Entry: PS51378

Forthcoming changes to the profile format
General information about the entry

Entry name [info] INVERT_DEFENSINS
Accession [info] PS51378
Entry type [info] MATRIX
Date [info] MAY-2008 (CREATED); OCT-2013 (DATA UPDATE); OCT-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC00356
Associated ProRule [info] PRU00710

Name and characterization of the entry

Description [info] Invertebrate defensins family profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=35;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=32;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.0351765; R2=0.0051399; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=-523.94118; R2=14.12418; TEXT='HScore';
/CUT_OFF: LEVEL=0; SCORE=1297; N_SCORE=8.7; H_SCORE=11750; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=869; N_SCORE=6.5; H_SCORE=11750; MODE=1; TEXT='?';
/DEFAULT: M0=-18; D=-80; I=-80; B1=-500; E1=-500; MI=-255; MD=-255; IM=-255; DM=-255;
...
                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='G'; M=-20,-53,-38,-15,-50, 45,-39, -5, -7,-30,-39, -2, -7, -5, 42,-30,-13,-42,-52,-45;
/M: SY='Y'; M= 21,-41,-42,-18, 38, 14,-35,  3,-37, -1,-22,-36,-45,-36,-15,-13, -7, 20,-30, 41;
/M: SY='T'; M= 10,-37,-33,-36,  5, 33,-36,-34,-33,-23,-31,-22,-36,-33,-39, 12, 67,-28,-43, 13;
/M: SY='C'; M=-32,143,-51,-52,-42,-47,-51,-49,-47,-39,-40,-38,-62,-55,-54,-34,-32,-36,-72,-53;
/I:         I=-8; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='D'; M=-23,-55, 58,  9,-56,-43,-37,-43,-15,-50,-45, -6, 58, -4,-39,-32,  2, -5,-64,-48; D=-8;
/I:         I=-8; DM=-25;
/M: SY='W'; M=-30,-50,-19,-48, 23,-55,-48, 11,-44, 29,-23,-47,-54,-45, -5, -9,  4, -3, 61,-26; D=-8;
/I:         I=-8; DM=-25;
/M: SY='N'; M=-33,  4, 25,-38,  9, -6,-39,-34,-20, 28,-30, 29,-55,-12,-44,-18,-37,-38,-55,-37; D=-8;
/I:         I=-8; DM=-25;
/M: SY='S'; M=-13,-52,  4, 20,-59,  4,-36,-56,-29,-55,-47,-13,-43, 33, -3, 38,  4,-50,-60,-47; D=-8;
/I:         I=-8; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='W'; M= 16,-44,  2,-32,-33,  4,-33, -3,-33,-37,  4,-27,-41, 14,-37, 44,  4,-32, 53, 29; D=-8;
/I:         I=-8; DM=-25;
/M: SY='A'; M= 40,-42,  5, -9,-42, -7,-31,-28,  7,-15,-32, 19,-41, 33,-29, -6,-10,-18,-47,  0; D=-8;
/I:         I=-8; DM=-25;
/M: SY='C'; M=-32,143,-51,-52,-42,-47,-51,-49,-47,-39,-40,-38,-62,-55,-54,-34,-32,-36,-72,-53;
/M: SY='H'; M= 42,-39,-26, -1,-10,-20, 50,-16,  4,-22,-29, 38,-39,  0, -9, -9, -5,-16,-50,-30;
/M: SY='A'; M= 48,-39, 16,-28,  7, -9,-33,-22,-29,  0,  2,-12,-10, -2,  6, 17,-25,-27,-45,-32;
/M: SY='H'; M=-36,-49,-27, -6, -1,-42,110,-39,-27,-33,-25,  2,-43,  2, -5,-12,-33, -7,-44, 47;
/M: SY='C'; M=-32,143,-51,-52,-42,-47,-51,-49,-47,-39,-40,-38,-62,-55,-54,-34,-32,-36,-72,-53;
/M: SY='K'; M=-32,-44,-35,-29,-31,-44, 13, 30, 36, 19,-18,  9,-43, 17, 16, -2,-27, 12,-47,-30;
/M: SY='S'; M=  0,-40, -7,  5,  6,-17,  5, -4,-29,  3, 27,-26,-39, -3, -7, 48, -4,-10,-44, -6;
/M: SY='K'; M=-32,-45,-33, -8,-13,-44,-15, 34, 43,  5, 11,  8,-41,-22, 31,  2,-27, -8,-45,-30;
/I:         I=-24; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='G'; M=-22,-48,-30,  2,-52, 81,  2,-59,  0,-54,-43,-21,-37,-29, -4, -8,-36,-52,-45,-44;
/M: SY='Y'; M= -8, 30,-16,-30, 11,-43,-20,-36, 29,-21,-28,  1,-47,-23, 43,-31,-32,-36,-22, 75;
/M: SY='R'; M=-13, -7,-27,  6,-45,-13,-28,-42, 47,-20,-33,  9,-13,  5, 53,  6,-10,-26,-47,-36;
/M: SY='G'; M=  7,-46,-36,-40,-44, 75,-38,-24,-35,-48,-40,-24,-39, -4,-15, 11,-33,-43, 34, -7;
/M: SY='G'; M= -8,-46,-36,-46,-13, 89,-41,-58,-40,-53,-44,-22,-39,-38,-47,-20,-38,-52,-42,-44;
/M: SY='Y'; M=-29,-49,-32,-31,  7,-41, 43,-35, -6,-31,-25, 10,-47, 24, 15, -2,-31,-38,-15, 92;
/M: SY='C'; M=-32,143,-51,-52,-42,-47,-51,-49,-47,-39,-40,-38,-62,-55,-54,-34,-32,-36,-72,-53;
/I:         I=-19; MI=0; MD=-61; IM=0; DM=-61;
/M: SY='N'; M=-24,-51,-39,-47, 18,-28,-41,-21,-42,-46,-43, 45,-29,-43,-48, 11, 25,-23,  7, -1; D=-19;
/I:         I=-19; DM=-61;
/M: SY='F'; M= 11,-42,  3,  7, 26,-12, -5,-33,  6,  0,-28, -4, -3, 20,-29, 25, -6,-23,-40,  3;
/I:         I=-22; MD=-71;
/M: SY='K'; M=-19,-49,-14,  4,-43,-25,-26,-31, 60,-46,-36, 38,-39, 28, 25,-26,-29,-44, 42, -2; D=-22;
/I:         I=-22; MI=-71; MD=-71; IM=-71; DM=-71;
/M: SY='K'; M=  6,-43, -2,  4,-44, 28,-33,-36, 32,-10,-32, -4,-38, 22,-16,  0, 13, -8,-49,-39; D=-22;
/I:         I=-22; DM=-71;
/M: SY='T'; M=-28,-39, -9, -9,-30,-29,-37, 19,-12, -6,-21, 24,-41,-32, -6,-24, 44, 42,-51, -2;
/M: SY='C'; M=-32,143,-51,-52,-42,-47,-51,-49,-47,-39,-40,-38,-62,-55,-54,-34,-32,-36,-72,-53;
/M: SY='V'; M=-15,-41,-38,-33,-30,-45,  8, 11, 10,-17,-22,-16,-41, -3, 17,-26, 41, 43, 35, -3;
/M: SY='C'; M=-32,143,-51,-52,-42,-47,-51,-49,-47,-39,-40,-38,-62,-55,-54,-34,-32,-36,-72,-53;
/M: SY='Y'; M=-32,-46,-30, -7,  1,-21,-22,-34, -6,-34,-29, 14,-43,  2, 52, -6, 27, -8,-30, 60;
/M: SY='R'; M=-23,-53,-12,  7,-52,-44, 10,-50, 21,-29,  5, 32,-47,  0, 32,  0, -9,-48,-60,-43;
/I:         E1=0; IE=-255; DE=-255;
» More

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_11 which contains 547'085 sequence entries.


Total number of hits 46 in 46 different sequences
Number of true positive hits 46 in 46 different sequences
Number of 'unknown' hits
Number of false positive hits
Number of false negative sequences 4
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 92.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] PS_Langendijk_Genevaux
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
46 sequences

DEF1_CRAVI  (P85008), DEF1_DERVA  (Q86QI5), DEF1_GALME  (P85213), 
DEF1_HOLDI  (Q7M426), DEF1_STOCA  (O16136), DEF2_APIME  (Q5MQL3), 
DEF2_GALME  (P85215), DEF2_STOCA  (O16137), DEF3_ANOGA  (Q5TWR9), 
DEF4_ANDAU  (P56686), DEF4_LEIQH  (P41965), DEFA_AEDAE  (P91793), 
DEFA_ANOCP  (P83669), DEFA_MYTED  (P81610), DEFA_ZOPAT  (P80033), 
DEFB_AEDAE  (P81602), DEFB_ANOCP  (P83668), DEFB_MYTED  (P81611), 
DEFC_AEDAE  (P81603), DEFI_AESCY  (P80154), DEFI_ANOGA  (Q17027), 
DEFI_APICA  (Q5J8R1), DEFI_APIME  (P17722), DEFI_BOMPA  (P81462), 
DEFI_DROME  (P36192), DEFI_MYTGA  (P80571), DEFI_ORNCO  (B2D2C0), 
DEFI_ORYRH  (O96049), DEFI_PALPR  (P80407), DEFI_PHLDU  (P83404), 
DEFI_PROTE  (P10891), DEFI_PYRAP  (P37364), DEFI_RHIMP  (Q86LE4), 
DEFI_TENMO  (Q27023), DEFI_TRYDI  (Q10745), DEFL1_CENLL (Q6GU94), 
DEFN_ARCDE  (P84156), DEFN_HELVI  (P81544), DEF_FORAQ   (Q5BU36), 
DEF_GLOMM   (Q8WTD4), LUCFE_LUCCU (B3EWY5), LUCFE_LUCSE (P86471), 
PLECT_PSENR (Q53I06), SAPB_SARPE  (P31529), SAPC_SARPE  (P31530), 
SAPE_SARPE  (P18313)
» More

UniProtKB/Swiss-Prot
False negative sequences
4 sequences

DEFLO_HAELO (B2MW54), DEF_TITDI   (P0CF77), DFP6_LONON  (Q5MGC9), 
NOD1_MEDTR  (P93331)
» More


View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission