Entry: PS51082

General information about the entry

Entry name [info] WH2
Accession [info] PS51082
Entry type [info] MATRIX
Date [info] FEB-2005 (CREATED); OCT-2013 (DATA UPDATE); MAY-2015 (INFO UPDATE).
PROSITE Doc. [info] PDOC51082
Associated ProRule [info] PRU00406

Name and characterization of the entry

Description [info] WH2 domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=20;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=20;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=5.1699438; R2=0.0172713; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1010.67391; R2=2.06522; TEXT='HScore';
/CUT_OFF: LEVEL=0; SCORE=141; N_SCORE=7.6; H_SCORE=1170; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=39; N_SCORE=5.9; H_SCORE=1050; MODE=1; TEXT='RR';
/DEFAULT: B0=*; B1=*; E0=*; E1=*; MM=*; II=*;
...
                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B0=-85; B1=-85; BM=-1; BD=-44;
/M: SY='D'; M= 12,-32, 14, -3,-36, 12,-14,-33,-10,-14,  7,  5,  6,  3,-15,  4, -6,-29,-34,-28; M0=-7;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='R'; M=-22,-36,-20, -3,-40,  1, 14,-37, -3,-36,-27, -1, -9,-13, 35,-21, -7,-33,-37,-31; M0=-16;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='S'; M=  8,-34, 14, -1,-38,  2,-16,-35,-12,-35,-25, 15,-30,  8,-17, 19, -4,-31,-36,-29; M0=-11;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='A'; M= 22,-33, 11, 11,-36,-28,-14,-33,-10,-12,-24,  5,  5,  8,-15,-17, -6,-13,-34,-28; M0=-9;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='L'; M=-49,-43,-72,-66,  0,-69,-55,-20,-64, 31, 10,-66,-61,  9,-59,-62,-47, -8,-42,-44; M0=-39;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='L'; M=-52,-46,-76,-70,  5,-75,-59,-20,-68, 30, 28,-72,-63,-54,-62,-69,-51,-29,-43,-45; M0=-45;
/I:         MM=-1; MI=-95; MD=-48; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='A'; M= 18,-32, 12, 14,-36,  3,-14,-33,  0,-12,-23,  1,-28,  1,-15,  4,-17,-29,-34,-27; M0=-9;
/I:         MM=0; MI=-94; MD=-105; IM=-9; II=-11; DM=-4; DD=-20;
/M: SY='Q'; M= 17,-43, 12, 17,-46,  0,-22,-44,-20,-43,-34,-19,-36, 24,-26, -1,-27,-39,-45,-37; M0=-17;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='I'; M=-59,-52,-69,-72,-56,-61,-65, 41,-72,-48,-48,-69,-64,-70,-68,-69,-60,-35,-60,-62; M0=-55;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='R'; M=-31,  7,-33, -5,-48,-39, 19,-44, 16,-11,-34,-26,-39, 16, 31,-30,-30,-40,-41,-38; M0=-21;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Q'; M=  8,-33,-16,  3,-36,  2,-14,-33, 13,-33, -1,  7,-29, 24,  4,  4, -6,-29,-34,-28; M0=-10;
/I:         MM=-46; MI=-21; MD=-4; IM=0; II=-52; DM=-7; DD=-14;
/M: SY='G'; M= -8,-22, 12,  0,-26, 17, -4,-23, 11,-23,-14, -3,-18,  0, -6,  5,  8,-19,-25,-18; M0=-6;
/I:         MM=0; MI=-76; MD=-86; IM=-9; II=-11; DM=-1; DD=-48;
/M: SY='G'; M=-31,-39,-27,-30,-59, 35,-37,-57,  4,-57,-50, -2,-43,-34,-37,-11,-34,-48,-58,-53; M0=-31;
/I:         MM=-24; MI=-38; MD=-4; IM=-1; II=-36; DM=-7; DD=-14;
/M: SY='I'; M=  5,-11,-13, -7,-11,-19, -6, 16,  9,  1, -2, -9,-20, -4,  9, -9,  7, -5,-14,-10; M0=-3;
/I:         MM=0; MI=-76; MD=-86; IM=-9; II=-11; DM=-1; DD=-48;
/M: SY='I'; M=  3,  7, -8,-35, 12,-13,-24, 14, 14, -9, 14,-31,  5,-28,-30,-26,  6,  6,-23,-20; M0=-8;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Q'; M= -8,-33, -3, -2,-36,-28,-14,-33, 22,-33,-24,-14,-29, 24, 14,  5,  0,-29,-35,-28; M0=-13;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='L'; M=-64,-56,-72,-73,-43,-63,-64,-40,-73, 34,-32,-73,-65,-66,-68,-74,-64,-48,-54,-58; M0=-53;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='K'; M=-44,-50,-56,-38,-60,-49,-26,-52, 32,-14,-41, -9,-48,-22, 27,-43,-40,-50,-45,-45; M0=-32;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='K'; M=-40,-48,-45,-33,-56,-46, 17,-50, 33,-46,-39,-32, 19,-21,  0, -5,-37,-47,-45,-43; M0=-28;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='V'; M=  6,-23,-50,-44,-25,-42,-33,  2,-40,-11,-16,-39,-43,-37,-39, -9, 21, 27,-31,-28; M0=-20;
/I:         E0=-10; E1=-10;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2015_07 which contains 548'872 sequence entries.


Total number of hits 121 in 97 different sequences
Number of true positive hits 121 in 97 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 29
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 80.67 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] PS_Langendijk_Genevaux
Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 3
Feature key [info] DOMAIN
Feature description [info] WH2
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
97 sequences

ACTOA_DICDI (Q55DU3), ACTOB_DICDI (Q55DU1), ACTO_ENTHI  (O15602), 
COBL1_HUMAN (Q53SF7), COBL_DANRE  (E7F568), COBL_HUMAN  (O75128), 
COBL_MOUSE  (Q5NBX1), COBL_RAT    (D3ZUI5), ESPN_HUMAN  (B1AK53), 
ESPN_MOUSE  (Q9ET47), ESPN_RAT    (Q63618), INF2_HUMAN  (Q27J81), 
INF2_MOUSE  (Q0GNC1), INF2_XENLA  (Q6NTV6), INF2_XENTR  (Q0IHV1), 
JMY_DANRE   (Q6NVC9), JMY_HUMAN   (Q8N9B5), JMY_MOUSE   (Q9QXM1), 
JMY_XENTR   (A8E4X8), LAS17_YEAST (Q12446), LMOD1_HUMAN (P29536), 
LMOD1_MOUSE (Q8BVA4), LMOD2_HUMAN (Q6P5Q4), MTSS1_HUMAN (O43312), 
MTSS1_MOUSE (Q8R1S4), PAN1_AJECN  (A6R7X5), PAN1_ASPCL  (A1CD74), 
PAN1_ASPFC  (B0YC95), PAN1_ASPFU  (Q4WG58), PAN1_ASPNC  (A2R180), 
PAN1_ASPOR  (Q2UDY8), PAN1_ASPTN  (Q0CPW4), PAN1_CANAL  (Q5AHB1), 
PAN1_CHAGB  (Q2H922), PAN1_COCIM  (Q1DQC1), PAN1_DEBHA  (Q6BNL1), 
PAN1_EMENI  (Q5B5B0), PAN1_LODEL  (A5DVD6), PAN1_NEOFI  (A1DC51), 
PAN1_PICGU  (A5DP36), PAN1_PICST  (A3LN86), PAN1_SCHPO  (Q10172), 
PXK_HUMAN   (Q7Z7A4), PXK_MOUSE   (Q8BX57), PXK_RAT     (Q4FZZ1), 
RICKA_RICBR (Q1RI78), RICKA_RICFE (Q4UMI6), RICKA_RICMO (Q9AKP3), 
SCAR2_ARATH (Q5XPJ9), SCAR_DICDI  (Q54NF8), SCRL1_ORYSJ (Q84TX2), 
SCRL2_ORYSJ (Q5QNA6), SLOB1_DICDI (Q54TC3), SPIR2_DANRE (Q5U3H9), 
SPIR2_HUMAN (Q8WWL2), SPIR_DROME  (Q9U1K1), SPIR_DROPS  (Q29KT5), 
VASP_DICDI  (Q5TJ65), VP61_NPVAC  (Q03209), VP61_NPVOP  (O10270), 
VRP1_SCHPO  (Q9P6R1), VRP1_YEAST  (P37370), WASF1_BOVIN (Q0IIJ3), 
WASF1_HUMAN (Q92558), WASF1_MOUSE (Q8R5H6), WASF1_PONAB (Q5NVG8), 
WASF1_RAT   (Q5BJU7), WASF2_BOVIN (A2VDK6), WASF2_HUMAN (Q9Y6W5), 
WASF2_MOUSE (Q8BH43), WASF3_HUMAN (Q9UPY6), WASF3_MOUSE (Q8VHI6), 
WASH1_BOVIN (A7Z063), WASH1_CHICK (Q5ZKA6), WASH1_DICDI (Q54CK9), 
WASH1_MOUSE (Q8VDD8), WASH1_RAT   (B2RYF7), WASH1_XENTR (Q28DN4), 
WASH2_HUMAN (Q6VEQ5), WASH3_HUMAN (C4AMC7), WASL_BOVIN  (Q95107), 
WASL_HUMAN  (O00401), WASL_MOUSE  (Q91YD9), WASL_RAT    (O08816), 
WASP_HUMAN  (P42768), WASP_MOUSE  (P70315), WHAMM_HUMAN (Q8TF30), 
WHAMM_MOUSE (Q571B6), WIPF1_HUMAN (O43516), WIPF1_MOUSE (Q8K1I7), 
WIPF1_RAT   (Q6IN36), WIPF2_HUMAN (Q8TF74), WIPF2_MOUSE (Q6PEV3), 
WIPF3_HUMAN (A6NGB9), WIPF3_MOUSE (P0C7L0), WIPF3_RAT   (Q9Z0G8), 
WSP1_SCHPO  (O36027)
» More

