To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
Entry: PS51140

General information about the entry

Entry name [info] CUE
Accession [info] PS51140
Entry type [info] MATRIX
Date [info] 01-JUL-2005 CREATED; 01-OCT-2013 DATA UPDATE; 22-NOV-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC51140
Associated ProRule [info] PRU00468

Name and characterization of the entry

Description [info] CUE domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=44;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=44;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.0788274; R2=0.0083074; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=966; N_SCORE=10.1; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1;  SCORE=846; N_SCORE=9.1; MODE=1; TEXT='R?';
/DEFAULT: M0=-31; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-105; BD=-105;
/M: SY='E'; M= -23, -13,  24,  45, -87, -86, -13,  16, -18, -48,  28, -29, -84,  43,   1,  31, -30,  20, -99, -81;
/M: SY='H'; M= -49, -90,  -6, -17,  -3, -87,  41,  -5, -20,   9,  29,  39,  11,  -1,  22,  -6,  39, -18, -97, -75;
/M: SY='D'; M= -19, -92,  47,  41, -30, -82,  -8, -87,   9, -13,  16,  42,   9,  28, -30,  15,  -2, -85, -99, -82;
/M: SY='N'; M=  18, -19,   6,  36, -93, -23,  -2, -86, -17, -54,  15,  40,  24,  30, -17,  26,  -2, -28, -99, -85;
/M: SY='M'; M=  14,  -7,   6,  27, -82, -45,  29,  -6,  34,  11,  58, -24, -86,   1, -73, -75, -10,   9, -97, -78;
/M: SY='V'; M=   3, -86, -98, -92,  -1, -97, -90,  37, -90,  45,  22, -93, -95, -88, -44, -83, -10,  57, -90,   2;
/M: SY='H'; M= -27,  -7,  16,  49, -90, -85,  61, -41,  16, -21,  17, -26, -82,  39,  -7,  23,  18, -84,-100, -79;
/M: SY='Q'; M= -13,  -3,  10,  19, -33, -84,  -9, -19,  -3, -51, -10, -25, -84,  57, -15,  24,  50, -24, -92,  21;
/M: SY='L'; M= -80, -87,-102, -96,   0,-103, -91,  44, -94,  67,  23, -98, -98, -91, -94, -91, -77,  48, -91, -71;
/M: SY='Q'; M= -25, -93, -80, -68, -83, -88,  16,  -2,  58,   1,  53, -73, -86,  73,   3, -19, -11, -23, -91, -18;
/M: SY='E'; M= -23, -93,  47,  71, -97, -46, -72, -52,   4, -55, -86,  16, -80,  42, -70,  28,  -1, -88,-100, -86;
/M: SY='M'; M=   0, -87, -92,   1, -69, -93, -82,  16, -37,  46, 102, -89, -91, -79, -85, -16, -75,  14, -93, -74;
/M: SY='F'; M= -21, -88,-104, -99, 120, -98, -86, -38, -95,  -1, -66, -94,-102,-103, -93, -90, -84, -69, -61, -40;
/M: SY='P'; M= -84,-109, -84, -73,-104, -86, -87, -91, -80,-102, -88, -91, 131, -84, -93, -81, -76, -97, -97,-101;
/M: SY='D'; M= -28, -92,  63,   8, -32, -23,  40, -40, -32, -90, -19,  47, -84,  57, -74,  22,  15, -88,-103, -80;
/M: SY='V'; M= -24,  -7, -98, -92,  10, -98,  -8,  31, -88,  46,  46, -92, -95, -87, -15, -85, -12,  47,  40, -23;
/M: SY='D'; M= -40, -94,  72,  25, -98,  12,  24, -97, -73, -97, -90, -19,  50, -70, -31,  38,  12, -92,-105, -87;
/M: SY='P'; M= -14,  -7,  22,  30, -87, -86, -78, -36,  17, -21, -77,  10,  49,  16,  -1,   5, -31,  21, -96,  -6;
/M: SY='E'; M= -24, -92,  42,  53, -31,  12, -13, -89, -16, -57, -85,  -2, -28,   2, -32,  37,   3, -22,   8, -20;
/M: SY='Q'; M=  -2, -90, -12,  -1,  36, -92,  14,  33, -17,  14, -65, -29, -90,  47, -80, -77,   4,  29, -88, -24;
