Entry: PS51092

General information about the entry
Entry name FN2_2
Accession number PS51092
Entry type MATRIX
Date MAR-2005 (CREATED); MAR-2005 (DATA UPDATE); MAR-2013 (INFO UPDATE).
PROSITE Documentation PDOC00022
Associated ProRule PRU00479
Name and characterization of the entry
DescriptionFibronectin type-II collagen-binding domain profile.
Matrix / Profile 
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=49;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=45;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.2742712; R2=0.0110785; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=788; N_SCORE=11.0; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=382; N_SCORE=8.5; MODE=1; TEXT='R?';
/DEFAULT: M0=-9; D=-20; I=-20; B1=-200; E1=-200; MI=-105; MD=-105; IM=-105; DM=-105;

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='S'; M=  8, -2,-17, -2,  3,-19, -7,-13,-15, -7,-18,-14, -1, -9, -3,-12, 14,  6, -8,-30,-17,  0;
/M: SY='D'; M= -8, 12,-25, 15, 10,-20,-11,  1,-23, -3,-19,-14,  8, -9,  2, -7,  1, -4,-21,-28,-11,  5;
/M: SY='G'; M= -5, -3,-29, -1,-11,-26, 42,-10,-35,-12,-27,-18,  1,-18,-13,-13, -1,-16,-27,-19,-17,-13;
/M: SY='E'; M= -1,  6,-27,  9, 18,-28,-11, -6,-25,  9,-22,-15,  2,  0,  7,  2, -1, -8,-22,-27,-18, 12;
/M: SY='P'; M= -6,-14,-31,-10,  0,-22,-15,-15,-18, -1,-19,-12,-13, 35, -6, -6, -7, -7,-21,-25,-19, -6;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='V'; M= -3,-17,-20,-18,-12,-10,-25, -4,  6, -6, -3,  3,-14,-21,-11, -8, -9, -6, 14,-26, -5,-13;
/M: SY='F'; M=-19,-30,-20,-39,-29, 74,-30,-20,  3,-30, 12,  2,-21,-30,-38,-20,-21,-10,  1,  8, 28,-29;
/M: SY='P'; M=-10,-20,-40,-10,  0,-30,-20,-20,-20,-10,-30,-20,-20, 90,-10,-20,-10,-10,-30,-30,-30,-10;
/M: SY='F'; M=-18,-28,-20,-37,-28, 73,-28,-19, -1,-29,  7, -1,-18,-29,-37,-19,-16, -8, -1,  7, 28,-28;
/M: SY='I'; M= -4,-14,-21,-19,-12,-10,-25,-18,  8, -7,  2,  4,-10,-18, -7, -8, -7,  3,  8,-24, -7,-11;
/M: SY='Y'; M=-19,-25,-26,-29,-25, 47,-31,  1,  4,-20,  5,  2,-20,-29,-23,-15,-20,-10, -2, 17, 52,-25;
/M: SY='R'; M=-12,  3,-27,  2,  5,-23, -9,  2,-23, 10,-17, -8,  6,-16, 10, 14, -5,-10,-22,-24,-10,  6;
/M: SY='G'; M= -2,  0,-28, -3,-12,-28, 46,-13,-34,-12,-28,-19, 10,-19,-12,-10,  2,-15,-28,-24,-26,-12;
/M: SY='R'; M=-11,  1,-26, -1,  6,-21,-19,  2,-22, 17,-21, -9,  4,-14,  9, 19, -3, -4,-18,-24, -7,  6;
/M: SY='T'; M= -4, -6,-22, -9, -2,-14,-16,-13,-12, -4,-13, -9, -3,-15, -2, -5,  3,  4,-10,-10, -8, -1;
/M: SY='Y'; M=-19,-18,-29,-19,-18, 24,-29, 25, -2,-13, -1,  1,-16,-28,-10,-10,-18,-11, -9, 16, 62,-18;
/M: SY='H'; M=-12,  2,-24,  2, -2, -1,-17, 15,-18, -8,-15,-10,  3,-18, -3, -6,  0, -3,-17,-17, 11, -3;
/M: SY='D'; M= -3, 13,-21, 18, 10,-27, -3, -7,-26, -1,-25,-19,  9,-10,  1, -6, 14,  4,-19,-34,-19,  5;
/M: SY='C'; M=-10,-20,118,-30,-30,-20,-30,-30,-30,-29,-20,-20,-20,-40,-30,-29,-10,-10,-10,-50,-30,-30;
/M: SY='T'; M= -3,-11,-16,-20,-17, -6,-26,-22,  9,-16,  1,  1, -8,-14,-13,-16,  6, 29, 10,-27, -7,-16;
