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Entry: PS51140

General information about the entry
Entry name	CUE
Accession number	PS51140
Entry type	MATRIX
Date	JUL-2005 (CREATED); JUL-2005 (DATA UPDATE); DEC-2011 (INFO UPDATE).
PROSITE Documentation	PDOC51140
Associated ProRule	PRU00468
Name and characterization of the entry
Description	CUE domain profile.
Matrix / Profile	/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=44; /DISJOINT: DEFINITION=PROTECT; N1=1; N2=44; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.0788274; R2=0.0083074; TEXT='-LogE'; /CUT_OFF: LEVEL=0; SCORE=966; N_SCORE=10.1; MODE=1; TEXT='R'; /CUT_OFF: LEVEL=-1; SCORE=846; N_SCORE=9.1; MODE=1; TEXT='R?'; /DEFAULT: M0=-31; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105; A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-105; BD=-105; /M: SY='E'; M= -23, -13, 24, 45, -87, -86, -13, 16, -18, -48, 28, -29, -84, 43, 1, 31, -30, 20, -99, -81; /M: SY='H'; M= -49, -90, -6, -17, -3, -87, 41, -5, -20, 9, 29, 39, 11, -1, 22, -6, 39, -18, -97, -75; /M: SY='D'; M= -19, -92, 47, 41, -30, -82, -8, -87, 9, -13, 16, 42, 9, 28, -30, 15, -2, -85, -99, -82; /M: SY='N'; M= 18, -19, 6, 36, -93, -23, -2, -86, -17, -54, 15, 40, 24, 30, -17, 26, -2, -28, -99, -85; /M: SY='M'; M= 14, -7, 6, 27, -82, -45, 29, -6, 34, 11, 58, -24, -86, 1, -73, -75, -10, 9, -97, -78; /M: SY='V'; M= 3, -86, -98, -92, -1, -97, -90, 37, -90, 45, 22, -93, -95, -88, -44, -83, -10, 57, -90, 2; /M: SY='H'; M= -27, -7, 16, 49, -90, -85, 61, -41, 16, -21, 17, -26, -82, 39, -7, 23, 18, -84,-100, -79; /M: SY='Q'; M= -13, -3, 10, 19, -33, -84, -9, -19, -3, -51, -10, -25, -84, 57, -15, 24, 50, -24, -92, 21; /M: SY='L'; M= -80, -87,-102, -96, 0,-103, -91, 44, -94, 67, 23, -98, -98, -91, -94, -91, -77, 48, -91, -71; /M: SY='Q'; M= -25, -93, -80, -68, -83, -88, 16, -2, 58, 1, 53, -73, -86, 73, 3, -19, -11, -23, -91, -18; /M: SY='E'; M= -23, -93, 47, 71, -97, -46, -72, -52, 4, -55, -86, 16, -80, 42, -70, 28, -1, -88,-100, -86; /M: SY='M'; M= 0, -87, -92, 1, -69, -93, -82, 16, -37, 46, 102, -89, -91, -79, -85, -16, -75, 14, -93, -74; /M: SY='F'; M= -21, -88,-104, -99, 120, -98, -86, -38, -95, -1, -66, -94,-102,-103, -93, -90, -84, -69, -61, -40; /M: SY='P'; M= -84,-109, -84, -73,-104, -86, -87, -91, -80,-102, -88, -91, 131, -84, -93, -81, -76, -97, -97,-101; /M: SY='D'; M= -28, -92, 63, 8, -32, -23, 40, -40, -32, -90, -19, 47, -84, 57, -74, 22, 15, -88,-103, -80; /M: SY='V'; M= -24, -7, -98, -92, 10, -98, -8, 31, -88, 46, 46, -92, -95, -87, -15, -85, -12, 47, 40, -23; /M: SY='D'; M= -40, -94, 72, 25, -98, 12, 24, -97, -73, -97, -90, -19, 50, -70, -31, 38, 12, -92,-105, -87; /M: SY='P'; M= -14, -7, 22, 30, -87, -86, -78, -36, 17, -21, -77, 10, 49, 16, -1, 5, -31, 21, -96, -6; /M: SY='E'; M= -24, -92, 42, 53, -31, 12, -13, -89, -16, -57, -85, -2, -28, 2, -32, 37, 3, -22, 8, -20; /M: SY='Q'; M= -2, -90, -12, -1, 36, -92, 14, 33, -17, 14, -65, -29, -90, 47, -80, -77, 4, 29, -88, -24; /M: SY='I'; M= -10, -90,-101, -96, -67,-102, -97, 84, -94, 38, -54, -95, -24, -91, -96, -88, -75, 37, -93, -75; /M: SY='R'; M= 5, -92, -31, 28, -87, -88, -13, -40, 30, -2, -15, -74, -86, 36, 58, -2, 3, 1, -95, -81; /M: SY='D'; M= 23, 30, 44, 19, -83, -24, -7, -89, -1, -52, -81, -71, -86, 38, 27, -1, -12, -44, 15, 40; /M: SY='C'; M= -12, 70, 48, -32, -79, -92, 32, 20, -85, 12, -68, -78, -92, -22, -88, -22, -31, 52,-104, -80; /M: SY='L'; M= -45, -11,-101, -94, -21,-102, -87, 0, -94, 85, 0, -99,-100, -89, -92, -92, -79, 7, -88, -14; /M: SY='R'; M= 3, -93, -30, 42, -5, -88, -77, 25, 9, -2, -72, -21, -86, 37, 42, 8, -75, -21, -91, -24; /M: SY='E'; M= 43, -89, -5, 43, -91, -80, -16, -19, 22, -55, -80, 19, -82, 34, 3, 14, 2, -80, -95, -26; /I: I=-13; MD=-27; /M: SY='Y'; M= -4, 21, -82, -85, -82, -88, 51, -98, -21, -96, -88, 53, -99, 2, -8, 32, -80, -96, -92, 65; D=-13; /I: I=-13; MI=-27; MD=-27; IM=-27; DM=-27; /M: SY='N'; M= -78, -2, 48, 10, -91, -2, 33, -92, -13, -38, -84, 54, -86, -6, 22, -20, 48, -88,-103, -16; D=-13; /I: I=-13; DM=-27; /M: SY='G'; M= -77, -95, -6, -40, -12, 66, -3, -96, -16, -95, -88, 55, -91, -4, 1, -18, -80, -45, 12, 27; D=-13; /I: I=-13; DM=-27; /M: SY='N'; M= -19, 6, 71, -65, -30, -76, -71, -90, -15, -93, -14, 76, -87, -14, -14, 40, -30, -32,-106, -84; /M: SY='V'; M= -27, -88, -94, -87, -3, -96, -89, 37, -19, 34, -8, -88, -35, -1, -10, -8, -35, 60, -92, -21; /M: SY='E'; M= -11, -10, 70, 80,-101, -27, -72, -99, -66, -95, -90, 1, -79, 29, -74, -20, -12, -92,-103, -89; /M: SY='Q'; M= 31, -89, -9, 5, -85, -45, -10, -5, -74, 22, -71, 2, 24, 51, -32, 8, 20, -39, -96, -82; /M: SY='T'; M= 58, 59, -85, -82, -85, -81, -90, -14, -35, -76, -74, -76, -85, -82, -86, -27, 71, 31,-101, -85; /M: SY='I'; M= -42, 49, -97, -94, 12, -98, -6, 76, -91, -37, 29, -88, -93, -89, -93, -4, -12, 41, -90, 7; /M: SY='N'; M= 20, -89, 53, 44, -95, -42, -72, -89, -33, -51, -85, 66, -83, 30, -75, 11, -20, -23,-103, -87; /M: SY='M'; M= 33, -87, -29, -2, -83, -80, -12, -73, 1, -17, 59, 44, -25, -2, 16, 21, -70, 13, -96, -18; /M: SY='L'; M= -14, 17,-101, -95, -28,-101, -89, 53, -94, 74, -51, -97, -98, -89, -94, -90, -78, -11, -88, -7; /M: SY='L'; M= -48, -12, -95, -89, 19, -98, -12, 5, -3, 72, -10, -31, -96, -84, -30, -38, -12, 6, -89, -70; /I: I=-15; MD=-32; /M: SY='E'; M= 4, -8, 23, 60, -40, -50, -73, -90, 13, -54, -9, 30, -83, 35, 1, 6, -30, -46, -95, -4; D=-15; /I: I=-15; MI=-32; IM=-32; DM=-32; /M: SY='M'; M= -23, -92, 28, 12, -31, 39, -78, 0, -78, 31, 44, -3, -89, 4, -2, -35, -78, -39, -91, 0; /M: SY='S'; M= -3, -90, -13, 18, -34, 6, -77, -39, 10, -48, -81, 20, -26, 18, 28, 41, 20, -22, 13, -82; /M: SY='H'; M= -10, -91, 39, 29, -29, -28, 46, 8, -13, 10, 15, -21, -30, -22, -79, 1, 14, -11, -96, -18; /I: E1=0; IE=-105; DE=-105;
Numerical results
UniProtKB/Swiss-Prot release number: 01, total number of sequence entries in that release: 534242. Total number of hits in UniProtKB/Swiss-Prot: 77 hits in 74 different sequences Number of hits on proteins that are known to belong to the set under consideration: 77 hits in 74 different sequences Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences Number of false hits (on unrelated proteins): 0 hits in 0 different sequences Number of known missed hits: 5 Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 0 Precision (true hits / (true hits + false positives)): 100.00 % Recall (true hits / (true hits + false negatives)): 93.90 %
Comments
MATRIX_TYPE: protein_domain Scaling database: UniProtKB/Swiss-Prot: window20 Matrix author: PS_Langendijk_Genevaux Taxonomic range: Eukaryotes Maximum known number of repetitions of the pattern in a single protein: 2 FT_KEY: DOMAIN FT_DESC: CUE VERSION: 1
Cross-references
UniProtKB/Swiss-Prot	True positive hits: AMFR2_HUMAN (Q9UKV5), AMFR_MOUSE (Q9R049), ASCC2_DICDI (Q54VC4), ASCC2_HUMAN (Q9H1I8), ASCC2_MOUSE (Q91WR3), AUP1_CAEEL (P34426), AUP1_DANRE (Q6PBN5), AUP1_HUMAN (Q9Y679), AUP1_MOUSE (P70295), AUP1_RAT (A1L134), AUP1_XENLA (B1H1N7), AUP1_XENTR (A9ULG4), CUE1_ASHGO (Q756I2), CUE1_CANAL (Q59NY7), CUE1_CANGA (Q6FS98), CUE1_DEBHA (Q6BKU8), CUE1_KLULA (Q6CNN5), CUE1_YEAST (P38428), CUE2_YEAST (P36075), CUE3_SCHPO (O74485), CUE3_YEAST (P53137), CUE4_SCHPO (P87238), CUE4_YEAST (Q04201), CUE5_SCHPO (O14319), CUE5_YEAST (Q08412), CUED1_HUMAN (Q9NWM3), CUED1_MOUSE (Q8R3V6), CUED2_BOVIN (Q3ZBN4), CUED2_HUMAN (Q9H467), CUED2_MOUSE (Q9CXX9), CUED2_RAT (A1L131), DEF1_CANAL (Q5AMM4), DEF1_CANAW (C4YHS3), DEF1_CANTT (C5M2B8), DEF1_CLAL4 (C4Y1P0), DEF1_DEBHA (Q6BRB3), DEF1_KLULA (Q6CTH5), DEF1_LACTC (C5DGU9), DEF1_LODEL (A5E406), DEF1_YEAS2 (C7GP20), DEF1_YEAS7 (A6ZZR2), DEF1_YEAST (P35732), DEF1_ZYGRC (C5E4K0), DON1_YEAST (Q05610), HRDL1_CAEBR (A8WWR3), HRDL1_CAEEL (P90859), N4BP2_HUMAN (Q86UW6), RIN2_ARATH (Q8VYC8), RIN3_ARATH (Q8W4Q5), SMRCD_HUMAN (Q9H4L7), SMRCD_MOUSE (Q04692), TAB2_DANRE (Q5RFW2), TAB2_HUMAN (Q9NYJ8), TAB2_MOUSE (Q99K90), TAB2_RAT (Q5U303), TAB3_HUMAN (Q8N5C8), TAB3_MOUSE (Q571K4), TAB3_XENLA (Q7ZXH3), TOIPA_ONCMY (Q4LBC8), TOIPA_XENLA (Q3B8H2), TOIPB_ONCMY (Q4LBC7), TOIPB_XENLA (Q6INE3), TOLIP_BOVIN (Q2LGB5), TOLIP_CHICK (Q5ZK05), TOLIP_DANRE (Q7ZV43), TOLIP_ESOLU (C1BZR1), TOLIP_HUMAN (Q9H0E2), TOLIP_MOUSE (Q9QZ06), TOLIP_RAT (A2RUW1), TOLIP_SALSA (B5X370), TOLIP_XENTR (Q6DFR0), VPS9_YEAST (P54787), YGVA_SCHPO (O43024), YR75_CAEEL (Q09394) False negative hits (sequences which belong to the set under consideration, but which have not been picked up by the pattern or profile): CUE2A_XENLA (Q6NU18), CUE2B_XENLA (Q68F60), CUED2_DANRE (Q6TLH3), DEF1_ASHGO (Q75DE9), DEF1_CANGA (Q6FIN4) Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
PDB [Detailed view]	1MN3; 1OTR; 1P3Q; 1WGL; 2DAE; 2DHY; 2DI0; 2EJS; 2EKF;

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