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	Entry: PS51330

General information about the entry
Entry name	DHFR_2
Accession number	PS51330
Entry type	MATRIX
Date	SEP-2007 (CREATED); SEP-2007 (DATA UPDATE); MAR-2013 (INFO UPDATE).
PROSITE Documentation	PDOC00072
Associated ProRule	PRU00660
Name and characterization of the entry
Description	Dihydrofolate reductase (DHFR) domain profile.
Matrix / Profile	/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=164; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=159; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.5709825; R2=0.0064342; TEXT='-LogE'; /CUT_OFF: LEVEL=0; SCORE=1077; N_SCORE=10.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=456; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-97; D=-155; I=-155; B1=-1500; E1=-1500; MI=-325; MD=-325; IM=-325; DM=-325; A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-325; BD=-325; /M: SY='M'; M= -64,-260, -29, 5, -89, -58, 9, -52, 28, -86, 99, -7, 12, -9, -28, -10, -4,-133,-264,-246; /M: SY='I'; M=-107,-258,-270,-265, 10, -76,-262, 73, -94, 35, -10,-263,-264,-260,-108,-257,-106, 33,-257, -50; /M: SY='S'; M= -14, -19, -91, -52,-254, -50, -33, 18, 36,-121, -71, 15,-253, -9, -34, 43, 22, 1,-265, -61; /M: SY='M'; M= 22, -3,-264,-258, -10, -25, -50, 33,-257, 50, 57,-256,-261, -87,-258, -27,-244, -58,-257, -58; /M: SY='I'; M=-246,-259,-270,-267,-235,-273,-269, 93,-262, -39, -32,-262,-261,-260,-265,-256,-241, 53,-262, -81; /M: SY='W'; M= 20, -52,-269,-260, 23, -94,-265, -98,-257, -30, -13,-263,-262,-258,-259,-250, -93, 70, 112, -47; /M: SY='A'; M= 99, 19,-253, -65,-260,-235,-255,-250,-248,-252,-246,-248,-252,-245,-253,-227,-238, -88,-262,-257; /M: SY='M'; M= 7, 36,-252, 4, -63,-111, -21, 17,-118, -39, 69, -71,-256, 43, -10, -70, -34, 33,-262, -51; /M: SY='D'; M= 36, 14, 76, -84,-261, 2,-246,-256,-243, -49,-253, -27,-251,-242,-250, 17, 36,-249,-271,-254; /M: SY='E'; M= -13, -74, -17, 33,-256,-108,-244, -38, 33, -7, -35, -10, 32, 22, 22, -22, -25, -23,-262,-251; /I: I=-21; MI=0; MD=-43; IM=0; DM=-43; /M: SY='N'; M= -74,-256, 28, 6, -20, -62, 11,-258, -15,-260,-252, 96,-253, 15, -15, -20, -39, -59,-270,-249; /M: SY='G'; M=-109, -53,-104,-250, -14, 64, 25,-103, -83, -27, 7, 32, -52, -55, 43, -62,-247,-256, -1, 19; /M: SY='V'; M= 2, -1,-255, -29, -81, 50, -74, -24, -91, 0, -47, -70, -84,-252,-257,-242, -48, 60, -51,-249; /M: SY='I'; M=-250,-261,-269,-268, 29,-273,-266, 105,-262, -43, -35, -51,-260,-260,-265,-258,-244,-127,-253,-235; /M: SY='G'; M= -67,-260,-249,-260,-267, 103,-255,-274,-254,-270,-259,-235,-252,-251,-261,-102, -76,-267,-258,-262; /M: SY='K'; M= -37,-258, 0,-115, -19,-254, -43, 6, 57, -2, -41, 35,-255, -20, 25, -47, -42, -45,-255, 20; /M: SY='N'; M= -47, -53, 62, -5,-265, 26, -51,-265, 28,-115,-255, 65, -78, 27, -58, -72,-241,-262,-268, -75; /M: SY='N'; M=-116,-257, -23, -41,-264, 66, -42,-265,-115,-138, -61, 89, -40, -9, -95,-112, -25,-263,-268,-257; /I: I=-32; MI=0; MD=-68; IM=0; DM=-68; /M: SY='Q'; M= -5, -62, 37, -46,-260, 29, -11,-257, 23, -96, -55, -20, -67, 44, -36, 0, 27, -65, -19, -49; /M: SY='M'; M=-249,-255,-267, -90,-229,-268,-252, 37,-259, 73, 83,-262,-263,-252,-258,-258, -61, -97,-257,-238; /M: SY='P'; M=-131,-274, -74,-241,-265,-100, -63, -97,-248, -34, -55,-257, 125,-251,-259,-248,-243,-132,-263,-264; /M: SY='W'; M=-259, -48,-285,-263,-225,-257,-284,-258,-256,-255,-258,-278,-263, -77,-259, -68,-270,-271, 178, -53; /I: I=-34; MI=0; MD=-72; IM=0; DM=-72; /M: SY='H'; M= -86, -63, -45,-103, -75, -91, 111,-262, -5,-125, -58, 2, -41, -27, 49, 14, -38,-260, -66, 18; /M: SY='L'; M= -83, 15,-264,-103,-229,-267, -55, 62,-259, 62, -44, -35,-263,-254,-259, -45,-244, -30,-254, 20; /M: SY='P'; M= -51,-266, -35,-235, -80,-251,-248, -64, 55, -87,-251,-244, 98, -54, -16, 2, -24,-256,-261, -98; /M: SY='E'; M= 20,-258, 5, 68,-264, -7, -67,-126, 19,-259,-252, 12,-247, 11, -37, -2, -42, -54,-264,-254; /M: SY='D'; M= -96,-265, 107, 59,-270,-252,-238, -68,-235,-265,-263,-225,-248,-232,-244,-240, -88,-263,-279,-255; /M: SY='M'; M=-250,-255,-265,-256, 21,-265,-246, -36, -57, 64, 100, -70,-262, -7, -70,-257,-246, -97, -44, -74; /M: SY='K'; M= 27,-258, -67, -20,-260, -99, -17,-123, 71, -45, -26, -13,-250, 57, 11, -32,-110,-105,-260,-249; /M: SY='H'; M=-115,-262,-247, -91, 47, -76, 93,-102,-238, -34,-238, 21,-261, -18, 39,-246,-249,-252, 23, 72; /M: SY='F'; M=-259,-256, -59,-266, 123,-267,-251,-233,-262, -77, -62,-260,-270,-272,-260,-258,-251, -86,-226, -37; /M: SY='K'; M= -23,-261,-243, -82, -89,-253, -44,-259, 87,-111, -51,-236,-251, -19, 57, -18, -40, -95,-256, -9; /M: SY='Q'; M= 23,-258, -5, 35,-262,-118,-240,-258, 43,-257, -57, -2,-249, 47, 32, -17, 0, -73,-262,-100; /M: SY='T'; M= -33,-253,-252, -37,-241,-114, -8, 13, -20, 30, 21, -54,-255, -26, -4,-123, 57, 28,-263,-244; /M: SY='T'; M=-236,-247,-243,-246,-250,-253,-253, -19,-243,-245, -66,-233, -86,-246,-251, -24, 115, -49,-271,-249; /M: SY='M'; M= -28,-253, -71, -20,-244,-112,-247, -15, 19, 16, 61, -50,-251, 1, -90, 4, 60, -50, 0, -51; /I: I=-9; MI=0; MD=-20; IM=0; DM=-20; /M: SY='G'; M=-241,-259, -20, -70, -50, 65, -2, -25, -4,-113, -41, 65,-254, 12, -9, -50,-112, -58,-263,-100; /M: SY='H'; M= -50, -44, -59, -78, -83, -29, 82,-262, 41,-260,-248, 77,-252, 31, -67, -9, -16,-260,-269, -82; /M: SY='P'; M= 36, -28, -56,-247,-251,-251, -40, 3, -66, -59, -31, -37, 66,-249,-254, -74, 39, 34, -31, -96; /M: SY='V'; M=-242, -12,-268,-262,-235,-269,-263, 50,-260, 21, 33,-100,-262,-258,-261,-254, -92, 77,-265,-243; /M: SY='I'; M=-242,-254,-267,-262,-232,-269,-265, 80,-259, 13, -54,-260,-260,-258,-261,-253,-238, 71,-261,-240; /M: SY='M'; M=-122,-251,-265,-255, -15,-258,-237, -63,-249, -52, 150,-252,-253,-241,-247,-252,-242, -54, -28,-230; /M: SY='G'; M=-231,-258,-246,-258,-265, 108,-253,-272,-251,-268,-257,-232,-250,-249,-259,-231,-250,-266,-255,-259; /M: SY='R'; M= -20,-262,-245,-234, -83, -71,-235,-260, -10,-105,-245, -77,-255, -66, 113, -36, -96,-254,-255, -16; /M: SY='K'; M= -60,-256,-236, -64,-257,-124,-238,-113, 94, -73,-245, 35, -90, -52, 39, -54, -9, -57,-258,-247; /M: SY='T'; M=-233, -36,-239,-242,-249,-249,-249,-241,-239,-245,-242, -75,-241,-243,-247, -24, 120,-120,-270,-247; /M: SY='W'; M= -73,-263,-269,-261, 92,-259, -51,-239,-255,-100, -69,-262,-264,-257,-254,-256,-254,-246, 136, 70; /M: SY='E'; M= -50,-260, 53, 94, -46,-253,-236,-257, -23, -33, -51,-233,-242, 19, -23,-237, -41,-124,-262,-249; /M: SY='S'; M= -44, -74, -75, -44,-254, -19,-241,-253,-238,-256,-250, -72,-245, -81,-243, 106, 11,-101,-262, -55; /M: SY='I'; M=-246,-253,-265,-260, 13,-266,-253, 78,-257, 56, 65,-258, -80,-252,-257,-255, -92, -57,-250,-231; /M: SY='P'; M=-138,-264, -28,-240,-262, 55,-247,-114, -15, -66,-250, 0, 105,-243, -42, -73,-241,-123,-259,-258; /I: I=-19; MD=-40; /M: SY='K'; M= -16, -37, 5, -2, -65, -4, -79, -81, 13, -34,-259, -29, 7, -12, -9, 3, -44, -42,-275,-263; D=-19; /I: I=-19; MI=0; MD=-40; IM=0; DM=-40; /M: SY='R'; M=-130,-268, -99, -74, -68, -52, -65,-264, 61, -44, -49,-243,-259, -78, 87, -85,-251,-261, 13,-249; D=-19; /I: I=-19; DM=-40; /M: SY='P'; M= -11, -65, -83,-239, -73, -63,-249, -19, -4, -37, -42, -41, 111,-244, -65, -80,-108, -2,-257, -26; /M: SY='L'; M=-247,-250,-264,-256, -10,-266,-249, -64, -31, 94,-211,-262,-264,-250,-253,-256, -88, -90,-250,-232; /M: SY='P'; M= -33,-264, -85, -31,-261,-116, -59, -96, 31, -91,-247, -36, 113, -35, -42, -27, -79, -36,-259,-256; /M: SY='N'; M=-238,-254, 41, -8, -88, 60, -61,-262, 11,-262, -78, 85,-249, -31, -80, -44,-237,-260,-264, -79; /M: SY='R'; M=-247, 7,-244,-232,-256,-257, -47,-263, -97,-255,-244,-237,-256, -59, 121, -92,-246,-256,-257,-243; /M: SY='I'; M= -53,-253, -33, -15, -63,-256, 2, 37, 18, 26, -39, -13, -29, 10, 12, -75, 34, 2,-256, -32; /M: SY='N'; M= -95, -10,-225,-240, -41,-238, 58, -25,-234,-128, -10, 112, -92, -69,-240, -26, 11, -28,-269, -30; /M: SY='I'; M= -51, -52, -76,-260, -19,-266,-259, 89,-256, -22, -37,-256,-257,-255,-258,-250,-238, 55, -24, 17; /M: SY='V'; M=-234,-248,-263,-258,-233,-265,-264, 34,-255, -62, -36,-258,-258,-257,-257,-247, -73, 103,-265,-241; /M: SY='L'; M=-110, -63,-265,-258, 4,-266,-254, 49,-257, 69, -3,-260,-260,-253,-256,-253,-239, 45,-252,-233; /M: SY='S'; M=-226, -53,-237,-239,-251, -63, -41,-246,-237,-250,-245,-226,-242,-234,-243, 91, 87, -90,-265,-246; /M: SY='R'; M= -79, -55, -31,-232, -77,-121, 30,-258, 13,-118,-244, -27,-251, -92, 99, 28, 16,-252,-259,-241; /I: I=-13; MD=-26; /M: SY='N'; M=-247,-261, 46, -71,-267, -88, -67,-104, -5,-266, -35, 59, -30, -7, -40, 38, 34,-260,-278,-258; D=-13; /I: I=-13; MI=0; MD=-26; IM=0; DM=-26; /M: SY='T'; M= -63, -24, -55, -35, -39,-274, 11, -96, -8, -25, -44,-260, -16, -62, -21, 10, 30, -91,-282, -39; D=-13; /I: I=-13; DM=-26; /M: SY='Q'; M= -55, -59, -29, 0, -13,-263, -91, -75, 18, -54, -75, -26, 10, 62, 15, -15, -50, -54,-267, -40; D=-13; /I: I=-13; DM=-26; /M: SY='E'; M= -13,-257, -17, 46,-255, -52, 7,-116, 20, -36, -19, 3, 46, 15, 45, -18, 2,-249,-259, -78; /M: SY='D'; M= -63,-255, 74, 40,-259, 23, 9, -68, -47,-109,-251, 48, -40, -49,-240, 9, -9, -51, -40,-249; /I: I=-11; MD=-23; /M: SY='Y'; M= -34, -40, -62, -16, 47,-103, -70, -9, -69, 5, -55, -57, -26, -11,-252, -59, -54, 12, 66, 73; D=-11; /I: I=-11; MD=-23; /M: SY='Q'; M= -14,-261, 6, 9,-102,-123, -9, -43, 13, -58, -2, 30, 20, 54, 4, -6, -11, -45,-266,-251; D=-11; /I: I=-11; MD=-23; /M: SY='A'; M= 36, -65, -15, -24, 1, -3, -5, -42, -17, -26, -77, 23, 20, -44,-116, -11,-244, -17,-264, -63; D=-11; /I: I=-11; MD=-23; /M: SY='E'; M= -29,-269, 46, 55,-272, -49,-248,-131, -14, -92,-262, 31, 36,-240,-249, -35, -35,-112,-276, -92; D=-11; /I: I=-11; MD=-23; /M: SY='N'; M= -84,-269, 14, -19,-271, 46, 0,-107, -25,-274,-265, 46, -35, -47,-257, -19, -4,-270,-276, -30; D=-11; /I: I=-11; MI=0; MD=-23; IM=0; DM=-23; /M: SY='V'; M= 41, 48, -37,-251, -56, -50,-257, 17,-251, -46, -71,-250, -89,-251,-254, -58, -51, 79,-262, -83; D=-11; /I: I=-11; DM=-23; /M: SY='H'; M= -82,-253, -8, 24, 9, -68, 55, 11, -7, 13, -24, -47, -11, 7, -20, -34, 18, 13, -38, -2; /I: I=-40; MI=0; MD=-83; IM=0; DM=-83; /M: SY='V'; M= -20, -62, -95,-116, -10, -82, 9, 43,-248, -4, -76,-249,-254, -68, -22, -35, 2, 73, 36, 1; /M: SY='C'; M= 34, 47,-250, -53, 30, -69,-247, 16, -71, -35, 9, -8, -46, -71, -41, -18, -13, 46, -39, 21; /M: SY='H'; M= -15, -37, 10, -29,-252, -5, 77, -58, 17,-252,-243, 36, 24, -44, -2, 31, 28,-249,-261, -21; /M: SY='S'; M= -61, -29, 43, -46,-255, 4, -48,-104, -81, -98,-249, 22, -79, -51, -45, 90, 4,-248,-264,-247; /M: SY='L'; M=-123,-252,-257, -24, 31, -82,-249, 52, -68, 57, 17,-255, 24,-248, -80,-250, -83, 6, -10, -2; /M: SY='E'; M= -6,-256, 60, 67,-259, -15, -21, -62, 3,-254, -84, -30, 10, 22, -43, 3, -18, -72, -30,-248; /I: I=-43; MI=0; MD=-90; IM=0; DM=-90; /M: SY='E'; M= 21,-253, 56, 59, -97, -74, -29, -61, -20, -76, -77, 11, -80, 24, -6, 18, -17, -81,-262,-247; /M: SY='A'; M= 84, -19,-253,-246, 3, -84,-250, -10,-247, 15,-230,-247,-251,-244, -97, -57,-234, 17,-252, -41; /M: SY='L'; M= -96,-251,-260, -72, -6,-106, -52, 44, -37, 73, -14,-256,-258, -18,-251,-116, -56, 13,-250, -39; /M: SY='E'; M= 23,-252, 19, 40,-105,-110, -57, -69, 32, -32,-243, 23, -21, 30, 3, 12, 15, -94,-259,-246; /M: SY='W'; M= 3,-253, -27, 18, 28, -95, 30, -18, -21, 38, -2, -29, -47, -11, -57, -22, -39, -25, 55, 20; /M: SY='A'; M= 54, 15, -91,-109, 3, -65, -48, -3,-121, 43, -54, -48, -44, -60,-119, -34, -38, -13,-245, 44; /M: SY='K'; M= 11, -59, 10, 34, -49, -8, -10, -82, 39, -73, -78, 9, -22, 4, 12, 27, -36, -52,-255, -5; /M: SY='N'; M= -10, -63, 29, 38,-109, -11, -19, -83, 27, -75, -57, 40, 2, 25, -20, 15, 19,-249,-261, -91; /I: I=-15; MI=0; MD=-31; IM=0; DM=-31; /M: SY='H'; M= -67,-279, 12, -24, -89, -80, 33, -51, -11, -16, -86, 16, -15, -19, -43, -20, -36, -86,-286, -74; D=-15; /I: I=-15; DM=-31; /M: SY='Q'; M= -67, -81, 2, -6,-270, 7, -75, -52, -8, -95,-259, 10, 14, 34, -41, 24, -21, -51, -55, -84; D=-15; /I: I=-15; DM=-31; /M: SY='I'; M= -13, -42, 26, 18, -53, -46, 0, 29, -49, -47, -51, -7, -33, -42, -49, -48, -4, 22,-264, -1; D=-15; /I: I=-15; DM=-31; /M: SY='E'; M= -62,-261, 38, 60,-260, -4, -54,-258, 17, -85,-251, 18, -18, 29, -26, -6, -50, -41,-263, -24; D=-15; /I: I=-15; DM=-31; /M: SY='E'; M= -65,-258, 50, 52,-258,-124, 13, -67, 33, -82, -23, -17, -16, -31, 21, -37, 31, -59,-265,-248; D=-15; /I: I=-15; DM=-31; /M: SY='I'; M= -9, 8,-261,-256, -98,-113,-258, 70,-254, 15, -15,-107, -82,-253,-256,-126, -23, 66,-257, -43; /M: SY='F'; M= -31, 26,-103,-256, 95,-255,-242, -57,-100, -84, 36, -71,-260,-252,-250, -14, -51, -72, 91, 69; /M: SY='V'; M=-119, -30,-263,-258,-104,-265,-262, 76,-255, -29, -22, -93,-256,-255,-257,-109,-233, 85,-259, -75; /M: SY='I'; M= -8, 3,-261,-258, -69, -93,-260, 102,-254, -38, -2,-251,-253,-251,-258, -24, -31, -7,-254,-237; /M: SY='G'; M=-228,-255,-243,-255,-262, 111,-250,-270,-248,-265,-254,-229,-247,-246,-256,-228,-247,-263,-252,-257; /M: SY='G'; M=-228,-255,-243,-254,-262, 110,-250,-269,-248,-265,-254,-229,-247,-246,-256, -67,-246,-263,-253,-256; /M: SY='A'; M= 61, -77,-239, 9, -80, 48,-243,-249, 20, -76, -51, -83, -19, -58,-100, 31,-233, -42,-253, -35; /M: SY='Q'; M= -19,-255, -23, 60, -93, -4, -37,-254, 3,-137,-244, -50,-243, 79, -3, 37, -20, -83,-253, -2; /M: SY='I'; M=-115,-250,-263,-258,-103,-265,-259, 84,-256, 40,-214,-256,-256,-253,-257, -93, -75, 58,-255,-236; /M: SY='Y'; M= -71, -60,-254,-254, 61,-258,-224, -30,-248, -2,-226,-253,-262,-245,-245,-247,-244,-120,-213, 126; /M: SY='K'; M= 20,-252, -10, 46,-104, -90, -28,-251, 52, -75,-243, 23,-244, 25, 31, -3, 8, -65,-256, -45; /M: SY='Q'; M= 26,-253, -42, 58,-248,-120, -31, -67, -51, 20, -72, -36,-245, 80, -73, 9, -51, -61,-254, -38; /M: SY='F'; M= 64, -4, -86,-113, 68, -30, -37,-115,-247, 10, -19,-244,-252,-246,-249, -22, 10, -16, -22, -22; /M: SY='M'; M= -32,-250, -96, -53, -1,-260,-246, 42, -69, 70, 77, -83,-256, -70, -92,-250, -86, -75, 20, -80; /I: I=-43; MI=0; MD=-90; IM=0; DM=-90; /M: SY='P'; M= -43,-260, 57, 38,-261, -56, -65,-117, -30,-104, -72, 15, 95, -35, -51, 2,-235,-255,-262,-253; /I: I=-17; MI=0; MD=-35; IM=0; DM=-35; /M: SY='Y'; M= -85, -4, -72, 4, 13, -87, 33, 17, 20, 23, 28, -72,-253, 13, 18, -64,-241, -25, 15, 52; D=-17; /I: I=-17; DM=-35; /M: SY='C'; M= 70, 79,-252,-247, -87,-243, -40, 6, -91, -7, -39,-245, -45,-246,-250, -60, -6, 35,-259, -80; /M: SY='D'; M=-241,-256, 100, 0,-260, -69, 29,-257, 1, -81, -54, -13,-245, -6, -29, 5, 15, -86,-271,-245; /M: SY='R'; M= -38, -24, -23, 43, -79, -82, 11, -23, 41, -55, -74, -40,-247, 20, 69, -95, -7, -21, -26, -33; /M: SY='I'; M= -74, -18,-263,-257, -19,-264, -84, 64,-256, 64, 39,-258,-258, -88,-255,-252,-239, 28, -41,-233; /M: SY='Y'; M=-119,-256, -95, 12, 38,-259, 61, 26,-245, 3, -76,-247,-256,-241,-106, -89, -86, 11, 4, 96; /M: SY='L'; M= -91, -53,-260,-100, -3,-263, -23, 55, -35, 57, 34,-255,-257,-248, -4,-251,-239, 36, -21, -94; /M: SY='T'; M= -77,-241,-236,-239,-248,-243,-245,-240,-236,-245,-241, -64,-239,-239,-244, 40, 117,-232,-266,-245; /M: SY='R'; M=-129,-256, -53, 50, -19,-254, 50, -16, 27, -22, -44, -74,-247, -21, 61, -46, -5, 10, -8, -52; /M: SY='I'; M=-239,-252,-262, -55, -54,-267,-262, 90,-255, -16, -20,-256,-255,-254,-258,-250,-235, 69,-257,-237; /M: SY='H'; M= -26,-256, 50, 2, -30, -39, 88, -90, 15, -34, 32, 29, -6, -6, -19, -59,-106, -49, -51, -8; /M: SY='H'; M= 22, -73, -16, 5,-248, 15, 32, -21, 29, -13, -6, 5, -44, 8, 0, -18, -10, -2,-258, -66; /M: SY='E'; M= -7, -63, 46, 55,-253,-120, -13, -28, 2, -69, -53, 29, 8, -29, -24, 19, 5, -29,-262, -40; /M: SY='F'; M=-117, -49, -39, -32, 77,-103, 5, 2, -86, -27, -37, -50, 9, -37, -65, -40, -21, 19,-232, 74; /M: SY='E'; M= -31,-256, 49, 69, -75, -40, -48, -61, 10, -72,-246, 10, 45, 15, -38, -19, -19, -58, -32,-247; /I: I=-17; MI=0; MD=-36; IM=0; DM=-36; /M: SY='C'; M= 9, 102, -85, -63, -19, 78,-249,-256, -94, -85, -9, -78,-252, -40, -86, -44, -72,-249,-256, -34; /M: SY='D'; M= -49, -70, 120, -51,-264,-242,-233,-261, -82,-261,-258, -2, -45, -84,-241,-105, -22,-100, -47,-249; /M: SY='T'; M= 25, -76,-245,-242,-242,-100,-249, -41, -64, -27,-232,-237, -79, -73, 2, -26, 87, 53,-262,-243; /M: SY='F'; M= -86,-254,-253, -64, 98,-256, 18, -81, -17, -75,-231,-248,-259, -51, -11, -43, -36, -59, 36, 87; /M: SY='F'; M= -17,-249, -72, -92, 105,-259,-245, -41,-253, 26, 40,-254,-260,-256, -93,-249,-242, 1,-230, -4; /M: SY='P'; M= -62,-265, 19, -41,-262, -80, -64, -96, -2,-260,-249, -9, 120, -51, -86, -41, -85,-255,-259, -70; /M: SY='E'; M= -4,-252, 14, 51, 12, -69, -24, -6, 16, 2, -9, 11, 0, -49, -25, -51, -3, -2, -23, -70; /M: SY='I'; M= -91,-254, 24, -10, 39, -95, -28, 54, -37, -2, -16, -28, 9, -35, -59, -19, -8, 5, 50, 0; /I: I=-34; MD=-72; /M: SY='D'; M= -68,-258, 75, -11, -2, -22, -35, -55, -69, 0, -69, 35, 41, -84, -31, -37, -58, -32,-260, -1; D=-34; /I: I=-34; MI=0; MD=-72; IM=0; DM=-72; /M: SY='W'; M= -21,-256, 36, 43, 34, -45, -46, -50, -21, 11, 10,-240, 9, -17, -29, -92, -18, -93, 82, 26; /M: SY='S'; M= -4,-250, 38, 34,-254, 4,-235,-254, 14, -88,-247, 37,-124, -25, -8, 51, 22,-248, -34, -29; /I: I=-23; MD=-49; /M: SY='K'; M= -2,-259, 15, 26,-261, -6, -9, -54, 38, -70, -54, 15, -59, 35, -43, 5, -29, -27,-265,-252; D=-23; /I: I=-23; MI=0; MD=-49; IM=0; DM=-49; /M: SY='W'; M=-133,-261,-268,-257, 93,-101,-253,-236, -57, -37, -70,-260, -84,-254, -83,-254, -73,-101, 146, 35; /M: SY='K'; M= -30, -75, -4, 44,-249,-247, 12, -46, 44, -52,-239, 21,-245, 20, 29, -1, 18, 3,-256, -8; /M: SY='L'; M= -59, -22, -85, 42,-237,-126, -55, -13, 27, 48, 23, -57, -12, -11, 20, -53, -64, 9,-254, -62; /M: SY='V'; M= -8, -90, 1, 5,-239, -63,-247, 24, -43, -21, -6, -16, -40, -25, -46, -18, 46, 56, -34, -29; /M: SY='S'; M= 2, -28, 15, 31, 9, -20, -91, -30, 4,-113,-244, -7, -32, 38, -27, 64, -46,-244,-254, -29; /M: SY='E'; M= -35, -84, -66, 49,-251, -62, 11, 0, 6, -78, -45, -8, -65, 29, 42, 24, 33, -14,-259,-243; /I: I=-11; MD=-24; /M: SY='E'; M= -42, -37, -10, 47, -61, -50, -14, 14, 6, -59,-242, -52, -39, 42,-238, 40, 9, -6,-262,-246; D=-11; /I: I=-11; MI=0; MD=-24; IM=0; DM=-24; /M: SY='Y'; M= -33,-268, -13, 16, -15, -43, -7, -14, 13, -99, -91, -42, 20, -17, -17, -9, -41, -18, -48, 35; D=-11; /I: I=-11; DM=-24; /M: SY='H'; M= -31, -55, -3, -20, 9, 12, 67, -42, -20, -53,-246, -63, -53, -21, 24, -22, -66, -33, -56, 30; D=-11; /I: I=-11; DM=-24; /M: SY='W'; M= -15,-257, 0, 40, -25, -17, 24, -24, 10,-102,-242, -23, 39, -4, 18, -35, 19, -24, 43, -17; /M: SY='K'; M= 8, -80, -32, -4, -23,-250, -9, -11, 45, -50, -87, -45, 24, -22, 7, -17, 34, 15, -16, -43; /M: SY='D'; M= -99, -76, 67, -34, 4, -38, -35, 9, -2, -33,-241, -1, -57, 32,-112, 0, -7, -17, 7, 23; /M: SY='E'; M= -18,-257, 28, 75,-262, -14, -15,-257, -29,-257,-251, -25, -21, 12, -86, 20, 16, -38,-265,-252; /M: SY='E'; M= -28,-261, -8, 67, -88, -40,-241,-262, 64,-111,-252, -48, -33, -5, 6, -25, -30,-129,-261,-252; /I: I=-30; MD=-64; /M: SY='N'; M= -52,-261, 8, 0,-267, 10, 32,-269, -2,-269,-258, 89,-258, -28, -61, -18, -78,-266,-277,-257; D=-30; /I: I=-30; MI=0; MD=-64; IM=0; DM=-64; /M: SY='G'; M= -15, -9, 23, -7, -26, 41, -11,-258, -27, -71,-253, 5, 25, -1, -40, -29, -32, -20,-266, -70; D=-30; /I: I=-30; DM=-64; /M: SY='Y'; M= -68, -85,-259, -66, 18,-265, -1, 35, -69, 3,-231, -47, -4,-253,-255,-251, 0, 22, -34, 79; /M: SY='P'; M= 11,-262, 15, -3, -90, -72, -58,-117, 17, -71,-253, 5, 41, -18, 8, 13, 9, -69,-268, -66; /M: SY='Y'; M=-107, 5,-264,-264, 61,-268, 19, -39,-259, -11, -24,-260,-271,-257,-257,-256, -30, -38, -29, 98; /M: SY='T'; M=-106,-261, 16, 27,-259,-257, -42, -80, -7,-138, -64, -9,-255, -5, 25, 22, 43, -7,-269, -12; /M: SY='F'; M= -91,-264, -88, -93, 97,-270, -19, 13,-261,-141, -22,-262,-271,-265, -50, -89,-118, -68, -24, 58; /M: SY='C'; M=-115, 40, -42, 24, -71, -74, -38, -22, -9, -2, -7, -29,-260, 40, -38, -30, 2, 13, -17, -39; /M: SY='T'; M=-109,-261, -55, 1, -92,-101, 8, 16, 14, -29, 8, -40,-258, -36, 11, -35, 45, 12,-269, -87; /M: SY='Y'; M=-262,-272,-269,-266, 7,-270,-242,-243, -88, 18, -78,-268,-273,-256, -58,-262,-259,-250, 98, 104; /M: SY='E'; M= -56, -62, -29, 51, -89,-113, -52, -11, 6, -57, -71, -71,-257, 19, 15, -35, -1, 17,-270, -94; /M: SY='R'; M=-113, -79,-251, -84,-112,-263, -34,-266, 41, -85,-255, -15, -1, -36, 86, -40,-116, -52,-268,-255; /I: E1=0; IE=-325; DE=-325;
Numerical results
UniProtKB/Swiss-Prot release number: 2013_05, total number of sequence entries in that release: 540052. Total number of hits in UniProtKB/Swiss-Prot: 94 hits in 94 different sequences Number of hits on proteins that are known to belong to the set under consideration: 94 hits in 94 different sequences Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences Number of false hits (on unrelated proteins): 0 hits in 0 different sequences Number of known missed hits: 0 Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 0 Precision (true hits / (true hits + false positives)): 100.00 % Recall (true hits / (true hits + false negatives)): 100.00 %
Comments
MATRIX_TYPE: protein_domain Scaling database: UniProtKB/Swiss-Prot: reversed Matrix author: CJA_Sigrist Taxonomic range: Archaea, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses Maximum known number of repetitions of the pattern in a single protein: 1 FT_KEY: DOMAIN FT_DESC: DHFR VERSION: 1
Cross-references
