
STK3_HUMAN  (Q13188    ), STK3_MOUSE  (Q9JI10    ), STK3_RAT    (O54748    ), 
STK3_XENLA  (Q6IP06    ), STK4_AOTNA  (A4K2W5    ), STK4_BOVIN  (Q5E9L6    ), 
STK4_CHICK  (Q5ZJK4    ), STK4_CHLAE  (A4K2Y1    ), STK4_COLGU  (A4K2P5    ), 
STK4_DICDI  (O61125    ), STK4_HUMAN  (Q13043    ), STK4_LEMCA  (A4K2S1    ), 
STK4_MACMU  (A4K2T0    ), STK4_MOUSE  (Q9JI11    ), STK4_OTOGA  (A4K2Q5    ), 
STK4_PAPAN  (A4K2M3    ), STK4_SQUAC  (Q802A6    ), STK4_XENLA  (Q6PA14    ), 
STK4_XENTR  (Q6P3Q4    )
» more

PDB
[Detailed view]
9 PDB

2JO8; 2YMY; 3WWS; 4HKD; 4L0N; 4LGD; 4NR2; 4OH8; 4OH9

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission