Entry: PS51140

Forthcoming changes to the profile format
General information about the entry

Entry name [info] CUE
Accession [info] PS51140
Entry type [info] MATRIX
Date [info] JUL-2005 (CREATED); OCT-2013 (DATA UPDATE); SEP-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC51140
Associated ProRule [info] PRU00468

Name and characterization of the entry

Description [info] CUE domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=44;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=44;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.0788274; R2=0.0083074; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=4406.36779; R2=11.91730; TEXT='HScore';
/CUT_OFF: LEVEL=0; SCORE=966; N_SCORE=10.1; H_SCORE=14333; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1;  SCORE=846; N_SCORE=9.1; H_SCORE=14333; MODE=1; TEXT='R?';
/DEFAULT: M0=-31; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-105; BD=-105;
/M: SY='E'; M= -23, -13,  24,  45, -87, -86, -13,  16, -18, -48,  28, -29, -84,  43,   1,  31, -30,  20, -99, -81;
/M: SY='H'; M= -49, -90,  -6, -17,  -3, -87,  41,  -5, -20,   9,  29,  39,  11,  -1,  22,  -6,  39, -18, -97, -75;
/M: SY='D'; M= -19, -92,  47,  41, -30, -82,  -8, -87,   9, -13,  16,  42,   9,  28, -30,  15,  -2, -85, -99, -82;
/M: SY='N'; M=  18, -19,   6,  36, -93, -23,  -2, -86, -17, -54,  15,  40,  24,  30, -17,  26,  -2, -28, -99, -85;
/M: SY='M'; M=  14,  -7,   6,  27, -82, -45,  29,  -6,  34,  11,  58, -24, -86,   1, -73, -75, -10,   9, -97, -78;
/M: SY='V'; M=   3, -86, -98, -92,  -1, -97, -90,  37, -90,  45,  22, -93, -95, -88, -44, -83, -10,  57, -90,   2;
/M: SY='H'; M= -27,  -7,  16,  49, -90, -85,  61, -41,  16, -21,  17, -26, -82,  39,  -7,  23,  18, -84,-100, -79;
/M: SY='Q'; M= -13,  -3,  10,  19, -33, -84,  -9, -19,  -3, -51, -10, -25, -84,  57, -15,  24,  50, -24, -92,  21;
/M: SY='L'; M= -80, -87,-102, -96,   0,-103, -91,  44, -94,  67,  23, -98, -98, -91, -94, -91, -77,  48, -91, -71;
/M: SY='Q'; M= -25, -93, -80, -68, -83, -88,  16,  -2,  58,   1,  53, -73, -86,  73,   3, -19, -11, -23, -91, -18;
/M: SY='E'; M= -23, -93,  47,  71, -97, -46, -72, -52,   4, -55, -86,  16, -80,  42, -70,  28,  -1, -88,-100, -86;
/M: SY='M'; M=   0, -87, -92,   1, -69, -93, -82,  16, -37,  46, 102, -89, -91, -79, -85, -16, -75,  14, -93, -74;
/M: SY='F'; M= -21, -88,-104, -99, 120, -98, -86, -38, -95,  -1, -66, -94,-102,-103, -93, -90, -84, -69, -61, -40;
/M: SY='P'; M= -84,-109, -84, -73,-104, -86, -87, -91, -80,-102, -88, -91, 131, -84, -93, -81, -76, -97, -97,-101;
/M: SY='D'; M= -28, -92,  63,   8, -32, -23,  40, -40, -32, -90, -19,  47, -84,  57, -74,  22,  15, -88,-103, -80;
/M: SY='V'; M= -24,  -7, -98, -92,  10, -98,  -8,  31, -88,  46,  46, -92, -95, -87, -15, -85, -12,  47,  40, -23;
/M: SY='D'; M= -40, -94,  72,  25, -98,  12,  24, -97, -73, -97, -90, -19,  50, -70, -31,  38,  12, -92,-105, -87;
/M: SY='P'; M= -14,  -7,  22,  30, -87, -86, -78, -36,  17, -21, -77,  10,  49,  16,  -1,   5, -31,  21, -96,  -6;
/M: SY='E'; M= -24, -92,  42,  53, -31,  12, -13, -89, -16, -57, -85,  -2, -28,   2, -32,  37,   3, -22,   8, -20;
/M: SY='Q'; M=  -2, -90, -12,  -1,  36, -92,  14,  33, -17,  14, -65, -29, -90,  47, -80, -77,   4,  29, -88, -24;
/M: SY='I'; M= -10, -90,-101, -96, -67,-102, -97,  84, -94,  38, -54, -95, -24, -91, -96, -88, -75,  37, -93, -75;
/M: SY='R'; M=   5, -92, -31,  28, -87, -88, -13, -40,  30,  -2, -15, -74, -86,  36,  58,  -2,   3,   1, -95, -81;
/M: SY='D'; M=  23,  30,  44,  19, -83, -24,  -7, -89,  -1, -52, -81, -71, -86,  38,  27,  -1, -12, -44,  15,  40;
/M: SY='C'; M= -12,  70,  48, -32, -79, -92,  32,  20, -85,  12, -68, -78, -92, -22, -88, -22, -31,  52,-104, -80;
/M: SY='L'; M= -45, -11,-101, -94, -21,-102, -87,   0, -94,  85,   0, -99,-100, -89, -92, -92, -79,   7, -88, -14;
/M: SY='R'; M=   3, -93, -30,  42,  -5, -88, -77,  25,   9,  -2, -72, -21, -86,  37,  42,   8, -75, -21, -91, -24;
/M: SY='E'; M=  43, -89,  -5,  43, -91, -80, -16, -19,  22, -55, -80,  19, -82,  34,   3,  14,   2, -80, -95, -26;
/I:         I=-13; MD=-27;
/M: SY='Y'; M=  -4,  21, -82, -85, -82, -88,  51, -98, -21, -96, -88,  53, -99,   2,  -8,  32, -80, -96, -92,  65; D=-13;
/I:         I=-13; MI=-27; MD=-27; IM=-27; DM=-27;
/M: SY='N'; M= -78,  -2,  48,  10, -91,  -2,  33, -92, -13, -38, -84,  54, -86,  -6,  22, -20,  48, -88,-103, -16; D=-13;
/I:         I=-13; DM=-27;
/M: SY='G'; M= -77, -95,  -6, -40, -12,  66,  -3, -96, -16, -95, -88,  55, -91,  -4,   1, -18, -80, -45,  12,  27; D=-13;
/I:         I=-13; DM=-27;
/M: SY='N'; M= -19,   6,  71, -65, -30, -76, -71, -90, -15, -93, -14,  76, -87, -14, -14,  40, -30, -32,-106, -84;
/M: SY='V'; M= -27, -88, -94, -87,  -3, -96, -89,  37, -19,  34,  -8, -88, -35,  -1, -10,  -8, -35,  60, -92, -21;
/M: SY='E'; M= -11, -10,  70,  80,-101, -27, -72, -99, -66, -95, -90,   1, -79,  29, -74, -20, -12, -92,-103, -89;
/M: SY='Q'; M=  31, -89,  -9,   5, -85, -45, -10,  -5, -74,  22, -71,   2,  24,  51, -32,   8,  20, -39, -96, -82;
/M: SY='T'; M=  58,  59, -85, -82, -85, -81, -90, -14, -35, -76, -74, -76, -85, -82, -86, -27,  71,  31,-101, -85;
/M: SY='I'; M= -42,  49, -97, -94,  12, -98,  -6,  76, -91, -37,  29, -88, -93, -89, -93,  -4, -12,  41, -90,   7;
/M: SY='N'; M=  20, -89,  53,  44, -95, -42, -72, -89, -33, -51, -85,  66, -83,  30, -75,  11, -20, -23,-103, -87;
/M: SY='M'; M=  33, -87, -29,  -2, -83, -80, -12, -73,   1, -17,  59,  44, -25,  -2,  16,  21, -70,  13, -96, -18;
/M: SY='L'; M= -14,  17,-101, -95, -28,-101, -89,  53, -94,  74, -51, -97, -98, -89, -94, -90, -78, -11, -88,  -7;
/M: SY='L'; M= -48, -12, -95, -89,  19, -98, -12,   5,  -3,  72, -10, -31, -96, -84, -30, -38, -12,   6, -89, -70;
/I:         I=-15; MD=-32;
/M: SY='E'; M=   4,  -8,  23,  60, -40, -50, -73, -90,  13, -54,  -9,  30, -83,  35,   1,   6, -30, -46, -95,  -4; D=-15;
/I:         I=-15; MI=-32; IM=-32; DM=-32;
/M: SY='M'; M= -23, -92,  28,  12, -31,  39, -78,   0, -78,  31,  44,  -3, -89,   4,  -2, -35, -78, -39, -91,   0;
/M: SY='S'; M=  -3, -90, -13,  18, -34,   6, -77, -39,  10, -48, -81,  20, -26,  18,  28,  41,  20, -22,  13, -82;
/M: SY='H'; M= -10, -91,  39,  29, -29, -28,  46,   8, -13,  10,  15, -21, -30, -22, -79,   1,  14, -11, -96, -18;
/I:         E1=0; IE=-105; DE=-105;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_10 which contains 546'790 sequence entries.


