Entry: PS51082

Forthcoming changes to the profile format
General information about the entry

Entry name [info] WH2
Accession [info] PS51082
Entry type [info] MATRIX
Date [info] FEB-2005 (CREATED); OCT-2013 (DATA UPDATE); SEP-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC51082
Associated ProRule [info] PRU00406

Name and characterization of the entry

Description [info] WH2 domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=20;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=20;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=5.1699438; R2=0.0172713; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1010.67391; R2=2.06522; TEXT='HScore';
/CUT_OFF: LEVEL=0; SCORE=141; N_SCORE=7.6; H_SCORE=1170; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=39; N_SCORE=5.9; H_SCORE=1050; MODE=1; TEXT='RR';
/DEFAULT: B0=*; B1=*; E0=*; E1=*; MM=*; II=*;
...
                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B0=-85; B1=-85; BM=-1; BD=-44;
/M: SY='D'; M= 12,-32, 14, -3,-36, 12,-14,-33,-10,-14,  7,  5,  6,  3,-15,  4, -6,-29,-34,-28; M0=-7;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='R'; M=-22,-36,-20, -3,-40,  1, 14,-37, -3,-36,-27, -1, -9,-13, 35,-21, -7,-33,-37,-31; M0=-16;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='S'; M=  8,-34, 14, -1,-38,  2,-16,-35,-12,-35,-25, 15,-30,  8,-17, 19, -4,-31,-36,-29; M0=-11;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='A'; M= 22,-33, 11, 11,-36,-28,-14,-33,-10,-12,-24,  5,  5,  8,-15,-17, -6,-13,-34,-28; M0=-9;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='L'; M=-49,-43,-72,-66,  0,-69,-55,-20,-64, 31, 10,-66,-61,  9,-59,-62,-47, -8,-42,-44; M0=-39;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='L'; M=-52,-46,-76,-70,  5,-75,-59,-20,-68, 30, 28,-72,-63,-54,-62,-69,-51,-29,-43,-45; M0=-45;
/I:         MM=-1; MI=-95; MD=-48; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='A'; M= 18,-32, 12, 14,-36,  3,-14,-33,  0,-12,-23,  1,-28,  1,-15,  4,-17,-29,-34,-27; M0=-9;
/I:         MM=0; MI=-94; MD=-105; IM=-9; II=-11; DM=-4; DD=-20;
/M: SY='Q'; M= 17,-43, 12, 17,-46,  0,-22,-44,-20,-43,-34,-19,-36, 24,-26, -1,-27,-39,-45,-37; M0=-17;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='I'; M=-59,-52,-69,-72,-56,-61,-65, 41,-72,-48,-48,-69,-64,-70,-68,-69,-60,-35,-60,-62; M0=-55;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='R'; M=-31,  7,-33, -5,-48,-39, 19,-44, 16,-11,-34,-26,-39, 16, 31,-30,-30,-40,-41,-38; M0=-21;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Q'; M=  8,-33,-16,  3,-36,  2,-14,-33, 13,-33, -1,  7,-29, 24,  4,  4, -6,-29,-34,-28; M0=-10;
/I:         MM=-46; MI=-21; MD=-4; IM=0; II=-52; DM=-7; DD=-14;
/M: SY='G'; M= -8,-22, 12,  0,-26, 17, -4,-23, 11,-23,-14, -3,-18,  0, -6,  5,  8,-19,-25,-18; M0=-6;
/I:         MM=0; MI=-76; MD=-86; IM=-9; II=-11; DM=-1; DD=-48;
/M: SY='G'; M=-31,-39,-27,-30,-59, 35,-37,-57,  4,-57,-50, -2,-43,-34,-37,-11,-34,-48,-58,-53; M0=-31;
/I:         MM=-24; MI=-38; MD=-4; IM=-1; II=-36; DM=-7; DD=-14;
/M: SY='I'; M=  5,-11,-13, -7,-11,-19, -6, 16,  9,  1, -2, -9,-20, -4,  9, -9,  7, -5,-14,-10; M0=-3;
/I:         MM=0; MI=-76; MD=-86; IM=-9; II=-11; DM=-1; DD=-48;
/M: SY='I'; M=  3,  7, -8,-35, 12,-13,-24, 14, 14, -9, 14,-31,  5,-28,-30,-26,  6,  6,-23,-20; M0=-8;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Q'; M= -8,-33, -3, -2,-36,-28,-14,-33, 22,-33,-24,-14,-29, 24, 14,  5,  0,-29,-35,-28; M0=-13;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='L'; M=-64,-56,-72,-73,-43,-63,-64,-40,-73, 34,-32,-73,-65,-66,-68,-74,-64,-48,-54,-58; M0=-53;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='K'; M=-44,-50,-56,-38,-60,-49,-26,-52, 32,-14,-41, -9,-48,-22, 27,-43,-40,-50,-45,-45; M0=-32;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='K'; M=-40,-48,-45,-33,-56,-46, 17,-50, 33,-46,-39,-32, 19,-21,  0, -5,-37,-47,-45,-43; M0=-28;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='V'; M=  6,-23,-50,-44,-25,-42,-33,  2,-40,-11,-16,-39,-43,-37,-39, -9, 21, 27,-31,-28; M0=-20;
/I:         E0=-10; E1=-10;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_10 which contains 546'790 sequence entries.


