Entry: PS51231

Forthcoming changes to the profile format
General information about the entry

Entry name [info] DAD
Accession [info] PS51231
Entry type [info] MATRIX
Date [info] JUL-2006 (CREATED); OCT-2013 (DATA UPDATE); JUL-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC51231
Associated ProRule [info] PRU00577

Name and characterization of the entry

Description [info] Diaphanous autoregulatory domain (DAD) profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=33;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=30;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.2037032; R2=0.0063220; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2155.83521; R2=13.12734; TEXT='HScore';
/CUT_OFF: LEVEL=0; SCORE=854; N_SCORE=7.6; H_SCORE=11082; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=680; N_SCORE=6.5; H_SCORE=11082; MODE=1; TEXT='?';
/DEFAULT: M0=-36; D=-50; I=-50; B1=-200; E1=-200; MI=-210; MD=-210; IM=-210; DM=-210;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-210; BD=-210;
/M: SY='D'; M= -58, -77,  94,  13, -84,  26, -57, -84, -56, -83, -78, -41,   0, -53, -64,  39, -54, -79, -91, -71;
/M: SY='D'; M=  -5, -79,  81,  76, -85, -67, -54, -82, -48, -79, -75,   1,  -2,   8, -57, -54, -58, -77, -88, -72;
/M: SY='T'; M=  30, -68, -56,  10, -70, -65, -61,   0, -48, -64, -60,  35, -67, -53,  51, -12,  61,  -6, -82, -66;
/I:         I=-14; MD=-58;
/M: SY='Q'; M=  -6, -99,  20, -27, -90, -91,  12, -86, -81, -91, -85, -79,  12,  21, -86, -29, -17,  -8, -98,  15; D=-14;
/I:         I=-14; MI=-58; MD=-58; IM=-58; DM=-58;
/M: SY='D'; M= -64, -82,  63,  32, -87,  11, -61, -88,  -3, -86, -79,  12, -71, -53,  30,  29, -60, -83, -91, -75; D=-14;
/I:         I=-14; DM=-58;
/M: SY='G'; M=  -4, -74,  20,  23, -81,  80, -64, -83, -61, -81, -73,  -2, -65, -58, -69,   5,   6, -76, -79, -74;
/M: SY='V'; M=  53, -68, -68,  28,  11, -69, -73,  32, -65, -49, -50, -69, -71, -63, -70, -56, -54,  59, -76, -60;
/M: SY='M'; M= -62, -70, -85, -76,  39, -80, -63,  33, -71,  -3, 120, -73, -74, -66, -70, -71, -59,  24, -69, -46;
/M: SY='D'; M= -65, -81, 106,  59, -87, -67, -53, -86, -51, -82, -80, -40, -63, -48, -60, -56, -58, -81, -96, -71;
/M: SY='D'; M= -59, -75,  81, -42, -78, -27, -55, -76,  15, -19, -69, -10, -68,  21,  29,  47, -53, -73, -86, -66;
/M: SY='L'; M= -66, -72, -85, -79, -43, -88, -73,  62, -78,  77, -30, -81, -81, -72, -77, -76, -62, -32, -72, -54;
/M: SY='L'; M= -63, -71, -85, -78, -45, -86, -74,  54, -77,  63,  36, -80, -79, -72, -76, -74, -59,  39, -75, -55;
/M: SY='E'; M= -54, -72,  14,  70, -74, -66, -57, -72,  -5, -19, -66, -51, -61, -44,  10,  52,  37, -67, -82, -68;
/M: SY='K'; M=  50, -69,  14, -51, -76,  -6, -63, -65,  52, -70, -63, -52, -65,  21, -50,  23,   9,   0, -78, -68;
/M: SY='L'; M=  12, -69, -82, -75, -45, -80, -69,  32, -75,  76,  36, -79, -79, -69, -74, -70, -61, -37, -72, -55;
/M: SY='R'; M=  -6, -77, -58, -46, -78, -70, -56, -76,  63, -73, -63, -51, -67,  59,  71, -52,  27, -70, -75, -64;
/M: SY='S'; M=  11, -67, -51,   2, -76,  -2, -57, -71, -53, -74, -66,  50, -64,  42, -59,  60,  49, -65, -83, -68;
/M: SY='G'; M=  33, -72, -64,  -2, -75,  74, -69, -62, -64, -69, -63, -57, -68,  24, -69, -50, -60,  31, -77, -72;
/M: SY='P'; M=  26, -78,  32,  33, -82,  20, -63, -77,   0, -79, -71, -56,  79, -54, -63,   6, -56, -73, -80, -75;
/I:         I=-10; MD=-41;
/M: SY='A'; M=  49, -73, -72, -66,  15, -21, -66, -58, -67, -64, -60, -68,  49,  -2, -70,   8, -57,  21, -66,  49; D=-10;
/I:         I=-10; MD=-41;
/M: SY='F'; M= -32, -76, -74, -65,  80, -78, -66,  16, -16, -53, -55, -65, -77,  50,  21, -26,  24, -18, -62, -42; D=-10;
/I:         I=-10; MD=-41;
/M: SY='R'; M=  19, -82,  -8, -12, -84,  28, -65, -86,  41, -82, -72, -59, -74, -52,  68, -59, -67, -78, -81, -73; D=-10;
/I:         I=-10; MD=-41;
/M: SY='K'; M=  33, -77,   2,  15, -82, -32, -63, -75,  39, -77, -70,  30, -71,   5,  24, -21, -12, -17, -85, -73; D=-10;
/I:         I=-10; MD=-41;
/M: SY='D'; M= -73, -87,  88, -47, -89, -77, -63, -82, -55, -84, -80, -51, -77,  22,  40, -63,   9, -20,-100, -75; D=-10;
/I:         I=-10; MI=-41; MD=-41; IM=-41; DM=-41;
/M: SY='P'; M= -67, -85, -70, -61, -76,  -3, -65, -67, -52,  -9,  24,  -3,  76,  21,  56, -65, -65, -10, -82, -72; D=-10;
/I:         I=-10; DM=-41;
/M: SY='R'; M= -13, -78, -60,   2, -79, -70, -59, -81,  40, -78, -68, -55, -71, -45,  83,  35, -11, -74, -80, -68; D=-10;
/I:         I=-10; DM=-41;
/M: SY='R'; M= -59, -78,  12,  34, -79, -67, -55, -80,  30, -77, -68, -51,  12,   8,  74,  42, -55, -74, -79, -66;
/M: SY='A'; M=  53, -68, -68, -62,   3, -13, -65,   0, -54,   2, -54, -60, -70,  -5,  45,   0,  22, -15, -74, -61;
/M: SY='R'; M= -61, -79, -59, -50, -78, -68, -54, -79,  33, -77, -65,  -1,  32,  19,  90,  28, -57, -75, -77, -65;
/M: SY='R'; M= -66, -82, -61, -49, -76, -75, -53, -82,  51, -76, -64, -54, -72, -40, 106, -60, -64, -76, -75, -63;
/M: SY='R'; M= -59, -75, -60, -53, -71, -68, -54, -70, -36,  -1, -59,  15, -72,  34,  89,  35,   8, -67, -78, -63;
/M: SY='R'; M=  47, -74,  10, -53,  -8, -66, -60, -67,  28, -11, -60, -58,  11, -51,  71, -55, -59, -35, -75, -63;
/M: SY='C'; M=  12,  42,  21, -54, -69, -26, -62,  -4,  15,   9, -57, -20,  21,  38,   9,  24, -55, -23, -79, -66;
/I:         E1=0; IE=-210; DE=-210;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_08 which contains 546'238 sequence entries.


Total number of hits 23 in 23 different sequences
Number of true positive hits 23 in 23 different sequences
Number of 'unknown' hits
Number of false positive hits
Number of false negative sequences 12
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 65.71 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] PS_Langendijk_Genevaux
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] DOMAIN
Feature description [info] DAD
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
23 sequences

BNI1_CANAL  (Q5AL52), BNI1_YEAST  (P41832), BNR1_YEAST  (P40450), 
DAAM1_HUMAN (Q9Y4D1), DAAM1_MOUSE (Q8BPM0), DAAM2_HUMAN (Q86T65), 
DAAM2_MOUSE (Q80U19), DIAP1_HUMAN (O60610), DIAP1_MOUSE (O08808), 
DIAP2_HUMAN (O60879), DIAP2_MOUSE (O70566), DIAP3_HUMAN (Q9NSV4), 
DIAP3_MOUSE (Q9Z207), DIA_DROME   (P48608), FHOD3_HUMAN (Q2V2M9), 
FHOD3_MOUSE (Q76LL6), FMNL2_HUMAN (Q96PY5), FMNL_HUMAN  (O95466), 
FMNL_MOUSE  (Q9JL26), FORA_DICDI  (Q54WH2), FORB_DICDI  (Q54SP2), 
SEPA_EMENI  (P78621), Y2138_DROME (Q9VUC6)
» More

UniProtKB/Swiss-Prot
False negative sequences
12 sequences

FHOD1_HUMAN (Q9Y613), FHOD1_MOUSE (Q6P9Q4), FMNL2_MOUSE (A2APV2), 
FMNL3_HUMAN (Q8IVF7), FMNL3_MOUSE (Q6ZPF4), FORC_DICDI  (Q54KF1), 
FORD_DICDI  (Q5TJ55), FORE_DICDI  (Q5TJ57), FORF_DICDI  (Q5TJ56), 
FORG_DICDI  (Q1ZXK2), FORH_DICDI  (Q54N00), FORJ_DICDI  (Q54ER5)
» More

PDB
[Detailed view]
4 PDB

2BAP; 2F31; 3O4X; 3OBV

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