PROSITE entry PS51055

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General information about the entry

Entry name [info]	ITAM_1
Accession [info]	PS51055
Entry type [info]	MATRIX
Date [info]	01-JAN-2005 CREATED; 01-OCT-2013 DATA UPDATE; 27-MAR-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51055
Associated ProRule [info]	PRU00379

Name and characterization of the entry

Description [info]

ITAM motif mammalian type profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=29;
/DISJOINT: DEFINITION=PROTECT; N1=3; N2=27;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.9674824; R2=0.0197046; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=337; N_SCORE=8.6; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=195; N_SCORE=5.8000; MODE=1; TEXT='R?';
/DEFAULT: M0=-7; D=-20; I=-20; B1=*; E1=*; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='D';  M= -4, 18,-25, 24, 15,-30,-12, -5,-26,  2,-23,-19,  8, -5,  6, -5,  4, -3,-21,-32,-18, 10;
/M: SY='R';  M= -6, -8,-26, -8,  0,-22,-17, -9,-15,  8,-17, -7, -5, -4,  6, 14, -2, -4,-12,-24,-13,  1;
/M: SY='R';  M= -1, -8,-27, -8,  3,-27,-15, -8,-21, 11,-21,-10, -6,  5, 11, 12, -3, -7,-18,-23,-16,  5;
/M: SY='R';  M= -3,  0,-24,  0,  2,-21,-14, -7,-19,  4,-21,-14,  1,  1,  0,  5,  2, -1,-16,-26,-12, -1;
/M: SY='R';  M=-11, -9,-29, -7,  0,-18,-11, -9,-16, -1, -9, -7, -8,  0,  0,  2,-10,-10,-18,-22,-11, -2;
/M: SY='M';  M=-10, -7,-24, -9, -2,-11,-22,  0, -2, -6, -2,  2, -4,-15, -1, -7,-10, -8, -5,-23, -3, -3;
/M: SY='P';  M= -7, -6,-32, -1,  8,-28, -5,-12,-25,  1,-25,-17, -5, 26, -1, -6, -5,-11,-26,-27,-23,  2;
/M: SY='N';  M= -9, 16,-25, 12, 11,-27,-10, 14,-23,  0,-26,-14, 22, -6, 14, -2,  6, -5,-27,-33,-14, 11;
/M: SY='D';  M=-14, 25,-30, 35, 26,-33,-14, -2,-31,  1,-26,-24, 12,  7,  4, -7,  0, -7,-29,-35,-21, 15;
/M: SY='Q';  M= -7,  7,-27,  9,  2,-31,  8,  5,-28, -5,-24,-13,  7,-12, 10, -7,  1,-11,-26,-27,-16,  5;
/I:         I=-6; MD=-32;
/M: SY='L';  M= -5,-23,-14,-24,-19,  3,-25,-20, 19,-21, 25, 12,-22,-23,-19,-17,-15,  0, 19,-21, -3,-19; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='Y';  M=-20,-20,-30,-20,-20, 30,-30, 20,  0,-10,  0,  0,-20,-30,-10,-10,-20,-10,-10, 30, 80,-20;
/M: SY='E';  M= -9, 13,-25, 10, 23,-28,-15,  3,-22,  5,-21,-13, 15, -9, 23,  2,  5,  1,-26,-29,-16, 23;
/M: SY='P';  M=  0,-10,-31, -6,  3,-29, 14,-16,-28,-10,-26,-19, -8, 24, -8,-16, -3,-12,-27,-25,-27, -4;
/M: SY='L';  M=-10,-30,-21,-31,-21,  9,-31,-21, 24,-30, 46, 20,-29,-29,-20,-21,-29,-10, 13,-20,  0,-21;
/M: SY='R';  M=-10,  7,-25,  4,  6,-25, -8,  1,-26, 12,-25,-14, 16,-15, 13, 21,  4, -5,-24,-28,-15,  8;
/M: SY='K';  M= -9, -1,-24, -1,  0,-18,-22,-10,-11,  6, -8, -5, -5,-15, -2,  2, -5,  1, -6,-26, -9, -2;
/M: SY='R';  M=-10,  7,-29, 12,  3,-28,  7, -7,-34,  7,-25,-18,  5,-16, -1, 17, -3,-12,-24,-26,-19, -1;
/M: SY='Q';  M=-10, 12,-26, 11, 15,-28,-15,  0,-25, 13,-24,-13, 13,-11, 17, 12,  3, -2,-24,-29,-15, 16;
/M: SY='R';  M=-13, -1,-17, -1,  2,-21,-21, -4,-16,  6,-13, -1, -3,-16,  9, 12, -6, -4,-14,-25, -9,  4;
/M: SY='E';  M=  7, 13,-22, 18, 20,-28, -7, -8,-26, -2,-21,-20,  3, -7,  3,-10,  7, -4,-19,-30,-20, 11;
/M: SY='T';  M= -4, -5,-19, -6,  8,-17,-21,-10, -8, -4, -6, -2, -7,-12,  6, -7,  2, 10, -5,-27,-11,  7;
/M: SY='Y';  M=-10,-19,-27,-20,-19, 23,-26, 14, -1,-10, -1, -1,-19,-27,-10,-11,-16, -9, -9, 23, 66,-19;
/M: SY='E';  M=  0,  7,-22, 12, 17,-19,-12, -2,-22, -3,-21,-18,  2,-10,  3, -8, 10,  0,-18,-25, -6,  9;
/M: SY='S';  M= -3,  1,-15,  2, -6,-22, -2, -2,-21, -8,-19,-13,  1,-17, -6, -6,  5,  1,-11,-31,-14, -7;
/M: SY='L';  M=-10,-24,-24,-25,-11,  2,-31,-19, 20,-24, 33, 14,-23,-23,-14,-19,-23,-10,  9,-21, -3,-14;
/M: SY='N';  M= -7,  3,-24,  1,  2,-21,-11,  0,-13, -1,-17, -9,  6,-14,  0, -5,  0, -3,-12,-29,-11,  0;
/M: SY='G';  M= -7, -4,-26, -6, -4,-23,  3,  3,-24,  1,-21, -7,  1, -9,  0,  2, -2, -7,-19,-25,-13, -3;
/M: SY='R';  M=-10, -2,-25, -5,  5,-16,-12, -4,-18,  7,-13, -4,  2,-16,  6, 14, -4, -6,-17,-23,-11,  4;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_02 which contains 571'282 sequence entries.

