PROSITE entry PS51269

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General information about the entry

Entry name [info]	COMM
Accession [info]	PS51269
Entry type [info]	MATRIX
Date [info]	01-NOV-2006 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51269
Associated ProRule [info]	PRU00602

Name and characterization of the entry

Description [info]

COMM domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=70;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=65;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.2327802; R2=0.0055337; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=9697.8144531; R2=2.2880867; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1133; H_SCORE=12290; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=772; H_SCORE=11464; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-27; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='H';  M= -23, -77, -55, -19, -75, -12,  76, -44,  44, -71, -44,   5, -68,  67,  33,  -4, -21, -35, -78, -29;
/M: SY='L';  M= -66, -71, -81, -40,  -7, -85, -66,  36, -75,  72,  13, -80, -81, -70, -74, -74, -62,   2, -64,  38;
/M: SY='H';  M= -13, -73,  -1,  26, -66, -72,  49,  31, -11, -28, -54, -27, -68,   6,  15,   1,  29,  27, -82, -60;
/M: SY='D';  M= -60, -75,  91, -24, -81,  15, -55, -81, -13, -82, -76,  43, -67, -53, -36,  23,   2, -77, -91, -49;
/M: SY='M';  M= -22, -69, -81, -39,  32, -81, -70,  17, -36,  46,  71, -76, -77, -69, -71, -69, -40,  46, -71, -50;
/M: SY='E';  M=  -6, -75,  45,  51, -81,  14, -56, -80,  10, -78, -71,  12, -64,  35,  -5,  38, -54, -74, -82, -69;
/M: SY='W';  M= -75, -15,-102, -80, -14, -74,-102, -73, -72, -70, -73, -95, -80, -72, -76, -82, -87, -87, 177, -27;
/M: SY='R';  M= -64, -81, -60, -48, -77, -73, -52, -81,  33, -75, -64,  -4, -72,  43, 101, -33, -34, -75, -76, -63;
/M: SY='V';  M= -62, -70, -82, -40,  40, -85, -74,  29, -75,  56, -37, -79, -80, -29, -75, -72, -59,  56, -70, -50;
/M: SY='D';  M= -25, -12,  82,  22, -81,  23,   3, -79, -12, -79, -73,  52, -67, -29, -17, -53, -57, -30, -90, -70;
/I:         I=-5; MD=-13;
/M: SY='Y';  M= -30,  10, -76, -35, -21, -15, -65,  14, -71,  22,  31, -32, -78, -23, -72, -22, -58,  55, -66,  56; D=-5;
/I:         I=-5; MD=-13;
/M: SY='Q';  M=  20,   0,  -1, -19, -34, -68, -11,  -3,  32, -41, -58, -54, -68,  78, -19, -51,  31, -12, -78, -63; D=-5;
/I:         I=-5; MI=0; MD=-13; IM=0; DM=-13;
/M: SY='M';  M= -28, -68, -74, -71, -24, -74, -70,  40, -69,  41,  42, -66, -73, -65, -71,  35,  29,  27, -77, -57;
/M: SY='S';  M=  40, -67, -59, -54, -75,   6, -60, -73,  25, -74, -66, -50, -65,  26, -27,  76, -46, -65, -76, -24;
/M: SY='S';  M=  -9, -65, -27, -56, -72, -54,   7, -68, -33, -45, -65,  13, -64, -13, -36,  88,  40, -35, -84, -65;
/M: SY='S';  M= -52, -71,  35, -30, -77, -35,  17, -78,  -3, -77, -69,  18, -67, -17,  51,  75, -26, -72, -84, -65;
/M: SY='H';  M=   5,   2,   1,  20, -37, -42,  58, -37,   6, -18, -60, -41, -32,  12, -28,  44,  30, -63, -78,   0;
/M: SY='Q';  M= -23,  26, -68, -40, -31, -43, -15,  22, -62,  44,   0,  16, -74,  46, -22,   9, -12,   7, -77, -59;
/M: SY='R';  M=  29, -73,   6,  15, -73, -64,  35, -71,  24, -28, -62, -52, -66,  37,  40,  28,   2, -46, -78, -33;
/M: SY='K';  M= -36, -10, -35,   3, -76, -68,  22, -71,  57, -72, -63,  -7, -26,  51,  49,   9,   9, -12, -78, -63;
/M: SY='M';  M= -32, -72, -23,   5, -58, -73, -25,  19, -62,  27,  47, -30, -24,  43, -64,  24, -40,  35, -77, -23;
/I:         I=-26; MI=0; MD=-65; IM=0; DM=-65;
/M: SY='N';  M=  -3,   7, -23,  -1, -69,  27,  33, -13,  27,  -3, -58,  50, -69,  37, -40, -30, -34, -38, -78, -14;
/M: SY='S';  M= -23, -71, -28,  14, -71, -62, -23, -65,  25, -49,  12,   8, -66,  35,  19,  58,  19,  -9, -78, -14;
/M: SY='P';  M=  -9, -17, -16, -58, -76, -69, -70,  13, -65, -33, -14, -70, 112, -66, -75, -34, -34, -32, -79, -76;
/M: SY='F';  M= -11,  -9, -44, -66,  35, -17, -21, -11, -41,  11,  22, -29, -25,  11, -39,  22,  23,  29, -69,  14;
/M: SY='V';  M=  33,  23, -76, -73,   3, -35, -70,  33, -71,  14, -10, -26, -76, -69, -73, -37, -56,  50, -69,  34;
/M: SY='H';  M= -14, -19, -65, -35, -30, -73,  56,   8, -35,  33, -46,   3, -73,  51, -62, -27,  17,  28, -77, -14;
/I:         I=-28; MI=0; MD=-71; IM=0; DM=-71;
/M: SY='M';  M= -63, -70, -84, -77, -34, -84, -70,  47, -75,  60,  77, -78, -78, -70, -74, -73, -59,  30, -74, -54;
/M: SY='Q';  M= -40, -76, -29,  47, -78, -66,  34, -75,  42, -63,  -5,  33, -64,  68,  -2,   7,   1, -72, -79, -42;
/M: SY='L';  M= -67, -69, -85, -77,  16, -84, -66, -20, -76,  82,  64, -81, -82, -70, -73, -76, -63, -40, -69, -49;
/M: SY='K';  M= -59, -76,   3,  35, -72,  13,  35, -42,  53, -71, -27,  23, -25,   6, -19,  -5, -10,  -7,  10, -13;
/M: SY='V';  M= -58, -68, -41, -71, -20, -78, -73,  30, -69,  40, -41, -10, -75, -69, -42,  -9,  38,  57, -79, -58;
/M: SY='Q';  M=  13, -71, -12,   3,  -2,  13,  -2, -63,  16, -24, -26,   6, -68,  41,  -5,  30,  -5,   3, -76, -62;
/M: SY='N';  M=  -3, -74,  46,  10, -80, -24, -54, -76,  36, -77, -68,  57, -11,  35,  14,   5, -17, -47, -83, -68;
/M: SY='N';  M= -12, -73, -14,  29, -73,  44,  17, -77,  -4, -75, -15,  47, -16,  -3, -16,  20,   1, -73, -77,   8;
/I:         I=-8; MD=-20;
/M: SY='D';  M= -70,-104,  53, -12,-106, -24, -84,-100, -50, -60, -97, -15,  38, -80, -89,  -7, -80, -65,-112, -97; D=-8;
/I:         I=-8; MI=0; MD=-20; IM=0; DM=-20;
/M: SY='N';  M= -45, -92, -41, -23, -97,  24, -79, -97, -49, -57, -89,  31, -89, -15, -12,  25,  -4, -92,-103, -91; D=-8;
/I:         I=-8; DM=-20;
/M: SY='Q';  M= -41, -87, -62,  19, -89,  29, -68, -48,   3, -64, -75,  35,  21,  45, -32, -61,  -4, -47, -89, -80; D=-8;
/I:         I=-8; DM=-20;
/M: SY='Q';  M= -36,   7, -30,  29, -86, -73,  -2, -50,  25, -81, -37,  18, -30,  43,  13,  27, -22, -55, -89, -74; D=-8;
/I:         I=-8; DM=-20;
/M: SY='V';  M= -16, -78, -22, -32, -67, -55,   0,  14, -19, -22, -17,  -8, -79, -25,  -8,  23,   6,  31, -84,  11; D=-8;
/I:         I=-8; DM=-20;
/M: SY='E';  M= -58, -76, -26,  54, -76, -69, -29, -35,  25, -52, -67, -16,  17,  29, -16,  38,  27, -44, -80, -27; D=-8;
/I:         I=-8; DM=-20;
/M: SY='P';  M=   0, -73,  25,   4,  14, -28,  11, -11,  13, -66, -26,  12,  47, -56, -34,  -1,  40, -30, -76, -15;
/M: SY='H';  M= -61, -73, -34, -66, -54, -36,  61,  43,   9,  20,  -9, -64, -74,  -9, -27, -41, -28,  50, -77,  -2;
/M: SY='C';  M= -36,  35, -59,  -6, -12, -67, -16, -17, -23, -17, -23,  31, -28,  30,   9,  35,  27,   1, -72,  32;
/M: SY='F';  M= -44, -70, -84, -78,  82, -46, -68,   1, -75,  35,  67, -75, -80, -74, -73, -30, -61,  20,   5, -37;
/M: SY='E';  M= -36, -77,  -8,  89, -81, -69, -54, -76, -25, -74, -68,   4, -60,  50, -52,  19, -11, -27, -81, -70;
/M: SY='M';  M= -63,  71, -80, -75,  53, -79, -69,  -7, -72,  34,  73, -71, -36, -72, -73, -65,  28,  13, -70, -48;
/M: SY='S';  M= -54, -69,  55, -51, -77, -33, -57, -73, -56, -77, -70,  53,  33, -54, -63,  57,  52, -68, -89, -70;
/M: SY='M';  M=  18, -73, -65,   8, -61, -71,  28,  21,  15,  24,  34, -26,  31, -23, -16, -21, -18,   0, -77, -61;
/M: SY='E';  M=  28,   9,  25,  58, -79, -43, -60, -70,  -1, -72, -16, -56,  46,  22, -57,  -2, -12, -17, -81, -71;
/M: SY='Q';  M= -58, -18, -26,  56, -79, -68, -55, -73,  51, -72,  -7,   1, -27,  72, -43,  -1,  18, -44, -78, -66;
/M: SY='F';  M= -69, -70, -85, -79,  78, -84, -69,  -5, -78,  66,   2, -80, -30, -76, -75, -75, -63,  -4, -59, -38;
/M: SY='Q';  M= -37, -76,  -1, -48, -26, -68,  22, -60,   5,   8,  -4,  39, -71,  87,  -1, -45, -30, -12, -72,  22;
/M: SY='H';  M= -19, -73,  26,  46, -70, -45,  49, -63, -25,  -8, -59,  19, -66,  38, -37,  21,   6,   6, -82, -28;
/M: SY='F';  M= -67, -70, -85, -78,  71, -84, -68,  -9, -77,  65,  51, -80, -82, -74, -74, -75, -63,   2, -61, -40;
/M: SY='Y';  M= -64, -14, -75, -70, -45, -81,   3,  43, -33,  38, -42, -70, -78, -62,  35, -24, -20,  21, -64,  59;
/M: SY='N';  M=  -3, -74,  12, -14, -21,   3,  40, -73,  34, -72, -63,  61, -69,  30,  -2, -23, -26, -45, -72,  37;
/M: SY='Q';  M= -31, -76, -10,  50, -78,  -6, -55, -39,  44, -50, -64,  26, -64,  60,  -8,  -1, -12, -18, -78, -67;
/M: SY='L';  M= -43, -12, -83, -76,   8, -82, -68,  13, -75,  72,  61, -78, -80, -70, -74, -39, -34,   6, -71, -52;
/M: SY='E';  M=  24, -73, -48,  62, -33, -14, -58, -75,  55, -74, -67, -24, -62,  -1, -15,  22, -31, -45, -76, -67;
/M: SY='Q';  M= -20, -77,  38,  42, -74, -69,  -7, -70,   9,   3, -60, -51, -66,  63,  34,   9,  -5, -68, -79, -64;
/M: SY='A';  M=  61, -68, -76, -70, -60, -25, -75,  60, -37, -10,  19, -69, -71, -66, -72, -56, -55,  27, -76, -63;
/M: SY='Q';  M=   0, -74, -58,  29, -65, -70, -19, -33,   6,  35, -51,  -1, -70,  59,  30,   6, -58, -18, -76, -62;
/M: SY='K';  M=  29, -72,  30,  35, -74, -40, -60, -42,  46, -30, -63,  -4, -65,  -8,   4,  -9,  14, -12, -80, -67;
/M: SY='E';  M= -32, -18, -13,  57, -70, -67,  13, -46, -29, -19,  36,  -4, -65,  41, -57,  43, -28,  19, -81, -64;
/M: SY='M';  M= -61,  30, -81, -74, -49, -79, -16,  32, -42,  50,  90, -73, -77, -66, -71,  -5, -58,  18, -76, -55;
/M: SY='E';  M= -19, -74,  47,  54, -77, -64, -54, -39,  17, -29, -66,  39, -64,  30, -13,  18,   0, -69, -83, -68;
/M: SY='Q';  M=  32,  29,  13, -34, -33, -42, -60, -70, -10, -70, -64, -28, -22,  51,  16,  32,  46, -63, -78, -25;
/M: SY='L';  M=  -1, -70, -74, -71,   9, -52, -19,   5, -68,  57,  27,  18, -78, -20, -24, -65, -23,  19, -70,   8;
/M: SY='T';  M=  27, -37, -53,  29, -70,  -8,  34, -47,   2, -35,   0,  36, -66, -10,  -6,   3,  39, -20, -80, -30;
/I:         E1=0; IE=-255; DE=-255;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_06 which contains 572'619 sequence entries.

Total number of hits	43 in 43 different sequences
Number of true positive hits	43 in 43 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	COMM
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

43 sequences

COMD1_BOVIN (Q2M2T5), COMD1_CANLF (Q8WMD0), COMD1_DICDI (Q54DR0),

COMD1_HUMAN (Q8N668), COMD1_MOUSE (Q8K4M5), COMD2_DICDI (Q54P14), 
COMD2_HUMAN (Q86X83), COMD2_MOUSE (Q8BXC6), COMD2_PONAB (Q5R610), 
COMD3_BOVIN (Q3SZ76), COMD3_DICDI (Q54QK4), COMD3_HUMAN (Q9UBI1), 
COMD3_MOUSE (Q63829), COMD3_RAT   (Q6P9U3), COMD4_BOVIN (Q5E9V6), 
COMD4_DICDI (Q550I8), COMD4_HUMAN (Q9H0A8), COMD4_MOUSE (Q9CQ02), 
COMD5_BOVIN (Q5E9K1), COMD5_DICDI (Q86IW8), COMD5_HUMAN (Q9GZQ3), 
COMD5_MOUSE (Q8R395), COMD5_RAT   (Q9ERR2), COMD6_BOVIN (Q2KIY0), 
COMD6_DICDI (Q54MA5), COMD6_HUMAN (Q7Z4G1), COMD6_MOUSE (Q3V4B5), 
COMD6_XENLA (Q05AV1), COMD6_XENTR (Q28HC7), COMD7_BOVIN (Q3MHX1), 
COMD7_DICDI (Q86I14), COMD7_HUMAN (Q86VX2), COMD7_MOUSE (Q8BG94), 
COMD8_DICDI (Q54CU8), COMD8_HUMAN (Q9NX08), COMD8_MOUSE (Q9CZG3), 
COMD9_BOVIN (Q2TBN5), COMD9_HUMAN (Q9P000), COMD9_MOUSE (Q8K2Q0), 
COMDA_DICDI (Q554G3), COMDA_DROME (Q9VYV9), COMDA_HUMAN (Q9Y6G5), 
COMDA_MOUSE (Q8JZY2)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

5 PDB

6BP6; 8ESD; 8F2R; 8F2U; 8P0W