Entry: PS51024

Forthcoming changes to the profile format
General information about the entry

Entry name [info] ZF_FCS
Accession [info] PS51024
Entry type [info] MATRIX
Date [info] NOV-2004 (CREATED); OCT-2013 (DATA UPDATE); MAR-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC51024
Associated ProRule [info] PRU00367

Name and characterization of the entry

Description [info] Zinc finger FCS-type profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=36;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=33;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.8880839; R2=0.0097104; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=804.84549; R2=10.17597; TEXT='HScore';
/CUT_OFF: LEVEL=0; SCORE=733; N_SCORE=9.0; H_SCORE=7206; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=475; N_SCORE=6.5; H_SCORE=5638; MODE=1; TEXT='?';
/DEFAULT: M0=-9; D=-20; I=-20; B1=-100; E1=-100; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='P'; M= -8, -7,-29, -2, 12,-25,-16, -9,-24,  4,-26,-18, -5, 24,  3,  8,  3, -4,-23,-30,-21,  5;
/M: SY='D'; M=  1,  9,-26, 12, -5,-26,  6,-14,-17,-12,-17,-14,  2,-14,-11,-18, -2,-10,-13,-27,-19, -9;
/M: SY='P'; M=-11,-14,-32,-14, -6,-23,-10,-12,-11, -3,-15, -6, -8,  5,  4,  5, -9,-12,-15,-22,-15, -4;
/M: SY='K'; M=-10, -9,-32, -7, -1,-28, -1,-12,-30, 17,-28,-15, -5, 10, -1, 16, -8,-12,-25,-22,-19, -3;
/M: SY='S'; M= 14,  7,-14,  8,  1,-24, -2,-11,-21, -8,-25,-19,  7,-10, -2,-12, 26, 10,-11,-35,-20, -1;
/M: SY='D'; M=-11, 17,-30, 26,  4,-34, 15, -9,-38,  5,-30,-22,  8,-13, -4, -4, -2,-13,-28,-28,-21,  0;
/M: SY='M'; M=-12,-13,-24,-19, -9,-11,-20, -2, -2, 12,  0, 29,-11,-18,  4, 18,-16,-10, -3,-20, -4, -3;
/M: SY='A'; M= 27,-18,-12,-24,-16,-10,-13,-22,  5,-16,  7,  0,-18,-18,-16,-20, -2, -2, 13,-22,-14,-16;
/M: SY='T'; M=  8, -8,-14,-14, -9,-14,-18,-20, -7,  1,-11, -6, -8,-14, -9, -6,  6, 18,  5,-26,-12, -9;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='E'; M= -8,  6,-25,  9, 34,-25,-20, -7,-25, 12,-19,-16,  0, -4, 11,  3,  3,  4,-21,-28,-16, 23;
/M: SY='W'; M=-16,-19,-33,-20,-10, -3,-22, -1,-11, -1, -9,  3,-17,-22,  7,  6,-19,-15,-18, 31, 20, -2;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='G'; M= -2,-14,-28,-14,-20,-22, 49,-20,-28,-22,-13,-12, -6,-22,-20,-20, -6,-18,-22,-20,-24,-20;
/M: SY='E'; M=  1,  6,-23,  1, 12,-21,-12, -4,-16,  9,-16, -3,  7,-11,  5,  1, -1, -6,-16,-27,-15,  8;
/M: SY='M'; M= -8,-23,-23,-29,-25,  9, -6,-19,  8,-22,  4, 13,-17,-24,-22,-20,-14,-11,  8,-15, -3,-23;
/M: SY='G'; M=  6, -3,-26, -3,  6,-28, 15,-13,-29,  5,-24,-16, -2,-11, -2, -4,  0,-11,-21,-22,-21,  2;
/M: SY='V'; M= -9,-22,-23,-20,-15, -8,-26,  2,  5,-18,  5,  4,-20, -3,-15,-16,-15, -9,  7,-28, -5,-17;
/M: SY='K'; M=  1, -9,-28, -8,  2,-26,-16,-13,-23, 20,-24,-12, -7, 12,  1, 14, -6, -8,-18,-22,-17, -1;
/M: SY='H'; M=  3, -1,-19,  0, -4,-16,-12,  7,-13,-13, -5, -6, -2,-17, -5,-13,  1, -3,-10,-29, -8, -5;
/M: SY='Q'; M=  1, -2,-23, -5,  8,-29,-17, -4,-19, 12,-19, -6, -2,-10, 26,  6,  3,  2,-18,-22,-12, 17;
/M: SY='F'; M=-18,-28,-22,-33,-25, 53,-30,-10,  4,-25, 16,  4,-22,-30,-29,-18,-22,-10,  0,  9, 36,-25;
/I:         I=-4; MI=0; MD=-22; IM=0; DM=-22;
/M: SY='Y'; M= -9, -7,-17, -7, -2,  1,-15,  9, -5, -1, -5,  0, -7,-13, 11, -1, -7, -6,-11,  5, 25,  3; D=-4;
/I:         I=-4; DM=-22;
/M: SY='T'; M= -3, -2,-12, -6, -4,-12,-13,-10,-14,  0,-13,-10,  2,-10, -2,  9, 13, 22, -6,-23,-10, -4; D=-4;
/I:         I=-4; DM=-22;
/M: SY='K'; M=-10, -4,-30, -4,  1,-28,  2,-10,-32, 29,-28,-12,  0,-14,  3, 26, -8,-12,-22,-20,-15,  1;
/M: SY='R'; M= -3, -2,-19, -4,  1,-21,-12,-10,-23, 13,-25,-14,  4,-12,  3, 16, 14, 11,-13,-29,-14,  1;
/M: SY='K'; M=-12, -2,-30, -2,  8,-28,-20, -8,-30, 46,-28,-10,  0,-12, 10, 37,-10,-10,-20,-20,-10,  8;
/M: SY='R'; M=-18, -5,-30, -3, 14,-22,-20,  0,-30, 25,-20,-12,  0,-15, 12, 53, -8,-10,-22,-22,-12, 10;
/M: SY='F'; M=-20,-28,-22,-36,-28, 70,-30,-12,  0,-26,  8,  0,-20,-30,-34,-18,-20,-10, -2, 14, 40,-28;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='S'; M=  8,  0,-10, -2, -2,-18, -4,-12,-18,-10,-26,-18,  8,-10, -2,-10, 36, 26, -8,-38,-18, -2;
/M: SY='M'; M= -8,-16,-27,-16,  0,-14,-26,-15,  7,-11, -2,  8,-17,  6, -6,-15,-11, -8,  3,-26,-13, -5;
/M: SY='S'; M= 13, -4,-14, -8, -8,-20, 10,-16,-20,-12,-22,-16,  2,-12, -8,-14, 21, 15,-10,-30,-20, -8;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='S'; M= 12, -9,-15,-13, -9,-15,-10,-17, -1,-15,-14, -9, -1,-12, -7,-17, 20,  9,  1,-32,-15, -9;
/M: SY='R'; M= -1, -8,-25,-10,  0,-22,-15, -7,-25, 25,-20,-10, -2,-16,  5, 40, -5, -8,-15,-20,-12,  0;
/I:         E1=0; IE=-105; DE=-105;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_04 which contains 544'996 sequence entries.


