Entry: PS51055

General information about the entry

Entry name [info] ITAM_1
Accession [info] PS51055
Entry type [info] MATRIX
Date [info] JAN-2005 (CREATED); OCT-2013 (DATA UPDATE); MAY-2015 (INFO UPDATE).
PROSITE Doc. [info] PDOC51055
Associated ProRule [info] PRU00379

Name and characterization of the entry

Description [info] ITAM motif mammalian type profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=29;
/DISJOINT: DEFINITION=PROTECT; N1=3; N2=27;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.9674824; R2=0.0197046; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=943.36431; R2=10.43123; TEXT='HScore';
/CUT_OFF: LEVEL=0; SCORE=337; N_SCORE=8.6; H_SCORE=3875; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=195; N_SCORE=5.8000; H_SCORE=2811; MODE=1; TEXT='R?';
/DEFAULT: M0=-7; D=-20; I=-20; B1=*; E1=*; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='D'; M= -4, 18,-25, 24, 15,-30,-12, -5,-26,  2,-23,-19,  8, -5,  6, -5,  4, -3,-21,-32,-18, 10;
/M: SY='R'; M= -6, -8,-26, -8,  0,-22,-17, -9,-15,  8,-17, -7, -5, -4,  6, 14, -2, -4,-12,-24,-13,  1;
/M: SY='R'; M= -1, -8,-27, -8,  3,-27,-15, -8,-21, 11,-21,-10, -6,  5, 11, 12, -3, -7,-18,-23,-16,  5;
/M: SY='R'; M= -3,  0,-24,  0,  2,-21,-14, -7,-19,  4,-21,-14,  1,  1,  0,  5,  2, -1,-16,-26,-12, -1;
/M: SY='R'; M=-11, -9,-29, -7,  0,-18,-11, -9,-16, -1, -9, -7, -8,  0,  0,  2,-10,-10,-18,-22,-11, -2;
/M: SY='M'; M=-10, -7,-24, -9, -2,-11,-22,  0, -2, -6, -2,  2, -4,-15, -1, -7,-10, -8, -5,-23, -3, -3;
/M: SY='P'; M= -7, -6,-32, -1,  8,-28, -5,-12,-25,  1,-25,-17, -5, 26, -1, -6, -5,-11,-26,-27,-23,  2;
/M: SY='N'; M= -9, 16,-25, 12, 11,-27,-10, 14,-23,  0,-26,-14, 22, -6, 14, -2,  6, -5,-27,-33,-14, 11;
/M: SY='D'; M=-14, 25,-30, 35, 26,-33,-14, -2,-31,  1,-26,-24, 12,  7,  4, -7,  0, -7,-29,-35,-21, 15;
/M: SY='Q'; M= -7,  7,-27,  9,  2,-31,  8,  5,-28, -5,-24,-13,  7,-12, 10, -7,  1,-11,-26,-27,-16,  5;
/I:         I=-6; MD=-32;
/M: SY='L'; M= -5,-23,-14,-24,-19,  3,-25,-20, 19,-21, 25, 12,-22,-23,-19,-17,-15,  0, 19,-21, -3,-19; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='Y'; M=-20,-20,-30,-20,-20, 30,-30, 20,  0,-10,  0,  0,-20,-30,-10,-10,-20,-10,-10, 30, 80,-20;
/M: SY='E'; M= -9, 13,-25, 10, 23,-28,-15,  3,-22,  5,-21,-13, 15, -9, 23,  2,  5,  1,-26,-29,-16, 23;
/M: SY='P'; M=  0,-10,-31, -6,  3,-29, 14,-16,-28,-10,-26,-19, -8, 24, -8,-16, -3,-12,-27,-25,-27, -4;
/M: SY='L'; M=-10,-30,-21,-31,-21,  9,-31,-21, 24,-30, 46, 20,-29,-29,-20,-21,-29,-10, 13,-20,  0,-21;
/M: SY='R'; M=-10,  7,-25,  4,  6,-25, -8,  1,-26, 12,-25,-14, 16,-15, 13, 21,  4, -5,-24,-28,-15,  8;
/M: SY='K'; M= -9, -1,-24, -1,  0,-18,-22,-10,-11,  6, -8, -5, -5,-15, -2,  2, -5,  1, -6,-26, -9, -2;
/M: SY='R'; M=-10,  7,-29, 12,  3,-28,  7, -7,-34,  7,-25,-18,  5,-16, -1, 17, -3,-12,-24,-26,-19, -1;
/M: SY='Q'; M=-10, 12,-26, 11, 15,-28,-15,  0,-25, 13,-24,-13, 13,-11, 17, 12,  3, -2,-24,-29,-15, 16;
/M: SY='R'; M=-13, -1,-17, -1,  2,-21,-21, -4,-16,  6,-13, -1, -3,-16,  9, 12, -6, -4,-14,-25, -9,  4;
/M: SY='E'; M=  7, 13,-22, 18, 20,-28, -7, -8,-26, -2,-21,-20,  3, -7,  3,-10,  7, -4,-19,-30,-20, 11;
/M: SY='T'; M= -4, -5,-19, -6,  8,-17,-21,-10, -8, -4, -6, -2, -7,-12,  6, -7,  2, 10, -5,-27,-11,  7;
/M: SY='Y'; M=-10,-19,-27,-20,-19, 23,-26, 14, -1,-10, -1, -1,-19,-27,-10,-11,-16, -9, -9, 23, 66,-19;
/M: SY='E'; M=  0,  7,-22, 12, 17,-19,-12, -2,-22, -3,-21,-18,  2,-10,  3, -8, 10,  0,-18,-25, -6,  9;
/M: SY='S'; M= -3,  1,-15,  2, -6,-22, -2, -2,-21, -8,-19,-13,  1,-17, -6, -6,  5,  1,-11,-31,-14, -7;
/M: SY='L'; M=-10,-24,-24,-25,-11,  2,-31,-19, 20,-24, 33, 14,-23,-23,-14,-19,-23,-10,  9,-21, -3,-14;
/M: SY='N'; M= -7,  3,-24,  1,  2,-21,-11,  0,-13, -1,-17, -9,  6,-14,  0, -5,  0, -3,-12,-29,-11,  0;
/M: SY='G'; M= -7, -4,-26, -6, -4,-23,  3,  3,-24,  1,-21, -7,  1, -9,  0,  2, -2, -7,-19,-25,-13, -3;
/M: SY='R'; M=-10, -2,-25, -5,  5,-16,-12, -4,-18,  7,-13, -4,  2,-16,  6, 14, -4, -6,-17,-23,-11,  4;
/I:         E1=0; IE=-105; DE=-105;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2015_07 which contains 548'872 sequence entries.