Total number of hits 121 in 97 different sequences
Number of true positive hits 121 in 97 different sequences
Number of 'unknown' hits
Number of false positive hits
Number of false negative sequences 28
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 81.21 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] PS_Langendijk_Genevaux
Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 3
Feature key [info] DOMAIN
Feature description [info] WH2
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
97 sequences

ACTOA_DICDI (Q55DU3), ACTOB_DICDI (Q55DU1), ACTO_ENTHI  (O15602), 
COBL1_HUMAN (Q53SF7), COBL_DANRE  (E7F568), COBL_HUMAN  (O75128), 
COBL_MOUSE  (Q5NBX1), COBL_RAT    (D3ZUI5), ESPN_HUMAN  (B1AK53), 
ESPN_MOUSE  (Q9ET47), ESPN_RAT    (Q63618), INF2_HUMAN  (Q27J81), 
INF2_MOUSE  (Q0GNC1), INF2_XENLA  (Q6NTV6), INF2_XENTR  (Q0IHV1), 
JMY_DANRE   (Q6NVC9), JMY_HUMAN   (Q8N9B5), JMY_MOUSE   (Q9QXM1), 
JMY_XENTR   (A8E4X8), LAS17_YEAST (Q12446), LMOD1_HUMAN (P29536), 
LMOD1_MOUSE (Q8BVA4), LMOD2_HUMAN (Q6P5Q4), MTSS1_HUMAN (O43312), 
MTSS1_MOUSE (Q8R1S4), PAN1_AJECN  (A6R7X5), PAN1_ASPCL  (A1CD74), 
PAN1_ASPFC  (B0YC95), PAN1_ASPFU  (Q4WG58), PAN1_ASPNC  (A2R180), 
PAN1_ASPOR  (Q2UDY8), PAN1_ASPTN  (Q0CPW4), PAN1_CANAL  (Q5AHB1), 
PAN1_CHAGB  (Q2H922), PAN1_COCIM  (Q1DQC1), PAN1_DEBHA  (Q6BNL1), 
PAN1_EMENI  (Q5B5B0), PAN1_LODEL  (A5DVD6), PAN1_NEOFI  (A1DC51), 
PAN1_PICGU  (A5DP36), PAN1_PICST  (A3LN86), PAN1_SCHPO  (Q10172), 
PXK_HUMAN   (Q7Z7A4), PXK_MOUSE   (Q8BX57), PXK_RAT     (Q4FZZ1), 
RICKA_RICBR (Q1RI78), RICKA_RICFE (Q4UMI6), RICKA_RICMO (Q9AKP3), 
SCAR2_ARATH (Q5XPJ9), SCAR_DICDI  (Q54NF8), SCRL1_ORYSJ (Q84TX2), 
SCRL2_ORYSJ (Q5QNA6), SLOB1_DICDI (Q54TC3), SPIR2_DANRE (Q5U3H9), 
SPIR2_HUMAN (Q8WWL2), SPIR_DROME  (Q9U1K1), SPIR_DROPS  (Q29KT5), 
VASP_DICDI  (Q5TJ65), VP61_NPVAC  (Q03209), VP61_NPVOP  (O10270), 
VRP1_SCHPO  (Q9P6R1), VRP1_YEAST  (P37370), WASF1_BOVIN (Q0IIJ3), 
WASF1_HUMAN (Q92558), WASF1_MOUSE (Q8R5H6), WASF1_PONAB (Q5NVG8), 
WASF1_RAT   (Q5BJU7), WASF2_BOVIN (A2VDK6), WASF2_HUMAN (Q9Y6W5), 
WASF2_MOUSE (Q8BH43), WASF3_HUMAN (Q9UPY6), WASF3_MOUSE (Q8VHI6), 
WASH1_BOVIN (A7Z063), WASH1_CHICK (Q5ZKA6), WASH1_DICDI (Q54CK9), 
WASH1_MOUSE (Q8VDD8), WASH1_RAT   (B2RYF7), WASH1_XENTR (Q28DN4), 
WASH2_HUMAN (Q6VEQ5), WASH3_HUMAN (C4AMC7), WASL_BOVIN  (Q95107), 
WASL_HUMAN  (O00401), WASL_MOUSE  (Q91YD9), WASL_RAT    (O08816), 
WASP_HUMAN  (P42768), WASP_MOUSE  (P70315), WHAMM_HUMAN (Q8TF30), 
WHAMM_MOUSE (Q571B6), WIPF1_HUMAN (O43516), WIPF1_MOUSE (Q8K1I7), 
WIPF1_RAT   (Q6IN36), WIPF2_HUMAN (Q8TF74), WIPF2_MOUSE (Q6PEV3), 
WIPF3_HUMAN (A6NGB9), WIPF3_MOUSE (P0C7L0), WIPF3_RAT   (Q9Z0G8), 
WSP1_SCHPO  (O36027)
» More

UniProtKB/Swiss-Prot
False negative sequences
28 sequences

ACTO_ACACA  (P18281), COBL1_MOUSE (Q3UMF0), LMOD2_MOUSE (Q3UHZ5), 
LMOD2_RAT   (A1A5Q0), LMOD3_HUMAN (Q0VAK6), MTSSL_HUMAN (Q765P7), 
MTSSL_MOUSE (Q6P9S0), PAN1_BOTFB  (A6S9N4), PAN1_MAGO7  (A4R8N4), 
PAN1_NEUCR  (Q7SAT8), PAN1_SCLS1  (A7EKZ0), PAN1_YARLI  (Q6C908), 
RICKA_RICCN (Q92H62), RICKA_RICRI (Q9AKJ0), SCAR1_ARATH (Q6AWX6), 
SCAR3_ARATH (Q9LP46), SCAR4_ARATH (Q5XPJ6), SPIR1_DANRE (Q1LYM3), 
SPIR1_HUMAN (Q08AE8), SPIR1_MACFA (Q4R707), SPIR1_MOUSE (Q52KF3), 
SPIR2_MOUSE (Q8K1S6), WASH1_DANRE (A4IG59), WASH1_DROME (Q7JW27), 
WASH1_HUMAN (A8K0Z3), WASH1_XENLA (Q5U4A3), WASH4_HUMAN (A8MWX3), 
WASH6_HUMAN (Q9NQA3)
» More

PDB
[Detailed view]
13 PDB

2A3Z; 2A40; 2A41; 2D1K; 2VCP; 3M3N; 3MN5; 3MN7; 3P8C; 3UE5; 4EFH; 4JHD; 4N78
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