UniProtKB/Swiss-Prot
False negative sequences
29 sequences

ACTO_ACACA  (P18281), COBL1_MOUSE (Q3UMF0), LMOD2_MOUSE (Q3UHZ5), 
LMOD2_RAT   (A1A5Q0), LMOD3_DANRE (E7F7X0), LMOD3_HUMAN (Q0VAK6), 
MTSSL_HUMAN (Q765P7), MTSSL_MOUSE (Q6P9S0), PAN1_BOTFB  (A6S9N4), 
PAN1_MAGO7  (A4R8N4), PAN1_NEUCR  (Q7SAT8), PAN1_SCLS1  (A7EKZ0), 
PAN1_YARLI  (Q6C908), RICKA_RICCN (Q92H62), RICKA_RICRI (Q9AKJ0), 
SCAR1_ARATH (Q6AWX6), SCAR3_ARATH (Q9LP46), SCAR4_ARATH (Q5XPJ6), 
SPIR1_DANRE (Q1LYM3), SPIR1_HUMAN (Q08AE8), SPIR1_MACFA (Q4R707), 
SPIR1_MOUSE (Q52KF3), SPIR2_MOUSE (Q8K1S6), WASH1_DANRE (A4IG59), 
WASH1_DROME (Q7JW27), WASH1_HUMAN (A8K0Z3), WASH1_XENLA (Q5U4A3), 
WASH4_HUMAN (A8MWX3), WASH6_HUMAN (Q9NQA3)
» More

PDB
[Detailed view]
13 PDB

2A3Z; 2A40; 2A41; 2D1K; 2VCP; 3M3N; 3MN5; 3MN7; 3P8C; 3UE5; 4EFH; 4JHD; 4N78
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