/M: SY='I'; M= -10, -90,-101, -96, -67,-102, -97,  84, -94,  38, -54, -95, -24, -91, -96, -88, -75,  37, -93, -75;
/M: SY='R'; M=   5, -92, -31,  28, -87, -88, -13, -40,  30,  -2, -15, -74, -86,  36,  58,  -2,   3,   1, -95, -81;
/M: SY='D'; M=  23,  30,  44,  19, -83, -24,  -7, -89,  -1, -52, -81, -71, -86,  38,  27,  -1, -12, -44,  15,  40;
/M: SY='C'; M= -12,  70,  48, -32, -79, -92,  32,  20, -85,  12, -68, -78, -92, -22, -88, -22, -31,  52,-104, -80;
/M: SY='L'; M= -45, -11,-101, -94, -21,-102, -87,   0, -94,  85,   0, -99,-100, -89, -92, -92, -79,   7, -88, -14;
/M: SY='R'; M=   3, -93, -30,  42,  -5, -88, -77,  25,   9,  -2, -72, -21, -86,  37,  42,   8, -75, -21, -91, -24;
/M: SY='E'; M=  43, -89,  -5,  43, -91, -80, -16, -19,  22, -55, -80,  19, -82,  34,   3,  14,   2, -80, -95, -26;
/I:         I=-13; MD=-27;
/M: SY='Y'; M=  -4,  21, -82, -85, -82, -88,  51, -98, -21, -96, -88,  53, -99,   2,  -8,  32, -80, -96, -92,  65; D=-13;
/I:         I=-13; MI=-27; MD=-27; IM=-27; DM=-27;
/M: SY='N'; M= -78,  -2,  48,  10, -91,  -2,  33, -92, -13, -38, -84,  54, -86,  -6,  22, -20,  48, -88,-103, -16; D=-13;
/I:         I=-13; DM=-27;
/M: SY='G'; M= -77, -95,  -6, -40, -12,  66,  -3, -96, -16, -95, -88,  55, -91,  -4,   1, -18, -80, -45,  12,  27; D=-13;
/I:         I=-13; DM=-27;
/M: SY='N'; M= -19,   6,  71, -65, -30, -76, -71, -90, -15, -93, -14,  76, -87, -14, -14,  40, -30, -32,-106, -84;
/M: SY='V'; M= -27, -88, -94, -87,  -3, -96, -89,  37, -19,  34,  -8, -88, -35,  -1, -10,  -8, -35,  60, -92, -21;
/M: SY='E'; M= -11, -10,  70,  80,-101, -27, -72, -99, -66, -95, -90,   1, -79,  29, -74, -20, -12, -92,-103, -89;
/M: SY='Q'; M=  31, -89,  -9,   5, -85, -45, -10,  -5, -74,  22, -71,   2,  24,  51, -32,   8,  20, -39, -96, -82;
/M: SY='T'; M=  58,  59, -85, -82, -85, -81, -90, -14, -35, -76, -74, -76, -85, -82, -86, -27,  71,  31,-101, -85;
/M: SY='I'; M= -42,  49, -97, -94,  12, -98,  -6,  76, -91, -37,  29, -88, -93, -89, -93,  -4, -12,  41, -90,   7;
/M: SY='N'; M=  20, -89,  53,  44, -95, -42, -72, -89, -33, -51, -85,  66, -83,  30, -75,  11, -20, -23,-103, -87;
/M: SY='M'; M=  33, -87, -29,  -2, -83, -80, -12, -73,   1, -17,  59,  44, -25,  -2,  16,  21, -70,  13, -96, -18;
/M: SY='L'; M= -14,  17,-101, -95, -28,-101, -89,  53, -94,  74, -51, -97, -98, -89, -94, -90, -78, -11, -88,  -7;
/M: SY='L'; M= -48, -12, -95, -89,  19, -98, -12,   5,  -3,  72, -10, -31, -96, -84, -30, -38, -12,   6, -89, -70;
/I:         I=-15; MD=-32;
/M: SY='E'; M=   4,  -8,  23,  60, -40, -50, -73, -90,  13, -54,  -9,  30, -83,  35,   1,   6, -30, -46, -95,  -4; D=-15;
/I:         I=-15; MI=-32; IM=-32; DM=-32;
/M: SY='M'; M= -23, -92,  28,  12, -31,  39, -78,   0, -78,  31,  44,  -3, -89,   4,  -2, -35, -78, -39, -91,   0;
/M: SY='S'; M=  -3, -90, -13,  18, -34,   6, -77, -39,  10, -48, -81,  20, -26,  18,  28,  41,  20, -22,  13, -82;
/M: SY='H'; M= -10, -91,  39,  29, -29, -28,  46,   8, -13,  10,  15, -21, -30, -22, -79,   1,  14, -11, -96, -18;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_11 which contains 556'196 sequence entries.


Total number of hits 87 in 82 different sequences
Number of true positive hits 87 in 82 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 6
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 93.55 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] PS_Langendijk_Genevaux
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 2
Feature key [info] DOMAIN
Feature description [info] CUE
Version [info] 3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
82 sequences

AMFR_HUMAN  (Q9UKV5    ), AMFR_MOUSE  (Q9R049    ), ASCC2_DICDI (Q54VC4    ), 
ASCC2_HUMAN (Q9H1I8    ), ASCC2_MOUSE (Q91WR3    ), AUP1_CAEEL  (P34426    ), 
AUP1_DANRE  (Q6PBN5    ), AUP1_HUMAN  (Q9Y679    ), AUP1_MOUSE  (P70295    ), 
AUP1_RAT    (A1L134    ), AUP1_XENLA  (B1H1N7    ), AUP1_XENTR  (A9ULG4    ), 
CID5_ARATH  (Q9LYE5    ), CID6_ARATH  (Q6NQH9    ), CUE1_ASHGO  (Q756I2    ), 
CUE1_CANAL  (Q59NY7    ), CUE1_CANGA  (Q6FS98    ), CUE1_DEBHA  (Q6BKU8    ), 
CUE1_KLULA  (Q6CNN5    ), CUE1_YEAST  (P38428    ), CUE2_YEAST  (P36075    ), 
CUE3_SCHPO  (O74485    ), CUE3_YEAST  (P53137    ), CUE4_SCHPO  (P87238    ), 
CUE4_YEAST  (Q04201    ), CUE5_SCHPO  (O14319    ), CUE5_YEAST  (Q08412    ), 
CUED1_HUMAN (Q9NWM3    ), CUED1_MOUSE (Q8R3V6    ), CUED2_BOVIN (Q3ZBN4    ), 
CUED2_HUMAN (Q9H467    ), CUED2_MOUSE (Q9CXX9    ), CUED2_RAT   (A1L131    ), 
DEF1_CANAL  (Q5AMM4    ), DEF1_CANAW  (C4YHS3    ), DEF1_CANTT  (C5M2B8    ), 
DEF1_CLAL4  (C4Y1P0    ), DEF1_DEBHA  (Q6BRB3    ), DEF1_KLULA  (Q6CTH5    ), 
DEF1_LACTC  (C5DGU9    ), DEF1_LODEL  (A5E406    ), DEF1_YEAS2  (C7GP20    ), 
DEF1_YEAS7  (A6ZZR2    ), DEF1_YEAST  (P35732    ), DEF1_ZYGRC  (C5E4K0    ), 
DON1_YEAST  (Q05610    ), HRDL1_CAEBR (A8WWR3    ), HRDL1_CAEEL (P90859    ), 
N4BP2_HUMAN (Q86UW6    ), RIN2_ARATH  (Q8VYC8    ), RIN3_ARATH  (Q8W4Q5    ), 
SMRCD_BOVIN (E1B7X9    ), SMRCD_HUMAN (Q9H4L7    ), SMRCD_MOUSE (Q04692    ), 
SMRCD_RAT   (D3Z9Z9    ), SMRCD_XENTR (Q5FWR0    ), SMRDA_DANRE (B0R061    ), 
SMRDB_DANRE (E7F1C4    ), TAB2_DANRE  (Q5RFW2    ), TAB2_HUMAN  (Q9NYJ8    ), 
TAB2_MOUSE  (Q99K90    ), TAB2_RAT    (Q5U303    ), TAB3_HUMAN  (Q8N5C8    ), 
TAB3_MOUSE  (Q571K4    ), TAB3_XENLA  (Q7ZXH3    ), TOIPA_ONCMY (Q4LBC8    ), 
TOIPA_XENLA (Q3B8H2    ), TOIPB_ONCMY (Q4LBC7    ), TOIPB_XENLA (Q6INE3    ), 
TOLIP_BOVIN (Q2LGB5    ), TOLIP_CHICK (Q5ZK05    ), TOLIP_DANRE (Q7ZV43    ), 
TOLIP_ESOLU (C1BZR1    ), TOLIP_HUMAN (Q9H0E2    ), TOLIP_MOUSE (Q9QZ06    ), 
TOLIP_RAT   (A2RUW1    ), TOLIP_SALSA (B5X370    ), TOLIP_XENTR (Q6DFR0    ), 
VPS91_SCHPO (O74396    ), VPS9_YEAST  (P54787    ), YGVA_SCHPO  (O43024    ), 
YR75_CAEEL  (Q09394    )
» more

UniProtKB/Swiss-Prot
False negative sequences
6 sequences

CID7_ARATH  (O64843    ), CUE2A_XENLA (Q6NU18    ), CUE2B_XENLA (Q68F60    ), 
CUED2_DANRE (Q6TLH3    ), DEF1_ASHGO  (Q75DE9    ), DEF1_CANGA  (Q6FIN4    )
» more

PDB
[Detailed view]
15 PDB

1MN3; 1OTR; 1P3Q; 1WGL; 2DAE; 2DHY; 2DI0; 2EJS; 2EKF; 2LVN; 2LVO; 2LVP; 2LVQ; 2MYX; 4G3O
» more

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission