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Entry: PS51052

General information about the entry

Entry name [info] CYCLOTIDE
Accession [info] PS51052
Entry type [info] MATRIX
Date [info] 01-DEC-2004 CREATED; 10-MAY-2017 DATA UPDATE; 27-SEP-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC51052
Associated ProRule [info] PRU00395

Name and characterization of the entry

Description [info] Cyclotides profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=29;
/DISJOINT: DEFINITION=PROTECT; N1=3; N2=27;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.1032069; R2=0.0062083; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1392.7818604; R2=1.9286714; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1031; H_SCORE=3381; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=709; H_SCORE=2760; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-11; D=-20; I=-20; B1=-100; E1=-100; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='G'; M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='L'; M= -5,-16,-15,-21,-15,  1,-25,-20,  6,-21, 22,  6,-16,-21,-15,-15, -7, 18,  5,-25, -5,-15;
/M: SY='P'; M=-10,-20,-40,-10,  0,-30,-20,-20,-20,-10,-30,-20,-20, 90,-10,-20,-10,-10,-30,-30,-30,-10;
/I:         I=-6; MD=-32;
/M: SY='V'; M=  0,-16, -5,-16,-16,  0,-16,-16, 16,-11,  5,  5,-16,-16,-16,-11, -5,  0, 27,-16, -5,-16; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='G'; M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='E'; M=-10, 10,-30, 20, 60,-30,-20,  0,-30, 10,-20,-20,  0,  0, 20,  0,  0,-10,-30,-30,-20, 40;
/M: SY='T'; M=  5,  0,-10, -5, -5,-15,-11,-15,-15,-10,-19,-15,  5,-10, -5,-10, 29, 36, -5,-35,-15, -5;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='V'; M=  0,-30,-10,-30,-30,  0,-30,-30, 30,-20, 10, 10,-30,-30,-30,-20,-10,  0, 50,-30,-10,-30;
/M: SY='W'; M= -9,-24,-39,-24,-25,-12, 29,-25,-31,-20,-25,-20,-18,-25,-20,-20,-18,-25,-30, 58, -2,-20;
/M: SY='G'; M= -5,-19,-30,-24,-25,-16, 19,-25,  1,-25, -7, -2, -9,-20,-20,-25, -9,-15, -2,-20,-16,-25;
/M: SY='P'; M= -5, -9,-24,-10, -5,-19,-20,-20,-15,-10,-19,-15, -9, 36,-10,-15,  6, 22,-14,-30,-19,-10;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='N'; M=-10,  8,-25, -8,-14,-11,-18, -8, 12,-14, -7, -2, 23,-20, -9,-14, -4, -5, -2,-31,-11,-14;
/M: SY='T'; M=  5,  0,-10, -5, -5,-15,-11,-15,-15,-10,-19,-15,  5,-10, -5,-10, 29, 36, -5,-35,-15, -5;
/M: SY='P'; M= -1,-11,-26, -5,  0,-25,-11,-15,-20,-10,-30,-20, -6, 44, -5,-15, 13,  4,-21,-35,-25, -5;
/I:         I=-6; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='G'; M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='T'; M=  5,  0,-10, -5, -5,-15,-11,-15,-15,-10,-19,-15,  5,-10, -5,-10, 29, 36, -5,-35,-15, -5;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='K'; M=  1,  0,-19,  0,  5,-25, -9,-10,-25, 18,-30,-15,  5,-10,  5,  8, 17,  6,-15,-31,-15,  5;
/M: SY='W'; M=-15, -3,-36,-12,-16, -4,-11,-12,-20,-11,-25,-20,  6,-25,-11,-11,-17,-16,-30, 63,  7,-11;
/M: SY='P'; M=-10,-11,-35, -5,  5,-30,-20,-15,-25, 18,-30,-15,-11, 44, -1,  3,-10,-10,-25,-25,-21, -1;
/M: SY='V'; M=  0,-30,-10,-30,-30,  0,-30,-30, 30,-20, 10, 10,-30,-30,-30,-20,-10,  0, 50,-30,-10,-30;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='Y'; M= -9, -9,-19,-15,-15,  8,-25, -2, -5,-10, -5, -5, -9,-19,-10,-10,  2, 22, -5, -2, 31,-15;
/M: SY='R'; M=-15, -5,-30, -5,  5,-25,-20, -5,-30, 39,-25,-10,  0,-15, 10, 52,-10,-10,-20,-20,-10,  5;
/M: SY='N'; M=-10, 40,-20, 20,  0,-20,  0, 10,-20,  0,-30,-20, 60,-20,  0,  0, 10,  0,-30,-40,-20,  0;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_09 which contains 555'594 sequence entries.


