PROSITE entry PS50958
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General information about the entry
Entry name [info] | SMB_2 |
Accession [info] | PS50958 |
Entry type [info] | MATRIX |
Date [info] |
01-JUN-2004 CREATED;
10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
PROSITE Doc. [info] | PDOC00453 |
Associated ProRule [info] | PRU00350 |
Name and characterization of the entry
Description [info] | Somatomedin B (SMB) domain profile. |
Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=43; /DISJOINT: DEFINITION=PROTECT; N1=1; N2=43; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.7050011; R2=0.0046693; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1596.1196289; R2=4.5231690; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=813; H_SCORE=5273; N_SCORE=6.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=813; H_SCORE=5273; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-9; D=-50; I=-50; B1=-100; E1=-100; MI=-105; MD=-105; IM=-105; DM=-105; ... A B C D E F G H I K L M N P Q R S T V W Y Z /I: B1=0; BI=-105; BD=-105; /M: SY='E'; M= -4, 10,-26, 15, 19,-28,-14, 8,-28, 8,-21,-15, 4,-10, 7, 6, -2, -9,-22,-28,-13, 12; /M: SY='Q'; M= -2,-13,-25,-13, 2,-20,-23,-12, 0, -8, -4, 0,-13, -5, 9,-10, -7, -7, -3,-24,-12, 4; /M: SY='G'; M= -5, -2,-27, -5, -3,-21, 11,-13,-27, -2,-26,-18, 3,-16, -6, -6, 1, -5,-24, -5,-14, -4; /M: SY='S'; M= 4, -1,-12, -4, -2,-18, -7,-11,-19, -5,-24,-16, 6,-11, -1, -1, 29, 24, -9,-35,-16, -2; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /I: I=-12; MI=0; MD=-25; IM=0; DM=-25; /M: SY='K'; M= -7, 2,-26, 3, 5,-27,-18, 5,-23, 19,-22, -9, 0,-14, 9, 15, -6, -9,-16,-24, -8, 6; /M: SY='G'; M= -7, -5,-30, -3,-11,-17, 28,-17,-32,-10,-25,-18, -2, -6,-16,-14, -5,-15,-25,-20,-19,-13; /M: SY='R'; M= -8, -9,-28,-10, -3,-22, -7, -6,-29, 21,-21,-11, -1,-18, 4, 44, -6,-10,-19,-20,-14, -3; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='F'; M= -8,-16,-22,-21,-20, 20, 5,-15,-16,-20,-10,-10, -8,-22,-23,-17, -2, -3,-11, -7, 7,-20; /M: SY='E'; M= -3, 7,-25, 14, 37,-26,-18, -6,-21, 3,-16,-16, -3, -6, 8, -6, 0, -8,-17,-30,-19, 22; /I: I=-12; MI=0; MD=-25; IM=0; DM=-25; /M: SY='S'; M= 1,-10,-23,-12, -7,-20, 1,-14,-18, -8,-14,-10, -6, -3, -4, -4, 2, 1,-15,-25,-17, -7; /M: SY='F'; M=-18,-20,-23,-24,-22, 42,-29,-15, 4,-25, 11, 1,-17,-26,-27,-19,-19,-10, 0, -1, 22,-23; /M: SY='S'; M= -4, 6,-19, 5, -1,-22, -3, -7,-24, 0,-25,-18, 12,-14, -1, 8, 16, 9,-17,-33,-17, -2; /I: I=-13; MD=-27; /M: SY='R'; M= -5, -9,-14, -9, -8,-10, -5,-10, -6, 4, -8, -3, -7,-13, -6, 9, -5, -5, 2,-14, -8, -8; D=-13; /I: I=-13; MI=-27; MD=-27; IM=-27; DM=-27; /M: SY='H'; M=-13, 7,-23, 9, -2,-13, -8, 10,-19, -3,-11, -9, 7,-17, -3, 2, -7, -9,-18,-19, 1, -4; D=-13; /I: I=-13; DM=-27; /M: SY='H'; M= 0, -1,-19, -2, 3,-19, -2, 9,-21, -1,-18,-10, 2,-11, 0, -4, 6, 1,-16,-24, -9, 1; D=-13; /I: I=-13; DM=-27; /M: SY='N'; M= -8, 0,-21, -8, -6,-12,-19, -9, -3, -6, -1, -2, 6,-18, -1, -5, -3, 5, -8,-27, -9, -4; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='R'; M= -8, -3,-25, -9, -5, -4,-16, 11,-17, 1,-15, -7, 6,-20, 3, 12, -5, -8,-18,-15, 6, -3; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='D'; M=-15, 43,-26, 56, 15,-35, -8, 0,-35, -1,-30,-28, 23,-11, 0, -9, 6, -5,-27,-40,-20, 8; /M: SY='E'; M= 3, -1,-23, 2, 9,-16,-17, -3,-14, -3,-12,-10, -7,-13, 4, -9, -2, -6,-11,-17, 0, 6; /M: SY='A'; M= 8, 2,-19, -4, -7, -7,-10,-10,-13, -7, -8,-10, 4,-17,-10, -6, -1, -5,-10,-22,-11, -8; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='K'; M=-10, -2,-24, 0, 2,-18,-19, -7,-17, 11,-18, -8, -2,-16, 8, 10, -2, -5,-11,-24, -9, 5; /M: SY='D'; M=-13, 4,-26, 11, 8,-16,-19, 6,-18, -2,-10,-10, -2,-16, 0, 1, -6, -8,-14,-24, -1, 3; /M: SY='Y'; M=-15, -6,-25, -6, -8, 2,-23, 3,-12, -2, -4, -4, -7,-21, -7, 2,-11, -4,-11,-11, 15, -9; /M: SY='G'; M= -4, -3,-29, -1,-11,-29, 42,-12,-32,-13,-24,-11, 0,-18, -7,-15, -2,-17,-26,-22,-24, -9; /I: I=-14; MI=0; MD=-29; IM=0; DM=-29; /M: SY='D'; M=-13, 35,-25, 41, 20,-31, -8, 1,-31, 1,-28,-25, 25,-11, 4, -6, 7, -4,-28,-38,-20, 12; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='P'; M=-11,-20,-30,-22,-13, -1,-25,-20, -4, -8, -4, -4,-18, 3,-14,-11,-15, -6, -8, -2, -3,-14; /M: SY='D'; M=-19, 49,-29, 64, 17,-37, -9, 1,-37, 0,-30,-29, 25,-11, 0, -9, 1, -9,-30,-40,-20, 9; /M: SY='Y'; M=-20,-25,-25,-29,-25, 53,-30, 2, 0,-19, 5, 0,-20,-30,-24,-15,-20,-10, -5, 21, 57,-25; /M: SY='E'; M= -9, 8,-25, 12, 22,-28,-16, -3,-26, 11,-22,-15, 4, -8, 16, 9, 5, 0,-22,-29,-15, 18; /M: SY='S'; M= -1, 7,-21, 11, 11,-25, -9, -6,-26, 3,-24,-19, 6,-11, 4, 8, 13, 2,-18,-32,-18, 7; /M: SY='V'; M= 1,-16,-16,-21,-12, 3,-24,-21, 6,-16, 4, 0,-15,-19,-17,-16, -3, 8, 11,-22, -6,-14; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /I: I=-11; MI=0; MD=-23; IM=0; DM=-23; /M: SY='G'; M= 2,-13,-20,-14,-14,-15, 5, -7, -7,-14,-11, -5, -9, -5,-13,-15, -4, -9, -3,-20,-13,-15; D=-11; /I: I=-11; DM=-23; /M: SY='E'; M= -9, 5,-25, 11, 38,-25,-16, 1,-24, 11,-16,-13, 0, -3, 20, 9, -1, -8,-24,-22,-14, 28; D=-11; /I: I=-11; DM=-23; /M: SY='P'; M= -3,-15,-19,-13, -9,-14,-18,-17, -1, -4,-11, -5,-14, 11,-11, -9, -3, -2, 5,-25,-15,-11; D=-11; /I: I=-11; DM=-23; /M: SY='T'; M= -1, 5, 1, 3, 0,-20,-13,-14,-21,-10,-21,-18, 3,-13, -6,-12, 19, 21,-10,-37,-18, -3; /I: E1=0; IE=-105; DE=-105;» more |
Numerical results [info]
Total number of hits | 60 in 38 different sequences |
Number of true positive hits | 60 in 38 different sequences |
Number of 'unknown' hits | 0 |
Number of false positive hits | 0 |
Number of false negative sequences | 0 |
Number of 'partial' sequences | 0 |
Precision (true positives / (true positives + false positives)) | 100.00 % |
Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
Taxonomic range [info] | Eukaryotes |
Maximum number of repetitions [info] | 2 |
Matrix type [info] | protein_domain |
Scaling database [info] | reversed |
Author [info] | CJA_Sigrist |
Feature key [info] | DOMAIN |
Feature description [info] | SMB |
Version [info] | 5 |
Cross-references [info]
UniProtKB/Swiss-Prot True positive sequences |
38 sequences
ENDOU_BOVIN (A6QLQ8), ENDOU_HUMAN (P21128), ENDOU_MOUSE (Q3V188), ENDOU_PAROL (Q9PTU6), ENPP1_HUMAN (P22413), ENPP1_MOUSE (P06802), ENPP1_RAT (Q924C3), ENPP2_BOVIN (A1A4K5), ENPP2_HUMAN (Q13822), ENPP2_MOUSE (Q9R1E6), ENPP2_RAT (Q64610), ENPP3_BOVIN (P15396), ENPP3_HUMAN (O14638), ENPP3_MOUSE (Q6DYE8), ENPP3_PONAB (Q5R5M5), ENPP3_RAT (P97675), PDE1_CROAD (J3SEZ3), PDE2_CROAD (J3SBP3), PDE_CRODO (P0DQQ4), PDE_MACLB (W8E7D1), PDE_NAJAT (A0A2D0TC04), PRG4_HUMAN (Q92954), PRG4_MOUSE (Q9JM99), SBSPO_BOVIN (Q32L50), SBSPO_HUMAN (Q8IVN8), SBSPO_MOUSE (Q3UPR9), SUSD2_HUMAN (Q9UGT4), SUSD2_MOUSE (Q9DBX3), TINAG_BOVIN (Q3SZI1), TINAG_HUMAN (Q9UJW2), TINAL_HUMAN (Q9GZM7), TINAL_MOUSE (Q99JR5), TINAL_RAT (Q9EQT5), VTNC_HUMAN (P04004), VTNC_MOUSE (P29788), VTNC_PIG(P48819), VTNC_RABIT (P22458), YCF2E_CAEEL (P90850)» more
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PDB [Detailed view] |
82 PDB
1OC0; 1S4G; 1SSU; 2CQW; 2JQ8; 2XR9; 2XRG; 2YS0; 3BT1; 3BT2; 3NKM; 3NKN; 3NKO; 3NKP; 3NKQ; 3NKR; 3WAV; 3WAW; 3WAX; 3WAY; 4B56; 4GTW; 4GTX; 4GTY; 4GTZ; 4K24; 4ZG6; 4ZG7; 4ZG9; 4ZGA; 5DLT; 5DLV; 5DLW; 5GZ4; 5GZ5; 5HRT; 5IJQ; 5IJS; 5INH; 5KXA; 5L0B; 5L0E; 5L0K; 5LIA; 5LQQ; 5M0D; 5M0E; 5M0M; 5M0S; 5M7M; 5MHP; 5OHI; 5OLB; 5S9L; 5S9M; 5S9N; 6C01; 6C02; 6G4G; 6LEH; 6WET; 6WEU; 6WEV; 6WEW; 6WFJ; 6XKD; 6Y5M; 7CBA; 7MFH; 7P0K; 7P4J; 7P4O; 7Z0N; 7Z3K; 7Z3L; 8C3O; 8C3P; 8C4W; 8C7R; 9ENT; 9EU5; 9FTW » more |