Total number of hits 55 in 44 different sequences
Number of true positive hits 55 in 44 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 28
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 66.27 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] V_Lesaux
Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 3
Feature key [info] DOMAIN
Feature description [info] ITAM
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
44 sequences

CD3D_BOVIN  (Q28072), CD3D_HUMAN  (P04234), CD3D_MACFA  (Q95LI8), 
CD3D_MOUSE  (P04235), CD3D_PIG    (Q764N2), CD3D_RAT    (P19377), 
CD3D_SHEEP  (P18438), CD3E_BOVIN  (Q28073), CD3E_CANFA  (P27597), 
CD3E_CHICK  (Q98910), CD3E_FELCA  (Q5R1Q1), CD3E_HUMAN  (P07766), 
CD3E_MACFA  (Q95LI5), CD3E_MOUSE  (P22646), CD3E_PIG    (Q7YRN2), 
CD3E_RABIT  (Q9TUF9), CD3E_SHEEP  (P29328), CD3G_BOVIN  (Q28074), 
CD3G_HUMAN  (P09693), CD3G_MACFA  (Q95LI7), CD3G_MOUSE  (P11942), 
CD3G_PIG    (Q5PXD3), CD3G_RAT    (Q64159), CD3G_SHEEP  (P18439), 
CD3H_MOUSE  (P29020), CD3Z_HUMAN  (P20963), CD3Z_MOUSE  (P24161), 
CD3Z_PIG    (Q9XSJ9), CD3Z_RABIT  (Q9TUF8), CD3Z_SHEEP  (P29329), 
CD79A_BOVIN (P40293), CD79A_CANFA (P0CAN6), CD79A_HUMAN (P11912), 
CD79A_MOUSE (P11911), CD79B_HUMAN (P40259), CD79B_MOUSE (P15530), 
FCERG_BOVIN (Q9BDR7), FCERG_CAVPO (Q07249), FCERG_HUMAN (P30273), 
FCERG_MACFA (Q8SPW1), FCERG_MOUSE (P20491), FCERG_PIG   (Q9XSZ6), 
FCERG_RAT   (P20411), NFAM1_HUMAN (Q8NET5)
» More

UniProtKB/Swiss-Prot
False negative sequences
28 sequences

GP_HANTB    (P28728), GP_HANTH    (P16493), GP_HANTL    (P16853), 
GP_HANTV    (P08668), GP_NYV      (Q83887), GP_PHV      (P27315), 
GP_PUUMG    (P21400), GP_PUUMK    (P41265), GP_PUUMP    (P41266), 
GP_PUUMS    (P27312), GP_SEOU8    (P33455), GP_SEOUR    (P28729), 
GP_SEOUS    (P17880), NFAM1_MOUSE (Q8R4V1), STAM1_CAEEL (O01498), 
STAM1_HUMAN (Q92783), STAM1_MOUSE (P70297), STAM2_CHICK (O93436), 
STAM2_HUMAN (O75886), STAM2_MOUSE (O88811), STAM2_RAT   (Q5XHY7), 
TYOBP_BOVIN (Q95J79), TYOBP_HUMAN (O43914), TYOBP_MACMU (Q8WNQ8), 
TYOBP_MOUSE (O54885), TYOBP_PANTR (A4F4L0), TYOBP_PIG   (Q9TU45), 
TYOBP_RAT   (Q6X9T7)
» More

PDB
[Detailed view]
1 PDB

2K4F

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