Entry: PS51529

Forthcoming changes to the profile format
General information about the entry

Entry name [info] CYSTATIN_FETUIN_A
Accession [info] PS51529
Entry type [info] MATRIX
Date [info] MAR-2011 (CREATED); OCT-2013 (DATA UPDATE); SEP-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC00966
Associated ProRule [info] PRU00861

Name and characterization of the entry

Description [info] Fetuin-A-type cystatin domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=113;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=108;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.8541539; R2=0.0089748; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=18386.05425; R2=18.32698; TEXT='HScore';
/CUT_OFF: LEVEL=0; SCORE=2134; N_SCORE=22.0; H_SCORE=57478; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=318; N_SCORE=5.7; H_SCORE=23793; MODE=1; TEXT='R?';
/DEFAULT: M0=-48; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='K'; M=   4, -96,  23, -13, -86, -89,   9, -86,  63, -53, -80, -73, -37,  28,  31, -75, -20,  -2, -90,  36;
/M: SY='R'; M=  -4, -91,   6, -78,  -2, -88, -10, -32,  19,  15, -72,  28, -93, -76,  36,  18, -74,  33, -98, -79;
/M: SY='C'; M= -25, 133, -92, -20, -89,   3, -92, -90, -18,   2, -82, -45, -40,   4, -58, -81, -81, -84,-108, -94;
/M: SY='P'; M= -40,-103,  -3, -73, -96, -87, -43, -83, -80,  -5, -81, -86, 112,  26, -53, -24, -77, -20, -98, -93;
/I:         I=-17; MI=0; MD=-42; IM=0; DM=-42;
/M: SY='D'; M=  -7, -94,  67,   9, -99,  13,   0, -99,  29, -98, -90,  48, -86,  -1,  17, -35, -12, -94,-104, -87;
/M: SY='C'; M= -80, 155,-100,-100, -90, -96,-100, -97, -96, -88, -88, -86,-111,-104,-102, -83, -80, -85,-120,-101;
/I:         I=-21; MD=-53;
/M: SY='P'; M= -57,-129,-110, -99,  -8,-109,-112,-113,-105,-119,-110,-114,  99,-109,-116, -48,-101,-117,  13,-111; D=-21;
/I:         I=-21; MI=-53; MD=-53; IM=-53; DM=-53;
/M: SY='L'; M=-105,-114, -10,-110, -92, -31,  23,  24,-114,  43, -80,-108,-118,-107,-114, -24,-102, -83,-118, -97; D=-21;
/I:         I=-21; DM=-53;
/M: SY='L'; M=-109,-111,-126,-118, -82,-128,-110, -73,-120,  72, -70,-125,-126,-112,-117,-119,-105, -81,-113, -95; D=-21;
/I:         I=-21; DM=-53;
/M: SY='A'; M=  37,-107,-115,-109, -96,-108,-111, -14,-110,  35, -84,-110,-114,-107,-113, -96,  12, -84,-116,-103; D=-21;
/I:         I=-21; DM=-53;
/M: SY='P'; M=-106,-129,-105, -97,-126,-108,-108,-116, -99,-125,-111, -22,  99,-103, -10, -31, -99,-120,-121,-121; D=-21;
/I:         I=-21; DM=-53;
/M: SY='L'; M=-109,-112,-124,-116,  28,-124,-110, -79,-117,  56, -77,-121,   5,-114,-116, -58,-104, -53,-107, -89; D=-21;
/I:         I=-21; DM=-53;
/M: SY='N'; M= -82, -92,  65, -65, -98, -75,  43, -98, -68,-100, -89, 103, -89,  32, -51, -32, -70, -99,-114, -85;
/M: SY='D'; M= -81, -96, 102,  32,-102, -43,  21,-102, -41,-100, -96,   8, -84, -69, -79,   9, -13, -98,-114, -87;
/M: SY='P'; M= -77, -92,   2, -34, -95, -85, -84, -87,   2, -92, -85, -10,  87, -78, -34,  -8,  78, -67,-103, -91;
/M: SY='Q'; M= -80, -98,  34,  55,-100, -26,  36,-100,  16, -96, -86,  33, -84,  59,  37, -12, -77, -97,-101, -84;
/M: SY='V'; M=  41, -85,  19, -83, -84,  11, -93, -35, -86, -73, -73, -80, -89, -86, -90, -71,  35,  71,-103, -85;
/M: SY='V'; M= -31, -89, -78,  45, -79, -95, -85, -59,  32,  27, -67,  18, -90, -75, -76, -80, -74,  64, -99, -82;
/M: SY='H'; M=  -3, -97,  54,  40, -93, -86, 100, -29, -34, -90, -81,   4, -85,  47, -73, -73, -31, -92,-105, -22;
/M: SY='W'; M=  74, -84, -88, -82,  -4, -75, -89, -79, -83, -24, -78, -81, -87, -80, -87,  35,  16, -15,  83, -77;
/M: SY='V'; M=  67, -83, -93, -87, -82, -83, -95,  -4, -87, -69, -69, -87, -90, -86, -90, -70,   9,  72,-100, -85;
/M: SY='D'; M= -82, -94,  54,  51, -85, -90, -75, -80,  28,  42, -73,  28, -87,   7, -73, -29, -77, -82, -99, -83;
/M: SY='A'; M=  63, -85, -42,  -1, -37, -81, -84,  -9, -81, -39, -10, -80, -86, -22, -85, -15,  44,  18, -90,  31;
/M: SY='A'; M=  90, -81, -86, -80, -93,  -5, -88, -80, -82, -85, -80, -79, -86, -78, -87,  16, -70,   4, -96, -89;
/M: SY='L'; M= -81, -88, -95,   3, -66, -54, -89, -23, -91,  74, -53, -97, -98, -18, -91, -90, -78,  48, -94, -76;
/M: SY='D'; M=  48, -90,  56, -68, -94, -44,  43, -50, -71, -35, -82,  35, -87,  32,  19, -21,  -4, -84,-103, -83;
/M: SY='Y'; M=  41, -90,  -3, -77,  29, -44, -18, -81,  35, -79, -75,  -4, -89, -75, -73, -24,   7, -71, -69,  90;
/M: SY='F'; M= -86, -91, -98, -96,  90,-100,  44,  65, -93,   7, -61, -89, -97, -93, -92, -16, -80, -57, -73,  -3;
/M: SY='N'; M= -80, -85, -53, -74, -94, -68, -60, -94, -65,-101, -87, 129, -91, -67, -74, -62, -64, -96,-114, -90;
/M: SY='E'; M=  48, -89, -13,  54, -97, -16, -74, -92,  14, -91, -83,  44, -81,  53, -70, -24,  -1, -85, -97, -87;
/M: SY='H'; M= -80, -96, -58,  -1, -63,  -2,  98, -98,  25, -91, -78,  56, -85,  84, -42, -69, -78, -97,-101, -73;
/M: SY='N'; M= -78, -87, -68, -76, -56, -79,  80, -80,  12,  25, -72,  86, -89, -70, -73,  28,  -6, -47,-104, -75;
/I:         I=-30; MD=-77;
/M: SY='H'; M=-103,-114, -22,-100,-103, -25,  47, -96, -98,  16, -91,  -2,  16, -59,   4, -98,   8, -34,-122, -99; D=-30;
/I:         I=-30; MI=-77; IM=-77; DM=-77;
/M: SY='H'; M= -67, -92, -27, -72, -87, -78, 107, -92, -71, -20, -77,  85, -18,  14, -28,  11, -73, -94,  47, -70;
/M: SY='G'; M= -69, -93,  -7, -37, -97,  91, -86, -97,  24, -97, -88, -67, -84, -79, -66, -67,  13, -21, -94, -91;
/M: SY='Y'; M= -52, -89, -81, -83,  -3, -85,  51, -74, -80, -76, -73, -74, -89, -76, -81,  49,  50,   5, -71,  97;
/M: SY='Y'; M= -83, -95, -78, -72, -38, -90,  15, -32,  80, -80, -74,   6, -89, -67, -17, -78, -77,  -7, -70,  94;
/M: SY='F'; M= -88, -92, -90, -85,  97, -95,  58, -72, -84, -13, -68, -29, -97,  41, -82, -82,  -9, -76, -65,  63;
/M: SY='K'; M=  31, -90, -77,  17, -89, -86, -80,  17,  60, -79,   1, -74, -83,  47,   2, -71,  12,   8, -94, -82;
/M: SY='L'; M= -83, -86,-102, -95,  32,-103, -87, -49, -95,  84,  23, -99,-101, -90, -92, -93, -79,  17, -86, -66;
/M: SY='N'; M= -80, -88, -74,   6,   1, -87,  31, -64, -79,  11,  41,  84, -94, -77, -83, -77, -73,  48,-102, -77;
/M: SY='E'; M= -77, -98, -61,  89, -98, -92, -74, -42, -62, -89, -84, -75, -81,  61,  14,  11, -77,   4, -98, -87;
/M: SY='I'; M= -82, -96,-101, -96, -71,-107,-100,  99, -39, -36, -57, -93, -93,  19, -94, -90, -77,  30, -95, -77;
/M: SY='S'; M= -30, -92,  59,  24,-100,  40, -78,-100,  12,-100, -93, -22, -84, -70, -78,  62, -70, -94,-102, -90;
/M: SY='R'; M= -81, -98, -23,  20, -95, -40, -73, -24,  17, -93, -84,   4, -89, -24,  94,  18, -78, -91, -97, -84;
/M: SY='A'; M=  56, -88, -92, -88, -10,   4, -90,  38, -82, -71,  24, -22, -91, -83,  16, -74, -75,  40, -95, -81;
/M: SY='Q'; M= -75, -20, -76, -64, -97, -85,  33, -88,  38, -89, -79, -69, -86,  95,   8,  36,   9,  -8, -97, -80;
/M: SY='V'; M=   2, -88, -87, -87, -31, -90,  44,  14, -30,  22, -65,  24, -58, -83, -86,   4,  10,  54,-101, -77;
/M: SY='W'; M= -79, -96, -88,   2, -76, -96, -86, -27,   8,   2, -70, -86, -92,  71, -76, -81, -32,  57,  94,  -3;
/M: SY='P'; M= -33,-105, -89, -80, -39, -11, -86, -12,  11, -93, -85, -87,  92,  -4, -85,   2, -81, -90,  70,  42;
/M: SY='W'; M= -84, -98, -84,  25, -18, -34,   2, -79,   2,  15,  41, -84,  10,   3,  41, -20, -32, -15,  51,   0;
/M: SY='P'; M=  14, -99,  13, -76,   2, -16, -84, -94, -75, -96, -88,  -9,  80,  -7,  33,  -2,  10, -91, -99, -89;
/I:         I=-22; MD=-57;
/M: SY='P'; M= -42,-119,  22, -97, -17,  20,-105,-113,-104,-115,  -9, -25,  60,-103,-112, -10, -98, -67,-119,-109; D=-22;
/I:         I=-22; MI=0; MD=-57; IM=0; DM=-57;
/M: SY='G'; M= -89,-109, -97, -37,-107,  50,-103, -97,-101, -42, -99,  17, -14, -99,-107,   1, -19,  12,  -1,-106; D=-22;
/I:         I=-22; DM=-57;
/M: SY='E'; M= -40,  50,   4,  56, -94, -69, -84, -40, -36, -36, -82,  -5,  45,  27, -24, -80, -79,  30,-104, -91;
/M: SY='S'; M=  17, -90, -83,  13, -88, -86, -86,  28,  -4, -53,  25, -79, -88,  10, -82,  54,   2,  17,-100, -85;
/M: SY='Y'; M= -47, -92, -96, -95,  60,-100,  11, -31, -91, -48, -70, -89, -99, -92, -91, -82,  38,  48, -74,  77;
/M: SY='Y'; M= -86, -97, -38,  23,  55, -98,  32, -15, -82, -23, -73, -86, -96,  15, -17,  -6, -82,  12, -75,  74;
/M: SY='V'; M=  -5, -89,-102, -96,  15,-100, -95,   3, -95,  42,  29, -97, -99, -93, -95, -27, -28,  63, -96, -76;
/M: SY='E'; M= -80,-102, -58,  99,-105,  16, -76,-106,  -3, -99, -93, -29, -80,  16, -73, -76, -83, -99,-100, -94;
/M: SY='F'; M= -90, -94,-106,-103,  89, -32, -91,  42, -99,  27, -64, -98,-103,-101, -98, -94, -85,  -8, -74,  16;
/M: SY='D'; M=  48, -90,  63, -17, -95, -82, -84, -39, -38, -88, -85,  26, -88, -79, -85, -69,  38,  13,-108, -90;
/M: SY='I'; M= -83, -92, -98, -23,  -2,-105, -96,  62, -94,  42,  -2, -93, -96, -91, -96, -86,  36,  22, -96, -76;
/M: SY='L'; M=  30, -90, -93,  12, -75, -94, -89,  -6, -89,  51,  42, -93, -95, -84, -91, -16, -78,  28, -97, -50;
/M: SY='E'; M=  38, -96, -62,  92,-102,   1, -80, -99, -70, -96, -91, -79, -81, -63, -79, -20, -79, -59,-100, -94;
/M: SY='T'; M= -73, -84, -81, -83, -88, -90, -90, -30, -81, -82, -79, -71, -30, -84, -88,   9, 105,   8,-109, -87;
/M: SY='N'; M= -29, -93,  54,  41,-100, -83, -74, -97,  -1, -99, -92,  77, -86, -70, -77, -69,  46, -92,-112, -92;
/M: SY='C'; M= -83, 153,-103,-103, -93, -98,-103,-100, -99, -91, -91, -89,-114,-106,-105, -85, -83, -88,-123,-104;
/M: SY='H'; M= -32, -94, -80, -79, -89, -89, 112, -43, -21, -86, -78, -71,  13, -76, -80,  19,  47,  12,-112, -73;
/M: SY='A'; M=  55, -89, -90, -86, -85, -56, -92,  17,  10, -33, -75,   4, -92, -83, -85,   7, -74,  41,  42, -85;
/M: SY='Q'; M= -30, -95, -88,  -2, -11, -97, -83, -68,  42,  42,   8, -87, -33,  44, -74, -84, -81,  20, -90,  12;
/M: SY='D'; M= -82, -99,  76,  64,-103, -87, -75, -97, -36, -98, -93,  32, -85,  30, -77,  -1, -77, -18,-110, -91;
/M: SY='P'; M=  48, -96,   0, -79, -97, -52, -91, -53, -85, -60, -84, -87,  91, -86, -93, -39, -16,  12,-102, -96;
/M: SY='T'; M= -27, -90,  -1, -76, -91, -89,  38, -85,  22, -52, -82, -26,   8,  -3, -49, -29,  87, -44,-105, -38;
/M: SY='P'; M= -48,-106,  62,  -5,-106, -87, -83, -97, -78, -59, -92, -77,  98,  27, -87,  -2, -78, -98,-105, -96;
/I:         I=-20; MD=-50;
/M: SY='V'; M=   4,  27,  20, -83, -85, -63, -89, -67, -37,  25, -73,  23,  37,  -4, -90, -39, -77,  44,-105, -88; D=-20;
/I:         I=-20; MI=0; MD=-50; IM=0; DM=-50;
/M: SY='A'; M=  59,  34,  20,  48, -97, -83,  44, -88, -45, -90, -85, -77, -39, -74, -83, -30, -21,  -3,-105, -89;
/M: SY='N'; M=  19, -92, -72, -73, -96, -53,  21, -89,  41, -49, -83,  79, -91,  48, -40, -22, -74, -11,-104, -87;
/M: SY='C'; M=   4, 145,-101,-100, -92, -72,-101, -13, -97, -88, -87, -89,-109,-102,-103, -83, -82, -82,-117,-101;
/M: SY='H'; M= -45, -93,   3, -21, -94, -83,  64, -93,   7, -22, -84,  59,  14, -10, -44,  33,  29, -91,-108, -84;
/M: SY='V'; M=  -2, -92, -97, -91, -80,  -9, -96, -29, -89,  26, -68, -92,  37, -91, -22, -82,  18,  62,-102, -86;
/M: SY='R'; M= -31, -98, -90, -83, -80, -13, -79, -79, -65,  45, -70,  -1, -42, -74,  83, -85, -85, -81, -94,   0;
/M: SY='C'; M=  23,  66, -33, -36, -97, -28, -86, -39, -44, -40, -17, -81,  58,  64, -84, -74,  24, -56,-102, -92;
/M: SY='E'; M=  -2, -99, -16,  52, -42,  14, -81, -88,  11,   8, -81, -80,   8,  51, -11, -78, -83, -38, -97, -88;
/M: SY='K'; M=  36, -93,  21, -22, -97,   1,  47, -29,  47, -92, -51, -72, -87, -20, -25, -32,  33, -85,-102, -86;
/M: SY='Q'; M= -81,-102, -66,  67, -99, -90,  -9, -97, -38, -95, -86,  25,  -8,  89, -70,  -5, -80, -46, -97,   2;
/M: SY='H'; M=  -3, -96,  11, -78, -76, -17,  98, -92, -80, -87, -79, -41, -91,   2, -81, -18,  45, -89, -89,  69;
/M: SY='A'; M=  58, -90, -84, -82, -96,  37,  44, -91,  11, -52, -84, -16, -89, -77,  -1,   3, -28, -27,-100, -88;
/M: SY='V'; M= -18, -91,-100, -96,  53, -31, -93,  11, -93, -66, -69, -93, -99, -24, -94,  -5, -76,  72, -86,  30;
/I:         I=-24; MD=-61;
/M: SY='E'; M= -17,-111, -79,  70,-110,  32, -95, -45, -86,-108,-103, -90, -95, -81, -95, -86,   3,-104,-110, -23; D=-24;
/I:         I=-24; MD=-61;
/M: SY='G'; M=   3,-120,-115, -45,-117,  47,-114,-112,-115, -30,  44,-106,-117,-110,-119,-101,-111,-110,-122,-116; D=-24;
/I:         I=-24; MI=0; MD=-61; IM=0; DM=-61;
/M: SY='D'; M=-104,-113,  83, -77,  52,-105, -93, -45,  10,-100,-103, -80,-106, -94, -94, -95, -95,-104,-108, -84; D=-24;
/I:         I=-24; DM=-61;
/M: SY='C'; M= -82, 147,-101, -99, -91, -98,-101, -92, -96, -50, -87, -89,-111,  -7,-102, -85, -82, -16,-120,-100;
/M: SY='D'; M=  -5, -97,  73, -64,-102, -86, -77, -99,  63,-100, -92,  41, -89, -70,   6, -75, -24, -47,-107, -90;
/M: SY='A'; M=  49,  28, -95, -91,  40,  -5, -94, -30, -91, -75,   7, -87, -95, -89, -94,  17, -75,  46, -94, -78;
/M: SY='T'; M= -38, -91, -79, -75, -94, -87,  45, -89,  46, -92, -84, -36,  -8, -13,   9,  35,  67, -30,-104, -84;
/M: SY='V'; M= -81, -92,-103, -96, -72,-106, -99,  48,   5,  34,   4, -97, -99, -92, -91, -92, -78,  67,-100, -80;
/M: SY='F'; M= -11, -91, -93, -88,  44, -94, -88,  12, -26,  19,  33, -30, -95,  13, -88,  15,  27,  14, -92, -72;
/M: SY='K'; M= -57, -98, -76,   6,  -2,  -1,  45, -99,  61, -96, -87,   5,  -9,  15,  25,  11, -24, -96, -97, -82;
