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PROSITE documentation PDOC00744 [for PROSITE entry PS00962]

Ribosomal protein S2 signatures


Ribosomal protein S2 is one of the proteins from the small ribosomal subunit. S2 belongs to a family of ribosomal proteins which, on the basis of sequence similarities [1,2], groups:

  • Eubacterial S2.
  • Algal and plant chloroplast S2.
  • Cyanelle S2.
  • Archaebacterial S2.
  • Higher eukaryotes P40 (previously thought to be a laminin receptor).
  • Yeast NAB1.
  • Plant mitochondrial S2.
  • Yeast mitochondrial MRP4.

S2 is a protein of 235 to 394 amino-acid residues. As signature patterns, we selected two conserved regions. One is located in the N-terminal section and the other in the central section.

Last update:

December 2004 / Pattern and text revised.

Technical section

PROSITE methods (with tools and information) covered by this documentation:

RIBOSOMAL_S2_1, PS00962; Ribosomal protein S2 signature 1  (PATTERN)

RIBOSOMAL_S2_2, PS00963; Ribosomal protein S2 signature 2  (PATTERN)


1AuthorsDavis S.C., Tzagoloff A., Ellis S.R.
TitleCharacterization of a yeast mitochondrial ribosomal protein structurally related to the mammalian 68-kDa high affinity laminin receptor.
SourceJ. Biol. Chem. 267:5508-5514(1992).
PubMed ID1531984

2AuthorsTohgo A., Takasawa S., Munakata H., Yonekura H., Hayashi N., Okamoto H.
TitleStructural determination and characterization of a 40 kDa protein isolated from rat 40 S ribosomal subunit.
SourceFEBS Lett. 340:133-138(1994).
PubMed ID8119397

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