Total number of hits 21 in 21 different sequences
Number of true positive hits 21 in 21 different sequences
Number of 'unknown' hits
Number of false positive hits
Number of false negative sequences 7
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 75.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] N_Hulo
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] ZN_FING
Feature description [info] FCS-type
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
21 sequences

LMBL2_BOVIN (Q1JQD9), LMBL2_HUMAN (Q969R5), LMBL2_MOUSE (P59178), 
LMBL2_PONAB (Q5R737), LMBL2_RAT   (Q3MIF2), MBTD1_HUMAN (Q05BQ5), 
MBTD1_MOUSE (Q6P5G3), MBTD1_XENLA (Q32N90), MBTD1_XENTR (Q6DIN3), 
PHC1_HUMAN  (P78364), PHC1_MOUSE  (Q64028), PHC2_DANRE  (Q8QHL5), 
PHC2_HUMAN  (Q8IXK0), PHC2_MOUSE  (Q9QWH1), PHC2_XENLA  (Q4V7W5), 
PHC3_HUMAN  (Q8NDX5), PHC3_MOUSE  (Q8CHP6), PHP_DROME   (P39769), 
SCM_DROME   (Q9VHA0), SMBT_DROME  (Q9VK33), SMBT_DROPS  (Q29L50)
» More

UniProtKB/Swiss-Prot
False negative sequences
7 sequences

SOBPA_DANRE (A5X7A0), SOBPB_DANRE (A7XYJ6), SOBP_BOVIN  (A7XYH9), 
SOBP_CHICK  (A7XYH5), SOBP_HUMAN  (A7XYQ1), SOBP_MOUSE  (Q0P5V2), 
SOBP_RAT    (A7XYI6)
» More

PDB
[Detailed view]
2 PDB

2L8E; 2W0T

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