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PROSITE entry PS51491


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General information about the entry

Entry name [info] TAU_MAP_2
Accession [info] PS51491
Entry type [info] MATRIX
Date [info] 01-MAY-2010 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00201
Associated ProRule [info] PRU00824

Name and characterization of the entry

Description [info] Tau and MAP proteins tubulin-binding repeat profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=31;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=28;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.3458040; R2=0.0151269; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1020.4832764; R2=0.5080545; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=341; H_SCORE=1194; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=209; H_SCORE=1127; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-23; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='I';  M=-11,-32,-24, -9, -4,-50,-18,-23,  7,-30,-14, -1,-31,-25,-15,-19,-26,-17,-16,-13,-57,-20;
/M: SY='Z';  M=-12, -2,-72,  3, 17,-64,-33,-17,-11,-19,-35,-21, -9,-26, 15,-25,-20,-13, -8,-52,-54, 20;
/M: SY='I';  M=-13,-41,-41,-38,-33,  1,-41,-43, 36,-51, -2, -2,-32,-42,-44,-41,-30,-14,  7,-56,-23,-43;
/M:         M=-26,-32,-53,-34,-33,-23,-40,-12,-10,-33,-21,-18,-21,-24,-27,-24,-27,-25,-24,-48,-29,-30;
/M:         M=-10, -8,-32,-11,-13,-36,-22,-12,-26,-27,-37,-28, -3,-24,-16,-26, -1, -7,-32,-36,-25,-14;
/M: SY='Z';  M=-15, -6,-76, -6,  5,-83,-29,-23,-40, -3,-50,-32,-11,  2,  1,-15,-13,-21,-25,-52,-67,  8;
/M: SY='K';  M=-32,-29,-82,-39,-32,-58,-46,-34,-24, 13,-16, 10,-21,-24,-15, -6,-24,-19,-28,-66,-59,-21;
/M: SY='P';  M=-20,-40,-54,-44,-36,-43,-43,-25,-16,-33, -6,-14,-36,  4,-19,-16,-22,-26,-20,-40,-61,-27;
/M: SY='D';  M=-12, 40,-90, 48, 36,-88,-16, -4,-40,-18,-62,-52, 22,-34, 13,-40,-14,-22, -8,-15,-70, 26;
/M: SY='L';  M=-44,-58,-75,-73,-65, 21,-70,-33,  1,-58, 31, -2,-46,-53,-46,-55,-46,-42,-16,-26, -2,-50;
/M: SY='K';  M=-18,-13,-49,-13,-16,-66,-21,-32,-27, 15,-40, -7, -5,-26,-22, -2, -4, -1,-35,-45,-52,-19;
/I:         I=-14; MD=-29;
/M: SY='N';  M=-13, 26,-58, 21,  3,-53,-13,  3,-27,  6,-44,-29, 29,-27, -6,-15,  0, -5,-27,-35,-36,  2; D=-14;
/I:         I=-14; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='I';  M=  4,-34,-15, -9, -8,-34,-11,-42, 28,-46, -6,  2,-32,-28,-36,-44,-24, -6,  6,-31,-46,-34;
/M: SY='Q';  M=-22, -9,-74,-16, -6,-73,-41, -1,-33,  7,-39,-17, -9,-18, 28, 12,-17,-14,-39,-63,-64, 16;
/M: SY='S';  M= 10,  0,-10,-10,-20,-40,  0,-30,-40,-20,-50,-30, 10,  0,-30,-10, 40, 20,-30,-30,-40,-20;
/M: SY='K';  M=-40,-10,-90,-20,-20,-90,-40,-30,-40, 60,-50,  0,  0,-40,-10, 20,-20,-10,-50,-70,-60,-10;
/M: SY='I';  M=-22,-49,  6,-47,-42,-31,-48,-48, 30,-57,-21,-17,-41,-46,-55,-40,-29,-19, 15,-41,-31,-55;
/M: SY='G';  M=  0,-10,-60,-10,-20,-60, 60,-50,-60,-40,-70,-50,-10,-30,-40,-60,  0,-20,  0,  0,-80,-20;
/M: SY='S';  M= 10,  0,-10,-10,-20,-40,  0,-30,-40,-20,-50,-30, 10,  0,-30,-10, 40, 20,-30,-30,-40,-20;
/M: SY='M';  M=-21,-34,-71,-44,-40,-33,-45,-41, -4,-12,  2, 17,-24,-35,-25,-28,-18, -1, -8,-61,-47,-31;
/M: SY='D';  M=-14, 24,-85, 30, 22,-85, -6,-22,-42, -8,-65,-44, 13,-37, -5,-37,-12,-20,-10,-13,-68, 13;
/M: SY='N';  M=-10, 40,-60, 30,  0,-50,-10, 20,-30,  0,-50,-40, 50,-30,-10,-20, 10,  0,-40,-50,-30,  0;
/M: SY='I';  M=-14,-39,-56,-43,-33,-13,-48,-46, 32,-34, 10, 19,-31,-39,-31,-33,-30,-13, 16,-70,-41,-32;
/M: SY='K';  M=-26,  1,-70, -9,-18,-66,-33, -4,-35, 23,-47,-19, 13,-32, -8,  1, -9, -3,-40,-63,-43, -8;
/M: SY='H';  M=-42, -8,-44,-21,-28,-17,-56, 63,-46,-36,-40,-52, 11,-31,  3,-13,-32,-40,-42,-36,  9, -3;
/M: SY='E';  M=-13,-21,-46, -3,  4,-62,-20,-17, -6,-18,-19, -2,-23,-25,  3,-21,-28,-17,-22,-39,-59, -4;
/M: SY='P';  M=  8,-26,-48,-34,-26,-66,-24,-24,-44,-40,-40,-46,-26, 57,-12,-24,  2,-14,-24,-88,-74,-18;
/M: SY='G';  M= -8,-10,-66,-12,-20,-66, 41,-46,-56,-21,-66,-41, -8,-32,-34,-45, -4,-18, -9,-13,-76,-18;
/M: SY='G';  M=  0,-10,-60,-10,-20,-60, 60,-50,-60,-40,-70,-50,-10,-30,-40,-60,  0,-20,  0,  0,-80,-20;
/M: SY='G';  M=  0,-10,-60,-10,-20,-60, 60,-50,-60,-40,-70,-50,-10,-30,-40,-60,  0,-20,  0,  0,-80,-20;
/M: SY='N';  M=-16, 13,-69,  6,  1,-66,-24,  5,-36,  4,-43,-25, 16,-21, 15, -5, -5, -9,-40,-61,-50, 13;
/I:         E1=0; IE=-105; DE=-105;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_06 which contains 572'619 sequence entries.


Total number of hits 72 in 19 different sequences
Number of true positive hits 72 in 19 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 4
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] REPEAT
Feature description [info] Tau/MAP
Version [info] 4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
19 sequences

MAP4_BOVIN  (P36225), MAP4_HUMAN  (P27816), MAP4_MOUSE  (P27546), 
MAP4_RAT(Q5M7W5), MTAP2_HUMAN (P11137), MTAP2_MOUSE (P20357), 
MTAP2_RAT   (P15146), TAU_BOVIN   (P29172), TAU_CAPHI   (O02828), 
TAU_GORGO   (Q5YCW0), TAU_HUMAN   (P10636), TAU_HYLLA   (Q5YCV9), 
TAU_MACMU   (P57786), TAU_MOUSE   (P10637), TAU_PANTR   (Q5YCW1), 
TAU_PAPHA   (Q9MYX8), TAU_PONPY   (Q5S6V2), TAU_RAT (P19332), 
TAU_SPECI   (Q6TS35)
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PDB
[Detailed view]
185 PDB

2MZ7; 5MO3; 5MP1; 5MP3; 5MP5; 5N5A; 5N5B; 5NVB; 5O3L; 5O3O; 5O3T; 6CVJ; 6CVN; 6GX5; 6HRE; 6HRF; 6NWP; 6NWQ; 6QJH; 6QJM; 6QJP; 6QJQ; 6TJO; 6TJX; 6VH7; 6VHA; 6VHL; 6VI3; 7MKF; 7MKG; 7MKH; 7NRQ; 7NRS; 7NRT; 7NRV; 7NRX; 7P65; 7P66; 7P67; 7P68; 7P6A; 7P6B; 7P6C; 7P6D; 7P6E; 7PQC; 7PQP; 7QJV; 7QJW; 7QJX; 7QJY; 7QJZ; 7QK1; 7QK2; 7QK3; 7QK5; 7QK6; 7QKF; 7QKG; 7QKH; 7QKI; 7QKJ; 7QKK; 7QKL; 7QKM; 7QKU; 7QKV; 7QKW; 7QKX; 7QKY; 7QKZ; 7QL0; 7QL1; 7QL2; 7QL3; 7QL4; 7R4T; 7R5H; 7SP1; 7U0Z; 7UPE; 7UPF; 7UPG; 7YMN; 7YPG; 8AZU; 8BGS; 8BGV; 8BYN; 8CAQ; 8CAX; 8FNZ; 8FUG; 8G54; 8G55; 8G58; 8OH2; 8OHI; 8OHP; 8OI0; 8OP0; 8OPI; 8ORE; 8ORF; 8ORG; 8OT6; 8OT9; 8OTC; 8OTG; 8OTH; 8OTI; 8OTJ; 8P34; 8PII; 8PPO; 8Q27; 8Q2J; 8Q2K; 8Q2L; 8Q7F; 8Q7L; 8Q7M; 8Q7P; 8Q7T; 8Q88; 8Q8C; 8Q8D; 8Q8E; 8Q8F; 8Q8L; 8Q8M; 8Q8R; 8Q8S; 8Q8U; 8Q8V; 8Q8W; 8Q8X; 8Q8Y; 8Q8Z; 8Q92; 8Q96; 8Q97; 8Q98; 8Q99; 8Q9A; 8Q9B; 8Q9C; 8Q9D; 8Q9E; 8Q9F; 8Q9G; 8Q9H; 8Q9I; 8Q9J; 8Q9K; 8Q9L; 8Q9M; 8Q9O; 8QCP; 8QCR; 8QJJ; 8R3T; 8SEH; 8SEI; 8TTL; 8TTN; 8UQ7; 8WCP; 8ZWL; 8ZWM; 8ZX6; 9BBL; 9BBM; 9BXI; 9BXO; 9BXQ; 9BXR; 9EO7; 9EO9; 9EOE; 9EOG; 9EOH; 9ERM; 9ERN; 9ERO
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