PROSITE entry PS51897

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PURL: https://purl.expasy.org/prosite/signature/PS51897

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General information about the entry

Entry name [info]	ANNEXIN_2
Accession [info]	PS51897
Entry type [info]	MATRIX
Date [info]	31-JUL-2019 CREATED; 31-JUL-2019 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00195
Associated ProRule [info]	PRU01245

Name and characterization of the entry

Description [info]

Annexin repeat profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=72;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=72;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.3844311; R2=0.0076669; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1124; N_SCORE=11.0; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=537; N_SCORE=6.5; MODE=1; TEXT='R?';
/DEFAULT: M0=-67; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='D';  M= -26, -33,  45,  19,  41,   1,  -8,-217, -23, -52,   8,  34,  37, -59, -29,   2,  11,-135,-223, -40;
/M: SY='P';  M= -12, -64,  20,-203,-216, -86, -69, -59,   2,  25,  24,  16,  64,  14,   4,  23,   9, -86,-227,-214;
/M: SY='P';  M=  61, -22, -83, -23, -49, -28,  35,  -1,-128, -53, -86, -44,  64, -57, -71, -34, -37,  23, -43, -58;
/M: SY='E';  M=   0, -35,  26,  48,-119, -41, -31, -81,  27, -17, -43, -15, -35,  40,   3,  16,  -8, -36,-224,  -4;
/M: SY='Y';  M=  10, -84, -28,  -3,  25, -42, -16,-107, -30,  -1, -32, -37, -98,  44,  15,  14, -20,  -4,-209,  67;
/M: SY='D';  M=  13,-224,  99,  26,  40,-215,-205, -67,-202, -36,-214,-196,-100, -91,   8,-205,-206, -19,-227, -61;
/M: SY='A';  M=  98,  -7,-214, -14, -80,-136,-217,-146,-210, -57,-206,-211,-215,-207,-133, -38,-200,  15,-224,-217;
/M: SY='E';  M=  -4,-109,  12,  63,  -9,-169,  -2, -82,  46, -60, -52, -27,-213,  62,  15, -62, -89, -95, -41,  14;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='E';  M=  16,-220,  22,  27,-210,-172, -17,  13,  -2,  21,  -6, -64,-217,  20,  22, -21,  -6,   9, -50, -12;
/M: SY='L';  M= -46, -46,-107,-224, -82,-232,-219,  32,-225,  88, -26,-228,-229,-219,-223,-152,-209,   1,-220,-202;
/M: SY='H';  M= -53, -13, -52, -35, -38,-103,  84,-218,  39, -72, -61,  34,-220, -34,  57, -61, -44, -62,  -9,  73;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='K';  M=   1, -22,  32,  49,-152, -47,  11,-221,  56, -57, -48,   5, -93,  50,  -8, -40, -16, -71,-225, -14;
/M: SY='A';  M=  98, -35,-213, -80,-220,-124,-215, -48, -28, -47,-207,-207,-214,-205,-212,  30, -72,-200,-223, -74;
/M: SY='M';  M=-125,  55,-225, -77,   2,  19,-216,  62,-219,  14,  97, -34, -76,-216,-221,-213, -24, -11,-221,-203;
/M: SY='K';  M=  -5,-221,  15,  48,-224, -50, -69,-220,  75, -89,  -5,   4, -72,   5, -28,  23, -22, -51,-226,-214;
/M: SY='G';  M=   5,-221,  -2, -14,-226,  81,-211,-225,  17, -62, -68, -21, -42,   6, -10,  -6, -25, -67,-224,-219;
/I:         I=-21; MI=0; MD=-53; IM=0; DM=-53;
/M: SY='W';  M=  13,-113, -46, -33,  -2,-115, -25, -20,  44,   9,  18, -72, -42, -66, -34, -27, -41, -54,  72,-212; D=-21;
/I:         I=-21; DM=-53;
/M: SY='G';  M= -11,-228, -53, -25,-122,  85, -48,-123,  17, -82,-222, -80,-221, -85, -39, -48, -23, -51,-229,-226; D=-21;
/I:         I=-21; DM=-53;
/M: SY='T';  M=-153, -36, -15, -52, -70,   1,-211, -72,  10, -91,-208, -10, -18, -59, -55,  18,  93,  10,-227,  -3;
/M: SY='D';  M= -65,-224, 107, -18,-229,-209, -30,-227,  -6, -67,-222,  59,-215, -71, -27, -19, -38,-121,-242,-216;
