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Entry: PS51051

General information about the entry

Entry name [info] DSL
Accession [info] PS51051
Entry type [info] MATRIX
Date [info] 01-DEC-2004 CREATED; 10-MAY-2017 DATA UPDATE; 20-DEC-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC51051
Associated ProRule [info] PRU00377

Name and characterization of the entry

Description [info] DSL domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=45;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=41;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.8295677; R2=0.0097802; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2493.5966797; R2=2.9556451; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=764; H_SCORE=4752; N_SCORE=10.3; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=376; H_SCORE=3605; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-9; D=-50; I=-50; B1=-200; E1=-200; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='I'; M= -7,-17,-19,-25,-25,  5,-28,-22, 24,-21,  6,  7,-10,-25,-22,-20,-11, -4, 24,-25, -5,-25;
/M: SY='K'; M= -4,-11,-21,-13,-10,-15,-10,-18, -7,  1, -9, -4, -8,-17,-10, -4, -2,  1,  1,-25,-12,-10;
/M: SY='C'; M=-10,-15, 90,-26,-27,-18,-28,-26,-21,-27,-17,-16,-12,-36,-26,-27, -9, -9, -8,-46,-26,-27;
/M: SY='B'; M= -4, 14,-24, 14,  4,-20,-13, -4,-16, -1,-18,-14, 10,-14, -2, -7,  0, -5,-15,-25, -7,  0;
/M: SY='R'; M=-12,  1,-28,  5, 19,-25,-18, -5,-27, 14,-22,-16,  0,  0,  8, 21,  0, -4,-23,-27,-16, 11;
/M: SY='N'; M=-12, 14,-22,  3, -5, -8,-13, 12,-12, -6,-14, -9, 25,-21,  0, -4, -1, -1,-20,-22,  4, -4;
/M: SY='W'; M=-19,-31,-39,-31,-25, 18,-25, -8, -8,-17, -5, -8,-31,-30,-16,-16,-31,-20,-18, 83, 48,-20;
/M: SY='Y'; M=-19,-16,-27,-19,-14, 24,-26, 20,-13, -6, -6, -2, -9,-25,-11,  1,-16,-12,-13, -1, 31,-14;
/M: SY='G'; M= -1, -8,-28, -9,-15,-29, 52,-17,-35,-16,-27,-17,  0,-18,-11,-16,  2,-12,-27,-21,-26,-13;
/M: SY='H'; M= -7, -1,-25, -2, 10,-15, -8, 12,-22, -4,-14,-10,  3,-15,  1,  0, -2, -9,-20,-26, -8,  4;
/M: SY='H'; M= -5,  1,-25,  2,  1,-22, -9, 11,-25,  6,-22,-11,  3,-15,  6,  9,  2, -6,-19,-24, -5,  2;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='E'; M= -3, 14,-24, 19, 21,-28, -4, -5,-29,  1,-24,-20,  8, -9,  4, -2,  8, -4,-23,-32,-20, 12;
/M: SY='K'; M=-10,  1,-25, -1, -1,-21,-19,  5,-16, 11,-19, -7,  4,-15,  1,  8, -3, -4,-11,-27, -7, -2;
/M: SY='F'; M=-11,-21,-21,-27,-20, 41,-24, -1, -5,-22,  3, -1,-14,-26,-23,-16,-11, -7, -5,  0, 25,-20;
/M: SY='C'; M=-10,-18,105,-27,-25,-22,-29,-26,-29,-26,-20,-18,-18,-37,-21,-26, -9,-10,-12,-47,-28,-23;
/M: SY='D'; M=-14, 11,-19, 12,  2,-25,-19,  2,-20,  8,-20,-12,  7,-16, -1,  3, -7,-10,-17,-30,-10, -1;
/M: SY='P'; M= -6,  4,-30, 12, 18,-31,-15, -8,-26,  2,-25,-18, -3, 23,  7, -7,  0, -7,-26,-30,-21, 11;
/M: SY='R'; M=-15,  7,-28, 10, 12,-25,-16,  7,-30, 16,-24,-15,  9,-14,  8, 30, -2, -8,-23,-28,-12,  8;
/M: SY='D'; M= -7,  8,-25, 12,  5,-20,-15, -7,-21, -3,-16,-13,  1, -5,  4, -7,  1, -2,-18,-27,-12,  4;
/M: SY='D'; M= 11, 24,-20, 27,  5,-29, -5, -7,-25, -4,-22,-20, 11,-11, -4,-13,  5, -5,-17,-32,-20,  0;
/M: SY='H'; M= -4, -9,-22,-13, -7,-10,-18,  9,-12, -4,-10, -4, -3,-17, -3,  3, -1, -2, -9,-24, -3, -7;
/M: SY='F'; M= -9, -9,-21,-15,-11, 11,-19,  7,-13, -8, -8, -5, -2,-20,-11, -2, -5, -3,-11,-17,  6,-11;
/I:         I=-14; MD=-29;
/M: SY='G'; M=  3,-11,-15,-14,-14,-12, 12,-14, -4,-13, -7, -1, -7,-14,-12,-14, -1, -6,  0,-17,-13,-14; D=-14;
/I:         I=-14; MI=-29; MD=-29; IM=-29; DM=-29;
/M: SY='H'; M= -8,  0,-21, -2, -5,-17, 11, 25,-23, -6,-18, -8,  8,-14, -2,  0, -3,-12,-21,-19, -5, -5; D=-14;
/I:         I=-14; DM=-29;
/M: SY='Y'; M=-17,-18,-29,-21,-14, 17,-25, -3,-11,  4, -8, -1,-14,-24, -9,  8,-18,-12,-12, 14, 29,-12;
/M: SY='R'; M= -9, -9,-23, -8,  2,-16,-20, -3,-14,  7,-11, -6, -6,-17,  0, 17, -3, -2, -6,-26,-10,  0;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='D'; M=-13, 36,-24, 40, 11,-31, -8,  1,-29, -1,-28,-23, 27,-13,  3, -6,  7,  0,-26,-38,-19,  7;
/M: SY='E'; M= -6, -1,-28,  3, 12,-20,-18, -3,-19,  2,-19,-12, -3,  3,  5, -4, -3, -8,-19,-25,-12,  8;
/M: SY='Q'; M=-13, 14,-27, 15,  8,-28,-15,  7,-21,  7,-18, -6, 10,-14, 16,  3, -4, -9,-23,-28,-10, 12;
/M: SY='G'; M= -2, -4,-30, -2,-16,-31, 62,-18,-40,-18,-30,-21,  2,-19,-18,-19,  0,-19,-30,-22,-29,-17;
/M: SY='N'; M= -7, 10,-24,  7, -1,-25,  2, -5,-23,  1,-24,-14, 14,-16,  4,  1,  4, -2,-20,-29,-17,  1;
/M: SY='L'; M=-14,-20,-26,-22,-13,  4,-26,-11,  0, -4,  8,  7,-17,-16,-10,  2,-19,-10, -4,-12,  6,-13;
/M: SY='G'; M= -3, -9,-21,-11,-11,-19,  6,-16,-18, -2,-18,-11, -4,-18,-10,  2,  4,  3, -6,-26,-17,-11;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='L'; M= -6,-12,-23,-13,-10, -8,-20, -3,  0,-18, 13,  6,-12, -8,-10,-15,-16, -9, -6,-25, -7,-11;
/M: SY='P'; M=-11, -5,-34,  0, 11,-26,-21,-12,-13, -6,-20,-14, -6, 35,  1,-13, -7, -9,-21,-29,-21,  3;
/M: SY='G'; M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='W'; M=-17,-32,-37,-34,-26, 19,-24,-21,-10,-16, -7,-10,-31,-29,-21,-16,-30,-20,-15, 82, 28,-20;
/M: SY='T'; M= -4, -4,-10, -8, -1,-18,-17, -1,-17, -2,-14, -5, -2,-14,  4,  3,  7, 11,-11,-29,-10,  1;
/M: SY='G'; M= -1, -5,-29, -7,-18,-29, 63,-17,-38,-18,-30,-20,  6,-20,-18,-18,  1,-18,-30,-22,-29,-18;
/M: SY='P'; M= -9,  3,-30,  9,  2,-27, -8,-12,-24, -6,-25,-19,  0, 25, -6,-12,  0, -6,-24,-32,-23, -4;
/M: SY='B'; M=-15, 16,-28, 16,  4,-18,-14,  6,-22,  1,-18,-14, 13,-17, -1, -2, -7,-10,-23,-16, -4,  1;
/M: SY='C'; M=-10,-14,106,-25,-27,-20,-27,-26,-29,-27,-21,-20,-12,-38,-27,-27, -8, -9,-12,-49,-29,-27;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_12 which contains 556'388 sequence entries.


Total number of hits 22 in 22 different sequences
Number of true positive hits 22 in 22 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 3
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 88.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] V_Lesaux
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] DOMAIN
Feature description [info] DSL
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
22 sequences

APX1_CAEEL  (P41990    ), DLL1_HUMAN  (O00548    ), DLL1_MOUSE  (Q61483    ), 
DLL1_RAT    (P97677    ), DLL4_HUMAN  (Q9NR61    ), DLL4_MOUSE  (Q9JI71    ), 
DLL4_RAT    (D3ZHH1    ), DLLA_DANRE  (Q6DI48    ), DLLB_DANRE  (O57409    ), 
DLLC_DANRE  (Q9IAT6    ), DLLD_DANRE  (Q8UWJ4    ), DL_DROME    (P10041    ), 
JAG1A_DANRE (Q90Y57    ), JAG1B_DANRE (Q90Y54    ), JAG1_HUMAN  (P78504    ), 
JAG1_MOUSE  (Q9QXX0    ), JAG1_RAT    (Q63722    ), JAG2_HUMAN  (Q9Y219    ), 
JAG2_MOUSE  (Q9QYE5    ), JAG2_RAT    (P97607    ), LAG2_CAEEL  (P45442    ), 
SERR_DROME  (P18168    )
» more

UniProtKB/Swiss-Prot
False negative sequences
3 sequences

DLL3_HUMAN  (Q9NYJ7    ), DLL3_MOUSE  (O88516    ), DLL3_RAT    (O88671    )

		
PDB
[Detailed view]
13 PDB

2VJ2; 4CBZ; 4CC0; 4CC1; 4XBM; 4XL1; 4XLW; 5BO1; 5MVX; 5MW5; 5MW7; 5MWF; 5UK5
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