Entry: PS51133

Forthcoming changes to the profile format
General information about the entry

Entry name [info] ZF_TFIIS_2
Accession [info] PS51133
Entry type [info] MATRIX
Date [info] JUN-2005 (CREATED); OCT-2013 (DATA UPDATE); JUN-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC00383
Associated ProRule [info] PRU00472

Name and characterization of the entry

Description [info] Zinc finger TFIIS-type profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=41;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=37;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.4266217; R2=0.0051143; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=-1593.86186; R2=16.47629; TEXT='HScore';
/CUT_OFF: LEVEL=0; SCORE=1384; N_SCORE=8.5; H_SCORE=17980; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=993; N_SCORE=6.5; H_SCORE=14751; MODE=1; TEXT='?';
/DEFAULT: M0=-23; D=-20; I=-20; B1=-200; E1=-200; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-105; BD=-105;
/M: SY='T'; M= -17, -49,  11,   4, -34,   0, -14,  14,  -6, -25, -36, -22, -30, -19,   5,  33,  36,   3, -54,   6;
/M: SY='D'; M=  -2, -52,  51,  20, -31, -11, -33, -44,  13, -21,  -8,  31, -45,  25,  -2,   0,  -3, -41, -12,  -6;
/M: SY='W'; M=   4, -52, -42,  22,  17, -52,  33,  28,  13,  -6, -30, -28, -48, -35,  -1, -31,  -3,  10,  53,   6;
/M: SY='K'; M= -26, -54, -32,  29, -52, -41, -38,  -9,  46, -35, -39,  11,  35,  26,   8, -15,  17,  -3, -56, -45;
/M: SY='C'; M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/I:         I=-6; MD=-32;
/M: SY='P'; M= -33, -63, -34,   3, -43,   6, -43, -51,   2, -48, -46, -42,  95,  -1,   2, -16, -23, -34, -54, -11; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='K'; M=   3, -52,   4,  12, -35, -22, -34, -47,  61, -42, -42,  31, -44,  11,  25,  -6, -30, -20, -54, -27;
/I:         I=-5; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='C'; M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='G'; M= -21, -54,   1, -32, -57,  65,  44, -62,  31, -58, -47,   6, -27,   2, -11,   3, -22, -57, -56, -45;
/M: SY='H'; M= -30, -32, -28, -16,  -4,   4,  87, -55,  16, -51, -41,  54, -47,  16, -30,  31, -28, -54, -61, -24;
/M: SY='N'; M= -29, -54,  29,  20, -53, -13,  34, -41,  27, -41,  -7,  40,   7, -12,  36,  -6,  -9, -44, -60, -30;
/M: SY='E'; M= -38, -54,  10,  58, -28,   1, -20, -54,  37, -52, -22,  38, -41,  -7,  16, -20,  -4, -33, -58, -45;
/M: SY='A'; M=  57,  40, -47, -44, -43, -18, -47, -16, -43, -12,  39, -19, -47, -41, -47, -20,  30,  16, -57, -28;
/M: SY='Y'; M=  -6, -49, -48, -34,  16, -51,  24,   1, -41, -11,   1, -42, -52, -11, -12,   5,  19,  41,  23,  53;
/I:         I=-6; MD=-29;
/M: SY='F'; M= -43, -56, -56, -42,  79, -55, -35, -34, -48, -29, -33, -52,  24, -50, -34, -21, -28, -30,  65,  78; D=-6;
/I:         I=-6; MI=-29; MD=-29; IM=-29; DM=-29;
/M: SY='F'; M= -28, -51, -53, -39,  62, -54,  22,  -7, -21,   1,  37, -22, -55, -35, -11, -24,  10,  -1,  62,  36; D=-6;
/I:         I=-6; DM=-29;
/M: SY='Q'; M= -36, -54, -34,  18, -50, -47,  -9,  -3, -26, -11,  38, -13, -44,  89, -29,  -4,  30, -32, -54, -38;