Total number of hits	53 in 43 different sequences
Number of true positive hits	53 in 43 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	28
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	65.43 %

Comments [info]

Matrix type [info]	protein_domain
Scaling database [info]	window20
Author [info]	V_Lesaux
Taxonomic range [info]	Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info]	3
Feature key [info]	DOMAIN
Feature description [info]	ITAM
Version [info]	3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

43 sequences

CD3D_BOVIN  (Q28072), CD3D_HUMAN  (P04234), CD3D_MACFA  (Q95LI8),

CD3D_MOUSE  (P04235), CD3D_PIG(Q764N2), CD3D_RAT(P19377), 
CD3D_SHEEP  (P18438), CD3E_BOVIN  (Q28073), CD3E_CANLF  (P27597), 
CD3E_CHICK  (Q98910), CD3E_FELCA  (Q5R1Q1), CD3E_HUMAN  (P07766), 
CD3E_MACFA  (Q95LI5), CD3E_MOUSE  (P22646), CD3E_PIG(Q7YRN2), 
CD3E_RABIT  (Q9TUF9), CD3E_SHEEP  (P29328), CD3G_BOVIN  (Q28074), 
CD3G_HUMAN  (P09693), CD3G_MACFA  (Q95LI7), CD3G_MOUSE  (P11942), 
CD3G_PIG(Q5PXD3), CD3G_RAT(Q64159), CD3G_SHEEP  (P18439), 
CD3Z_HUMAN  (P20963), CD3Z_MOUSE  (P24161), CD3Z_PIG(Q9XSJ9), 
CD3Z_RABIT  (Q9TUF8), CD3Z_SHEEP  (P29329), CD79A_BOVIN (P40293), 
CD79A_CANLF (P0CAN6), CD79A_HUMAN (P11912), CD79A_MOUSE (P11911), 
CD79B_HUMAN (P40259), CD79B_MOUSE (P15530), FCERG_BOVIN (Q9BDR7), 
FCERG_CAVPO (Q07249), FCERG_HUMAN (P30273), FCERG_MACFA (Q8SPW1), 
FCERG_MOUSE (P20491), FCERG_PIG   (Q9XSZ6), FCERG_RAT   (P20411), 
NFAM1_HUMAN (Q8NET5)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

28 sequences

GP_HANTB(P28728), GP_HANTH(P16493), GP_HANTL(P16853),

GP_HANTV(P08668), GP_NYV  (Q83887), GP_PHV  (P27315), 
GP_PUUMG(P21400), GP_PUUMK(P41265), GP_PUUMP(P41266), 
GP_PUUMS(P27312), GP_SEOU8(P33455), GP_SEOUR(P28729), 
GP_SEOUS(P17880), NFAM1_MOUSE (Q8R4V1), STAM1_CAEEL (O01498), 
STAM1_HUMAN (Q92783), STAM1_MOUSE (P70297), STAM2_CHICK (O93436), 
STAM2_HUMAN (O75886), STAM2_MOUSE (O88811), STAM2_RAT   (Q5XHY7), 
TYOBP_BOVIN (Q95J79), TYOBP_HUMAN (O43914), TYOBP_MACMU (Q8WNQ8), 
TYOBP_MOUSE (O54885), TYOBP_PANTR (A4F4L0), TYOBP_PIG   (Q9TU45), 
TYOBP_RAT   (Q6X9T7)

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PDB
[Detailed view]

21 PDB

1A81; 1CV9; 1TCE; 2K4F; 2OQ1; 3IK5; 3IOZ; 4XZ1; 6JXR; 7FJD; 7FJE; 7FJF; 7Q5T; 7Q5U; 7Q5W; 7XQ8; 8E4C; 8EMA; 8ES7; 8ES8; 8ES9
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