/M: SY='E';  M= -48,-225,  38,  92, -23, -77,  38, -95,   5,-108,-214, -30, -83,-190, -21, -41, -65, -15,-224,   7;
/M: SY='D';  M=   1,-222,  54,  27, -75, -17, -51, -35,  35, -54, -16,  32, -65,   7,  21,   3, -20, -53,   4, -89;
/M: SY='T';  M=  43,  15,   3,  -1,-216, -84, -45,-113,  -5, -69,   7,-204,-215, -23,  29, -23,  59,  25, -41, -37;
/M: SY='L';  M= -95,-220,-233,-227,  43,-233,-222,  65,-225,  65,  10,-227,-119,-222,-224,-222,-100,   4,  43,-195;
/M: SY='I';  M= -14,   8,-222,-222, -44,-103, -38,  85,-217, -17,   4,  14,-221, -68, -39, -47,  13,  34,-225,-206;
/M: SY='R';  M= -87,-225,  45,  59, -54, -92, -65,-224, -62, -88,  -5,  -5, -96, -31,  78,  10,  13,-219,-228, -51;
/M: SY='I';  M=-119,-107,-231,-228,   0,-234,-228,  97,-224,   1,   3, -77,-223,-222,-226,-218, -17,  40,-221,-202;
/M: SY='L';  M= -13,-216,-226,-221,   7,-226,-117,  15,-220,  69,  56,-220,-224,-216,-220, -65,  39,  11,-220,-201;
/M: SY='C';  M=  39,  80,-216,-215, -81,  10,-219,   7,-212, -57,-205,-206,-218,-213, -34,  26,  55,  23, -71,-215;
/M: SY='T';  M= -38,-104,-108, -26, -82, -84,  19, -63,  -8,  -5,  21,   9,-147,  -2, -11,  51,  81,-205,-229, -92;
/M: SY='R';  M= -72,  35,-213,-204,-212,-222, -27, -90, -57, -92,  23,-206,-222, -63, 107, -10,  -9, -39,  10,  32;
/M: SY='S';  M= -17, -53, -65, -86, -17, -66, -91,-211, -78, -80, -21,  17,   2, -27,-150,  88,  49, -17, -39, -45;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='N';  M=   6,-225,-202,  40, -39, -90, -85, -96,  14, -67,-215,  62,  50,-105, -13,   7, -38, -39, -77,  20; D=-36;
/I:         I=-36; DM=-90;
/M: SY='E';  M=  27, -12,  32,  45, -95, -42, -34,   9, -13, -40, -51, -17,  28,   4, -37, -16, -21, -16,-228, -28; D=-36;
/I:         I=-36; DM=-90;
/M: SY='Q';  M=-120,-230,  73,  55,-229,-108,  80,-230,-195,-223,-214, -99,-213,  92,-199, -81,-209,-228,-232, -29;
/M: SY='W';  M=-215,  20,-225,-216, -53,-229,-212,   8, -15,  57,  49,-219,-111,-207,  65,-149, -85, -73,  72,  11;
/M: SY='Q';  M= -26,  17, -57,  -7, -42, -95,  22, -51,  32,  14,   3,  13, -85,  66,  47, -61, -61, -45, -53,  -4;
/M: SY='Q';  M=  18,-127,   5,  38, -83, -38,  16,-115,  35,  16, -45,  17, -72,  39,  20, -28, -56, -73,-226,-100;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='I';  M= -25,  35,-227,-225, -39, -96,-227,  87,-117,  -7, -10, -47,-222,-221,-225,-211,  33,  35,-226,-207;
/M: SY='R';  M=  30, -15,-213,-114,  50, -80, -40, -87,  50, -26, -24,   7,-171, -36,  53, -39, -92,  -5,-215,  -9;
/M: SY='Q';  M=  18, -82,  13,  24, -24, -63, -12, -97,  35, -67,-210,  12, -89,  67,  12, -33,  -1, -31,-221,  14;
/M: SY='A';  M=  59,  -9,-124,  44, -79,-119,  42, -65, -15, -93, -22,  -8,-215,  19,  -6, -33,  -7,   5,-224,   4;
/M: SY='Y';  M= -45,-226,-223,-224,  75,-226,-193, -82,-217,-198,-199,-221,-231,-215,-214, -51,-213,-207,-181, 128;
/M: SY='Q';  M= -53, -19,-203,  23, -51,-159,  18, -39,  62, -56,   5,  -8,-215,  67,  18, -10,   4, -63,-221,  11;
/M: SY='K';  M=   8, -84,   7,  39,-224,-137, -47,-100,  50, -63,-212,   5,-213,  28,  25,  30,  10, -26, -41,-214;
/I:         I=-23; MD=-58;
/M: SY='M';  M= -40, -72, -13,  15, -39,-223,   1,  26,  18,  12,  55, -12,-219,  12,  15, -62,  17, -43,-218,  36; D=-23;
/I:         I=-23; MD=-58;
/M: SY='Y';  M= -45,-121,-107,-219,  56, -24, -24, -67, -74, -63,-203, -19,-224, -92,-214,   8,  46,-208,-195, 105; D=-23;
/I:         I=-23; MD=-58;
/M: SY='G';  M= -92,-227, -29, -43,-232,  80, -52,-233,  34,-232,-222,  35, -53,  24, -62, -24,-212, -57,-228,-224; D=-23;
/I:         I=-23; MD=-58;
/M: SY='K';  M=-109,-131, -48,   3, -66, -87,  15, -19,  70, -58, -13, -17,-221,  12,  28, -41,   1, -27,-227,   6; D=-23;
/I:         I=-23; MI=0; MD=-58; IM=0; DM=-58;
/M: SY='D';  M= -56,-116,  77,  24, -66, -79, -11, -93, -22,-224,-219, -37,  22, -46,-209,  63,  10, -43,-235, -72;
/M: SY='L';  M= -57,-219,-230, -49, -25, -60, -61,  38,-223,  78,  57,-227, -35,-217,-223,-221,-210, -30,-220,-202;
/M: SY='E';  M=  -9, -33,  23,  65, -96,   1, -32,  -2, -29,  -5, -41,  -2, -10, -25, -55, -10, -42, -15,-224,  14;
/M: SY='E';  M=  13,-224,  50,  51,-227,-127,  12,-226,  43,-223, -48, -30,-212,  44,  -6,  20, -25,-220,-229, -61;
/M: SY='D';  M=  51,-219,  82, -21,  -3, -83, -13,-214,-123, -57,  12, -68,-115, -69, -39,   6,  -2, -27, -35, -49;
/M: SY='I';  M=-213, -40,-234,-229,  28,-236,-226,  85,-226,  49,  -3,-227,-227,-112,-227,-222,-208,  17,-219,-200;
/M: SY='K';  M=  14, -16,  12,  23, -51, -49, -52, -52,  66, -43,  -7, -43,-215,  10,  29, -25, -24, -15,-225,-100;
/M: SY='K';  M= -22,-221,   6,   5,-223,  11, -33,-118,  61, -74, -42,   1,-214, -49,  15,  57, -15,-218,-226, -31;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='E';  M=  12,  50,  68,  72, -96, -80,  24,-222,-103, -66, -57, -53, -27, -45, -19, -80, -56, -32,-233, -37;
/M: SY='T';  M= -71, -19, -78,-218,  38, -90, -12, -11,-216,  42,  19,-212, -64,-216,-219, -25,  75, -18,  19,  11;
/M: SY='S';  M= -71, -64,  23, -42,-225,   1,  14,-123,  49,-186,-217, -72, -43, -55, -51,  82,   9, -73,-230,-215;
/M: SY='G';  M= -49,-223,  22, -61, -63,  88,  -6,-232,  -8,-230,-221,   2, -70,-208, -69,   6,   1,-151,-226,-220;
/M: SY='D';  M= -37,-225,  81, -36, -22,   0,  57, -86,  14, -96, -61,  39, -20, -53, -10, -13, -62, -64,-231,  -4;
/M: SY='Y';  M= -50, -37,  -4, -12,  72,-227, -56, -11,-217,  26,  -3,-219, -17, -85, -92, -58, -32,  -3,  -7,  75;
/M: SY='E';  M=  -1, -66, -53,  70, -51, -44, -26,-118,  21, -32,  -9, -48, -52,  48,  45, -56, -93,-117,-221,  13;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='K';  M= -13,-225,  25,  35,-221,-216,   9, -57,  59,-128,-214,  10, -19,  -9,  40,  -6, -11, -85,  25,  -7;
/M: SY='L';  M=  47,  13, -37, -49, -16, -32, -48,  -4,-218,  52,   2, -85, -44,-215,-220, -42, -15,  19,-224,-208;
/M: SY='L';  M= -43, -26,-231,-224,   7,-232,-217,  25, -33,  78,  33,-227,-229,-218,-220,-221,-210,   4,-217,   0;
/M: SY='L';  M= -74,  40,-225,-121, -88,-229,  -9,  -7,   8,  61,  26, -74,-226,-214, -10, -72, -18,  47,-226, -82;
/M: SY='A';  M=  65, -67, -69, -49,-215,  -6, -66,  -6, -59, -14,  15, -14, -46, -69,-123,  22,  27,   3,-227, -85;
/M: SY='L';  M=   4,  -4, -74, -73, -23,-227,   2,  25,-220,  70,  -4, -57,-227,-216, -41,-217, -44,  -9,  64, -34;
/M: SY='W';  M=   2,  56,-226,-147, -36, -45,  36,  13, -75,  24,  38,-218,-225,-216,-220, -23, -20,  45,  84, -42;
/M: SY='W';  M= -40,-226, -44, -50, -20,  15, -59,-219,  48, -26, -15, -78,-107,  47,  48,  -9,  -3,-113,  79,   8;
/I:         E1=0; IE=-380; DE=-380;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	425 in 103 different sequences
Number of true positive hits	425 in 103 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	8
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	REPEAT
Feature description [info]	Annexin
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

103 sequences

ANX10_DROME (P22465), ANX10_HUMAN (Q9UJ72), ANX10_MOUSE (Q9QZ10),

ANX11_BOVIN (P27214), ANX11_COLLI (P14950), ANX11_DROME (Q9VXG4), 
ANX11_HUMAN (P50995), ANX11_MOUSE (P97384), ANX11_RABIT (P33477), 
ANX12_COLLI (Q92040), ANX12_HYDVU (P26256), ANX13_CANLF (Q29471), 
ANX13_HUMAN (P27216), ANX13_MOUSE (Q99JG3), ANX13_SCHJA (C1L7Y4), 
ANX1_GOSHI  (P93157), ANX22_SCHMA (C4QH88), ANX2A_XENLA (P27006), 
ANX2B_XENLA (P24801), ANX4_FRAAN  (P51074), ANXA1_BOVIN (P46193), 
ANXA1_CAVCU (P14087), ANXA1_CHICK (Q92108), ANXA1_HORSE (Q8HZM6), 
ANXA1_HUMAN (P04083), ANXA1_MOUSE (P10107), ANXA1_PANTR (A5A6M2), 
ANXA1_PIG   (P19619), ANXA1_PONAB (Q5REL2), ANXA1_RABIT (P51662), 
ANXA1_RAT   (P07150), ANXA1_RODSP (P24551), ANXA2_BOVIN (P04272), 
ANXA2_CANLF (Q6TEQ7), ANXA2_CEREL (Q2Q1M6), ANXA2_CHICK (P17785), 
ANXA2_HUMAN (P07355), ANXA2_MESAU (C0HJG9), ANXA2_MOUSE (P07356), 
ANXA2_PIG   (P19620), ANXA2_PONAB (Q5R5A0), ANXA2_RAT   (Q07936), 
ANXA2_SHEEP (A2SW69), ANXA3_BOVIN (Q3SWX7), ANXA3_HUMAN (P12429), 
ANXA3_MOUSE (O35639), ANXA3_RAT   (P14669), ANXA4_BOVIN (P13214), 
ANXA4_CANLF (P50994), ANXA4_HUMAN (P09525), ANXA4_MOUSE (P97429), 
ANXA4_PIG   (P08132), ANXA4_RAT   (P55260), ANXA5_BOVIN (P81287), 
ANXA5_CHICK (P17153), ANXA5_CYNPY (P70075), ANXA5_HUMAN (P08758), 
ANXA5_MACFA (Q4R4H7), ANXA5_MOUSE (P48036), ANXA5_PANTR (Q5R1W0), 
ANXA5_RAT   (P14668), ANXA6_BOVIN (P79134), ANXA6_CHICK (P51901), 
ANXA6_HUMAN (P08133), ANXA6_MOUSE (P14824), ANXA6_RABIT (Q9TS53), 
ANXA6_RAT   (P48037), ANXA7_BOVIN (P20072), ANXA7_DICDI (P24639), 
ANXA7_HUMAN (P20073), ANXA7_MACFA (Q4R5L5), ANXA7_MOUSE (Q07076), 
ANXA7_XENLA (Q92125), ANXA8_BOVIN (Q95L54), ANXA8_HUMAN (P13928), 
ANXA8_MOUSE (O35640), ANXA8_PANTR (A5A6L7), ANXA8_RABIT (O97529), 
ANXA8_RAT   (Q4FZU6), ANXA9_BOVIN (Q3ZC08), ANXA9_HUMAN (O76027), 
ANXA9_MOUSE (Q9JHQ0), ANXB9_DROME (P22464), ANXC1_CRYNH (J9VS56), 
ANXD1_ARATH (Q9SYT0), ANXD2_ARATH (Q9XEE2), ANXD3_ARATH (Q9SE45), 
ANXD4_ARATH (Q9ZVJ6), ANXD5_ARATH (Q9C9X3), ANXD6_ARATH (Q9LX08), 
ANXD7_ARATH (Q9LX07), ANXD8_ARATH (Q94CK4), ANXE1_GIAIN (Q9NFS4), 
AXA2L_HUMAN (A6NMY6), AXA81_HUMAN (Q5VT79), GIA1_GIAIN  (P17063), 
GIA2_GIAIN  (P19389), GIA3_GIAIN  (Q4VPP7), GIA4_GIAIN  (Q4VPQ3), 
GIA5_GIAIN  (Q4VPQ4), GIA6_GIAIN  (Q4VPP5), GIA8_GIAIN  (Q4VPP9), 
GIA9_GIAIN  (Q4VPP0)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

108 PDB

pdb_00001a8a; pdb_00001a8b; pdb_00001aei; pdb_00001aii; pdb_00001ain; pdb_00001ala; pdb_00001ann; pdb_00001anw; pdb_00001anx; pdb_00001aow; pdb_00001avc; pdb_00001avh; pdb_00001avr; pdb_00001axn; pdb_00001bc0; pdb_00001bc1; pdb_00001bc3; pdb_00001bcw; pdb_00001bcy; pdb_00001bcz; pdb_00001bo9; pdb_00001dm5; pdb_00001g5n; pdb_00001hak; pdb_00001hm6; pdb_00001hvd; pdb_00001hve; pdb_00001hvf; pdb_00001hvg; pdb_00001i4a; pdb_00001m9i; pdb_00001mcx; pdb_00001n00; pdb_00001n41; pdb_00001n42; pdb_00001n44; pdb_00001sav; pdb_00001w3w; pdb_00001w45; pdb_00001w7b; pdb_00001xjl; pdb_00001ycn; pdb_00001yii; pdb_00001yj0; pdb_00002h0k; pdb_00002h0l; pdb_00002h0m; pdb_00002hyu; pdb_00002hyv; pdb_00002hyw; pdb_00002ie6; pdb_00002ie7; pdb_00002q4c; pdb_00002ran; pdb_00002xo2; pdb_00002xo3; pdb_00002zhi; pdb_00002zhj; pdb_00002zoc; pdb_00003brx; pdb_00003chj; pdb_00003chk; pdb_00003chl; pdb_00004evf; pdb_00004evh; pdb_00004hre; pdb_00004mdu; pdb_00004mdv; pdb_00004x9p; pdb_00005lpu; pdb_00005lpx; pdb_00005lq0; pdb_00005lq2; pdb_00005n7d; pdb_00005n7f; pdb_00005n7g; pdb_00006b3i; pdb_00006k22; pdb_00006k25; pdb_00006twq; pdb_00006twu; pdb_00006twx; pdb_00006twy; pdb_00007dto; pdb_00007eq7; pdb_00007nmi; pdb_00007p70; pdb_00007p71; pdb_00007p72; pdb_00007p73; pdb_00007p74; pdb_00007pc3; pdb_00007pc4; pdb_00007pc5; pdb_00007pc7; pdb_00007pc8; pdb_00007pc9; pdb_00007pcb; pdb_00007qql; pdb_00007qqm; pdb_00007qqn; pdb_00007zvn; pdb_00007zvx; pdb_00008ael; pdb_00008gyc; pdb_00008h0j; pdb_00008h9z; pdb_00008w5s
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