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PROSITE entry PS01259


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PURL: https://purl.expasy.org/prosite/signature/PS01259

Direct ScanProsite submission
General information about the entry

Entry name [info] BH3
Accession [info] PS01259
Entry type [info] PATTERN
Date [info] 01-NOV-1997 CREATED;
01-JUL-1998 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00829

Name and characterization of the entry

Description [info] Apoptosis regulator, Bcl-2 family BH3 motif signature.
Pattern [info] 
[LIVAT]-x(3)-L-[KARQ]-x-[IVAL]-G-D-[DESG]-[LIMFV]-[DENSHQ]-[LVSHRQ]-
[NSR].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 30 in 30 different sequences
Number of true positive hits 30 in 30 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 38
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 44.12 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 30 sequences 

B2CL1_CHICK (Q07816), B2CL1_HUMAN (Q07817), B2CL1_MOUSE (Q64373), 

B2CL1_PIG   (O77737), B2CL1_RAT   (P53563), BAK_HUMAN   (Q16611), 
BAK_MOUSE   (O08734), BAX_BOVIN   (O02703), BAX_HUMAN   (Q07812), 
BAX_MOUSE   (Q07813), BAX_RAT (Q63690), BCL2_BOVIN  (O02718), 
BCL2_CANLF  (Q6R755), BCL2_CHICK  (Q00709), BCL2_CRIGR  (Q9JJV8), 
BCL2_HUMAN  (P10415), BCL2_MOUSE  (P10417), BCL2_RAT(P49950), 
BID_HUMAN   (P55957), BID_MOUSE   (P70444), BID_RAT (Q9JLT6), 
BIK_HUMAN   (Q13323), HRK_HUMAN   (O00198), HRK_MOUSE   (P62816), 
HRK_RAT (P62817), MCL1_CANLF  (Q8HYS5), MCL1_FELCA  (Q7YRZ9), 
MCL1_HUMAN  (Q07820), MCL1_MOUSE  (P97287), MCL1_RAT(Q9Z1P3)
» more

UniProtKB/Swiss-Prot
False negative sequences		 38 sequences 

APR_CANLF   (Q1PCT2), APR_HUMAN   (Q13794), APR_MOUSE   (Q9JM54), 

APR_RAT (Q5U777), B2L11_HUMAN (O43521), B2L11_MOUSE (O54918), 
B2L11_RAT   (O88498), B2L13_HUMAN (Q9BXK5), B2L13_MOUSE (P59017), 
B2L14_BOVIN (Q5E9L4), B2L14_HUMAN (Q9BZR8), B2L14_MOUSE (Q9CPT0), 
B2L14_RAT   (Q6AYK4), BAD_HUMAN   (Q92934), BAD_MOUSE   (Q61337), 
BAD_RAT (O35147), BBC3_HUMAN  (Q9BXH1), BBC3_MOUSE  (Q99ML1), 
BBC3_RAT(Q80ZG6), BID_CHICK   (Q8JGM8), BID_PIG (Q4JHS0), 
BMF_HUMAN   (Q96LC9), BMF_MOUSE   (Q91ZE9), BMF_RAT (Q8K589), 
BNI3L_BOVIN (Q3T013), BNI3L_HUMAN (O60238), BNI3L_MOUSE (Q9Z2F7), 
BNIP3_BOVIN (Q32KN2), BNIP3_HUMAN (Q12983), BNIP3_MOUSE (O55003), 
BOKA_DANRE  (Q6DC66), BOKB_DANRE  (Q7T381), BOK_CHICK   (Q9I8I2), 
BOK_HUMAN   (Q9UMX3), BOK_MOUSE   (O35425), BOK_RAT (Q792S6), 
BOP_HUMAN   (Q7L3V2), BOP_PONAB   (Q5R6M8)
» more

PDB
[Detailed view]		 372 PDB

pdb_00001af3; pdb_00001bxl; pdb_00001ddb; pdb_00001f16; pdb_00001g5j; pdb_00001g5m; pdb_00001gjh; pdb_00001lxl; pdb_00001maz; pdb_00001pq0; pdb_00001pq1; pdb_00001r2d; pdb_00001r2e; pdb_00001r2h; pdb_00001r2i; pdb_00001wsx; pdb_00001ysg; pdb_00001ysi; pdb_00001ysn; pdb_00001ysw; pdb_00001zy3; pdb_00002b48; pdb_00002bid; pdb_00002bzw; pdb_00002ims; pdb_00002imt; pdb_00002jby; pdb_00002jcn; pdb_00002jm6; pdb_00002k7w; pdb_00002kbw; pdb_00002l58; pdb_00002lp8; pdb_00002lpc; pdb_00002lr1; pdb_00002m03; pdb_00002m04; pdb_00002m5b; pdb_00002m5i; pdb_00002me8; pdb_00002me9; pdb_00002mej; pdb_00002mhs; pdb_00002nl9; pdb_00002nla; pdb_00002o1y; pdb_00002o21; pdb_00002o22; pdb_00002o2f; pdb_00002o2m; pdb_00002o2n; pdb_00002p1l; pdb_00002pon; pdb_00002pqk; pdb_00002roc; pdb_00002rod; pdb_00002voh; pdb_00002voi; pdb_00002w3l; pdb_00002xa0; pdb_00002xpx; pdb_00002yj1; pdb_00002yq6; pdb_00002yq7; pdb_00002yv6; pdb_00002yxj; pdb_00003cva; pdb_00003d7v; pdb_00003fdl; pdb_00003fdm; pdb_00003ihc; pdb_00003ihd; pdb_00003ihe; pdb_00003ihf; pdb_00003iig; pdb_00003iih; pdb_00003ilb; pdb_00003ilc; pdb_00003inq; pdb_00003io8; pdb_00003io9; pdb_00003kj0; pdb_00003kj1; pdb_00003kj2; pdb_00003kz0; pdb_00003mk8; pdb_00003pk1; pdb_00003pl7; pdb_00003qbr; pdb_00003qkd; pdb_00003r85; pdb_00003sp7; pdb_00003spf; pdb_00003wix; pdb_00003wiy; pdb_00003wiz; pdb_00003zk6; pdb_00003zln; pdb_00003zlo; pdb_00003zlr; pdb_00004a1u; pdb_00004a1w; pdb_00004aq3; pdb_00004bd2; pdb_00004bd6; pdb_00004bd7; pdb_00004bd8; pdb_00004bdu; pdb_00004bpi; pdb_00004bpj; pdb_00004bpk; pdb_00004c52; pdb_00004c5d; pdb_00004cin; pdb_00004d2l; pdb_00004ehr; pdb_00004g35; pdb_00004hnj; pdb_00004hw2; pdb_00004hw3; pdb_00004hw4; pdb_00004ieh; pdb_00004lvt; pdb_00004lxd; pdb_00004man; pdb_00004oq5; pdb_00004oq6; pdb_00004ppi; pdb_00004qnq; pdb_00004qve; pdb_00004qvf; pdb_00004qvx; pdb_00004s0o; pdb_00004tuh; pdb_00004u2u; pdb_00004u2v; pdb_00004uf1; pdb_00004uf2; pdb_00004wgi; pdb_00004wmr; pdb_00004wms; pdb_00004wmt; pdb_00004wmu; pdb_00004wmv; pdb_00004wmw; pdb_00004wmx; pdb_00004yj4; pdb_00004yk9; pdb_00004z9v; pdb_00004zbf; pdb_00004zbi; pdb_00004zeq; pdb_00004zie; pdb_00004zif; pdb_00004zig; pdb_00004zih; pdb_00004zii; pdb_00005agw; pdb_00005agx; pdb_00005ajj; pdb_00005ajk; pdb_00005b1z; pdb_00005c3f; pdb_00005c3g; pdb_00005c6h; pdb_00005fc4; pdb_00005fcg; pdb_00005fdo; pdb_00005fdr; pdb_00005fmi; pdb_00005fmj; pdb_00005fmk; pdb_00005iez; pdb_00005if4; pdb_00005jsb; pdb_00005jsn; pdb_00005ku9; pdb_00005lof; pdb_00005mes; pdb_00005mev; pdb_00005uum; pdb_00005vau; pdb_00005vax; pdb_00005vay; pdb_00005vkc; pdb_00005vwv; pdb_00005vww; pdb_00005vwx; pdb_00005vwy; pdb_00005vwz; pdb_00005vx0; pdb_00005vx1; pdb_00005vx2; pdb_00005vx3; pdb_00005w5x; pdb_00005w5z; pdb_00005w60; pdb_00005w61; pdb_00005w62; pdb_00005w89; pdb_00005w8f; pdb_00006b4l; pdb_00006b4u; pdb_00006bf2; pdb_00006bw2; pdb_00006bw8; pdb_00006dcn; pdb_00006dco; pdb_00006dm8; pdb_00006eb6; pdb_00006fs0; pdb_00006fs1; pdb_00006fs2; pdb_00006gl8; pdb_00006hjl; pdb_00006ijq; pdb_00006iwb; pdb_00006l8v; pdb_00006lhd; pdb_00006mbd; pdb_00006mbe; pdb_00006mcy; pdb_00006ne5; pdb_00006o0k; pdb_00006o0m; pdb_00006o4u; pdb_00006o6f; pdb_00006o6g; pdb_00006odh; pdb_00006oqb; pdb_00006oqc; pdb_00006oqd; pdb_00006oqn; pdb_00006ovc; pdb_00006p3p; pdb_00006qb3; pdb_00006qb4; pdb_00006qb6; pdb_00006qfc; pdb_00006qfi; pdb_00006qfm; pdb_00006qfq; pdb_00006qg8; pdb_00006qgd; pdb_00006qxj; pdb_00006qyk; pdb_00006qyl; pdb_00006qyn; pdb_00006qyo; pdb_00006qyp; pdb_00006qz5; pdb_00006qz6; pdb_00006qz7; pdb_00006qz8; pdb_00006qzb; pdb_00006rnu; pdb_00006st2; pdb_00006stj; pdb_00006trr; pdb_00006u63; pdb_00006u64; pdb_00006u65; pdb_00006u67; pdb_00006u6f; pdb_00006ua3; pdb_00006uab; pdb_00006ud2; pdb_00006udi; pdb_00006udt; pdb_00006udu; pdb_00006udv; pdb_00006udx; pdb_00006udy; pdb_00006uvc; pdb_00006uvd; pdb_00006uve; pdb_00006uvf; pdb_00006uvg; pdb_00006uvh; pdb_00006uxm; pdb_00006uxn; pdb_00006uxo; pdb_00006uxp; pdb_00006uxq; pdb_00006uxr; pdb_00006vbx; pdb_00006vwc; pdb_00006xy4; pdb_00006xy6; pdb_00006ybg; pdb_00006ybj; pdb_00006ybk; pdb_00006ybl; pdb_00006yli; pdb_00006zhc; pdb_00006zie; pdb_00007adt; pdb_00007ca4; pdb_00007jgv; pdb_00007jgw; pdb_00007k02; pdb_00007lh7; pdb_00007lhb; pdb_00007lk4; pdb_00007m5a; pdb_00007m5b; pdb_00007nb4; pdb_00007nb7; pdb_00007p0u; pdb_00007p33; pdb_00007qtw; pdb_00007wjh; pdb_00007xge; pdb_00007xgf; pdb_00007xgg; pdb_00007y8d; pdb_00007y90; pdb_00007y99; pdb_00007yaa; pdb_00008av9; pdb_00008czf; pdb_00008czg; pdb_00008czh; pdb_00008ekx; pdb_00008el0; pdb_00008el1; pdb_00008fy0; pdb_00008fy1; pdb_00008fy2; pdb_00008g1t; pdb_00008g3s; pdb_00008g3t; pdb_00008g3u; pdb_00008g3w; pdb_00008g3x; pdb_00008g3y; pdb_00008gsv; pdb_00008h7b; pdb_00008hll; pdb_00008hlm; pdb_00008hln; pdb_00008hog; pdb_00008htr; pdb_00008hts; pdb_00008igc; pdb_00008iqk; pdb_00008iql; pdb_00008iqm; pdb_00008ivb; pdb_00008qso; pdb_00008spe; pdb_00008spf; pdb_00008spz; pdb_00008srx; pdb_00008sry; pdb_00008svk; pdb_00008svy; pdb_00008t6f; pdb_00008u27; pdb_00008uky; pdb_00008vjp; pdb_00008vxm; pdb_00008vxn; pdb_00008wls; pdb_00008xp5; pdb_00008y1y; pdb_00008y1z; pdb_00008y20; pdb_00008zeb; pdb_00009aqz; pdb_00009bcg; pdb_00009ckn
» more