PROSITE entry PS51036

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General information about the entry

Entry name [info]	ZF_A20
Accession [info]	PS51036
Entry type [info]	MATRIX
Date [info]	01-NOV-2004 CREATED; 01-OCT-2013 DATA UPDATE; 27-MAR-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51036
Associated ProRule [info]	PRU00451

Name and characterization of the entry

Description [info]

Zinc finger A20-type profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=35;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=32;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.1970136; R2=0.0075218; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=838; N_SCORE=7.5; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=573; N_SCORE=5.5; MODE=1; TEXT='R?';
/DEFAULT: M0=-6; D=-30; I=-30; B1=-100; E1=-100; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='P';  M=  2, -2,-25,  0,  1,-18, -5, -3,-15,  1,-13,-12, -4, 10, -2, -7,  5,  0,-15,-28,-15, -3;
/M: SY='P';  M=  3, -7,-19, -7,  4,-23,-11, -6,-12, -1,-11,-12, -8, 21, 14, -7,  2, 10,-17,-28,-12,  6;
/M: SY='A';  M=  4,  1,-18,  0,  4,-23, -3,-10,-10,  2, -9, -5,  2, -2,  0,-11,  3,  4,-13,-27,-16,  2;
/M: SY='P';  M=  2, -1,-27,  8,  4,-30,-12, -4,-20,  4,-17,-16, -9, 30,  9, -1, -2,  1,-18,-32,-16,  2;
/M: SY='P';  M=  0,-12,-21,-13, -5,-14,-10, -8, -3,  2, -4,  1,-10,  4,  1,  0, -4,  2, -7,-23, -7, -4;
/M: SY='M';  M= -5, -8,-17, -7,  2, -1,-15,-11, -6,  9,  3, 13,-12, -3, -4,  5, -9, -7, -8,-19,  6, -1;
/M: SY='C';  M=-30,-20,170,-30, 10,-30,-40,-50,-20,-30,  0,-20,-10,-30,-20,-20,-20,-20,-20,-20,-60,  0;
/M: SY='R';  M=  5, -9,-19, -6,  0,-14,-15,-12,-10,  3,-10, -1,-11, -7, 14, 19, -2, -6, -3,-20, -9,  3;
/I:         I=-8; MD=-27;
/M: SY='N';  M=  4,  5,-19, -2, -4,-13, -4,-13,-10,  6,-15,  0, 14, -9,  5,  7,  5,  2,-11,-30,-18, -3; D=-8;
/I:         I=-8; MI=0; MD=-27; IM=0; DM=-27;
/M: SY='G';  M=  6,  9,-26, -2, -9,-22, 36,-20, -7, -4,-18,-11, 18,-13,-11,-17,  5, -5,-20,-21,-31,-10; D=-8;
/I:         I=-8; DM=-27;
/M: SY='C';  M=-30,-20,170,-30, 10,-30,-40,-50,-20,-30,  0,-20,-10,-30,-20,-20,-20,-20,-20,-20,-60,  0;
/M: SY='G';  M=  1, -1,-33, -3,-11,-25, 43,-22,-10, -4,-15,-15, -5,  2,-15,-15, -1,-12,-22, -6,-21,-13;
/M: SY='F';  M=-17,-22,-31,-37,-30, 66,-27,-15, -3, -9, 13,-14, -5,-31,-18, -9, -9,-12,  3,  0, 24,-28;
/M: SY='F';  M=-22,-23,-37,-23,-25, 44,-24,-17, -2,-10, 18,-13,-20,-23,-18, -9,-12,-11,  7, 17, 41,-25;
/M: SY='G';  M=  0, -3,-32,-11,-18,-20, 53,-24, -2,-10, -9,-10, -4,-16,-20,-18, -3,-13,-18,  1,-19,-18;
/M: SY='N';  M=  8, 12,-19,  0, -8,-14, -6, -8, -5, -2,-15, -4, 28,-14, -4,-13, 15, 18, -8,-49,-25, -8;
/M: SY='P';  M=  3,-12,-11, -9, -1,-23,-13,-10,-12, -1,-16,-18,-15, 30, -2, -5,  2,  5,-11,-31,-20, -5;
/M: SY='Q';  M= 11, -3,-19, -3,  9,-20,-12,-10,-13,  8,-12,  4, -1, -6, 20,  9,  2,  0,-11,-27,-18, 11;
/M: SY='T';  M= -5, -4,-11,-16,-16,  1,-16,-16, -6,-10, -4, -7,  8,-15, -8,-20,  6, 15, -3,-19, -7,-13;
/M: SY='E';  M=  3,  8, -9,  2, 19,-25,-13, -2,-13, 12,-11,  5, 19,-11, 13, -4, -5, -4,-22,-32,-22, 18;
/M: SY='G';  M= -1, 13,-26,  0, -8,-25, 34,-11,-10, -4,-19,-12, 24, -8,-12,-18, -1, -9,-27,-24,-30, -9;
/M: SY='Y';  M=-14,-19,-20,-21,-18, 27,-23, -8, 11,-10, 29, 12,-18,-30,-17, -9,-18, -6, 10, -4, 32,-17;
/M: SY='C';  M=-30,-20,170,-30, 10,-30,-40,-50,-20,-30,  0,-20,-10,-30,-20,-20,-20,-20,-20,-20,-60,  0;
/M: SY='S';  M=  7, -1,-20, -4,  3,-15, -7,  1,-10,  1,-15, -9,  3,-10,  0, -7, 24, 13,-13,-31,-18, -2;
/M: SY='K';  M= -1, -4,-12, -4, 13,-13,-17,-13,-12, 16, -7,  9, -2, -5,  2,  1, -4, -6,-11,-20, -7,  9;
/M: SY='C';  M=-30,-20,170,-30, 10,-30,-40,-50,-20,-30,  0,-20,-10,-30,-20,-20,-20,-20,-20,-20,-60,  0;
/M: SY='F';  M=-25,-27,-40,-27,-21, 44,-25, -4, -9,-10, 13,-13,-24,-24,-10, -3,-12,-15,  0, 28, 44,-20;
/M: SY='R';  M= -3, -7,-22, -8,  1,-13,-13, -2,-12,  9,-12,  6, -2, -7, 12, 23, -6,-14,-11,-20, -9,  3;
/M: SY='D';  M=  2,  7,-15, 18, 18,-26,-12,-11,-24,  7,-11,-14, -3,  3,  6, -1,  0,-11,-18,-23,-16, 13;
/M: SY='M';  M= -2, -7,-22,-10, -2, -3,-17,  0, -7,  2, -2,  4, -1,-11,  0,  0, -2, -3, -5,-24, -3, -2;
/M: SY='Q';  M= -2,-11, -7,-12,  0, -6,-21,-10, -5, -7,  2,  0,-12,-13, 24,  8, -9,  1, -8,-15,  4,  9;
/M: SY='Q';  M=  3, -4,-19, -6,  4,-11,-14, -2,-11,  7, -8,  9,  1,-10, 10, 10, -5, -7,-11,-27,-12,  5;
/M: SY='K';  M= -2, -1,-21,  1, 10,-19,-16,  0,-18, 12,-11,  4,  1, -6, 12, 11, -3, -8,-17,-21, -7,  9;
/M: SY='Q';  M=  8, -6,-21, -5, 11,-24, -3,-11,-16,  8,-15,  0, -6, -3, 25, 12, -2, -6,-17,-16,-17, 15;
/M: SY='Q';  M=  1, -2,-20, -3,  6,-15,-12, -1,-17,  5,-17,-10,  1,  5, 13,  6,  4, -2,-20,-26,-15,  6;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_02 which contains 571'282 sequence entries.

Total number of hits	66 in 47 different sequences
Number of true positive hits	66 in 47 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	1
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	98.51 %

Comments [info]

Matrix type [info]	protein_domain
Scaling database [info]	window20
Author [info]	N_Hulo
Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	7
Feature key [info]	ZN_FING
Feature description [info]	A20-type
Version [info]	3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

47 sequences

OTU7A_HUMAN (Q8TE49), OTU7A_MOUSE (Q8R554), OTU7B_HUMAN (Q6GQQ9),

OTU7B_MOUSE (B2RUR8), RABX5_BOVIN (O18973), RABX5_HUMAN (Q9UJ41), 
RABX5_MOUSE (Q9JM13), SAP10_ARATH (Q9STJ9), SAP10_ORYSJ (Q69LE0), 
SAP11_ORYSJ (Q84PD8), SAP12_ORYSJ (Q6Z541), SAP18_ORYSJ (P0C282), 
SAP1_ARATH  (Q6NNI8), SAP1_ORYSI  (A2Z2J6), SAP1_ORYSJ  (A3C039), 
SAP2_ARATH  (Q8H0X0), SAP2_ORYSJ  (Q942F8), SAP3_ARATH  (Q9ZNU9), 
SAP3_ORYSJ  (Q5JN07), SAP4_ARATH  (Q9SJM6), SAP4_ORYSJ  (Q6H7P8), 
SAP5_ARATH  (Q9LHJ8), SAP5_ORYSJ  (Q6H754), SAP6_ARATH  (Q94B40), 
SAP6_ORYSJ  (Q852K5), SAP7_ARATH  (Q9SZ69), SAP7_ORYSJ  (Q852K6), 
SAP8_ARATH  (Q3EA33), SAP8_ORYSI  (A2YEZ6), SAP8_ORYSJ  (A3BDI8), 
SAP9_ARATH  (O49663), SAP9_ORYSJ  (Q7Y1W9), TNAP3_HUMAN (P21580), 
TNAP3_MACFA (Q4R8W3), TNAP3_MOUSE (Q60769), ZFAN3_HUMAN (Q9H8U3), 
ZFAN3_MOUSE (Q497H0), ZFAN3_RAT   (Q5U2M7), ZFAN3_XENLA (Q66J85), 
ZFAN5_HUMAN (O76080), ZFAN5_MOUSE (O88878), ZFAN5_RAT   (B5DF11), 
ZFAN6_BOVIN (Q3SZY7), ZFAN6_HUMAN (Q6FIF0), ZFAN6_MOUSE (Q9DCH6), 
ZFAN6_PONAB (Q5R7S6), ZFAN6_RAT   (Q6DGF4)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

1 sequence

RL37B_CANAL (A0A1D8PF45)

PDB
[Detailed view]

21 PDB

2C7M; 2C7N; 2EQE; 2EQF; 2EQG; 2FID; 2FIF; 2KZY; 2L00; 3OJ3; 3OJ4; 3VUW; 3VUX; 3VUY; 7PZY; 7Q08; 7Q0F; 7Q0P; 7Q0R; 7QXW; 8Q5I
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