To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
Entry: PS51113

General information about the entry

Entry name [info] ZF_BTK
Accession [info] PS51113
Entry type [info] MATRIX
Date [info] 01-APR-2005 CREATED; 10-MAY-2017 DATA UPDATE; 27-SEP-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC51113
Associated ProRule [info] PRU00432

Name and characterization of the entry

Description [info] Zinc finger Btk-type profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=37;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=34;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.4293971; R2=0.0121034; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2214.9492188; R2=2.0891609; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=543; H_SCORE=3349; N_SCORE=9.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=337; H_SCORE=2919; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-9; D=-20; I=-20; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='N'; M=-10, 40,-20, 20,  0,-20,  0, 10,-20,  0,-30,-20, 60,-20,  0,  0, 10,  0,-30,-40,-20,  0;
/M: SY='T'; M= -2,  0,-21, -3,  0,-22,-13,-10,-17, -6,-23,-15,  4, 12,  3, -9, 14, 15,-17,-32,-18,  0;
/M: SY='N'; M=-11, 13,-28,  9, -4,-23, -1,  7,-18, -9,-23,-14, 20, -4, -5,-10, -1, -9,-23,-32,-15, -6;
/M: SY='R'; M=-12,-18,-26,-19, -9, -8,-26,-14, -1,  4, 10,  5,-14,-22, -5, 13,-19,-10, -2,-20, -5, -9;
/M: SY='L'; M= -6,-24,-17,-26,-19,  2,-24,-15, 16,-21, 27, 23,-23,-25,-14,-16,-16, -5, 13,-24, -4,-16;
/M: SY='Q'; M=  1,-12,-23,-14, -9,-15, -7, -8, -5,-10,-11, -3, -8,-18,  4,-11,  0, -5, -5,-17, -3, -3;
/M: SY='K'; M= -4, -9,-24,-11, -4, -5,-17, -8,-19, 14,-18, -9, -5,-16, -2, 13, -3, -4,-13,-13,  3, -4;
/M: SY='Y'; M=-19,-21,-12,-24,-22, 30,-30, 10, -3,-15, -1, -2,-20,-31,-16,-13,-19,-10, -9, 19, 62,-22;
/M: SY='H'; M=-20,  0,-30,  0,  0,-20,-20,100,-30,-10,-20,  0, 10,-20, 10,  0,-10,-20,-30,-30, 20,  0;
/M: SY='P'; M= -8,-18,-36, -9,  0,-29,-18,-19,-20,-10,-30,-20,-16, 78, -9,-19, -4, -6,-28,-31,-29, -9;
/M: SY='G'; M=  0, -8, -5, -9,-13,-26, 30,-18,-33,-11,-29,-19,  0,-19,-13,-13,  7, -8,-21,-29,-25,-13;
/M: SY='F'; M=  3,-25,-15,-31,-24, 26,-23,-23,  8,-23, 11,  3,-22,-25,-28,-20,-12, -5, 15,-12,  4,-24;
/M: SY='W'; M=-20,-32,-32,-37,-29, 48,-26,-19, -7,-24, -2, -7,-27,-30,-29,-19,-27,-17,-12, 65, 36,-25;
/M: SY='V'; M= -6,-18,-19,-20,-15, -8,-24,-17,  5, -7,  1,  1,-12,-21,-11,  4, -4,  3, 11,-26, -9,-15;
/M: SY='D'; M= -6, 21,-24, 25,  2,-30, 16, -7,-33, -8,-30,-24, 17,-14, -6,-11, 11, -5,-25,-34,-23, -2;
/M: SY='G'; M=  1,  0,-28,  2, -9,-30, 39,-16,-35, -7,-28,-19,  2,-16,-12,-12,  0,-15,-25,-23,-25,-11;
/M: SY='K'; M=-10,  0,-25, -3,  3,-15,-16, -5,-23, 20,-23,-10,  6,-15,  8, 18, -2, -5,-19,-21, -8,  6;
/M: SY='W'; M=-20,-32,-39,-33,-26, 26,-25,-11,-10,-18, -9,-10,-30,-30,-19,-16,-30,-20,-19, 89, 48,-21;
/M: SY='T'; M= -1,-11,-16,-13, -7,-10,-16,-13, -4,-15,  4, -1, -7,-18, -2,-12,  7,  9, -3,-29,-10, -4;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='Q'; M= -9, -6,-26, -6,  2,-24, -8, 10,-22,  4,-16, -5, -1,-16, 14,  8, -2, -9,-20,-24, -8,  7;
/M: SY='Q'; M=-10, -1,-30,  0, 18,-35, -8,  4,-25,  9,-21, -6,  0,-11, 39, 12, -1,-11,-29,-21,-14, 27;
/M: SY='T'; M=  5, -5,-14,-10, -6,-14,-14,-16,-11, -4,-10, -9, -3,-13, -6, -7, 13, 21, -4,-29,-12, -6;
/M: SY='E'; M=  1,  5, -7,  8, 17,-27, -3,-10,-29, -5,-22,-20,  0,-11,  0,-11,  5, -6,-21,-32,-22,  8;
/M: SY='K'; M=-12,  0,-30,  3, 20,-28,-20, -5,-30, 35,-25,-12,  0,-10, 12, 32, -8,-10,-22,-22,-12, 15;
/M: SY='N'; M=  2, 11,-15, -1, -6,-14, -9, -7,-12, -8,-13,-12, 19,-16, -6, -9, 12, 15,-11,-33,-15, -6;
/M: SY='A'; M= 25, -6,-13,-14,-10,-19,  5,-19,-16,-11,-15,-13, -4,-11,-10,-16, 15, 12, -6,-25,-19,-10;
/M: SY='P'; M= -5,-19,-27,-19, -7, -7,-20,-13, -6,-12, -4,  2,-17, 19, -4,-14,-11, -9,-12,-20,-10, -7;
/M: SY='G'; M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='K'; M= -9,  7,-25, 10, 13,-28,-16, -5,-27, 16,-24,-14,  4,-10, 13, 14,  3,  1,-20,-27,-14, 12;
/M: SY='K'; M= -3,-13,-27,-14, -4,-19,-21,-15, -9, 12,-10, -4,-10, -2, -3,  8,-11, -9, -8,-21,-11, -5;
/M: SY='T'; M= -1,-18, -2,-24,-20, -2,-22,-19, -4,-18, -1, -5,-18,-24,-17,-18, -7,  6,  1, -1,  2,-19;
/M: SY='E'; M= -4,  1,-23, -2, 10,-18,-16,  5,-18,  0,-10, -9,  3,-14,  3,  4, -1, -1,-16,-27,-10,  5;
/M: SY='S'; M=  8,  6,-17,  3, -2,-19, -7,  4,-17,-10,-15,-12,  8,-15, -3,-11, 10,  0,-13,-32,-13, -3;
/M: SY='R'; M= -8,-16,-29,-18,-12, -2, -9,-10,-21,  4,-16,-10,-11,-21, -8, 12,-13,-13,-17, 11,  7,-11;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_09 which contains 555'594 sequence entries.