Total number of hits 175 in 170 different sequences
Number of true positive hits 175 in 170 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 12
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 93.58 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 3
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
170 sequences

CIRA_CHACT  (C0HKH8    ), CIRA_CHAPA  (P56871    ), CIRB_CHAPA  (P56879    ), 
CIRC_CHAPA  (P84641    ), CIRD_CHAPA  (P84642    ), CIRE_CHAPA  (P84643    ), 
CIRF_CHAPA  (P84644    ), CYC10_CLITE (C0HKG2    ), CYC11_CHACT (C0HKH6    ), 
CYC12_CLITE (G1CWH8    ), CYC13_CHACT (I0B6G2    ), CYC13_CLITE (C0HJS0    ), 
CYC14_CLITE (C0HJS1    ), CYC15_CLITE (C0HJS2    ), CYC16_CLITE (C0HJS3    ), 
CYC17_CLITE (P86849    ), CYC18_CLITE (C0HJS5    ), CYC19_CLITE (C0HJS6    ), 
CYC1_CLITE  (G1CWH0    ), CYC20_CLITE (C0HJS7    ), CYC2_CHACT  (I0B6F2    ), 
CYC2_CLITE  (G1CWH1    ), CYC4_CLITE  (G1CWH3    ), CYC5_CLITE  (G1CWH4    ), 
CYC6_CLITE  (C0HKF9    ), CYC7_CHACT  (I0B6F4    ), CYC7_CLITE  (G1CWH5    ), 
CYC8_CHACT  (I0B6F5    ), CYC8_CLITE  (G1CWH6    ), CYC9_CHACT  (C0HKH0    ), 
CYC9_CLITE  (C0HKG0    ), CYCA_CLITE  (P86841    ), CYCA_PETHY  (B3EWH5    ), 
CYCB_CLITE  (P86842    ), CYCC_CLITE  (P86843    ), CYCD_CLITE  (P86844    ), 
CYCE_CLITE  (P86845    ), CYCF_CLITE  (P86846    ), CYCG_CLITE  (P86847    ), 
CYCH_CLITE  (P86848    ), CYCJ_CLITE  (P86850    ), CYCK_CLITE  (P86851    ), 
CYCL_CLITE  (P86852    ), CYCM_CLITE  (P86899    ), CYCN_CLITE  (P86900    ), 
CYCO_CLITE  (P86901    ), CYCP_CLITE  (P86902    ), CYCQ_CLITE  (P86904    ), 
CYCR_CLITE  (P86903    ), CYH1_VIOHE  (P58433    ), CYH2_VIOHE  (P85233    ), 
CYH3_VIOHE  (P85232    ), CYH4_VIOHE  (P85234    ), CYLA_PSYLO  (P56872    ), 
CYLRA_LEOTR (C0HKI2    ), CYMBA_MELOB (C0HKJ7    ), CYMBB_MELOB (C0HKJ8    ), 
CYMC1_MELCT (C0HK35    ), CYMC2_MELCT (C0HK36    ), CYMC3_MELCT (C0HK37    ), 
CYMC4_MELCT (C0HK38    ), CYMC5_MELCT (C0HK39    ), CYMC6_MELCT (C0HK40    ), 
CYMC7_MELCT (C0HK41    ), CYMEA_MELDN (C0HKI4    ), CYMEB_MELDN (C0HKI5    ), 
CYMEC_MELDN (C0HKI6    ), CYMEE_MELDN (C0HKI7    ), CYMEF_MELDN (C0HKI8    ), 
CYMEG_MELDN (C0HKI9    ), CYMEH_MELDN (C0HKJ0    ), CYMEI_MELDN (C0HKJ1    ), 
CYMEJ_MELDN (C0HKJ2    ), CYMEK_MELDN (C0HKJ3    ), CYMEL_MELDN (C0HKJ4    ), 
CYMEM_MELDN (C0HKJ5    ), CYMEN_MELDN (C0HKJ6    ), CYML1_MELLF (C0HK28    ), 
CYML2_MELLF (C0HK29    ), CYML3_MELLF (C0HK30    ), CYML4_MELLF (C0HK31    ), 
CYML5_MELLF (C0HK32    ), CYML6_MELLF (C0HK33    ), CYML7_MELLF (C0HK34    ), 
CYMNA_MELAG (C0HKI3    ), CYO10_VIOOD (P58442    ), CYO11_VIOOD (P58443    ), 
CYO12_VIOAR (P83835    ), CYO12_VIOOD (P83836    ), CYO13_VIOOD (Q5USN8    ), 
