To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
Entry: PS51390

General information about the entry

Entry name [info] WAP
Accession [info] PS51390
Entry type [info] MATRIX
Date [info] 01-JUL-2008 CREATED; 01-OCT-2013 DATA UPDATE; 27-SEP-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC00026
Associated ProRule [info] PRU00722

Name and characterization of the entry

Description [info] WAP-type 'four-disulfide core' domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=48;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=48;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.7587812; R2=0.0052219; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=1426; N_SCORE=10.2; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=774; N_SCORE=6.8; MODE=1; TEXT='R?';
/DEFAULT: M0=-49; D=-200; I=-200; B1=-300; E1=-300; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-105; BD=-105;
/M: SY='P'; M= -17,  22, -25,-122,   7, -33, -25, -11,  12,  -1,   2, -12,  66, -28,  16, -59,  11,  18, -25, -44;
/M: SY='K'; M=   8,   9, -59, -10, -52,  -4, -37,  -2,  34, -14,-113,   4,  18,   9,   5,  11,  20, -29,  26,  12;
/M: SY='P'; M=  24, -49, -57,  44, -47, -51, -29,-119,  -5, -36, -26,  19,  44,  15, -33,  26,  16,   8, -21, -28;
/M: SY='K'; M= -44,-149, -56, -28,  -5,-135,  54, -68,  90, -16, -36,-108,-129,  12,  34, -13, -22, -57,-146, -30;
/M: SY='P'; M=  27,-140,   4,  -7, -23, -52,-119, -25,   2, -42,-120, -23,  86,  19, -37, -11, -44,  -7, -37,  26;
/I:         I=-44; MD=-23;
/M: SY='G'; M= -24,-150, -30, -61,-151,  95,-133,-153, -18, -64,  -1, -48, -41,-125, -32, -29, -11,-144, -18,-153; D=-44;
/I:         I=-44; MI=0; MD=-23; IM=0; DM=-23;
/M: SY='T'; M=  -4,-136, -12,   3, -15, -52, -26, -22,  24, -30,   6, -37, -16,  29,  29,  19,  31,  21,-144, -24;
/M: SY='C'; M= -47, 151,-169,-169,-143,-154,-155,-124,-157,-131,-124,-148,-154,-149,-167,-120,-120,-120,-160,-151;
/M: SY='P'; M= -66,-150,-130, -23,-154, -73, -10, -63,-119, -57,-135,-129, 129,   8,-127,  -9,-119, -51,-166,-152;
/M: SY='P'; M=  12,-143,  24,  24, -70,-131,-118, -37,  29, -39,-121,  -2,  58,  22,  32,  -8,   7, -18,   5,-137;
/I:         I=-44; MD=-23;
/M: SY='P'; M= -37,-141,  -1,   9,  10, -82, -38,   3, -14, -24, -48,   5,  64,  11,  11, -25,   0,  27,-146, -34; D=-44;
/I:         I=-44; MI=0; MD=-23; IM=0; DM=-23;
/M: SY='P'; M= -43,-151, -44,  11, -31, -78,-137, -27, -20, -35, -17, -35,  75,-121, -16,  23,  12, -37, -10,-144; D=-44;
/I:         I=-44; DM=-23;
/M: SY='P'; M= -19,-148, -70, -22, -11, -15,-128, -18,  18, -37, -19, -58,  60,  32, -41,  18, -15, -30,-151, -13; D=-44;
/I:         I=-44; DM=-23;
/M: SY='P'; M=  -2,-139, -26,   3,-131,   0,   7,  -2,  -6, -14, -42,  -5,  61,   3,  18,  23,  -9,  -1,-150, -21;
/I:         I=-19; MD=-10;
/M: SY='P'; M=  -4,-141,  12, -13, -62,  18,-122, -18,   8,   1,  11,  16,  49,   9, -17,  -2,  -8, -22,-148, -12; D=-19;
/I:         I=-19; MD=-10;
/M: SY='P'; M= -40,-153,  16, -37,   2, -63,-138, -14, -65, -39, -39,-130,  37, -26,  -7,   8,  15, -11,-155, -10; D=-19;
/I:         I=-19; MI=0; MD=-10; IM=0; DM=-10;
/M: SY='Q'; M= -48,-153, -13,  16, -59,  -5,-124, -21,  -5, -21, -41,  20,  10,  29, -36,   3,  -4, -44,-152,   8; D=-19;
/I:         I=-19; DM=-10;
/M: SY='C'; M=-114, 146, -60, -61,-141,-154,-151,-122,-150, -39,-121,-143,-153,-143, -59, -56, -31,-120,-160,-150; D=-19;
/I:         I=-19; DM=-10;
/M: SY='P'; M=  13,-137, -12,  21,-134, -79,-132,  18,  -8,  -9, -35, -66,  57, -48,  -8,  -7,  23,  20,-156,-141; D=-19;
/I:         I=-19; MI=0; MD=-10; IM=0; DM=-10;
/M: SY='P'; M= -34,-170, -37, -46, -83, -37, -32, -34,  20, -40,-144,-142,  55, -49,  -6, -23, -62, -85,-169,  -8; D=-19;
/I:         I=-19; DM=-10;
/M: SY='N'; M=-130,-159,  38, -68, -69, -49,  29, -15, -38,-152,-145,  44,  29,-126,-135,  13,  18,-141,-167,  -6; D=-19;
