Entry: PS51496

Forthcoming changes to the profile format
General information about the entry

Entry name [info] CVC
Accession [info] PS51496
Entry type [info] MATRIX
Date [info] JUN-2010 (CREATED); OCT-2013 (DATA UPDATE); JUN-2010 (INFO UPDATE).
PROSITE Doc. [info] PDOC51496
Associated ProRule [info] PRU00829

Name and characterization of the entry

Description [info] CVC domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=54;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=49;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.9688087; R2=0.0082100; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=-4790.41176; R2=25.51471; TEXT='HScore';
/CUT_OFF: LEVEL=0; SCORE=918; N_SCORE=8.5; H_SCORE=17050; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=674; N_SCORE=6.5; H_SCORE=12407; MODE=1; TEXT='?';
/DEFAULT: M0=-14; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='K'; M=-18,  0,-67,  0, -1,-68,-18,-11,-18, 55,-38,  8,  9,-18,  8, 36,  2,  3,-28,-42,-48, -1;
/M: SY='C'; M=-18,-28, 28,-35,-38,-50,-32,-18,-13,-18,-41,-24,-23,-21,-31,  0, -3,-12,-11,-52,-25,-33;
/M: SY='W'; M=-70,-60,-90,-80,-90,  0,-80,-30,-60,-40,-20,-50,-50,-70,-60, 20,-30,-60,-80,180,-10,-70;
/M: SY='G'; M= 10,  0,-40,  0,  0,-60, 60,-30,-30,-20,-50,-40,  0,-10,-20,-40, 10,  0,-20,-80,-60,-10;
/M: SY='R'; M= -7, -2,-45, -6, -6,-55,  7, -1,-25, 13,-43,-21,  3, -8, -1, 14,  0, -5,-26,-37,-50, -2;
/M: SY='S'; M= 10, 10,  0,  0,  0,-40, 10,-10,-20,  0,-40,-20, 10, 10,-10,-10, 20, 20,-10,-30,-30,-10;
/M: SY='T'; M= 10,  6,-13,  0, -4,-40,  6,-14,-11,  0,-31,-16,  6,  6,-10,-10, 20, 29, -6,-43,-30,-10;
/M: SY='I'; M= -6,-27,-28,-27,-22,-13,-24,-28, 42,-18, 15, 19,-17,-24,-26,-20,-13,  0, 39,-69,-28,-22;
/M: SY='M'; M=-20,-30,-60,-40,-30,  0,-40,-30, 20, 10, 40, 80,-20,-30,-10,-10,-20,-10, 20,-50,-30,-20;
/M: SY='A'; M= 30,  0,-30,  0,  0,-40, 10,-20,-10,-20,-20,-20,  0, 10,-10,-20, 10, 10,  0,-70,-40,  0;
/M: SY='E'; M=  0, 30,-70, 40, 50,-70,  0,  0,-30,  0,-40,-30, 20,-10, 30,-20,  0,-10,-20,-90,-50, 40;
/M: SY='Y'; M=-40,-40,  0,-50,-50, 70,-60,  0,-20,-50,-20,-30,-20,-60,-50,-50,-30,-30,-30,-10,110,-50;
/M: SY='G'; M= 10,  0,-40,  0,  0,-60, 60,-30,-30,-20,-50,-40,  0,-10,-20,-40, 10,  0,-20,-80,-60,-10;
/M: SY='L'; M=-20,-40,-70,-50,-40, 20,-50,-30, 20,-40, 70, 40,-40,-30,-20,-40,-40,-20, 20,-20,-20,-30;
/M: SY='Y'; M=-40,-40,  0,-50,-50, 70,-60,  0,-20,-50,-20,-30,-20,-60,-50,-50,-30,-30,-30,-10,110,-50;
/M: SY='G'; M= 10,  0,-40,  0,  0,-60, 60,-30,-30,-20,-50,-40,  0,-10,-20,-40, 10,  0,-20,-80,-60,-10;
/M: SY='A'; M= 30,  0,-30,  0,  0,-40, 10,-20,-10,-20,-20,-20,  0, 10,-10,-20, 10, 10,  0,-70,-40,  0;
/M: SY='M'; M=-20,-30,-60,-40,-30,  0,-40,-30, 20, 10, 40, 80,-20,-30,-10,-10,-20,-10, 20,-50,-30,-20;
/M: SY='V'; M=  0,-30,-20,-30,-20,-20,-20,-30, 40,-30, 20, 20,-20,-20,-30,-30,-10,  0, 50,-80,-30,-20;
/M: SY='R'; M=-20,-10,-40,-20,-20,-50,-40, 20,-20, 40,-40,-10,  0,  0, 10, 70,-10,-10,-30, 20,-50,  0;
/M: SY='H'; M=-20, 10,-40,  0,  0,-20,-30, 80,-30,-10,-30,-30, 20,-10, 30, 20,-10,-20,-30,-30,  0, 20;
/M: SY='C'; M= -1, -6, 33,-16,-19,-45, -4,-18,-23,-19,-48,-31, -6, -4,-26,-18, 15,  6,-13,-46,-22,-26;
/M: SY='L'; M=-15,-35,-49,-39,-35, 15,-39,-30, 41,-29, 44, 29,-29,-30,-25,-29,-29, -9, 31,-41,-20,-30;
/M: SY='P'; M= 10,-10,-40,-20,-10,-60,-10,-10,-30,-20,-30,-30,-10, 70,  0,  0, 10,  0,-20,-70,-60,-10;
/M: SY='L'; M=-20,-40,-70,-50,-40, 20,-50,-30, 20,-40, 70, 40,-40,-30,-20,-40,-40,-20, 20,-20,-20,-30;
/M: SY='P'; M= 10,-10,-40,-20,-10,-60,-10,-10,-30,-20,-30,-30,-10, 70,  0,  0, 10,  0,-20,-70,-60,-10;
/I:         I=-5; MI=0; MD=-11; IM=0; DM=-11;
/M: SY='E'; M= -2, 32,-66, 41, 42,-70, -2, -1,-29,  5,-44,-31, 23,-15, 25,-15,  0, -5,-25,-82,-50, 33;
/M: SY='T'; M= 10,  5,-14,  0, -5,-40,  5,-15,-11,  0,-31,-15,  5,  5,-10,-10, 20, 29, -5,-44,-30,-10;
/M: SY='I'; M= -7,-30,-27,-30,-27,  2,-27,-30, 55,-23, 20, 20,-20,-27,-30,-23,-17,  0, 43,-65,-23,-27;
/M: SY='L'; M=-15,-35,-58,-42,-35, 13,-42,-29, 27,-32, 52, 32,-32,-27,-21,-33,-31,-11, 23,-32,-21,-28;
/M: SY='K'; M=-11, 11,-61, 11,  7,-58, -7,  0,-21, 36,-41, -4, 17,-16,  8, 20,  4,  0,-26,-46,-40,  3;
/M: SY='S'; M= 10, 10,  0,  0,  0,-40, 10,-10,-20,  0,-40,-20, 10, 10,-10,-10, 20, 20,-10,-30,-30,-10;
/M: SY='A'; M= 27,  0,-31,  0, -1,-41, 13,-21,-11,-18,-22,-21,  0,  8,-11,-21, 11, 12, -1,-70,-41, -1;
/M: SY='K'; M=-13,  9,-69, 11, 14,-63,-15, -8,-21, 31,-33, -3, 11,-18, 14, 13, -3, -4,-24,-55,-48, 11;
/I:         I=-15; MD=-32;
/M: SY='D'; M=  5, 21,-46, 25, 23,-54, 12, -6,-24, -4,-39,-30, 16, -9,  7,-19,  5,  0,-19,-68,-42, 15; D=-15;
/I:         I=-15; MI=-32; IM=-32; DM=-32;
/M: SY='G'; M=  8, 14,-40, 14, 10,-51, 28,-10,-24, -7,-44,-30, 13, -7, -6,-22, 10,  3,-18,-66,-43,  0;
/I:         I=-13; MI=0; MD=-27; IM=0; DM=-27;
/M: SY='L'; M= -9,-18,-39,-23,-19,  0,-24,-15, 10,-16, 24, 19,-16,-11,-10,-17,-16, -8,  9,-26,-18,-15; D=-13;
/I:         I=-13; DM=-27;
/M: SY='M'; M= -7, -9,-38,-10, -4,-17,-19, -8,  4, -5, 10, 17, -7,-13,  2,-10,-11, -6,  6,-40,-25,  0; D=-13;
