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PROSITE documentation PDOC51358 [for PROSITE entry PS51358]

Nop domain profile





Description

The ~120-residue Nop domain is present in various pre-RNA processing ribonucleoproteins (RNP):

  • Eukaryotic Prp31, part of a tri-snRNP complex. It is involved in pre-mRNA splicing.
  • Eukaryotic Nucleolar proteins 56 and 58 (Nop56 and Nop58), components of box C/D small nucleolar ribonucleoprotein (snoRNP) particles.
  • Archaeal Nop5, an homolog of Nop56/Nop58.

The Nop domain is a RNP binding module, exhibiting RNA and protein binding surfaces. It is oval-shaped and exclusively α-helical (see <PDB:2OZB>) [1,2].

The profile we developed covers the entire Nop domain.

Last update:

June 2012 / First entry.

Technical section

PROSITE method (with tools and information) covered by this documentation:

NOP, PS51358; Nop domain profile  (MATRIX)


References

1AuthorsAittaleb M., Rashid R., Chen Q., Palmer J.R., Daniels C.J., Li H.
TitleStructure and function of archaeal box C/D sRNP core proteins.
SourceNat. Struct. Biol. 10:256-263(2003).
PubMed ID12598892
DOI10.1038/nsb905

2AuthorsLiu S., Li P., Dybkov O., Nottrott S., Hartmuth K., Luehrmann R., Carlomagno T., Wahl M.C.
TitleBinding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP.
SourceScience 316:115-120(2007).
PubMed ID17412961
DOI10.1126/science.1137924



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Miscellaneous

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