Total number of hits 23 in 23 different sequences
Number of true positive hits 23 in 23 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] PS_Langendijk_Genevaux
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] ZN_FING
Feature description [info] Btk-type
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
23 sequences

BMX_HUMAN   (P51813    ), BMX_MOUSE   (P97504    ), BTKL_DROME  (P08630    ), 
BTK_CHICK   (Q8JH64    ), BTK_HUMAN   (Q06187    ), BTK_MOUSE   (P35991    ), 
GAP1_DROME  (P48423    ), ITK_HUMAN   (Q08881    ), ITK_MOUSE   (Q03526    ), 
RAS4B_HUMAN (C9J798    ), RASA2_HUMAN (Q15283    ), RASA2_MOUSE (P58069    ), 
RASA2_RAT   (Q63713    ), RASA3_BOVIN (Q28013    ), RASA3_HUMAN (Q14644    ), 
RASA3_MOUSE (Q60790    ), RASA3_RAT   (Q9QYJ2    ), RASL1_HUMAN (O95294    ), 
RASL1_MOUSE (Q9Z268    ), RASL2_HUMAN (O43374    ), RASL2_MOUSE (Q6PFQ7    ), 
TEC_HUMAN   (P42680    ), TEC_MOUSE   (P24604    )
» more

PDB
[Detailed view]
7 PDB

1B55; 1BTK; 1BWN; 2E6I; 2LUL; 2YS2; 2Z0P

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission