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PROSITE entry PS51082

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General information about the entry

Entry name [info]	WH2
Accession [info]	PS51082
Entry type [info]	MATRIX
Date [info]	01-FEB-2005 CREATED; 01-OCT-2013 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51082
Associated ProRule [info]	PRU00406

Name and characterization of the entry

Description [info]

WH2 domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=20;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=20;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=5.1699438; R2=0.0172713; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=141; N_SCORE=7.6; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=43; N_SCORE=5.9; MODE=1; TEXT='RR';
/DEFAULT: B0=*; B1=*; E0=*; E1=*; MM=*; II=*;

...

                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B0=-85; B1=-85; BM=-1; BD=-44;
/M: SY='D';  M= 12,-32, 14, -3,-36, 12,-14,-33,-10,-14,  7,  5,  6,  3,-15,  4, -6,-29,-34,-28; M0=-7;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='R';  M=-22,-36,-20, -3,-40,  1, 14,-37, -3,-36,-27, -1, -9,-13, 35,-21, -7,-33,-37,-31; M0=-16;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='S';  M=  8,-34, 14, -1,-38,  2,-16,-35,-12,-35,-25, 15,-30,  8,-17, 19, -4,-31,-36,-29; M0=-11;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='A';  M= 22,-33, 11, 11,-36,-28,-14,-33,-10,-12,-24,  5,  5,  8,-15,-17, -6,-13,-34,-28; M0=-9;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='L';  M=-49,-43,-72,-66,  0,-69,-55,-20,-64, 31, 10,-66,-61,  9,-59,-62,-47, -8,-42,-44; M0=-39;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='L';  M=-52,-46,-76,-70,  5,-75,-59,-20,-68, 30, 28,-72,-63,-54,-62,-69,-51,-29,-43,-45; M0=-45;
/I:         MM=-1; MI=-95; MD=-48; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='A';  M= 18,-32, 12, 14,-36,  3,-14,-33,  0,-12,-23,  1,-28,  1,-15,  4,-17,-29,-34,-27; M0=-9;
/I:         MM=0; MI=-94; MD=-105; IM=-9; II=-11; DM=-4; DD=-20;
/M: SY='Q';  M= 17,-43, 12, 17,-46,  0,-22,-44,-20,-43,-34,-19,-36, 24,-26, -1,-27,-39,-45,-37; M0=-17;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='I';  M=-59,-52,-69,-72,-56,-61,-65, 41,-72,-48,-48,-69,-64,-70,-68,-69,-60,-35,-60,-62; M0=-55;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='R';  M=-31,  7,-33, -5,-48,-39, 19,-44, 16,-11,-34,-26,-39, 16, 31,-30,-30,-40,-41,-38; M0=-21;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Q';  M=  8,-33,-16,  3,-36,  2,-14,-33, 13,-33, -1,  7,-29, 24,  4,  4, -6,-29,-34,-28; M0=-10;
/I:         MM=-46; MI=-21; MD=-4; IM=0; II=-52; DM=-7; DD=-14;
/M: SY='G';  M= -8,-22, 12,  0,-26, 17, -4,-23, 11,-23,-14, -3,-18,  0, -6,  5,  8,-19,-25,-18; M0=-6;
/I:         MM=0; MI=-76; MD=-86; IM=-9; II=-11; DM=-1; DD=-48;
/M: SY='G';  M=-31,-39,-27,-30,-59, 35,-37,-57,  4,-57,-50, -2,-43,-34,-37,-11,-34,-48,-58,-53; M0=-31;
/I:         MM=-24; MI=-38; MD=-4; IM=-1; II=-36; DM=-7; DD=-14;
/M: SY='I';  M=  5,-11,-13, -7,-11,-19, -6, 16,  9,  1, -2, -9,-20, -4,  9, -9,  7, -5,-14,-10; M0=-3;
/I:         MM=0; MI=-76; MD=-86; IM=-9; II=-11; DM=-1; DD=-48;
/M: SY='I';  M=  3,  7, -8,-35, 12,-13,-24, 14, 14, -9, 14,-31,  5,-28,-30,-26,  6,  6,-23,-20; M0=-8;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Q';  M= -8,-33, -3, -2,-36,-28,-14,-33, 22,-33,-24,-14,-29, 24, 14,  5,  0,-29,-35,-28; M0=-13;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='L';  M=-64,-56,-72,-73,-43,-63,-64,-40,-73, 34,-32,-73,-65,-66,-68,-74,-64,-48,-54,-58; M0=-53;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='K';  M=-44,-50,-56,-38,-60,-49,-26,-52, 32,-14,-41, -9,-48,-22, 27,-43,-40,-50,-45,-45; M0=-32;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='K';  M=-40,-48,-45,-33,-56,-46, 17,-50, 33,-46,-39,-32, 19,-21,  0, -5,-37,-47,-45,-43; M0=-28;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='V';  M=  6,-23,-50,-44,-25,-42,-33,  2,-40,-11,-16,-39,-43,-37,-39, -9, 21, 27,-31,-28; M0=-20;
/I:         E0=-10; E1=-10;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_05 which contains 572'214 sequence entries.