UniProtKB/Swiss-Prot	True positive hits: DRTS1_ARATH (Q05762), DRTS2_ARATH (Q05763), DRTS_CRIFA (Q23695), DRTS_DAUCA (P45350), DRTS_LEIAM (P16126), DRTS_LEIMA (P07382), DRTS_MAIZE (O81395), DRTS_MIMIV (Q5UQG3), DRTS_ORYSJ (Q2QRX6), DRTS_PARTE (Q27828), DRTS_PLABA (Q27713), DRTS_PLACH (P20712), DRTS_PLAFK (P13922), DRTS_PLAVI (O02604), DRTS_PLAVN (P46103), DRTS_SOYBN (P51820), DRTS_TOXGO (Q07422), DRTS_TRYBB (Q27783), DRTS_TRYCR (Q27793), DYR10_ECOLX (Q04515), DYR13_ECOLX (Q59408), DYR15_ECOLX (P78218), DYR1_ECOLX (P00382), DYR1_HALMA (Q5V3R2), DYR2_HALMA (Q5V600), DYR3_SALTM (P12833), DYR5_ECOLX (P11731), DYR6_PROMI (P95524), DYR7_ECOLX (P27422), DYR8_ECOLX (P0ABQ7), DYR8_SHISO (P0ABQ8), DYR9_ECOLX (Q59397), DYRA_STAAU (P13955), DYRL1_HUMAN (Q86XF0), DYR_AEDAL (P28019), DYR_BACSU (P11045), DYR_BOVIN (P00376), DYR_BPT4 (P04382), DYR_BUCAI (P57243), DYR_BUCAP (Q8K9Z8), DYR_BUCBP (Q89AV2), DYR_CAEEL (Q93341), DYR_CANAX (P22906), DYR_CHICK (P00378), DYR_CITFR (P31073), DYR_CRYNJ (Q07801), DYR_DROME (P17719), DYR_ECOL6 (P0ABQ5), DYR_ECOLI (P0ABQ4), DYR_ENCCU (O62583), DYR_ENTAE (P31074), DYR_ENTFC (P00380), DYR_HAEIN (P43791), DYR_HALVD (P15093), DYR_HELVI (Q9U8B8), DYR_HUMAN (P00374), DYR_LACCA (P00381), DYR_LACLA (Q59487), DYR_MESAU (P04753), DYR_MOUSE (P00375), DYR_MYCBO (P0A547), DYR_MYCGE (P47470), DYR_MYCLE (Q9CBW1), DYR_MYCPN (P78028), DYR_MYCPU (Q98Q32), DYR_MYCTU (P0A546), DYR_NEIGO (P04174), DYR_NEIMA (Q9JSQ9), DYR_NEIMB (Q9K168), DYR_PIG (P00377), DYR_PNECA (P16184), DYR_RAT (Q920D2), DYR_SCHPO (P36591), DYR_SHIFL (P0ABQ6), DYR_SHV21 (P09503), DYR_SHV24 (P27421), DYR_SHV2C (P22573), DYR_STAAC (Q5HFZ7), DYR_STAAM (P0A016), DYR_STAAN (P99079), DYR_STAAR (Q6GGY1), DYR_STAAS (Q6G9D5), DYR_STAAU (P0A017), DYR_STAAW (Q8NWQ9), DYR_STAEP (P0C0P0), DYR_STAEQ (Q5HPB1), DYR_STAES (P0C0P1), DYR_STAHA (Q54277), DYR_STRPN (Q54801), DYR_THEMA (Q60034), DYR_UREPA (Q9PR30), DYR_YEAST (P07807), SCPA_MYCGA (Q7NB76), SCPA_MYCPN (P75478) Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
PDB [Detailed view]	1AI9; 1AO8; 1AOE; 1BOZ; 1BZF; 1CD2; 1CZ3; 1D1G; 1DAJ; 1DDR; 1DDS; 1DF7; 1DG5; 1DG7; 1DG8; 1DHF; 1DHI; 1DHJ; 1DIS; 1DIU; 1DLR; 1DLS; 1DR1; 1DR2; 1DR3; 1DR4; 1DR5; 1DR6; 1DR7; 1DRA; 1DRB; 1DRE; 1DRF; 1DRH; 1DYH; 1DYI; 1DYJ; 1DYR; 1E26; 1HFP; 1HFQ; 1HFR; 1IA1; 1IA2; 1IA3; 1IA4; 1J3I; 1J3J; 1J3K; 1JOL; 1JOM; 1JUV; 1KLK; 1KMS; 1KMV; 1LUD; 1LY3; 1LY4; 1M78; 1M79; 1M7A; 1MVS; 1MVT; 1OHJ; 1OHK; 1PD8; 1PD9; 1PDB; 1RA1; 1RA2; 1RA3; 1RA8; 1RA9; 1RB2; 1RB3; 1RC4; 1RD7; 1RE7; 1RF7; 1RG7; 1RH3; 1RX1; 1RX2; 1RX3; 1RX4; 1RX5; 1RX6; 1RX7; 1RX8; 1RX9; 1S3U; 1S3V; 1S3W; 1S3Y; 1TDR; 1U70; 1U71; 1U72; 1VDR; 1VJ3; 1YHO; 2ANO; 2ANQ; 2BL9; 2BLA; 2BLB; 2BLC; 2C2S; 2C2T; 2CD2; 2CIG; 2D0K; 2DHF; 2DRC; 2FZH; 2FZI; 2FZJ; 2H2Q; 2HM9; 2HQP; 2INQ; 2ITH; 2JYB; 2L28; 2LF1; 2W3A; 2W3B; 2W3M; 2W9G; 2W9H; 2W9S; 2W9T; 3CD2; 3CL9; 3CLB; 3D80; 3D84; 3DAU; 3DFR; 3DG8; 3DGA; 3DRC; 3EIG; 3F8Y; 3F8Z; 3F91; 3FRA; 3FRB; 3FRD; 3FRE; 3FRF; 3FS6; 3FY8; 3FY9; 3FYV; 3FYW; 3GHC; 3GHV; 3GHW; 3GI2; 3GYF; 3HBB; 3I8A; 3INV; 3IRM; 3IRN; 3IRO; 3IX9; 3K45; 3K47; 3K74; 3KFY; 3L3R; 3LG4; 3M08; 3M09; 3N0H; 3NTZ; 3NU0; 3NXO; 3NXR; 3NXT; 3NXV; 3NXX; 3NXY; 3NZ6; 3NZ9; 3NZA; 3NZB; 3NZC; 3NZD; 3OAF; 3OCH; 3QFX; 3QL3; 3QLR; 3QLS; 3QLW; 3QYL; 3QYO; 3R33; 3RG9; 3S3V; 3S7A; 3SGY; 3SH2; 3SQY; 3SR5; 3SRQ; 3SRR; 3SRS; 3SRU; 3SRW; 3TD8; 4CD2; 4DDR; 4DFR; 4FGG; 4FGH; 5DFR; 6DFR; 7DFR; 8DFR;

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