Entry: PS51055

Forthcoming changes to the profile format
General information about the entry

Entry name [info] ITAM_1
Accession [info] PS51055
Entry type [info] MATRIX
Date [info] JAN-2005 (CREATED); OCT-2013 (DATA UPDATE); JUL-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC51055
Associated ProRule [info] PRU00379

Name and characterization of the entry

Description [info] ITAM motif mammalian type profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=29;
/DISJOINT: DEFINITION=PROTECT; N1=3; N2=27;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.9674824; R2=0.0197046; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=943.36431; R2=10.43123; TEXT='HScore';
/CUT_OFF: LEVEL=0; SCORE=337; N_SCORE=8.6; H_SCORE=3875; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=195; N_SCORE=5.8000; H_SCORE=2811; MODE=1; TEXT='R?';
/DEFAULT: M0=-7; D=-20; I=-20; B1=*; E1=*; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='D'; M= -4, 18,-25, 24, 15,-30,-12, -5,-26,  2,-23,-19,  8, -5,  6, -5,  4, -3,-21,-32,-18, 10;
/M: SY='R'; M= -6, -8,-26, -8,  0,-22,-17, -9,-15,  8,-17, -7, -5, -4,  6, 14, -2, -4,-12,-24,-13,  1;
/M: SY='R'; M= -1, -8,-27, -8,  3,-27,-15, -8,-21, 11,-21,-10, -6,  5, 11, 12, -3, -7,-18,-23,-16,  5;
/M: SY='R'; M= -3,  0,-24,  0,  2,-21,-14, -7,-19,  4,-21,-14,  1,  1,  0,  5,  2, -1,-16,-26,-12, -1;
/M: SY='R'; M=-11, -9,-29, -7,  0,-18,-11, -9,-16, -1, -9, -7, -8,  0,  0,  2,-10,-10,-18,-22,-11, -2;
/M: SY='M'; M=-10, -7,-24, -9, -2,-11,-22,  0, -2, -6, -2,  2, -4,-15, -1, -7,-10, -8, -5,-23, -3, -3;
/M: SY='P'; M= -7, -6,-32, -1,  8,-28, -5,-12,-25,  1,-25,-17, -5, 26, -1, -6, -5,-11,-26,-27,-23,  2;
/M: SY='N'; M= -9, 16,-25, 12, 11,-27,-10, 14,-23,  0,-26,-14, 22, -6, 14, -2,  6, -5,-27,-33,-14, 11;
/M: SY='D'; M=-14, 25,-30, 35, 26,-33,-14, -2,-31,  1,-26,-24, 12,  7,  4, -7,  0, -7,-29,-35,-21, 15;
/M: SY='Q'; M= -7,  7,-27,  9,  2,-31,  8,  5,-28, -5,-24,-13,  7,-12, 10, -7,  1,-11,-26,-27,-16,  5;
/I:         I=-6; MD=-32;
/M: SY='L'; M= -5,-23,-14,-24,-19,  3,-25,-20, 19,-21, 25, 12,-22,-23,-19,-17,-15,  0, 19,-21, -3,-19; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='Y'; M=-20,-20,-30,-20,-20, 30,-30, 20,  0,-10,  0,  0,-20,-30,-10,-10,-20,-10,-10, 30, 80,-20;
/M: SY='E'; M= -9, 13,-25, 10, 23,-28,-15,  3,-22,  5,-21,-13, 15, -9, 23,  2,  5,  1,-26,-29,-16, 23;
/M: SY='P'; M=  0,-10,-31, -6,  3,-29, 14,-16,-28,-10,-26,-19, -8, 24, -8,-16, -3,-12,-27,-25,-27, -4;
/M: SY='L'; M=-10,-30,-21,-31,-21,  9,-31,-21, 24,-30, 46, 20,-29,-29,-20,-21,-29,-10, 13,-20,  0,-21;
/M: SY='R'; M=-10,  7,-25,  4,  6,-25, -8,  1,-26, 12,-25,-14, 16,-15, 13, 21,  4, -5,-24,-28,-15,  8;
/M: SY='K'; M= -9, -1,-24, -1,  0,-18,-22,-10,-11,  6, -8, -5, -5,-15, -2,  2, -5,  1, -6,-26, -9, -2;
/M: SY='R'; M=-10,  7,-29, 12,  3,-28,  7, -7,-34,  7,-25,-18,  5,-16, -1, 17, -3,-12,-24,-26,-19, -1;
/M: SY='Q'; M=-10, 12,-26, 11, 15,-28,-15,  0,-25, 13,-24,-13, 13,-11, 17, 12,  3, -2,-24,-29,-15, 16;
/M: SY='R'; M=-13, -1,-17, -1,  2,-21,-21, -4,-16,  6,-13, -1, -3,-16,  9, 12, -6, -4,-14,-25, -9,  4;
/M: SY='E'; M=  7, 13,-22, 18, 20,-28, -7, -8,-26, -2,-21,-20,  3, -7,  3,-10,  7, -4,-19,-30,-20, 11;
/M: SY='T'; M= -4, -5,-19, -6,  8,-17,-21,-10, -8, -4, -6, -2, -7,-12,  6, -7,  2, 10, -5,-27,-11,  7;
/M: SY='Y'; M=-10,-19,-27,-20,-19, 23,-26, 14, -1,-10, -1, -1,-19,-27,-10,-11,-16, -9, -9, 23, 66,-19;
/M: SY='E'; M=  0,  7,-22, 12, 17,-19,-12, -2,-22, -3,-21,-18,  2,-10,  3, -8, 10,  0,-18,-25, -6,  9;
/M: SY='S'; M= -3,  1,-15,  2, -6,-22, -2, -2,-21, -8,-19,-13,  1,-17, -6, -6,  5,  1,-11,-31,-14, -7;
/M: SY='L'; M=-10,-24,-24,-25,-11,  2,-31,-19, 20,-24, 33, 14,-23,-23,-14,-19,-23,-10,  9,-21, -3,-14;
/M: SY='N'; M= -7,  3,-24,  1,  2,-21,-11,  0,-13, -1,-17, -9,  6,-14,  0, -5,  0, -3,-12,-29,-11,  0;
/M: SY='G'; M= -7, -4,-26, -6, -4,-23,  3,  3,-24,  1,-21, -7,  1, -9,  0,  2, -2, -7,-19,-25,-13, -3;
/M: SY='R'; M=-10, -2,-25, -5,  5,-16,-12, -4,-18,  7,-13, -4,  2,-16,  6, 14, -4, -6,-17,-23,-11,  4;
/I:         E1=0; IE=-105; DE=-105;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_08 which contains 546'238 sequence entries.