/I:         I=-19; MI=0; MD=-10; IM=0; DM=-10;
/M: SY='Q'; M= -40,-144, -12,  39, -18, -33,   2, -49,   3,  10, -33,  -4,  -4,  50,  25,  12, -29, -24,  17,  15;
/M: SY='C'; M=-114, 152,-171,-171,-143,-156,-156,-124,-159,-131,-124,-149,-156,-150,-168,-121,-120,-121,-161,-152;
/M: SY='H'; M= -12,-141,  -2,  18,  -8, -51,  43, -56,  26, -58,-121,  14, -49,  35,  32,  38,  26, -42,  -3, -59;
/I:         I=-61; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='S'; M= -47, -33, -10,  20, -58, -31,  11, -65,  -7, -67, -25,  28,-130,   5,  24,  53,  41,  -2, -26,   4;
/M: SY='D'; M=-133,-168, 119, -81, -46,-127,  21,-163,-116,-164,-159,  -4, -46,-110,-129,-110,-122,-157,-181,-142;
/M: SY='S'; M=  -4,-142,  23,  24,  -3, -24,-109, -50, -10, -34,-120,   9,-131,  45,  26,  46, -27, -78,  33,  30;
/M: SY='D'; M= -69,-157,  95,  27,-151, -22,   6, -80, -18,-153,-139,   1,-131,  58,-113,  -1, -37,-145,-163, -48;
/M: SY='C'; M=-114, 152,-171,-171,-143,-156,-156,-124,-159,-131,-124,-149,-156,-150,-168,-121,-120,-121,-161,-152;
/M: SY='P'; M=   9,-146, -34,  29, -37, -36,-119, -75,  32, -89, -22,-115,  93,  40,   3,  14, -55,-132,-156,-140;
/I:         I=-37; MI=0; MD=-19; IM=0; DM=-19;
/M: SY='G'; M=   2,-149,  11,  -2, -60,  66, -32,-151, -22, -48,-134,   2, -17,  45, -50,  11, -44,-142,-154, -49; D=-37;
/I:         I=-37; MI=0; MD=-19; IM=0; DM=-19;
/M: SY='N'; M= -38,-142,  18, -21,-134,  23,  31, -24,  -4, -34, -23,  74, -30, -27, -13, -15,  22,  -3,-153, -23;
/M: SY='Q'; M= -73,-150,  13,  32,   3, -81,  12,-129,  63, -38,  43, -24,-131,  69,  14, -29, -33, -71,-140, -11;
/M: SY='K'; M= -67,-151,-123, -36,-140,-137, -23,   5, 102, -83,  10,-110,-129, -33,  46,-112,-115, -21,-152, -54;
/M: SY='C'; M=-114, 152,-171,-171,-143,-156,-156,-124,-159,-131,-124,-149,-156,-150,-168,-121,-120,-121,-161,-152;
/I:         I=-61; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='C'; M=-114, 150,-170,-170,-142,-156,-156,-119,-158,-128,-122,-149,-155,-150,-167,-122,-120, -28,-160,-151;
/I:         I=-51; MD=-27;
/M: SY='P'; M= -34,-143,  18, -28,  29, -60, -41, -78, -14, -35, -38,  19,  55,  23,  -7,  39, -32, -28, -19,  46; D=-51;
/I:         I=-51; MI=0; MD=-27; IM=0; DM=-27;
/M: SY='N'; M= -10,-138,  39, -62,  -2,   4, -41, -79, -68, -32, -38,  61,-133, -16, -19,  26,  44, -21,  13,   1;
/M: SY='G'; M=   6,-140, -34, -69,   9,  70, -16, -71,-119, -77,  -1, -26,   4, -40,  -8,  36, -36, -29,-138,  17;
/I:         I=-56; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='C'; M=-112, 147,-160, -61,-143, -42, -31,-125,-149,-131,-124,-141,-152,-142, -61, -33, -51, -71,-160,-148;
/M: SY='G'; M= -40,-145, -41,-125, -67,  83,  -9, -40, -45,  -9,-126,   9, -25, -23, -25,  25,-116, -50,-151, -49;
/M: SY='R'; M= -23,-144, -72, -65,   6, -39,  29, -76,  36,  -8,  31,  27,-135,   7,  59,  -4,  -7, -78,  -8,  38;
/I:         I=-51; MI=0; MD=-27; IM=0; DM=-27;
/M: SY='S'; M=  -5,-132, -35,  -3,-131, -80, -42,  10,  35, -61, -26,-113, -57,   9,  23,  42,  38,  36,-149, -48;
/M: SY='C'; M=-114, 152,-171,-171,-143,-156,-156,-124,-159,-131,-124,-149,-156,-150,-168,-121,-120,-121,-161,-152;
/I:         I=-61; MD=-32;
/M: SY='M'; M= -35,-132,-138, -22,  -2,-146,-128, -34,  30,  12,  65,-128,-138, -31,  20, -25,  27,  49,-138, -30; D=-61;
/I:         I=-61; MI=-32; IM=-32; DM=-32;
/M: SY='P'; M=   7,-141,  37,   6,-134, -55, -16, -14,  -4, -77,  -8,  -5,  38,  22,   0,  25,  12,  -9,-150,  -2;
/M: SY='P'; M=  -4,-146, -73,-125, -57, -18,-136, -15, -19, -45,-129, -19, 114,-124, -68, -12, -30, -28,-164,-148;
/M: SY='V'; M=  -2, -49, -13, -12, -77, -37, -35,  23, -17, -18,-107, -25,  -9, -34, -25,  -2, -32,  51,   7, -58;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_09 which contains 555'594 sequence entries.


Total number of hits 168 in 123 different sequences
Number of true positive hits 168 in 123 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 26
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 86.60 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] PS_Langendijk_Genevaux
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 4
Feature key [info] DOMAIN
Feature description [info] WAP
Version [info] 3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
123 sequences

CALU_CAVPO  (P22075    ), ELAF_HUMAN  (P19957    ), ELAF_PIG    (Q29125    ), 
EPPI_HUMAN  (O95925    ), EPPI_MACMU  (Q9BDL1    ), EPPI_MOUSE  (Q9DA01    ), 
EPPI_RAT    (D4A2Z2    ), IBP_CARCR   (P00993    ), KALM_CHICK  (P33005    ), 
KALM_COTJA  (Q90369    ), KALM_HUMAN  (P23352    ), LEV9_CAEEL  (Q22328    ), 
PPN_DROME   (Q868Z9    ), PWAPL_LOTGI (B3A0S1    ), PWAP_HALAI  (P86730    ), 
PWAP_HALLA  (P84811    ), SLPI_HUMAN  (P03973    ), SLPI_MOUSE  (P97430    ), 
SLPI_PIG    (P22298    ), SLPI_SHEEP  (Q6V9X0    ), SPAI_PIG    (P16225    ), 
UROL1_HUMAN (Q5DID0    ), UROL1_MOUSE (Q5DID3    ), VKT_SISCA   (A5X2X1    ), 
WAP1_ERYPO  (A7X4L4    ), WAP1_PHIOL  (A7X4K1    ), WAP1_PSEPL  (A7X4M1    ), 
WAP1_RHATT  (A7X4J4    ), WAP1_THRJA  (A7X4I7    ), WAP2_PHIOL  (A7X4K7    ), 
WAP3_PHIOL  (A7X4M7    ), WAP3_PIG    (Q29126    ), WAPA_AUSSU  (B5KGY9    ), 
WAPA_CRYNI  (B5G6H1    ), WAPA_DEMVE  (B5L5P8    ), WAPA_HOPST  (B5G6H3    ), 
WAPA_NOTSC  (B5G6H4    ), WAPA_OXYMI  (P83952    ), WAPA_OXYSC  (B5G6G8    ), 
WAPA_PSEAU  (B5G6G9    ), WAPA_PSEPO  (B5G6H0    ), WAPA_PSETE  (B5L5P9    ), 
WAPA_TROCA  (B5G6H2    ), WAPB_AUSSU  (B5L5P2    ), WAPB_CRYNI  (B5L5N6    ), 
WAPB_DEMVE  (B5L5P5    ), WAPB_NOTSC  (B5G6H5    ), WAPB_OXYMI  (B5G6G7    ), 
WAPB_PSEAU  (B5L5N1    ), WAPB_PSEPO  (B5L5N2    ), WAPB_TROCA  (B5L5P0    ), 
WAPC_AUSSU  (B5L5P3    ), WAPC_DEMVE  (B5L5P6    ), WAPC_OXYMI  (B5L5M9    ), 
WAPC_PSEPO  (B5L5N3    ), WAPD_AUSSU  (B5L5P4    ), WAPD_DEMVE  (B5L5P7    ), 
WAPD_PSEPO  (B5L5N4    ), WAPN_NAJNG  (P60589    ), WAP_CAMDR   (P09837    ), 
WAP_MACEU   (Q9N0L8    ), WAP_MOUSE   (P01173    ), WAP_PIG     (O46655    ), 
WAP_RABIT   (P09412    ), WAP_RAT     (P01174    ), WF10A_HUMAN (Q9H1F0    ), 
WF10B_HUMAN (Q8IUB3    ), WF15A_MOUSE (Q8BH89    ), WF15B_MOUSE (Q9JHY4    ), 
WFC6A_MOUSE (Q3UW55    ), WFC6B_MOUSE (F6ULY1    ), WFD12_AOTNA (A4K2W8    ), 
WFD12_CALJA (A4K2U1    ), WFD12_CHLAE (A4K2Y4    ), WFD12_COLGU (A4K2P8    ), 
WFD12_GORGO (A4K2R5    ), WFD12_HUMAN (Q8WWY7    ), WFD12_LEMCA (A4K2S4    ), 
WFD12_MACMU (A4K2T3    ), WFD12_MOUSE (Q9JHY3    ), WFD12_PANTR (A4K2P0    ), 
WFD12_PAPAN (A4K2M6    ), WFD12_PONAB (A4K2V4    ), WFD12_RAT   (Q6IE40    ), 
WFD12_SAIBB (A4K2X6    ), WFD18_BOVIN (P62811    ), WFD18_MOUSE (P62810    ), 
WFD18_RAT   (P14730    ), WFDC1_CHICK (Q8JG33    ), WFDC1_HUMAN (Q9HC57    ), 
WFDC1_MOUSE (Q9ESH5    ), WFDC1_RAT   (O70280    ), WFDC2_CANLF (Q28894    ), 
WFDC2_HUMAN (Q14508    ), WFDC2_MOUSE (Q9DAU7    ), WFDC2_PIG   (Q8MI69    ), 
WFDC2_RABIT (Q28631    ), WFDC2_RAT   (Q8CHN3    ), WFDC3_HUMAN (Q8IUB2    ), 
WFDC3_MOUSE (Q14AE4    ), WFDC5_AOTNA (A4K2W7    ), WFDC5_CALJA (A4K2U0    ), 
WFDC5_CHLAE (A4K2Y3    ), WFDC5_COLGU (A4K2P7    ), WFDC5_GORGO (A4K2R4    ), 
WFDC5_HUMAN (Q8TCV5    ), WFDC5_LEMCA (A4K2S3    ), WFDC5_MACMU (A4K2T2    ), 
WFDC5_OTOGA (A4K2Q7    ), WFDC5_PANTR (A4K2N9    ), WFDC5_PAPAN (A4K2M5    ), 
WFDC5_PONAB (A4K2V3    ), WFDC5_SAIBB (A4K2X5    ), WFDC6_HUMAN (Q9BQY6    ), 
WFDC8_HUMAN (Q8IUA0    ), WFDC8_MOUSE (Q4KUS1    ), WFKN1_HUMAN (Q96NZ8    ), 
WFKN1_MOUSE (Q8R0S6    ), WFKN1_RAT   (P0C5J5    ), WFKN2_BOVIN (Q08E66    ), 
WFKN2_HUMAN (Q8TEU8    ), WFKN2_MOUSE (Q7TQN3    ), WFKN_DANRE  (Q6NUX0    )
» more