Total number of hits 87 in 82 different sequences
Number of true positive hits 87 in 82 different sequences
Number of 'unknown' hits
Number of false positive hits
Number of false negative sequences 6
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 93.55 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] PS_Langendijk_Genevaux
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 2
Feature key [info] DOMAIN
Feature description [info] CUE
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
82 sequences

AMFR_HUMAN  (Q9UKV5), AMFR_MOUSE  (Q9R049), ASCC2_DICDI (Q54VC4), 
ASCC2_HUMAN (Q9H1I8), ASCC2_MOUSE (Q91WR3), AUP1_CAEEL  (P34426), 
AUP1_DANRE  (Q6PBN5), AUP1_HUMAN  (Q9Y679), AUP1_MOUSE  (P70295), 
AUP1_RAT    (A1L134), AUP1_XENLA  (B1H1N7), AUP1_XENTR  (A9ULG4), 
CID5_ARATH  (Q9LYE5), CID6_ARATH  (Q6NQH9), CUE1_ASHGO  (Q756I2), 
CUE1_CANAL  (Q59NY7), CUE1_CANGA  (Q6FS98), CUE1_DEBHA  (Q6BKU8), 
CUE1_KLULA  (Q6CNN5), CUE1_YEAST  (P38428), CUE2_YEAST  (P36075), 
CUE3_SCHPO  (O74485), CUE3_YEAST  (P53137), CUE4_SCHPO  (P87238), 
CUE4_YEAST  (Q04201), CUE5_SCHPO  (O14319), CUE5_YEAST  (Q08412), 
CUED1_HUMAN (Q9NWM3), CUED1_MOUSE (Q8R3V6), CUED2_BOVIN (Q3ZBN4), 
CUED2_HUMAN (Q9H467), CUED2_MOUSE (Q9CXX9), CUED2_RAT   (A1L131), 
DEF1_CANAL  (Q5AMM4), DEF1_CANAW  (C4YHS3), DEF1_CANTT  (C5M2B8), 
DEF1_CLAL4  (C4Y1P0), DEF1_DEBHA  (Q6BRB3), DEF1_KLULA  (Q6CTH5), 
DEF1_LACTC  (C5DGU9), DEF1_LODEL  (A5E406), DEF1_YEAS2  (C7GP20), 
DEF1_YEAS7  (A6ZZR2), DEF1_YEAST  (P35732), DEF1_ZYGRC  (C5E4K0), 
DON1_YEAST  (Q05610), HRDL1_CAEBR (A8WWR3), HRDL1_CAEEL (P90859), 
N4BP2_HUMAN (Q86UW6), RIN2_ARATH  (Q8VYC8), RIN3_ARATH  (Q8W4Q5), 
SMRCD_BOVIN (E1B7X9), SMRCD_HUMAN (Q9H4L7), SMRCD_MOUSE (Q04692), 
SMRCD_RAT   (D3Z9Z9), SMRCD_XENTR (Q5FWR0), SMRDA_DANRE (B0R061), 
SMRDB_DANRE (E7F1C4), TAB2_DANRE  (Q5RFW2), TAB2_HUMAN  (Q9NYJ8), 
TAB2_MOUSE  (Q99K90), TAB2_RAT    (Q5U303), TAB3_HUMAN  (Q8N5C8), 
TAB3_MOUSE  (Q571K4), TAB3_XENLA  (Q7ZXH3), TOIPA_ONCMY (Q4LBC8), 
TOIPA_XENLA (Q3B8H2), TOIPB_ONCMY (Q4LBC7), TOIPB_XENLA (Q6INE3), 
TOLIP_BOVIN (Q2LGB5), TOLIP_CHICK (Q5ZK05), TOLIP_DANRE (Q7ZV43), 
TOLIP_ESOLU (C1BZR1), TOLIP_HUMAN (Q9H0E2), TOLIP_MOUSE (Q9QZ06), 
TOLIP_RAT   (A2RUW1), TOLIP_SALSA (B5X370), TOLIP_XENTR (Q6DFR0), 
VPS91_SCHPO (O74396), VPS9_YEAST  (P54787), YGVA_SCHPO  (O43024), 
YR75_CAEEL  (Q09394)
» More

UniProtKB/Swiss-Prot
False negative sequences
6 sequences

CID7_ARATH  (O64843), CUE2A_XENLA (Q6NU18), CUE2B_XENLA (Q68F60), 
CUED2_DANRE (Q6TLH3), DEF1_ASHGO  (Q75DE9), DEF1_CANGA  (Q6FIN4)
» More

PDB
[Detailed view]
14 PDB

1MN3; 1OTR; 1P3Q; 1WGL; 2DAE; 2DHY; 2DI0; 2EJS; 2EKF; 2LVN; 2LVO; 2LVP; 2LVQ; 4G3O
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