Total number of hits 55 in 44 different sequences
Number of true positive hits 55 in 44 different sequences
Number of 'unknown' hits
Number of false positive hits
Number of false negative sequences 28
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 66.27 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] V_Lesaux
Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 3
Feature key [info] DOMAIN
Feature description [info] ITAM
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
44 sequences

CD3D_BOVIN  (Q28072), CD3D_HUMAN  (P04234), CD3D_MACFA  (Q95LI8), 
CD3D_MOUSE  (P04235), CD3D_PIG    (Q764N2), CD3D_RAT    (P19377), 
CD3D_SHEEP  (P18438), CD3E_BOVIN  (Q28073), CD3E_CANFA  (P27597), 
CD3E_CHICK  (Q98910), CD3E_FELCA  (Q5R1Q1), CD3E_HUMAN  (P07766), 
CD3E_MACFA  (Q95LI5), CD3E_MOUSE  (P22646), CD3E_PIG    (Q7YRN2), 
CD3E_RABIT  (Q9TUF9), CD3E_SHEEP  (P29328), CD3G_BOVIN  (Q28074), 
CD3G_HUMAN  (P09693), CD3G_MACFA  (Q95LI7), CD3G_MOUSE  (P11942), 
CD3G_PIG    (Q5PXD3), CD3G_RAT    (Q64159), CD3G_SHEEP  (P18439), 
CD3H_MOUSE  (P29020), CD3Z_HUMAN  (P20963), CD3Z_MOUSE  (P24161), 
CD3Z_PIG    (Q9XSJ9), CD3Z_RABIT  (Q9TUF8), CD3Z_SHEEP  (P29329), 
CD79A_BOVIN (P40293), CD79A_CANFA (P0CAN6), CD79A_HUMAN (P11912), 
CD79A_MOUSE (P11911), CD79B_HUMAN (P40259), CD79B_MOUSE (P15530), 
FCERG_BOVIN (Q9BDR7), FCERG_CAVPO (Q07249), FCERG_HUMAN (P30273), 
FCERG_MACFA (Q8SPW1), FCERG_MOUSE (P20491), FCERG_PIG   (Q9XSZ6), 
FCERG_RAT   (P20411), NFAM1_HUMAN (Q8NET5)
» More

UniProtKB/Swiss-Prot
False negative sequences
28 sequences

GP_HANTB    (P28728), GP_HANTH    (P16493), GP_HANTL    (P16853), 
GP_HANTV    (P08668), GP_NYV      (Q83887), GP_PHV      (P27315), 
GP_PUUMG    (P21400), GP_PUUMK    (P41265), GP_PUUMP    (P41266), 
GP_PUUMS    (P27312), GP_SEOU8    (P33455), GP_SEOUR    (P28729), 
GP_SEOUS    (P17880), NFAM1_MOUSE (Q8R4V1), STAM1_CAEEL (O01498), 
STAM1_HUMAN (Q92783), STAM1_MOUSE (P70297), STAM2_CHICK (O93436), 
STAM2_HUMAN (O75886), STAM2_MOUSE (O88811), STAM2_RAT   (Q5XHY7), 
TYOBP_BOVIN (Q95J79), TYOBP_HUMAN (O43914), TYOBP_MACMU (Q8WNQ8), 
TYOBP_MOUSE (O54885), TYOBP_PANTR (A4F4L0), TYOBP_PIG   (Q9TU45), 
TYOBP_RAT   (Q6X9T7)
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PDB
[Detailed view]
1 PDB

2K4F

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