/M: SY='T'; M= -4, -5,-19, -6,  0,-14,-18, -4,-14, -2,-12, -8, -2,-14, -1,  2,  7, 11, -7,-28, -9, -1;
/M: SY='E'; M= -9, 11,-26, 17, 25,-28,-13,  1,-27,  4,-21,-17,  4, -8,  9, -2,  3, -3,-23,-30,-15, 16;
/M: SY='G'; M= -5,  0,-29,  1, -6,-29, 44,-11,-37,-12,-28,-20,  6,-17,-11,-11,  0,-16,-30,-24,-25, -9;
/M: SY='R'; M= -8,  0,-23,  1,  3,-23,-12, -3,-27, 12,-25,-15,  5,-15,  8, 29,  9,  1,-18,-29,-14,  4;
/I:         I=-6; MD=-29;
/M: SY='E'; M= -5,  2,-15,  2,  4, -9, -8,  0,-15, -2,-13, -9,  3, -6,  1, -1,  3,  0,-12,-17, -7,  2; D=-6;
/I:         I=-6; MD=-29;
/M: SY='D'; M= -9, 18,-17, 26,  6,-16, -3, -3,-19, -4,-13,-14,  7, -8, -3, -7,  0, -5,-15,-20,-10,  2; D=-6;
/I:         I=-6; MI=-29; IM=-29; DM=-29;
/M: SY='G'; M= -3, -8,-25,-11,-15,-14, 23,-13,-21,-15,-15,-12,  1,-17,-16,-14, -3,-11,-17,-21,-17,-16;
/I:         I=-6; MD=-32;
/M: SY='Y'; M=-13,-13,-26,-15, -8,  0,-21,  1,-11,  3, -7, -1,-10,-20, -2,  6,-12, -9,-12, -1, 13, -6; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='L'; M=-11,-22,-28,-19,-10, -8,-25,-13, -3,-10, 10,  3,-20,  5,-10, -3,-19,-10, -8,-22, -8,-12;
/M: SY='W'; M=-19,-36,-48,-35,-23,  7,-20,-28,-21,-18,-20,-20,-37,-28,-17,-18,-37,-28,-30,136, 26,-15;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='A'; M= 27, -7,-13,-11, -6,-21,  3,-16,-16,-11,-20,-15, -2, -5, -7,-16, 20,  6, -8,-28,-21, -7;
/M: SY='T'; M= -2, -8,-12,-16,-14, -6,-23,-21,  0,-14,  1, -3, -8,-15,-14,-13,  9, 34,  8,-28, -8,-14;
/M: SY='T'; M= -3,  1,-13, -6, -8,-12,-20,-18,-11, -8,-11,-10,  1,-11, -8, -6, 16, 40, -2,-30,-10, -9;
/M: SY='A'; M=  7, -4,-20, -4,  4,-18,-10, -8,-16, -7,-15,-12, -5, -3, -1,-11,  7,  2,-13,-24,-10,  0;
/M: SY='N'; M=-10, 28,-22, 25,  4,-23, -8,  1,-22, -1,-25,-19, 29,-16, -2, -3,  7, -1,-20,-36,-16,  1;
/M: SY='Y'; M=-19,-23,-28,-26,-23, 40,-29,  7,  1,-15,  3,  3,-21,-29,-17,-13,-21,-11, -7, 26, 61,-22;
/M: SY='D'; M=-14, 32,-27, 44, 19,-33, -9, -1,-32,  0,-26,-22, 15,-10,  4, -7,  3, -7,-25,-36,-19, 12;
/M: SY='R'; M= -8, -2,-27, -2,  6,-23, -1, -6,-25,  9,-21,-11,  1,-14,  5, 10, -2, -7,-21,-22,-12,  4;
/I:         I=-6; MD=-29;
/M: SY='D'; M=-15, 37,-23, 49, 15,-30, -8,  0,-30,  2,-24,-22, 17, -8,  1, -6,  0, -7,-23,-31,-15,  8; D=-6;
/I:         I=-6; MI=-29; MD=-29; IM=-29; DM=-29;
/M: SY='Q'; M= -7, -2,-24, -2,  6,-24,  1, -1,-23, 10,-19, -8,  0,-11, 14,  9, -3,-10,-20,-16,-10,  9; D=-6;
/I:         I=-6; DM=-29;
/M: SY='K'; M= -9, -2,-27, -2,  8,-27,-17, -6,-25, 28,-22, -8,  0,-13, 15, 24, -5, -7,-20,-22,-11, 11;
/M: SY='W'; M=-20,-34,-42,-34,-27, 21,-24,-15,-13,-18,-12,-13,-33,-30,-19,-17,-33,-23,-22,106, 44,-21;
/M: SY='G'; M=  0, -6,-26, -6, -8,-28, 31,-15,-33,  1,-29,-17,  1,-16, -8, -2,  4,-10,-23,-23,-22, -8;
/M: SY='F'; M=-19,-25,-24,-31,-23, 53,-30, -7,  2,-22,  7,  1,-19,-28,-26,-16,-19,-10, -3, 12, 41,-23;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='P'; M= -2,-14,-27,-12, -1,-19,-19,-16,-12, -7,-11, -8,-14, 26, -6, -9, -6, -1,-13,-26,-18, -6;
/M: SY='D'; M= -5,  7,-21,  9,  9,-20,-15, -1,-17, -5,-15,-11,  3,-11,  3, -8,  3, -1,-15,-28,-10,  5;
/I:         E1=0; IE=-105; DE=-105;
Numerical results
  • UniProtKB/Swiss-Prot release number: 2013_05, total number of sequence entries in that release: 540052.
  • Total number of hits in UniProtKB/Swiss-Prot: 102 hits in 57 different sequences
  • Number of hits on proteins that are known to belong to the set under consideration: 102 hits in 57 different sequences
  • Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences
  • Number of false hits (on unrelated proteins): 0 hits in 0 different sequences
  • Number of known missed hits: 0
  • Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 1
  • Precision (true hits / (true hits + false positives)): 100.00 %
  • Recall (true hits / (true hits + false negatives)): 100.00 %
Comments
  • MATRIX_TYPE: protein_domain
  • Scaling database: UniProtKB/Swiss-Prot: window20
  • Matrix author: N_Hulo
  • Taxonomic range: Eukaryotes
  • Maximum known number of repetitions of the pattern in a single protein: 4
  • FT_KEY: DOMAIN
  • FT_DESC: Fibronectin type-II
  • VERSION: 1
Cross-references
UniProtKB/Swiss-Prot True positive hits:
BSPH1_HUMAN (Q075Z2), BSPH1_MOUSE (Q3UW26), ESPB1_CANFA (Q9GL25), 
ESPB1_HUMAN (Q96BH3), ESPB1_PIG   (Q7YR83), FA12_BOVIN  (P98140), 
FA12_CAVPO  (Q04962), FA12_HUMAN  (P00748), FA12_MOUSE  (Q80YC5), 
FA12_PIG    (O97507), FA12_RAT    (D3ZTE0), FINC_BOVIN  (P07589), 
FINC_HUMAN  (P02751), FINC_MOUSE  (P11276), FINC_NOTVI  (Q91400), 
FINC_RAT    (P04937), FINC_XENLA  (Q91740), HGFA_CANFA  (Q6QNF4), 
HGFA_HUMAN  (Q04756), HGFA_MOUSE  (Q9R098), LY75_HUMAN  (O60449), 
LY75_MESAU  (Q920P9), LY75_MOUSE  (Q60767), MMP2_BOVIN  (Q9GLE5), 
MMP2_CHICK  (Q90611), MMP2_HUMAN  (P08253), MMP2_MOUSE  (P33434), 
MMP2_RABIT  (P50757), MMP2_RAT    (P33436), MMP9_BOVIN  (P52176), 
MMP9_CANFA  (O18733), MMP9_HUMAN  (P14780), MMP9_MOUSE  (P41245), 
MMP9_RABIT  (P41246), MMP9_RAT    (P50282), MPRI_BOVIN  (P08169), 
MPRI_HUMAN  (P11717), MPRI_MOUSE  (Q07113), MRC1_HUMAN  (P22897), 
MRC1_MOUSE  (Q61830), MRC2_HUMAN  (Q9UBG0), MRC2_MOUSE  (Q64449), 
MRC2_RAT    (Q4TU93), PB1_PIG     (P80964), PLA2R_BOVIN (P49259), 
PLA2R_HUMAN (Q13018), PLA2R_MOUSE (Q62028), PLA2R_PONAB (Q5R880), 
PLA2R_RABIT (P49260), SE1L1_HUMAN (Q9UBV2), SE1L1_MESAU (Q9ESM7), 
SE1L1_MOUSE (Q9Z2G6), SE1L1_RAT   (Q80Z70), SFP1_BOVIN  (P02784), 
SFP3_BOVIN  (P04557), SFP4_BOVIN  (P81019), SP1_HORSE   (P81121)
`Potential' hits (partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences):
SFP1_BOSIN  (B3EWK6)
Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:

[Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format]

Retrieve the sequence logo from the alignment

PDB
[Detailed view]		 1CK7; 1CXW; 1E88; 1E8B; 1EAK; 1GXD; 1H8P; 1J7M; 1KS0; 1L6J; 1LKG; 1PDC; 1QO6; 2CEB; 2CEC; 2FN2; 2V5O; 2V5P; 3M7P; 3MQL;

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