/M: SY='M'; M=   5, -49, -31, -41, -23, -50, -42,  19,   4,  37,  48, -43, -12,   4,   2,  11, -21,  -2, -52, -36;
/I:         I=-6; MD=-32;
/M: SY='Q'; M= -26, -62, -34, -15, -65, -46,  23, -53, -19, -48, -10, -29,  -1, 113,  -2, -28, -40, -55, -52, -38; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='T'; M= -27, -45, -39,   0, -41, -16, -44,  24, -37,  -1,   9, -32, -42,  16, -43,  -7,  78, -19, -59, -41;
/M: SY='R'; M= -16, -59, -41, -29, -54, -16, -32, -59,  25, -43, -42, -33, -51, -20,  98, -37, -42, -52, -53, -41;
/I:         I=-5; MD=-27;
/M: SY='S'; M=  19, -19, -22, -14, -52, -16, -39, -17,  -9, -50, -44, -29, -45, -28,  27,  73, -23, -26, -59, -45; D=-5;
/I:         I=-5; MI=-27; MD=-27; IM=-27; DM=-27;
/M: SY='A'; M=  71,  -2, -43, -16, -54,  18, -46, -33, -18, -39, -41, -37, -45, -36, -32,  18, -23, -28, -55, -49; D=-5;
/I:         I=-5; DM=-27;
/M: SY='D'; M= -45, -59, 101,  25, -59, -44, -31, -62, -32, -60, -58, -17, -44, -30, -41, -20, -23, -59, -71,   0; D=-5;
/I:         I=-5; DM=-27;
/M: SY='E'; M= -37, -56,  -2,  93, -58, -51, -32, -55, -10, -52, -48,   9, -35, -15, -30, -32,  12, -27, -60, -50;
/M: SY='P'; M=   7, -57, -39,   1, -59,  39, -44, -53, -39, -57, -18, -11,  87, -38, -48,  13, -20, -52, -56, -55;
/M: SY='M'; M= -19, -50, -44,   9, -40, -47, -35, -18, -37,   0,  98, -40,  37,  31, -39,  13,  -1, -31, -54, -37;
/M: SY='T'; M= -11, -42, -39, -39, -43, -45, -45,  -4, -35, -11, -34, -29, -41, -38,   0,  20,  87, -12, -62, -42;
/M: SY='V'; M= -37, -48, -53, -47, -31, -59, -50,  35, -15,  34, -19, -46, -52, -43,  22, -30,  31,  43, -56, -37;
/M: SY='F'; M= -38, -51, -59, -40,  96, -59, -41,  11, -28, -16,  -1, -51, -60, -53,   5, -49, -43, -17, -23,  39;
/M: SY='Y'; M= -15,  14, -52, -52,  51, -55,  22, -21, -46, -24, -28, -49, -60, -44, -44, -43, -41,  11, -17, 101;
/M: SY='V'; M= -14, -11, -33,  -2, -14, -52, -44,   4,  30, -10, -15, -24, -47, -22,  12, -16,  36,  40, -55,  -9;
/M: SY='C'; M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/I:         I=-5; MD=-27;
/M: SY='C'; M=  -5,  56, -26, -19, -43, -49, -28, -13,  14,   2,   3,  -8,   1, -19,  -9,  -8,  43,   8, -60, -23; D=-5;
/I:         I=-5; MI=0; MD=-27; IM=0; DM=-27;
/M: SY='N'; M= -14, -52,  34,  24, -54, -20,  33, -55,  34, -52, -24,  47, -44,  -3,   8,  22, -18, -42, -61, -24;
/M: SY='C'; M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/I:         I=-6; MD=-32;
/M: SY='G'; M= -14, -54, -30, -16, -39,  65, -25, -58,  31, -45, -27,  11, -46,  21, -13,  -1, -33, -54, -51,  -9; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='H'; M= -44, -55, -22,  -2,  25, -47,  99, -51,  35, -44, -36,  26, -48,  -7, -26, -19, -39, -52, -46,  44;
/M: SY='R'; M= -24, -55, -29, -15, -34, -49,  22, -14,  28, -20, -36,   8, -48,  32,  62, -24,  10, -14,  40, -14;
/M: SY='W'; M= -50, -65, -50,  -2,  56, -54, -57, -41, -46, -37, -12, -60, -55, -31, -36, -52, -22, -32, 148,  17;
/M: SY='R'; M= -24, -52, -36,  -8, -51, -48, -36, -15,  47, -47, -40,  -9, -45, -14,  64,   6,  38, -22, -56, -42;
/I:         E1=0; IE=-105; DE=-105;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_07 which contains 546'000 sequence entries.


Total number of hits 60 in 60 different sequences
Number of true positive hits 60 in 60 different sequences
Number of 'unknown' hits
Number of false positive hits
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] N_Hulo
Taxonomic range [info] Archaea, Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 1
Feature key [info] ZN_FING
Feature description [info] TFIIS-type
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
60 sequences

081R_FRG3G  (Q6GZP4), RP30_VACCC  (P21082), RP30_VACCW  (P21603), 
RP30_VAR67  (P33796), RPA12_BOVIN (Q1RMP0), RPA12_HUMAN (Q9P1U0), 
RPA12_MACMU (Q5TM50), RPA12_MOUSE (Q791N7), RPA12_PANTR (Q1XHV8), 
RPA12_RAT   (Q6MFY5), RPA12_SCHPO (O94703), RPA12_YEAST (P32529), 
RPB9A_ARATH (Q6NLH0), RPB9B_ARATH (Q8L5V0), RPB9_ASHGO  (Q755B3), 
RPB9_BOVIN  (Q32P73), RPB9_CANGA  (Q6FS48), RPB9_DROME  (P36958), 
RPB9_ENCCU  (Q8SQU1), RPB9_HUMAN  (P36954), RPB9_MOUSE  (P60898), 
RPB9_PIG    (P60899), RPB9_SCHPO  (O74635), RPB9_YEAST  (P27999), 
RPC10_BOVIN (Q2M2S7), RPC10_HUMAN (Q9Y2Y1), RPC10_MOUSE (Q9CQZ7), 
RPC10_SCHPO (O13896), RPC10_YEAST (Q04307), RPO5_FOWPN  (Q9J5C0), 
RPO5_VACCA  (O57187), RPOM_ARCFU  (O29033), RPOM_METJA  (Q58548), 
RPOM_METTH  (O27369), RPOM_SULAC  (Q07271), RPOM_THECE  (Q56254), 
TCEA1_BOVIN (Q29RL9), TCEA1_DICDI (Q54YG9), TCEA1_HUMAN (P23193), 
TCEA1_MOUSE (P10711), TCEA1_RAT   (Q4KLL0), TCEA2_BOVIN (Q148K0), 
TCEA2_HUMAN (Q15560), TCEA2_MOUSE (Q9QVN7), TCEA2_RAT   (Q63799), 
TCEA3_BOVIN (Q2KI09), TCEA3_HUMAN (O75764), TCEA3_MOUSE (P23881), 
TFS2_ASFB7  (P27948), TFS2_ASFK5  (P0C8F5), TFS2_ASFM2  (P0C8F6), 
TFS2_ASFP4  (P0C8F7), TFS2_ASFWA  (P0C8F8), TFS2_CAEEL  (P52652), 
TFS2_DROME  (P20232), TFS2_MIMIV  (Q5UQS8), TFS2_SCHPO  (P49373), 
TFS2_YEAST  (P07273), VF349_IIV3  (Q197A5), VF349_IIV6  (Q91FH5)
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PDB
[Detailed view]
104 PDB

1I3Q; 1I50; 1I6H; 1K83; 1NIK; 1NT9; 1PQV; 1QYP; 1R5U; 1R9S; 1R9T; 1SFO; 1TFI; 1TWA; 1TWC; 1TWF; 1TWG; 1TWH; 1WCM; 1Y1V; 1Y1W; 1Y1Y; 1Y77; 2B63; 2B8K; 2E2H; 2E2I; 2E2J; 2JA5; 2JA6; 2JA7; 2JA8; 2NVQ; 2NVT; 2NVX; 2NVY; 2NVZ; 2R7Z; 2R92; 2R93; 2VUM; 2YU9; 3CQZ; 3FKI; 3GTG; 3GTJ; 3GTK; 3GTL; 3GTM; 3GTO; 3GTP; 3GTQ; 3H0G; 3H3V; 3HOU; 3HOV; 3HOW; 3HOX; 3HOY; 3HOZ; 3I4M; 3I4N; 3J0K; 3J1N; 3K1F; 3K7A; 3M3Y; 3M4O; 3PO2; 3PO3; 3RZD; 3RZO; 3S14; 3S15; 3S16; 3S17; 3S1M; 3S1N; 3S1Q; 3S1R; 3S2D; 3S2H; 4A3B; 4A3C; 4A3D; 4A3E; 4A3F; 4A3G; 4A3I; 4A3J; 4A3K; 4A3L; 4A3M; 4A93; 4BBR; 4BBS; 4BXX; 4BXZ; 4BY1; 4BY7; 4C2M; 4C3H; 4C3I; 4C3J
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