/I:         I=-13; DM=-27;
/M: SY='E'; M=  4, 17,-55, 23, 25,-65, 24,-11,-30, -8,-45,-35, 12,-11,  8,-26,  4, -4,-23,-81,-54, 16;
/M: SY='S'; M= 10,  5,  1, -3, -4,-41,  7,-13,-19, -6,-38,-22,  5,  7,-13,-13, 18, 17, -9,-39,-30,-12;
/M: SY='C'; M=-16,-39, 63,-46,-48,-46,-29,-35, -6,-53,-37,-31,-36,-29,-52,-35, -2,-17,  4,-85,-13,-48;
/M: SY='A'; M= 30,  0,-30,  0,  0,-40, 10,-20,-10,-20,-20,-20,  0, 10,-10,-20, 10, 10,  0,-70,-40,  0;
/M: SY='P'; M= 10,-10,-40,-20,-10,-60,-10,-10,-30,-20,-30,-30,-10, 70,  0,  0, 10,  0,-20,-70,-60,-10;
/M: SY='W'; M=-70,-60,-90,-80,-90,  0,-80,-30,-60,-40,-20,-50,-50,-70,-60, 20,-30,-60,-80,180,-10,-70;
/M: SY='L'; M=-20,-40,-70,-50,-40, 20,-50,-30, 20,-40, 70, 40,-40,-30,-20,-40,-40,-20, 20,-20,-20,-30;
/M: SY='L'; M=-20,-40,-70,-50,-40, 20,-50,-30, 20,-40, 70, 40,-40,-30,-20,-40,-40,-20, 20,-20,-20,-30;
/I:         I=-5; MI=0; MD=-11; IM=0; DM=-11;
/M: SY='G'; M=  9,  0,-40, -1, -1,-60, 56,-28,-30,-18,-50,-39,  0,-10,-19,-35,  9,  0,-20,-76,-60,-10;
/M: SY='M'; M=-20,-30,-60,-40,-30,  0,-40,-30, 20, 10, 40, 80,-20,-30,-10,-10,-20,-10, 20,-50,-30,-20;
/M: SY='H'; M=-20, 10,-40,  0,  0,-20,-30, 80,-30,-10,-30,-30, 20,-10, 30, 20,-10,-20,-30,-30,  0, 20;
/M: SY='K'; M=-20, -2,-64, -4, -4,-66,-24, -4,-20, 56,-40,  6,  8,-16, 10, 46, -2, -2,-30,-28,-50,  0;
/M: SY='K'; M=-20,  0,-70,  0,  0,-70,-20,-10,-20, 60,-40, 10, 10,-20, 10, 40,  0,  0,-30,-40,-50,  0;
/M: SY='S'; M= 10, 10,  0,  0,  0,-40, 10,-10,-20,  0,-40,-20, 10, 10,-10,-10, 20, 20,-10,-30,-30,-10;
/M: SY='M'; M= -7,-22,-45,-28,-24, -7,-26,-26, 18,-14, 24, 28,-18,-19,-17,-21,-13,  2, 17,-46,-26,-20;
/M: SY='E'; M=  1, 19,-62, 25, 32,-62, 11, -9,-26, -4,-37,-25, 13,-12, 15,-24,  1, -7,-18,-84,-51, 23;
/I:         E1=0; IE=-105; DE=-105;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_09 which contains 546'439 sequence entries.


Total number of hits 13 in 13 different sequences
Number of true positive hits 13 in 13 different sequences
Number of 'unknown' hits
Number of false positive hits
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] DOMAIN
Feature description [info] CVC
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
13 sequences

HM10_CAEEL  (P41935), VSX1_BOVIN  (Q9GMA3), VSX1_CARAU  (Q90277), 
VSX1_CHICK  (Q9IAL2), VSX1_DANRE  (O42250), VSX1_HUMAN  (Q9NZR4), 
VSX1_MOUSE  (Q91V10), VSX1_XENLA  (Q0P031), VSX2_CHICK  (Q9IAL1), 
VSX2_DANRE  (O42477), VSX2_HUMAN  (P58304), VSX2_MOUSE  (Q61412), 
VSX2_ORYLA  (Q9I9A3)
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