PROSITE documentation PDOC51224 [for PROSITE entry PS51224]MVP (vault) repeat profile
Vaults are large ribonucleoprotein particles, composed of three different proteins and one or more small vault RNA (vRNA) molecules packed into barrel-shaped assemblies that are found in all higher eukaryotes. Their main component is major vault protein (MVP) or lung resistance-related protein (LRP), which is implicated in resistance to cancer therapy and correlates with poor prognosis.
The N-terminal part of MVP contains ~8 copies of the vault repeat or MVP repeat in tandem. The MVP repeat is composed of ~53 amino acids and forms a structural part of the vault wall. The C-terminal part of MVP may be involved in oligomerization and be located in the vault cap, while the MVP repeats in the N-terminal part can be packed like staves in a barrel to form the vault wall. The 3D structure of the repeat forms a fold that consists of a three stranded (B) antiparallel β-sheet in a unique topology B2-B1-B3 and two loops (see <PDB:1Y7X>). MVP repeats can be interaction-mediating modules, as MVP repeats 3 and 4 bind vault poly(ADP-ribose) polymerase (VPARP/PARP-4) (see <PDOC51059>), which is one of the other vault proteins [1].
The profile we developed covers the entire MVP repeat.
Last update:July 2006 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Kozlov G. Vavelyuk O. Minailiuc O. Banville D. Gehring K. Ekiel I. |
| Title | Solution structure of a two-repeat fragment of major vault protein. | |
| Source | J. Mol. Biol. 356:444-452(2006). | |
| PubMed ID | 16373071 | |
| DOI | 10.1016/j.jmb.2005.11.064 |
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