PROSITE entry PS51985
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General information about the entry
| Entry name [info] | CPB2 |
| Accession [info] | PS51985 |
| Entry type [info] | MATRIX |
| Date [info] |
23-FEB-2022 CREATED;
23-FEB-2022 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC51984 |
| Associated ProRule [info] | PRU01329 |
Name and characterization of the entry
| Description [info] | Cryptic Polo-Box 2 (CPB2) domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=115; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=110; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.3278432; R2=0.0079868; TEXT='-LogE'; /CUT_OFF: LEVEL=0; SCORE=1086; N_SCORE=11.0; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=523; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-24; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-380; BD=-380; /M: SY='T'; M= -52, -62, -57, -61, -68, -29, -67, -60, -57, -64, -60, -12, -60, -61, -66, -22, 112, -52, -88, -66; /M: SY='P'; M= -1, -85, -67, -57, -80, -67, -70, -31, -63, -32, -65, -71, 119, -66, -74, -60, -3, -70, -79, -79; /M: SY='K'; M= -63, -77, -56, -42, -78, -70, -58, -35, 104, -75, -64, -49, -64, 8, 11, -57, -34, -72, -72, -65; /M: SY='V'; M= -31, -70, -82, -77, -21, -84, -5, 59, -75, 9, -40, -75, -77, -74, -76, -67, -21, 77, -80, -57; /M: SY='T'; M= -54, -65, -65, -66, -61, -73, -73, 34, -63, -53, -24, -55, -64, -66, -70, -44, 98, 26, 21, -62; /M: SY='Y'; M= -40, -73, -80, -76, 54, -82, -59, 11, -72, 53, 26, -77, -82, -33, -49, -71, -63, -12, -51, 74; /M: SY='Y'; M= -19, -79, -71, -72, 33, -76, 32, -40, -66, -32, -50, -69, -81, -62, -64, -64, -27, -60, 4, 122; /M: SY='T'; M= -29, -64, -56, -32, -71, -36, -62, -30, -56, -69, -64, 5, -16, -7, -63, 67, 83, -57, -85, -66; /M: SY='D'; M= -13, -76, 57, 32, -79, -65, -57, -74, 22, -76, -69, 11, 37, 24, 11, 8, 8, -31, -13, -69; /M: SY='Q'; M= -46, -77, 4, 6, -20, -13, 31, -29, 40, 4, -56, -21, -69, 57, 29, -40, -18, -33, -71, 21; /M: SY='A'; M= 84, 10, -67, -62, -74, 14, -68, -66, -62, -41, -62, -59, -67, -59, -21, 18, -39, -38, -77, -71; /M: SY='K'; M= -48, -77, -56, -42, -78, -70, -58, -78, 104, -58, -65, -49, -64, -6, 19, -56, -22, -73, -73, -65; /M: SY='C'; M= -43, 142, -78, -79, 18, -26, -78, -28, -75, -64, -65, -38, -87, -81, -80, -23, -28, -32, -88, -70; /M: SY='M'; M= -47, -3, -70, -64, -12, -52, 31, 25, -63, 14, 86, -18, -72, 44, -63, -7, 20, -6, -73, 2; /M: SY='L'; M= -67, -70, -84, -76, 