CYO14_VIOOD (P85177    ), CYO15_VIOOD (P85178    ), CYO16_VIOOD (P85179    ), 
CYO17_VIOOD (P85180    ), CYO18_VIOOD (P85181    ), CYO19_VIOOD (P85182    ), 
CYO1_VIOOD  (P82230    ), CYO20_VIOOD (P85183    ), CYO21_VIOOD (P85184    ), 
CYO22_VIOOD (P85185    ), CYO23_VIOOD (P85186    ), CYO24_VIOOD (P85187    ), 
CYO2_VIOBI  (P85526    ), CYO2_VIOOD  (P58434    ), CYO3_VIOOD  (P58435    ), 
CYO4_VIOOD  (P58436    ), CYO5_VIOOD  (P58437    ), CYO6_VIOOD  (P58438    ), 
CYO7_VIOOD  (P58439    ), CYO8_VIOOD  (P58440    ), CYO9_VIOBI  (B1NRR2    ), 
CYO9_VIOOD  (P58441    ), CYPLA_PALGU (C0HKJ9    ), CYVA_LEOCM  (P84637    ), 
CYVA_VIOBI  (P85239    ), CYVA_VIOCT  (P84635    ), CYVB_LEOCM  (P84638    ), 
CYVB_VIOBI  (P85240    ), CYVB_VIOCT  (P84636    ), CYVC_LEOCM  (P84639    ), 
CYVC_VIOBI  (P85241    ), CYVD_LEOCM  (P84640    ), CYVD_VIOBI  (P85242    ), 
CYVE_VIOBI  (B1NRQ8    ), CYVF_VIOBI  (P85244    ), CYVG_VIOBI  (P85245    ), 
CYVH_VIOBI  (P85246    ), CYVIA_VIODI (C0HKK0    ), CYVI_VIOBI  (B1NRQ9    ), 
CYVJ_VIOBI  (B1NRR0    ), CYVK_VIOBI  (B1NRR1    ), CYVNA_VIOIN (C0HKK1    ), 
CYVNB_VIOIN (C0HKK2    ), CYVUA_VIOPU (C0HKK3    ), CYVUB_VIOPU (C0HKK4    ), 
CYVUC_VIOPU (C0HKK5    ), HYFLA_HYBFL (P84647    ), HYFLB_HYBFL (P84648    ), 
HYFLC_HYBFL (P84649    ), HYPAA_HYBPA (P58445    ), KAB10_OLDAF (P85128    ), 
KAB11_OLDAF (P85129    ), KAB13_OLDAF (P85131    ), KAB14_OLDAF (P85132    ), 
KAB15_OLDAF (P85133    ), KAB16_OLDAF (P85134    ), KAB17_OLDAF (P85135    ), 
KAB1_OLDAF  (P56254    ), KAB2_OLDAF  (P58454    ), KAB3_OLDAF  (P58455    ), 
KAB4_OLDAF  (P83938    ), KAB5_OLDAF  (P58456    ), KAB7_OLDAF  (P58457    ), 
KABS_OLDAF  (P58458    ), PABR1_PALRI (B3EWF1    ), VARA_VIOAR  (P58446    ), 
VARA_VIOBI  (P85525    ), VARA_VIOOD  (Q5USN7    ), VARB_VIOAR  (P58447    ), 
VARC_VIOAR  (P58448    ), VARD_VIOAR  (P58449    ), VARF_VIOAR  (P58451    ), 
VARG_VIOAR  (P58452    ), VARH_VIOAR  (P58453    ), VHL2_VIOHE  (P85231    ), 
VHR1_VIOHE  (P83937    ), VITA_VIOAR  (P83840    ), VITA_VIOBI  (B1NRR3    ), 
VODM_VIOOD  (P83839    ), VODN_VIOOD  (P83838    )
» more

UniProtKB/Swiss-Prot
False negative sequences
12 sequences

CYC10_CHACT (C0HKH7    ), CYC21_CLITE (C0HJS8    ), CYCK_PETHY  (B3EWH6    ), 
CYCM_PETHY  (B3EWH7    ), CYO25_VIOOD (P85188    ), KAB12_OLDAF (P85130    ), 
KAB8_OLDAF  (P85175    ), KAB9_OLDAF  (P85127    ), PALIC_PALCO (P84645    ), 
TRIC_VIOAR  (P0C589    ), VHL1_VIOHE  (P84522    ), VIOLA_VIOOD (Q2HY54    )
» more

PDB
[Detailed view]
33 PDB

1BH4; 1JJZ; 1K48; 1KAL; 1N1U; 1NB1; 1NBJ; 1ORX; 1PT4; 1VB8; 1ZNU; 2ERI; 2F2I; 2F2J; 2GJ0; 2JWM; 2K7G; 2KCG; 2KCH; 2KHB; 2KNM; 2KNN; 2KUK; 2KUX; 2LAM; 2M9O; 2MH1; 2MN1; 2MW0; 3E4H; 4TTM; 4TTN; 4TTO
» more

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