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	Entry: PS51231

General information about the entry
Entry name	DAD
Accession number	PS51231
Entry type	MATRIX
Date	JUL-2006 (CREATED); JUL-2006 (DATA UPDATE); MAR-2013 (INFO UPDATE).
PROSITE Documentation	PDOC51231
Associated ProRule	PRU00577
Name and characterization of the entry
Description	Diaphanous autoregulatory domain (DAD) profile.
Matrix / Profile	/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=33; /DISJOINT: DEFINITION=PROTECT; N1=4; N2=30; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.2037032; R2=0.0063220; TEXT='-LogE'; /CUT_OFF: LEVEL=0; SCORE=854; N_SCORE=7.6; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=680; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-36; D=-50; I=-50; B1=-200; E1=-200; MI=-210; MD=-210; IM=-210; DM=-210; A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-210; BD=-210; /M: SY='D'; M= -58, -77, 94, 13, -84, 26, -57, -84, -56, -83, -78, -41, 0, -53, -64, 39, -54, -79, -91, -71; /M: SY='D'; M= -5, -79, 81, 76, -85, -67, -54, -82, -48, -79, -75, 1, -2, 8, -57, -54, -58, -77, -88, -72; /M: SY='T'; M= 30, -68, -56, 10, -70, -65, -61, 0, -48, -64, -60, 35, -67, -53, 51, -12, 61, -6, -82, -66; /I: I=-14; MD=-58; /M: SY='Q'; M= -6, -99, 20, -27, -90, -91, 12, -86, -81, -91, -85, -79, 12, 21, -86, -29, -17, -8, -98, 15; D=-14; /I: I=-14; MI=-58; MD=-58; IM=-58; DM=-58; /M: SY='D'; M= -64, -82, 63, 32, -87, 11, -61, -88, -3, -86, -79, 12, -71, -53, 30, 29, -60, -83, -91, -75; D=-14; /I: I=-14; DM=-58; /M: SY='G'; M= -4, -74, 20, 23, -81, 80, -64, -83, -61, -81, -73, -2, -65, -58, -69, 5, 6, -76, -79, -74; /M: SY='V'; M= 53, -68, -68, 28, 11, -69, -73, 32, -65, -49, -50, -69, -71, -63, -70, -56, -54, 59, -76, -60; /M: SY='M'; M= -62, -70, -85, -76, 39, -80, -63, 33, -71, -3, 120, -73, -74, -66, -70, -71, -59, 24, -69, -46; /M: SY='D'; M= -65, -81, 106, 59, -87, -67, -53, -86, -51, -82, -80, -40, -63, -48, -60, -56, -58, -81, -96, -71; /M: SY='D'; M= -59, -75, 81, -42, -78, -27, -55, -76, 15, -19, -69, -10, -68, 21, 29, 47, -53, -73, -86, -66; /M: SY='L'; M= -66, -72, -85, -79, -43, -88, -73, 62, -78, 77, -30, -81, -81, -72, -77, -76, -62, -32, -72, -54; /M: SY='L'; M= -63, -71, -85, -78, -45, -86, -74, 54, -77, 63, 36, -80, -79, -72, -76, -74, -59, 39, -75, -55; /M: SY='E'; M= -54, -72, 14, 70, -74, -66, -57, -72, -5, -19, -66, -51, -61, -44, 10, 52, 37, -67, -82, -68; /M: SY='K'; M= 50, -69, 14, -51, -76, -6, -63, -65, 52, -70, -63, -52, -65, 21, -50, 23, 9, 0, -78, -68; /M: SY='L'; M= 12, -69, -82, -75, -45, -80, -69, 32, -75, 76, 36, -79, -79, -69, -74, -70, -61, -37, -72, -55; /M: SY='R'; M= -6, -77, -58, -46, -78, -70, -56, -76, 63, -73, -63, -51, -67, 59, 71, -52, 27, -70, -75, -64; /M: SY='S'; M= 11, -67, -51, 2, -76, -2, -57, -71, -53, -74, -66, 50, -64, 42, -59, 60, 49, -65, -83, -68; /M: SY='G'; M= 33, -72, -64, -2, -75, 74, -69, -62, -64, -69, -63, -57, -68, 24, -69, -50, -60, 31, -77, -72; /M: SY='P'; M= 26, -78, 32, 33, -82, 20, -63, -77, 0, -79, -71, -56, 79, -54, -63, 6, -56, -73, -80, -75; /I: I=-10; MD=-41; /M: SY='A'; M= 49, -73, -72, -66, 15, -21, -66, -58, -67, -64, -60, -68, 49, -2, -70, 8, -57, 21, -66, 49; D=-10; /I: I=-10; MD=-41; /M: SY='F'; M= -32, -76, -74, -65, 80, -78, -66, 16, -16, -53, -55, -65, -77, 50, 21, -26, 24, -18, -62, -42; D=-10; /I: I=-10; MD=-41; /M: SY='R'; M= 19, -82, -8, -12, -84, 28, -65, -86, 41, -82, -72, -59, -74, -52, 68, -59, -67, -78, -81, -73; D=-10; /I: I=-10; MD=-41; /M: SY='K'; M= 33, -77, 2, 15, -82, -32, -63, -75, 39, -77, -70, 30, -71, 5, 24, -21, -12, -17, -85, -73; D=-10; /I: I=-10; MD=-41; /M: SY='D'; M= -73, -87, 88, -47, -89, -77, -63, -82, -55, -84, -80, -51, -77, 22, 40, -63, 9, -20,-100, -75; D=-10; /I: I=-10; MI=-41; MD=-41; IM=-41; DM=-41; /M: SY='P'; M= -67, -85, -70, -61, -76, -3, -65, -67, -52, -9, 24, -3, 76, 21, 56, -65, -65, -10, -82, -72; D=-10; /I: I=-10; DM=-41; /M: SY='R'; M= -13, -78, -60, 2, -79, -70, -59, -81, 40, -78, -68, -55, -71, -45, 83, 35, -11, -74, -80, -68; D=-10; /I: I=-10; DM=-41; /M: SY='R'; M= -59, -78, 12, 34, -79, -67, -55, -80, 30, -77, -68, -51, 12, 8, 74, 42, -55, -74, -79, -66; /M: SY='A'; M= 53, -68, -68, -62, 3, -13, -65, 0, -54, 2, -54, -60, -70, -5, 45, 0, 22, -15, -74, -61; /M: SY='R'; M= -61, -79, -59, -50, -78, -68, -54, -79, 33, -77, -65, -1, 32, 19, 90, 28, -57, -75, -77, -65; /M: SY='R'; M= -66, -82, -61, -49, -76, -75, -53, -82, 51, -76, -64, -54, -72, -40, 106, -60, -64, -76, -75, -63; /M: SY='R'; M= -59, -75, -60, -53, -71, -68, -54, -70, -36, -1, -59, 15, -72, 34, 89, 35, 8, -67, -78, -63; /M: SY='R'; M= 47, -74, 10, -53, -8, -66, -60, -67, 28, -11, -60, -58, 11, -51, 71, -55, -59, -35, -75, -63; /M: SY='C'; M= 12, 42, 21, -54, -69, -26, -62, -4, 15, 9, -57, -20, 21, 38, 9, 24, -55, -23, -79, -66; /I: E1=0; IE=-210; DE=-210;
Numerical results
UniProtKB/Swiss-Prot release number: 2013_05, total number of sequence entries in that release: 540052. Total number of hits in UniProtKB/Swiss-Prot: 22 hits in 22 different sequences Number of hits on proteins that are known to belong to the set under consideration: 22 hits in 22 different sequences Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences Number of false hits (on unrelated proteins): 0 hits in 0 different sequences Number of known missed hits: 12 Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 0 Precision (true hits / (true hits + false positives)): 100.00 % Recall (true hits / (true hits + false negatives)): 64.71 %
Comments
MATRIX_TYPE: protein_domain Scaling database: UniProtKB/Swiss-Prot: reversed Matrix author: PS_Langendijk_Genevaux Taxonomic range: Eukaryotes Maximum known number of repetitions of the pattern in a single protein: 1 FT_KEY: DOMAIN FT_DESC: DAD VERSION: 1
Cross-references
UniProtKB/Swiss-Prot	True positive hits: BNI1_YEAST (P41832), BNR1_YEAST (P40450), DAAM1_HUMAN (Q9Y4D1), DAAM1_MOUSE (Q8BPM0), DAAM2_HUMAN (Q86T65), DAAM2_MOUSE (Q80U19), DIAP1_HUMAN (O60610), DIAP1_MOUSE (O08808), DIAP2_HUMAN (O60879), DIAP2_MOUSE (O70566), DIAP3_HUMAN (Q9NSV4), DIAP3_MOUSE (Q9Z207), DIA_DROME (P48608), FHOD3_HUMAN (Q2V2M9), FHOD3_MOUSE (Q76LL6), FMNL2_HUMAN (Q96PY5), FMNL_HUMAN (O95466), FMNL_MOUSE (Q9JL26), FORA_DICDI (Q54WH2), FORB_DICDI (Q54SP2), SEPA_EMENI (P78621), Y2138_DROME (Q9VUC6) False negative hits (sequences which belong to the set under consideration, but which have not been picked up by the pattern or profile): FHOD1_HUMAN (Q9Y613), FHOD1_MOUSE (Q6P9Q4), FMNL2_MOUSE (A2APV2), FMNL3_HUMAN (Q8IVF7), FMNL3_MOUSE (Q6ZPF4), FORC_DICDI (Q54KF1), FORD_DICDI (Q5TJ55), FORE_DICDI (Q5TJ57), FORF_DICDI (Q5TJ56), FORG_DICDI (Q1ZXK2), FORH_DICDI (Q54N00), FORJ_DICDI (Q54ER5) Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
PDB [Detailed view]	2BAP; 2F31; 3O4X; 3OBV;

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