Total number of hits	126 in 101 different sequences
Number of true positive hits	126 in 101 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	30
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	80.77 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info]	3
Matrix type [info]	protein_domain
Scaling database [info]	window20
Author [info]	PS_Langendijk_Genevaux
Feature key [info]	DOMAIN
Feature description [info]	WH2
Version [info]	4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

101 sequences

ACTOA_DICDI (Q55DU3), ACTOB_DICDI (Q55DU1), ACTO_ENTHI  (O15602),

BIMA_BURTA  (Q2T6X7), COBL1_HUMAN (Q53SF7), COBL_DANRE  (E7F568), 
COBL_HUMAN  (O75128), COBL_MOUSE  (Q5NBX1), COBL_RAT(D3ZUI5), 
ESPN_HUMAN  (B1AK53), ESPN_MOUSE  (Q9ET47), ESPN_RAT(Q63618), 
INF2_HUMAN  (Q27J81), INF2_MOUSE  (Q0GNC1), INF2_XENLA  (Q6NTV6), 
INF2_XENTR  (Q0IHV1), JMY_DANRE   (Q6NVC9), JMY_HUMAN   (Q8N9B5), 
JMY_MOUSE   (Q9QXM1), JMY_XENTR   (A8E4X8), LAS17_YEAST (Q12446), 
LMOD1_HUMAN (P29536), LMOD1_MOUSE (Q8BVA4), LMOD1_RAT   (A0A0G2K0D3), 
LMOD2_CHICK (E1BTG2), LMOD2_HUMAN (Q6P5Q4), MTSS1_HUMAN (O43312), 
MTSS1_MOUSE (Q8R1S4), P78_NPVAC   (Q03209), PAN1_AJECN  (A6R7X5), 
PAN1_ASPCL  (A1CD74), PAN1_ASPFC  (B0YC95), PAN1_ASPFU  (Q4WG58), 
PAN1_ASPNC  (A2R180), PAN1_ASPOR  (Q2UDY8), PAN1_ASPTN  (Q0CPW4), 
PAN1_CANAL  (Q5AHB1), PAN1_CHAGB  (Q2H922), PAN1_COCIM  (Q1DQC1), 
PAN1_DEBHA  (Q6BNL1), PAN1_EMENI  (Q5B5B0), PAN1_LODEL  (A5DVD6), 
PAN1_NEOFI  (A1DC51), PAN1_PICGU  (A5DP36), PAN1_PICST  (A3LN86), 
PAN1_SCHPO  (Q10172), PXK_HUMAN   (Q7Z7A4), PXK_MOUSE   (Q8BX57), 
PXK_RAT (Q4FZZ1), RICKA_RICBR (Q1RI78), RICKA_RICFE (Q4UMI6), 
RICKA_RICMO (Q9AKP3), SCAR2_ARATH (Q5XPJ9), SCAR_DICDI  (Q54NF8), 
SCRL1_ORYSJ (Q84TX2), SCRL2_ORYSJ (Q5QNA6), SLOB1_DICDI (Q54TC3), 
SPIR2_DANRE (Q5U3H9), SPIR2_HUMAN (Q8WWL2), SPIR2_MOUSE (Q8K1S6), 
SPIR_DROME  (Q9U1K1), SPIR_DROPS  (Q29KT5), VASP_DICDI  (Q5TJ65), 
VP61_NPVOP  (O10270), VRP1_SCHPO  (Q9P6R1), VRP1_YEAST  (P37370), 
WASF1_BOVIN (Q0IIJ3), WASF1_HUMAN (Q92558), WASF1_MOUSE (Q8R5H6), 
WASF1_PONAB (Q5NVG8), WASF1_RAT   (Q5BJU7), WASF2_BOVIN (A2VDK6), 
WASF2_HUMAN (Q9Y6W5), WASF2_MOUSE (Q8BH43), WASF3_HUMAN (Q9UPY6), 
WASF3_MOUSE (Q8VHI6), WASH1_BOVIN (A7Z063), WASH1_CHICK (Q5ZKA6), 
WASH1_DICDI (Q54CK9), WASH1_MOUSE (Q8VDD8), WASH1_RAT   (B2RYF7), 
WASH1_XENTR (Q28DN4), WASH2_HUMAN (Q6VEQ5), WASH3_HUMAN (C4AMC7), 
WASL_BOVIN  (Q95107), WASL_HUMAN  (O00401), WASL_MOUSE  (Q91YD9), 
WASL_RAT(O08816), WASP_HUMAN  (P42768), WASP_MOUSE  (P70315), 
WHAMM_HUMAN (Q8TF30), WHAMM_MOUSE (Q571B6), WIPF1_HUMAN (O43516), 
WIPF1_MOUSE (Q8K1I7), WIPF1_RAT   (Q6IN36), WIPF2_HUMAN (Q8TF74), 
WIPF2_MOUSE (Q6PEV3), WIPF3_HUMAN (A6NGB9), WIPF3_MOUSE (P0C7L0), 
WIPF3_RAT   (Q9Z0G8), WSP1_SCHPO  (O36027)