UniProtKB/Swiss-Prot
False negative sequences
26 sequences

PWAPL_MYTGA (P86855    ), TXE01_LYCSI (B6DD34    ), TXE02_LYCSI (B6DD35    ), 
TXE03_LYCSI (B6DD36    ), TXE04_LYCSI (B6DD37    ), TXE05_LYCSI (B6DD38    ), 
TXE06_LYCSI (B6DD39    ), TXF07_LYCSI (B6DD40    ), TXF08_LYCSI (B6DD41    ), 
TXF09_LYCSI (B6DD42    ), TXF10_LYCSI (B6DD43    ), TXF11_LYCSI (B6DD44    ), 
TXF12_LYCSI (B6DD45    ), TXF13_LYCSI (B6DD46    ), TXF14_LYCSI (B6DD47    ), 
TXF15_LYCSI (B6DD48    ), TXF16_LYCSI (B6DD49    ), TXF17_LYCSI (B6DD50    ), 
TXF18_LYCSI (B6DD51    ), TXK01_LYCSI (B6DD60    ), TXK02_LYCSI (B6DD61    ), 
TXK03_LYCSI (B6DD62    ), TXK04_LYCSI (B6DCY1    ), WFD13_HUMAN (Q8IUB5    ), 
WFD13_MOUSE (Q5DQQ6    ), WFD21_MOUSE (Q8BTE6    )
» more

UniProtKB/Swiss-Prot
'Partial' sequences
1 sequence

ENA2_HORSE  (P56928    )

		
PDB
[Detailed view]
7 PDB

1FLE; 1UDK; 1ZLG; 2REL; 2Z7F; 3NGG; 4DOQ

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission