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Entry: PS51024

General information about the entry

Entry name [info] ZF_FCS
Accession [info] PS51024
Entry type [info] MATRIX
Date [info] 01-NOV-2004 CREATED; 10-MAY-2017 DATA UPDATE; 22-NOV-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC51024
Associated ProRule [info] PRU00367

Name and characterization of the entry

Description [info] Zinc finger FCS-type profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=36;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=33;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.8880839; R2=0.0097104; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1506.6335449; R2=1.4524887; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=733; H_SCORE=2571; N_SCORE=9.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=475; H_SCORE=2197; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-9; D=-20; I=-20; B1=-100; E1=-100; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='P'; M= -8, -7,-29, -2, 12,-25,-16, -9,-24,  4,-26,-18, -5, 24,  3,  8,  3, -4,-23,-30,-21,  5;
/M: SY='D'; M=  1,  9,-26, 12, -5,-26,  6,-14,-17,-12,-17,-14,  2,-14,-11,-18, -2,-10,-13,-27,-19, -9;
/M: SY='P'; M=-11,-14,-32,-14, -6,-23,-10,-12,-11, -3,-15, -6, -8,  5,  4,  5, -9,-12,-15,-22,-15, -4;
/M: SY='K'; M=-10, -9,-32, -7, -1,-28, -1,-12,-30, 17,-28,-15, -5, 10, -1, 16, -8,-12,-25,-22,-19, -3;
/M: SY='S'; M= 14,  7,-14,  8,  1,-24, -2,-11,-21, -8,-25,-19,  7,-10, -2,-12, 26, 10,-11,-35,-20, -1;
/M: SY='D'; M=-11, 17,-30, 26,  4,-34, 15, -9,-38,  5,-30,-22,  8,-13, -4, -4, -2,-13,-28,-28,-21,  0;
/M: SY='M'; M=-12,-13,-24,-19, -9,-11,-20, -2, -2, 12,  0, 29,-11,-18,  4, 18,-16,-10, -3,-20, -4, -3;
/M: SY='A'; M= 27,-18,-12,-24,-16,-10,-13,-22,  5,-16,  7,  0,-18,-18,-16,-20, -2, -2, 13,-22,-14,-16;
/M: SY='T'; M=  8, -8,-14,-14, -9,-14,-18,-20, -7,  1,-11, -6, -8,-14, -9, -6,  6, 18,  5,-26,-12, -9;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='E'; M= -8,  6,-25,  9, 34,-25,-20, -7,-25, 12,-19,-16,  0, -4, 11,  3,  3,  4,-21,-28,-16, 23;
/M: SY='W'; M=-16,-19,-33,-20,-10, -3,-22, -1,-11, -1, -9,  3,-17,-22,  7,  6,-19,-15,-18, 31, 20, -2;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='G'; M= -2,-14,-28,-14,-20,-22, 49,-20,-28,-22,-13,-12, -6,-22,-20,-20, -6,-18,-22,-20,-24,-20;
/M: SY='E'; M=  1,  6,-23,  1, 12,-21,-12, -4,-16,  9,-16, -3,  7,-11,  5,  1, -1, -6,-16,-27,-15,  8;
/M: SY='M'; M= -8,-23,-23,-29,-25,  9, -6,-19,  8,-22,  4, 13,-17,-24,-22,-20,-14,-11,  8,-15, -3,-23;
/M: SY='G'; M=  6, -3,-26, -3,  6,-28, 15,-13,-29,  5,-24,-16, -2,-11, -2, -4,  0,-11,-21,-22,-21,  2;
/M: SY='V'; M= -9,-22,-23,-20,-15, -8,-26,  2,  5,-18,  5,  4,-20, -3,-15,-16,-15, -9,  7,-28, -5,-17;
/M: SY='K'; M=  1, -9,-28, -8,  2,-26,-16,-13,-23, 20,-24,-12, -7, 12,  1, 14, -6, -8,-18,-22,-17, -1;
/M: SY='H'; M=  3, -1,-19,  0, -4,-16,-12,  7,-13,-13, -5, -6, -2,-17, -5,-13,  1, -3,-10,-29, -8, -5;
/M: SY='Q'; M=  1, -2,-23, -5,  8,-29,-17, -4,-19, 12,-19, -6, -2,-10, 26,  6,  3,  2,-18,-22,-12, 17;
/M: SY='F'; M=-18,-28,-22,-33,-25, 53,-30,-10,  4,-25, 16,  4,-22,-30,-29,-18,-22,-10,  0,  9, 36,-25;
/I:         I=-4; MI=0; MD=-22; IM=0; DM=-22;
/M: SY='Y'; M= -9, -7,-17, -7, -2,  1,-15,  9, -5, -1, -5,  0, -7,-13, 11, -1, -7, -6,-11,  5, 25,  3; D=-4;
/I:         I=-4; DM=-22;
/M: SY='T'; M= -3, -2,-12, -6, -4,-12,-13,-10,-14,  0,-13,-10,  2,-10, -2,  9, 13, 22, -6,-23,-10, -4; D=-4;
/I:         I=-4; DM=-22;
/M: SY='K'; M=-10, -4,-30, -4,  1,-28,  2,-10,-32, 29,-28,-12,  0,-14,  3, 26, -8,-12,-22,-20,-15,  1;
/M: SY='R'; M= -3, -2,-19, -4,  1,-21,-12,-10,-23, 13,-25,-14,  4,-12,  3, 16, 14, 11,-13,-29,-14,  1;
/M: SY='K'; M=-12, -2,-30, -2,  8,-28,-20, -8,-30, 46,-28,-10,  0,-12, 10, 37,-10,-10,-20,-20,-10,  8;
/M: SY='R'; M=-18, -5,-30, -3, 14,-22,-20,  0,-30, 25,-20,-12,  0,-15, 12, 53, -8,-10,-22,-22,-12, 10;
/M: SY='F'; M=-20,-28,-22,-36,-28, 70,-30,-12,  0,-26,  8,  0,-20,-30,-34,-18,-20,-10, -2, 14, 40,-28;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='S'; M=  8,  0,-10, -2, -2,-18, -4,-12,-18,-10,-26,-18,  8,-10, -2,-10, 36, 26, -8,-38,-18, -2;
/M: SY='M'; M= -8,-16,-27,-16,  0,-14,-26,-15,  7,-11, -2,  8,-17,  6, -6,-15,-11, -8,  3,-26,-13, -5;
/M: SY='S'; M= 13, -4,-14, -8, -8,-20, 10,-16,-20,-12,-22,-16,  2,-12, -8,-14, 21, 15,-10,-30,-20, -8;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='S'; M= 12, -9,-15,-13, -9,-15,-10,-17, -1,-15,-14, -9, -1,-12, -7,-17, 20,  9,  1,-32,-15, -9;
/M: SY='R'; M= -1, -8,-25,-10,  0,-22,-15, -7,-25, 25,-20,-10, -2,-16,  5, 40, -5, -8,-15,-20,-12,  0;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_11 which contains 556'196 sequence entries.


Total number of hits 21 in 21 different sequences
Number of true positive hits 21 in 21 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 7
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 75.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] N_Hulo
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] ZN_FING
Feature description [info] FCS-type
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
21 sequences

LMBL2_BOVIN (Q1JQD9    ), LMBL2_HUMAN (Q969R5    ), LMBL2_MOUSE (P59178    ), 
LMBL2_PONAB (Q5R737    ), LMBL2_RAT   (Q3MIF2    ), MBTD1_HUMAN (Q05BQ5    ), 
MBTD1_MOUSE (Q6P5G3    ), MBTD1_XENLA (Q32N90    ), MBTD1_XENTR (Q6DIN3    ), 
PHC1_HUMAN  (P78364    ), PHC1_MOUSE  (Q64028    ), PHC2_DANRE  (Q8QHL5    ), 
PHC2_HUMAN  (Q8IXK0    ), PHC2_MOUSE  (Q9QWH1    ), PHC2_XENLA  (Q4V7W5    ), 
PHC3_HUMAN  (Q8NDX5    ), PHC3_MOUSE  (Q8CHP6    ), PHP_DROME   (P39769    ), 
SCM_DROME   (Q9VHA0    ), SMBT_DROME  (Q9VK33    ), SMBT_DROPS  (Q29L50    )
» more

UniProtKB/Swiss-Prot
False negative sequences
7 sequences

SOBPA_DANRE (A5X7A0    ), SOBPB_DANRE (A7XYJ6    ), SOBP_BOVIN  (A7XYH9    ), 
SOBP_CHICK  (A7XYH5    ), SOBP_HUMAN  (A7XYQ1    ), SOBP_MOUSE  (Q0P5V2    ), 
SOBP_RAT    (A7XYI6    )
» more

PDB
[Detailed view]
2 PDB

2L8E; 2W0T

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