14, -85, -67, -34, -77, 83, 30, -82, -22, -71, -74, -76, -63, -17, -67, -10; /M: SY='M'; M= -61, -69, -82, -72, -26, -75, -54, -37, -66, -11, 140, -69, -39, -58, -64, -27, -39, -44, -71, 0; /M: SY='E'; M= -18, -79, 3, 103, -83, -50, -20, -83, -43, -76, -72, -55, -57, -19, -19, -10, -59, -75, -81, -72; /M: SY='N'; M= -59, -68, 9, -54, -76, -53, -17, -75, -17, -81, -69, 111, -70, -50, -33, 20, 17, -74, -93, -70; /I: I=-26; MD=-67; /M: SY='G'; M= -16, -84, -12, 21, -37, 41, -75, -63, -69, -68, -50, -28, -15, -47, -29, 32, -17, -22, -90, -80; D=-26; /I: I=-26; MI=0; MD=-67; IM=0; DM=-67; /M: SY='P'; M= -31,-106, -83, -73,-103, -84, -86, -91, -79,-101, -87, -26, 105, -38, -91, -79, -76, -95, -97, -99; D=-26; /I: I=-26; DM=-67; /M: SY='P'; M= -52, -82, 18, -28, -71, -25, 19, 8, -27, 16, 23, 35, 38, 19, -49, -26, -44, -41, -87, -69; D=-26; /I: I=-26; DM=-67; /M: SY='P'; M= 46, -75, -11, 7, -79, 19, -9, -71, -27, -74, -16, -23, 80, -31, -47, -14, -27, -34, -79, -73; /M: SY='D'; M= -45, -24, 107, -21, -85, -62, -52, -83, -52, -83, -79, 41, -68, -53, -10, -17, -29, -80, -99, -70; /M: SY='F'; M= -44, 42, -83, -79, 97, -80, -25, 7, -76, 4, -48, -74, -83, -79, -74, -27, -63, 4, -50, 37; /M: SY='E'; M= -24, -77, -13, 99, -76, -74, -57, -27, -26, -33, -25, -58, -59, -39, -54, -11, -42, -8, -80, -70; /M: SY='V'; M= 47, -7, -75, -70, 2, -48, -71, 14, -68, -19, 49, -67, -72, -67, -71, -23, 15, 53, -75, -5; /M: SY='C'; M= -48, 68, -21, 14, -6, -47, 57, 4, 4, -20, -2, -2, -71, 3, -39, 22, -7, 0, 17, -2; /M: SY='F'; M= -44, -71, -84, -80, 114, -81, -66, -18, -76, -7, -14, -22, -84, -43, -74, -72, -66, -52, -44, -2; /M: SY='Y'; M= -57, -79, -66, -8, -3, -75, 44, -58, -62, -12, -51, -66, -28, -31, -29, -3, -62, -45, -38, 117; /M: SY='N'; M= -4, -8, 66, -4, -78, -58, 33, -77, -28, -78, -71, 67, -18, -32, -59, 40, 5, -73, -91, -67; /I: I=-45; MD=-115; /M: SY='G'; M= -27, -77, 19, -65, -79, 87, -27, -81, -37, -16, -69, -30, -26, 7, -71, -27, -65, -78, -77, -73; D=-45; /I: I=-45; MI=-115; IM=-115; DM=-115; /M: SY='G'; M= 31, -36, -64, -23, -68, 34, -31, -1, -14, -33, -5, -29, 7, -20, -9, 15, 26, 5, 3, -35; /M: SY='K'; M= -47, -12, -10, -3, -73, -49, -31, -46, 86, -35, -63, -34, -2, -45, 19, 0, -3, -36, -75, -26; /M: SY='I'; M= 3, -40, -72, 4, 15, -77, -12, 56, -27, -13, -6, -69, -48, -63, 10, -13, -56, 45, -72, -7; /M: SY='H'; M= -22, -71, -61, -15, -63, -26, 75, 28, -11, -12, -51, -6, -68, 4, -44, 16, 40, 24, -83, -57; /M: SY='K'; M= -38, -43, -62, -21, 0, -71, 12, -9, 51, 3, -15, -7, -70, 41, 40, 1, -26, -17, 29, -27; /M: SY='S'; M= -23, 19, -43, -31, -27, -20, -28, 1, 4, -19, -7, 27, -68, -22, -25, 53, 44, 2, -81, -63; /I: I=-14; MD=-35; /M: SY='S'; M= -19, 16, -60, -82, -55, -15, -89, -79, -4, -35, -81, -79, 2, -26, -34, 18, -13, 2, 17, -85; D=-14; /I: I=-14; MI=0; MD=-35; IM=0; DM=-35; /M: SY='S'; M= -10, -71, 36, 4, -75, -5, -58, -68, 19, -60, -28, 29, -27, -2, 13, 38, 33, -11, -83, -68; /M: SY='E'; M= -34, -16, 29, 45, -72, 40, -60, -69, -5, -11, -64, 9, -66, -23, -17, 26, -18, -12, -79, -25; /M: SY='G'; M= -38, -7, -27, -16, 11, 38, -10, -2, 7, -16, 19, -37, -6, -8, 0, 31, 5, -9, -75, -60; /M: SY='I'; M= -28, -17, -76, -69, -22, -58, -72, 61, -18, 17, 13, -42, -75, 28, -68, -64, -3, 47, -74, -8; /M: SY='K'; M= -62, -45, -38, 9, -74, -72, -57, -31, 62, -27, -61, -53, -34, 49, 61, -22, 12, -39, 8, -63; /M: SY='I'; M= -6, -71, -79, -75, -31, -79, -75, 69, -73, 24, 13, -24, -12, -40, -75, -31, -27, 45, -75, -16; /M: SY='T'; M= -43, -11, -43, -66, 2, -73, -67, 40, -23, -17, 10, -33, -70, -63, 7, 15, 60, 24, -74, 13; /M: SY='D'; M= -37, -76, 61, 59, -74, -69, -55, -25, -49, -36, 5, 8, -19, 36, -5, -17, 19, -44, -82, -14; /M: SY='K'; M= -25, -76, 20, -10, -77, -20, -23, -34, 47, -73, -25, -13, 37, 35, 22, 33, -6, -32, -79, -67; /M: SY='S'; M= -18, -7, 40, -21, -45, 0, 23, -72, 10, -32, -66, 34, -34, -4, -1, 46, 23, -48, -84, -65; /M: SY='G'; M= -20, -76, 19, -39, -42, 81, -67, -11, 4, -61, -68, -19, -26, -61, -7, -27, -63, -30, -76, -71; /M: SY='K'; M= -18, 5, -3, -11, -70, -9, 6, 9, 49, -15, -58, -11, -32, 29, 15, 14, 4, -16, -78, -64; /M: SY='S'; M= -26, 8, -40, -14, -38, -17, -66, 6, -21, 10, -53, -13, -4, 4, -43, 49, 34, 22, -80, -64; /M: SY='Y'; M= -44, -73, 4, 14, 27, -54, 23, -8, -28, 11, -21, -15, -72, -12, -31, -5, 26, -4, 15, 62; /M: SY='T'; M= -54, -8, -2, -40, -5, -26, -62, -17, 2, -5, -19, -8, -31, -4, -8, 49, 53, -3, -77, -7; /M: SY='L'; M= -22, 29, -9, -17, 0, -19, -65, -8, -23, 43, -29, -7, -43, -61, 14, -5, 22, 3, -74, -10; /M: SY='P'; M= -31, -75, 30, 31, -15, -29, -7, -70, 26, -35, -42, 1, 33, 27, -3, 30, -1, -29, -78, -34; /I: I=-6; MD=-14; /M: SY='H'; M= 20, -30, -16, -8, -13, 20, 23, -67, -33, -21, -1, -45, -1, 2, -46, 23, 0, -15, -77, 9; D=-6; /I: I=-6; MD=-14; /M: SY='E'; M= -28, -36, 10, 33, -78, -35, -69, -49, 14, -35, -43, -19, 11, -33, -64, 27, 20, 5, -88, -39; D=-6; /I: I=-6; MD=-14; /M: SY='S'; M= -16, 5, -73, -1, -28, 11, -5, -27, -25, -23, -14, 3, -4, -9, -46, 14, -18, -20, -92, -77; D=-6; /I: I=-6; MI=0; MD=-14; IM=0; DM=-14; /M: SY='E'; M= -39, -93, 7, 36, -88, -18, -48, -7, -73, -18, -14, -12, -23, -40, -34, 4, -28, -50, -99, -85; D=-6; /I: I=-6; DM=-14; /M: SY='M'; M= -1, 12, -33, -19, -73, -48, 5, -2, -59, 2, 12, -48, 11, -39, -18, 2, -17, 2, 12, -44; D=-6; /I: I=-6; DM=-14; /M: SY='Q'; M= -2, -83, 23, -9, -17, -30, -22, -31, -47, -39, 0, 20, -29, 30, 7, 22, -30, -74, -87, -25; D=-6; /I: I=-6; DM=-14; /M: SY='S'; M= 6, 3, -15, -18, -42, -2, 11, -28, 2, -41, -68, 6, -75, 15, -6, 33, 0, -32, -82, 3; D=-6; /I: I=-6; DM=-14; /M: SY='L'; M= -52, 5, -58, -78, 17, -65, -70, 25, -76, 60, 30, -25, -17, -73, -41, -74, -25, -16, -70, 11; D=-6; /I: I=-6; DM=-14; /M: SY='P'; M= -34, -15, 21, -54, -33, -39, -1, -74, 7, -55, -68, 9, 66, -36, -25, 59, -1, -71, 13, -14; D=-6; /I: I=-6; DM=-14; /M: SY='P'; M= -5, -75, 6, 43, -48, 1, -4, -71, -9, -47, -67, 5, 55, -14, -24, 34, 1, -24, -81, -70; /M: SY='D'; M= -9, -76, 56, 54, -26, -39, 46, -9, -39, -35, -64, 0, -4, -12, -60, -1, 5, -33, -83, -32; /M: SY='M'; M= 5, -22, -4, 26, -5, -71, -25, 6, -62, 29, 33, -4, -5, -18, -66, 6, 3, 1, -74, 2; /M: SY='R'; M= -22, -34, 4, 3, -73, -38, -6, -17, 47, -42, -61, -8, -68, 57, 58, -30, -17, -41, -75, -9; /M: SY='D'; M= -29, -18, 41, 25, -32, -29, -12, -11, -10, -13, 19, 17, 16, 9, -9, 21, -16, -13, -25, -13; /M: SY='M'; M= -17, -12, -74, -51, -46, -42, 22, 9, -34, 43, 68, -47, -28, -15, 5, -38, -61, -12, -5, 52; /M: SY='W'; M= -46, -11, -38, -45, -5, -77, -68, 21, -7, 27, 46, -74, -28, -4, -66, -42, -46, 6, 111, 42; /M: SY='Q'; M= -4, -78, 50, 38, -80, -66, -1, -56, 31, -75, -67, 10, -7, 63, 19, -27, -27, -73, -80, -31; /M: SY='H'; M= -67, -31, -36, -20, -18, -72, 122, -53, -10, 2, -52, -15, -72, -23, -25, -27, -15, -70, -74, 52; /M: SY='A'; M= 49, -28, -71, -66, 46, -19, -1, -29, -47, 9, -27, -65, -27, -3, -67, -7, -3, 7, -63, 34; /M: SY='Q'; M= -39, -4, -11, 25, -24, -67, 27, -2, 27, -30, 19, 41, -68, 42, 12, 8, -21, -32, -76, 0; /M: SY='E'; M= -34, -79, 10, 77, -77, -40, -55, -77, 32, -40, -66, -53, -61, 58, -24, -21, -2, -73, 22, -23; /M: SY='C'; M= -3, 120, -39, -31, -15, -15, -70, -46, -66, -16, -31, -30, -79, -12, -19, -3, 0, -7, 17, -11; /M: SY='H'; M= -36, -75, -33, -34, 25, -75, 70, -54, 3, 35, 20, -62, -38, -20, 25, -20, -62, -47, -61, 61; /M: SY='Q'; M= -33, -77, -3, 29, -77, -38, 40, -74, 16, -53, -30, 2, 4, 58, 45, 18, 4, -48, -80, -63; /M: SY='H'; M= -26, -78, -37, -15, -38, -71, 104, 12, -14, -33, -24, -52, -28, 46, 31, -19, 4, -50, -80, -2; /M: SY='C'; M= -46, 141, -74, -30, -3, -74, -12, -48, -45, -39, -65, -33, -41, -76, -77, -3, -36, -42, -91, -72; /M: SY='L'; M= -38, 9, -40, 4, -30, -60, -39, 3, 5, 60, -14, -45, -37, -7, 18, -46, -39, -4, 1, -57; /M: SY='A'; M= 36, -21, 28, 6, -71, -37, -35, -68, 3, -4, -10, 9, -33, 31, 23, 25, -23, -64, -78, -28; /M: SY='L'; M= -27, -72, -43, -31, -15, -48, -10, 53, -71, 53, 0, -75, -16, -68, -27, -70, -60, 24, -71, 4; /M: SY='E'; M= -21, 45, 25, 90, -52, -72, 13, -49, -27, -48, -69, -55, -14, -26, -29, -8, -58, -47, -83, -69; /M: SY='S'; M= 17, -70, -12, 19, -74, -42, -57, -68, 19, -27, -63, 34, -66, 15, 27, 52, -9, -24, -80, -67; /M: SY='A'; M= 53, -39, -25, -27, -65, -62, -24, 3, -62, 5, 15, -14, -33, 2, -66, 20, 33, 8, -79, -64; /M: SY='L'; M= -22, -71, -35, -5, -50, -20, -69, 43, -69, 59, 26, -28, -75, -40, -43, -27, -11, -1, -75, -58; /M: SY='S'; M= 6, -8, -33, 41, -24, -8, -60, -65, 0, -14, -28, 8, -33, -4, -4, 50, 9, -18, -79, -65; /M: SY='S'; M= 23, -5, 0, 2, -38, -50, -8, -51, 5, 6, -27, -9, -34, 12, 21, 42, -2, -16, -19, -63; /M: SY='L'; M= 6, -71, 5, 9, -18, -19, -64, 22, -62, 35, 13, -25, -70, 9, -24, 3, 23, -12, -76, -34; /M: SY='E'; M= 22, -1, -1, 60, -46, -15, -30, -71, -16, -41, -19, 9, 15, 21, -38, 22, -8, -40, -80, -69; /M: SY='T'; M= -11, -37, 0, 25, -72, -9, 29, -51, -8, -45, -64, 17, 23, 14, 8, 29, 38, -38, -80, -16; /M: SY='C'; M= -2, 33, -3, 23, -26, -12, -61, -34, 11, -23, -62, 27, 0, 12, 4, 18, 23, -20, 12, -65; /I: I=-17; MD=-44; /M: SY='W'; M= -15, -19, -33, 8, -27, 24, -29, -25, -34, -37, -4, 26, 11, -59, -5, 27, 22, -18, 31, -9; D=-17; /I: I=-17; MD=-44; /M: SY='P'; M= -41, -80, -14, 14, -81, 11, -15, -74, -9, -44, -30, 24, 37, -27, -6, 27, 11, -15, -88, -75; D=-17; /I: I=-17; MD=-44; /M: SY='C'; M= -7, 37, 10, -24, -81, 6, 26, -49, -12, -32, -73, -14, 7, -14, -52, 11, -32, -27, -91, -10; D=-17; /I: I=-17; MD=-44; /M: SY='S'; M= -25, -98, 2, -83, -36, -22, -27, -4, -27, -33, -20, -40, -26, -81, 0, 12, -26, -81,-103, -87; D=-17; /I: I=-17; MI=0; MD=-44; IM=0; DM=-44; /M: SY='S'; M= -47, -50, -47, -31, -90, -38, -45, -43, -5, -55, -80, -34, 48, 2, -22, 51, -1, -81, -94, -83; D=-17; /I: I=-17; DM=-44; /M: SY='C'; M= -29, 83, -81, -78, 22, -80, -32, -8, -77, -4, -2, -74, 10, -20, -79, 15, -20, 1, -77, 24; D=-17; /I: I=-17; DM=-44; /M: SY='F'; M= -53, -70, -34, -76, 108, -78, -65, -51, -73, -33, -52, -69, -29, -79, -73, -12, 23, -27, -47, 23; /M: SY='P'; M= -11, -87, 0, -54, -82, -66, -67, -72, -62, -81, -70, -33, 119, -64, -73, -28, -40, -58, -79, -34; /M: SY='I'; M= 29, 3, -33, -35, -38, -74, -73, 53, -51, 15, 2, -34, -37, -67, -28, -33, -38, 46, -77, -29; /M: SY='I'; M= -35, -72, -71, -17, -30, -37, -74, 75, -67, -34, -14, -42, -70, -30, -33, 11, 37, 30, -77, -30; /M: SY='I'; M= -42, -18, -81, -76, -7, -82, -76, 68, -38, 21, 9, -74, -76, -35, -74, -10, -56, 54, -74, -9; /M: SY='G'; M= -27, -18, -23, -67, -80, 87, -9, -82, -9, -58, -71, -24, 9, -24, -69, 10, -62, -46, -76, -74; /M: SY='R'; M= -63, -79, -22, -22, -72, -73, -21, -42, 27, -70, -3, -32, -72, -43, 97, -4, -7, -31, -15, -28; /M: SY='R'; M= -35, -78, -13, -33, -28, -41, -10, -47, 46, -31, -62, -54, -41, -19, 87, -4, -29, -70, -72, 4; /M: SY='P'; M= -63, -84, -64, -56, -44, -46, 12, -43, -6, -25, -65, -17, 109, -38, 2, 3, -30, -72, -79, -72; /M: SY='S'; M= 11, -21, 14, -40, -73, -15, 4, -2, -9, -59, -62, 39, 27, 1, -19, 39, 26, -7, -83, -67; /M: SY='S'; M= 14, -28, -9, -28, -71, -6, -4, -3, 12, -53, -24, 5, 31, 20, 8, 35, -1, -2, -78, -19; /M: SY='P'; M= 17, -2, -11, -31, -38, -16, 26, -8, -24, -18, -32, 19, 32, 22, -41, 30, 23, -2, -81, -64; /M: SY='M'; M= 10, -40, -5, 3, -67, -4, -36, -16, 7, -7, 32, 4, -13, -14, 1, 25, 24, 8, -80, -65; /M: SY='S'; M= -5, -70, 0, -25, -26, -16, 28, 6, -21, -24, -25, 29, -3, 3, -23, 54, 23, -26, -81, -62; /M: SY='P'; M= -23, -29, -6, -3, -17, -4, -31, -28, 0, -21, -26, 16, 50, 19, 8, 30, 18, -19, -79, -65; /I: E1=0; IE=-380; DE=-380;» more |
Numerical results [info]
| Total number of hits | 23 in 23 different sequences |
| Number of true positive hits | 23 in 23 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Feature key [info] | DOMAIN |
| Feature description [info] | Cryptic POLO box 2 (CPB2) |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
23 sequences
PLK4_AEDAE (Q16W24), PLK4_BOVIN (A2VDZ4), PLK4_CULQU (B0WAU8), PLK4_DANRE (Q7ZVS3), PLK4_DROAN (B3M6I4), PLK4_DROER (B3NE99), PLK4_DROGR (B4J3F1), PLK4_DROME (O97143), PLK4_DROMO (B4KYX8), PLK4_DROPE (B4HBU3), PLK4_DROPS (Q2LYK3), PLK4_DROSE (B4IAQ8), PLK4_DROSI (B4QK53), PLK4_DROVI (B4LDJ6), PLK4_DROWI (B4MXR8), PLK4_DROYA (B4PDM5), PLK4_HUMAN (O00444), PLK4_MOUSE (Q64702), PLK4_NEMVE (A7SNN5), PLK4_PONAB (Q5R9Z7), PLK4_RAT(B2GUY1), PLK4_XENLA (Q6PAD2), PLK4_XENTR (B3DL84)» more
|
| PDB [Detailed view] |
11 PDB
4G7N; 4N7V; 4N7Z; 4N9J; 4NK7; 6N45; 6N46; 6W38; 6W3I; 6W3J; 8XPG |