» more

Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

30 sequences

ACTO_ACACA  (P18281), COBL1_MOUSE (Q3UMF0), LMOD2_MOUSE (Q3UHZ5),

LMOD2_RAT   (A1A5Q0), LMOD3_DANRE (E7F7X0), LMOD3_HUMAN (Q0VAK6), 
LMOD3_MOUSE (E9QA62), MTSS2_HUMAN (Q765P7), MTSS2_MOUSE (Q6P9S0), 
PAN1_BOTFB  (A6S9N4), PAN1_NEUCR  (Q7SAT8), PAN1_PYRO7  (A4R8N4), 
PAN1_SCLS1  (A7EKZ0), PAN1_YARLI  (Q6C908), RICKA_RICCN (Q92H62), 
RICKA_RICRI (Q9AKJ0), SCAR1_ARATH (Q6AWX6), SCAR3_ARATH (Q9LP46), 
SCAR4_ARATH (Q5XPJ6), SPIR1_DANRE (Q1LYM3), SPIR1_HUMAN (Q08AE8), 
SPIR1_MACFA (Q4R707), SPIR1_MOUSE (Q52KF3), WASH1_CAEEL (O18195), 
WASH1_DANRE (A4IG59), WASH1_DROME (Q7JW27), WASH1_HUMAN (A8K0Z3), 
WASH1_XENLA (Q5U4A3), WASH4_HUMAN (A8MWX3), WASH6_HUMAN (Q9NQA3)

» more

PDB
[Detailed view]

27 PDB

2A3Z; 2A40; 2A41; 2D1K; 2VCP; 3M3N; 3MN5; 3MN7; 3P8C; 3TU5; 3UE5; 4EFH; 4JHD; 4N78; 4RWT; 5WFN; 5YPU; 6JBK; 6JCU; 6JH8; 6JH9; 6UHC; 7USC; 7USD; 7USE; 8RV2; 9AZP
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