/M: SY='Q'; M= -48, -96,  25, -25, -37, -40, -82, -25,  26,   5, -78,  11,  25,  45, -46,  17, -77,  12,-101, -86;
/M: SY='H'; M=   0,  -6,  26,  43, -90, -54,  44, -20, -80,   9, -78,  22,  25, -76, -86, -78,  -4,  -1,-106, -86;
/M: SY='G'; M=  12, -96, -40,  29, -99,  75, -85,-102, -82, -60, -91, -13, -88,  10, -88,  -7, -38, -96, -96, -21;
/M: SY='Q'; M= -12, -96, -81, -48, -97,  18, -84, -15,  27, -91, -84,  -3,  36,  51, -45,   8,  34, -14,-100, -90;
/M: SY='F'; M=   4, -95,  -4,  41,  70, -51, -86, -75, -83,   5, -76, -86, -10,  15, -87, -82,  -9,   0, -86, -68;
/M: SY='E'; M=  -2, -95,  12,  64, -95, -89,   4, -39,   4, -44, -85, -75, -85, -19, -18,  26,  16,   0,-104, -88;
/I:         I=-19; MD=-47;
/M: SY='V'; M= -96,-111,  14,  27,-107,-114,-104, -84,   7, -97, -96, -96,-106, -25, -47, -95,   7,  46,-124,-105; D=-19;
/I:         I=-19; MI=0; MD=-47; IM=0; DM=-47;
/M: SY='V'; M= -31, -94,   9,  40, -89, -95, -88, -15, -30, -50, -41, -16, -91, -14,  -6,   8,   7,  55,-107, -88; D=-19;
/I:         I=-19; DM=-47;
/M: SY='F'; M= -14, -93,-105,-100,  67,-102, -89,  34, -96,  11,  45, -98,-101, -96, -96, -91, -70,  34, -80,  35;
/M: SY='Y'; M= -27, -99,   4,  21,  43, -11,  16, -21,  -4, -82,  -9,   4, -20,  28,  -4, -61, -83, -27, -83,  51;
/M: SY='C'; M=  20,  85, -90,  -6, -90, -44, -95, -73, -88, -82, -13, -85,  -9, -88, -94,  18,  28,  45,-109, -92;
/M: SY='Q'; M= -33,-101,  48, -62,-106, -29,  -7,-102,  63, -99, -89, -34, -88,  79, -63, -16, -37, -99,-102, -88;
/M: SY='C'; M= -84, 119, -93, -87, -94, -96, -94, -91, -26, -13, -85, -85,  44,  32, -92, -80,  37, -86,-111, -96;
/M: SY='H'; M=  -7, -96,  33,  29, -25, -93,  62, -77,  -3, -13, -79,   8, -92, -77, -82, -41, -14,  34,-104, -10;
/I:         E1=0; IE=-255; DE=-255;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_10 which contains 546'790 sequence entries.


Total number of hits 34 in 17 different sequences
Number of true positive hits 34 in 17 different sequences
Number of 'unknown' hits
Number of false positive hits
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 2
Feature key [info] DOMAIN
Feature description [info] Cystatin fetuin-A-type
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
17 sequences

FETAF_PROFL (P29695), FETCA_GLOBR (Q5KQS3), FETCB_GLOBR (Q5KQS2), 
FETC_GLOBR  (Q5KQS4), FETHP_PROFL (Q5KQS5), FETJ_GLOBL  (Q5KQS1), 
FETUA_BOVIN (P12763), FETUA_CAVPO (O70159), FETUA_HUMAN (P02765), 
FETUA_MERUN (P97515), FETUA_MOUSE (P29699), FETUA_PANTR (Q9N2D0), 
FETUA_PIG   (P29700), FETUA_RABIT (P80191), FETUA_RAT   (P24090), 
FETUA_SHEEP (P29701), FTE46_BOTJA (Q9DGI0)
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